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Archives of pharmacal research : a publication of ... 19건

  1. [국내논문]   Optimization of Culture Conditions for Production of Pneumococcal Capsular Polysaccharide Type IV  

    Kim, S.N. (College of Pharmacy, Sungkyunkwan University ) , Min, K.K. (College of Pharmacy, Sungkyunkwan University ) , Choi, I.H. (College of Pharmacy, Sungkyunkwan University ) , Kim, S.W. (College of Pharmacy, Sungkyunkwan University ) , Pyo, S.N. (College of Pharmacy, Sungkyunkwan University ) , Rhee, D.K. (College of Pharmacy, Sungkyunkwan University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 173 - 177 , 1996 , 0253-6269 ,

    초록

    The Pneumococcus, Streptococcus pneumoniae, has an ample polysaccharide (PS) capsule that is highly antigenic and is the main virulence factor of the organism. The capsular PS is the source of PS vaccine. This investigation was undertaken to optimize the culture conditions for the production of capsular PS by type 4 pneumococcus. Among several culture media, brain heart infusion (BHI) and Casitone based medium were found to support luxuriant growth of pneumococcus type 4 at the same level. Therefore in this study, the Casitone based medium was used to study optimization of the culture condition because of BHI broth's high cost and complex nature. The phase of growth which accomodated maximum PS production was exponential phase. Concentrations of glucose greater than 0.8% did not enhance growth or PS production. Substitution of nitrogen sources with other resources or supplementation of various concentrations of metal ion (with the exception of calcium, copper, and magnesium ions) had adverse effects on growth and PS production. On the other hand, low level aeration and supplementation of 3 mg/l concentration of asparagine, phenylalanine, or threonine were beneficial for increased PS production. The synergistic effect of all the favorable conditions observed in pneumococcal growth assays provided a two-fold cumulative increase in capsular PS production.

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  2. [국내논문]   Effect of Copper Ion on Oxygen Damage in Superoxide Dismutase-Deficient Saccharomyces Cerevisiae  

    Lee, Jeong-Ki (College of Pharmacy, Yeungnam University ) , Kim, Ji-Myon (College of Pharmacy, Yeungnam University ) , Kim, Su-Won (College of Pharmacy, Yeungnam University ) , Nam, Doo-Hyun (College of Pharmacy, Yeungnam University ) , Yong, Chul-Soon (College of Pharmacy, Yeungnam University ) , Huh, Keun (College of Pharmacy, Yeungnam University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 178 - 182 , 1996 , 0253-6269 ,

    초록

    Using superoxide dismutase (SOD)-deficient mutants of Saccharomyces cerevisiae, the oxidative stresses induced by 0.1 mM of copper ion $(Cu^{++})$ was studied. In aerobic culture condition, yeasts lacking MnSOD (mitochondrial SOD) showed more significant growth retardation than CuZnSOD (cytoplasmic SOD)-deficient yeasts. However, not so big differences in growth pattern of those mutants compared withwild type were observed under anaerobic condition. It was found that, under aerobic condition, the supplementation of 0.1 mM copper ioh:(Cu") into culture medium caused the remarkable increase of CuZnSOD but not so significant change in MnSOD. It was also observed that catalase activities appeared to be relatively high in the presence of copper ion in spite of the remarkable reduction of glutathion peroxidase in CuZnSOD-deficient yeasts, but the slight increments of catalase and glutathion peroxidase were detected in MnSOD-deficient strains. It implies that the lack of cytoplasmic SOD could be compensated mainly by catalase. However, these phenomena resulted in the significantincrease of cellular lipid peroxides content in CuZnSOD-deficient yeasts and the slight increment of lipid peroxides in MNSOD-deficient cells. In anaerobic cultivation supplementing copper ion, the cellular enzyme activities of catalase and glutathion peroxidase in SOD-deficient yeasts were slightly increased without any significant changes of lipid peroxides in cell membrane. It suggests that a little amount of free radicals generated by copper ion under anaerobic condition could be sufficiently overcome by catalase as well as glutathion peroxidase.dase.

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  3. [국내논문]   A Study on Flow Properties of Semisolid Dosage Forms  

    Shon, Sung-Gil (College of Pharmacy, Pusan National University ) , Lee, Chi-Ho (College of Pharmacy, Pusan National University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 183 - 190 , 1996 , 0253-6269 ,

    초록

    There are a wide variety of semi-solid ointments used for healing the skin diseases, whose therapeutic and skin penetration abililties may greatly differ from one another depending on the compositions of ointment vehicles. A computer optimization technique was applied to obtain the optimum formula of o/w type ointment giving the in vitro maximum absorption rate through hairless rat skin membrane. Some of the formulations were selected to find out a relationship between skin penetration of ointment and its Theological characteristics. The experimental value of absorption rate obtained from the ointment by optimum formula agreed well with the theoretical value obtained from a polynomial regression analysis, Three kinds of ointments selected among 15 formulations were obtained with a concentric cylinder type rheometer (Model; Rheolab SM-HM Physica, Germany) at 20, 30, 40 and $50^{\circ}C$ for rheograms of rhelolgical properties of o/w type ointments. As the temperature was raised, all products showed a decrease in both shear stress and yield values. The higher skin penetration, the lower shear stress showed.

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  4. [국내논문]   Base Specificity for DNA Interstrand Cross-Linking Induced by Anticancer Agent Bizelesin  

    Lee, Chong-Soon (Department of Biochemistry, College of Natural Sciences, Yeungnam University ) , Myung, Pyung-Keun (Department of Pharmacy, College of Pharmacy, Chungnam National University ) , Gibson, Neil W. (Central Research Division, Pfizer Inc.)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 191 - 196 , 1996 , 0253-6269 ,

    초록

    Bizelesin is a promising novel anticancer agent which is known to alkylate N3 of adenine to induce DNA interstrand cross-links (ISC) with in $5^I-TAATTA\; and\; 5^I-TAAAAAA$ . We have investigated the base specificity for DNA ISC induced by bizelesin using oligomers containing the cross-linkable sequence $5^I-TAATTA\; and\; 5^I-TAAAAAA$ . in which "N" was either A, C, G, or T. An analysis of denaturing polyacrylamide gel showed that bizelesin is able to induce DNA ISC in the duplex oligomer containing sequences $5^I-TAATTA\; and\; 5^I-TAAAAAA$ . The formation of interstrand crosslinking did not occur in the sequences $5^I-TAATTA\; and\; 5^I-TAAAAAA$ . DNA strand cleavage assay to determine the cross-linking site within $5^I-TAATTA$ sequence showed that bizelesin alkylates guanine. These results demonstrate that bizelesin is able to induce DNA ISC at guanine but not at cytosine or thymine. In addition, guanine adducts have been found to be susceptible to DNA strand cleavage by exposure to hot piperidine. The extent of DNA strand cleavage, however, was not 100% efficient in either neutral pH buffer or hot piperidine.

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  5. [국내논문]   6-[(N-2,3-Dichlorophenyl)amino]-7-Chloro-5,8-Quinoline-dione Treatment of Candidiasis in Normal Mice  

    Ryu, Chung-Kyu (College of Pharmacy, Ewha Womans University ) , Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University ) , Lee, In-Kyung (College of Pharmacy, Ewha Womans University ) , Kim, Sung-Hee (College of Pharmacy, Ewha Womans University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 197 - 200 , 1996 , 0253-6269 ,

    초록

    6-[(N-2,3-Dichlorophenyl)aminol-7-chloro-5,8-quinolinedione (RCK1 1) was tested for in vivo antifungal activities in the treatment of systemic infection with Canclicla albicans in normal mice compared with ketoconazole. The therapeutic potential of RCK11 had been assessed by evaluating their activities (survival rates) against systemic infections in normal mice. $ED_{50}$ of intraperitoneally administered RCK11 was $0.10\pm0.01 mg/kg$ but that of ketoconazole had $8.00\pm0.73 mg/kg$ respectively. When RCK11 was administered intravenously at the $ED_{50}$ (0.10 mg/kg), the colony counts of Canoliola albicans in the liver after 7 days and 14 days were reduced as likely as ketoconazole at the $ED_{50}$ (8.00 mg/kg), and the better survival rates than ketoconazole were achieved after 14 days. The results suggest that RCK11 may be a potent antifungal agent.

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  6. [국내논문]   Vasoactive Intestinal Peptide (VIP)-induced Enzyme Secretion in Rat Pancreatic Tissue is not associated with Activation of Nitric Oxide Synthase(NOS) and Increase in Cyclic GMP Level  

    Nam, Tae-Kyun (College of Pharmacy, Sungkyunkwan University ) , Han, Jeung-Whan (College of Pharmacy, Sungkyunkwan University ) , Nam, Suk-Woo (College of Pharmacy, Sungkyunkwan University ) , Seo, Dong-Wan (College of Pharmacy, Sungkyunkwan University ) , Lee, Young-Jin (College of Pharmacy, Sungkyunkwan University ) , Ko, Young-Kwon (College of Pharmacy, Sungkyunkwan University ) , Lee, Hyang-Woo (College of Pharmacy, Sungkyunkwan University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 201 - 206 , 1996 , 0253-6269 ,

    초록

    Nitric oxide (NO) is thought to be a second messenger involved in secretion. Upon stimulating pancreatic acinar cells with cholecystokinin-pancreozymin (CCK-PZ), NO formation has been shown to be associated with increased levels of cGMP (Seo et al., 1995). To elucidate the signaling pathway of VIP-induced enzyme secretion, we investigated the NO and cGMP synthesis steps as potential steps where two signal pathways triggered by CCK-PZ and VIP interact. The results obtained in this work provide evidence that increase in pancreatic enzyme secretion by treatment with VIP has no relationship with NOS activity and cGMP level. This conclusion was derived from the following findings that VIP treatment of rat pancreatic tissue increased amylase release as well as protein output in a dose- and time-dependent manner, whereas NOS activity and cGMP synthesis were not affected by VIP treatment as monitored by NOS activity assay and determining cGMP level, which was further confirmed by a NOS-inhibitor study. Consequently, CCK-PZ or VIP increases enzyme secretion in rat pancreatic tissue, but the two hormones are different in their mode of action. Together the results suggest that signaling pathway of VIP-induced enzyme secretion might either bypass the NO and cGMP synthesis steps or lie on a distinct pathway from CCK-PZ-induced pathway.

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  7. [국내논문]   Antitumor Components of Agrocybe cylindracea  

    Hyun, Jin-won (College of Pharmacy, Seoul National University ) , Kim, Chae-Kyun (College of Pharmacy, Seoul National University ) , Park, Seol-Hee (College of Pharmacy, Seoul National University ) , Yoon, Jong-Myung (College of Pharmacy, Seoul National University ) , Shim, Mi-Ja (Seoul City University ) , Kang, Chary-Yuil (College of Pharmacy, Seoul National University ) , Choi, Eung-Chil (College of Pharmacy, Seoul National University ) , Kim, Byong-Kak (College of Pharmacy, Seoul National University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 207 - 212 , 1996 , 0253-6269 ,

    초록

    To find pharmacologically active components of Agrocybe cylin(Iracea, its basidiocarps were extracted with water. The extracts were separated by DEAE cellulose column chromatography, Sepharose CL-4B gel filtration, and Concanavalin A-Sepharose 4B affinity chromatography. Among the obtained fractions from A, cylinclracea, fraction IN which was the neutral proteinbound-polysaccharide fraction exhibited a marked antitumor activity and it was tentatively named "Cylindan". It showed about 70% of tumor inhibition against the solid form of sarcoma 180 when a dose of 30 mg/kg/day was intraperitoneally injected into ICR mice. When each fraction was examined by chemical analysis, Cylindan consisted of 85% polysaccharide, 3% protein and 1% hexosamine. Its polysaccharide moiety contained glucose, mannose, fucose and galactose and its protein moiety contained the comparatively large amounts of aspartic acid and glycine, and other 11 amino acids.

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  8. [국내논문]   Effects of Ginseng Saponin on Modulation of Multidrug Resistance  

    Park, Jong-Dae (Korea GinsengandTobacco Research Institute ) , Kim, Dong-Sun (Korea GinsengandTobacco Research Institute ) , Kwon, Hyeok-Young (College of Pharmacy, Sung Kyun Kwan University ) , Son, Sang-Kwon (College of Pharmacy, Sung Kyun Kwan University ) , Lee, You-Hui (Korea GinsengandTobacco Research Institute ) , Baek, Nam-In (Korea GinsengandTobacco Research Institute ) , Kim, Shin-Il (Korea GinsengandTobacco Research Institute ) , Lee, Dong-Kwon (College of Pharmacy, Sung Kyun Kwan University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 213 - 218 , 1996 , 0253-6269 ,

    초록

    Multidrug resistance (MDR) has been a major problem in cancer chemotherapy. To overcome this problem, we prepared minor ginsenosides stereoselectively from ginseng saponins and searched for a ginseng component which is effective for inhibition of MDR. MDR inhibition activity was determined by measuring cytotoxicity to MDR cells using multidrug resistant human fibrocarcinoma KB V20C, which is resistant to 20 nM vincristine and expresses high level of mdr1 gene. Of several ginseng components, 20(S)-ginsenoside Rg_3$ , a red ginseng saponin, was found to have the most potent inhibitory activity on MDR and it's concentration capable of inhibiting 50% growth was $82\muM$ .

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  9. [국내논문]   Elicitor-induced phenylalanine-ammonia lyase, cinnamic acid 4-hydroxylase andp-coumaroyl transferase activity inEphedra distachya cultures  

    Song, Kyung-Sik , Ebizuka, Yutaka
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 219 - 222 , 1996 , 0253-6269 ,

    초록

    Multidrug resistance (MDR) has been a major problem in cancer chemotherapy. To overcome this problem, we prepared minor ginsenosides stereoselectively from ginseng saponins and searched for a ginseng component which is effective for inhibition of MDR. MDR inhibition activity was determined by measuring cytotoxicity to MDR cells using multidrug resistant human fibrocarcinoma KB V20C, which is resistant to 20 nM vincristine and expresses high level of mdr1 gene. Of several ginseng components, 20(S)-ginsenoside Rg_3$ , a red ginseng saponin, was found to have the most potent inhibitory activity on MDR and it's concentration capable of inhibiting 50% growth was $82\muM$ .

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  10. [국내논문]   The Antioxidant Activity of Ecklonia stolonifera   피인용횟수: 2

    Lee, Ji-Hyeon (Dept. of Nutrition and Food Sceience, National Fisheries University of Pusan ) , Park, Jong-Cheol (Dept. of Oriental Medicine Resources, Sunchon National University ) , Choi, Jae-Sue (Dept. of Nutrition and Food Sceience, National Fisheries University of Pusan)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 223 - 227 , 1996 , 0253-6269 ,

    초록

    The antioxidant activity of Ecklonia stolonifera was determined by measuring lipid peroxide produced when a mouse liver homogenate was exposed to the air at $37^{\circ}C$ using 2-thiobarbituric acid (TBA) and the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. The methanol extract of Ecklonia stolonifera showed strong antioxidant activity. And the methanol extract was fractionated with several solvents. With regard their fractions, the antioxidative activity were in the order of ethyl acetate>dichloromethane insoluble intermediated phase>dichloromethane>n-butanol>water fraction. The ethyl acetate soluble fraction exhibiting the strongest antioxidant activity was further purified by repeated silica gel and Sephadex LH-20 column chromatography. Antioxidant phloroglucinol was isolated and identified by $ ^1H-NMR\; and\; ^{13}C-NMR$ . Its antioxidant activity was simlilar to that of L-ascorbic acid.

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