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Archives of pharmacal research : a publication of ... 22건

  1. [국내논문]   Anti-inflammatory Activity of Propolis  

    Park, Eun-Hee (College of Pharmacy, Sookmyung Women's University ) , Kim, Sun-Hee (College of Pharmacy, Sookmyung Women's Univeristy ) , Park, Soo-Sun (College of Pharmacy, Sookmyung Women's University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.5 ,pp. 337 - 341 , 1996 , 0253-6269 ,

    초록

    Propolid (bee-glue), known as a folk medicine, is a lipo;hilic material found in honeybee hives. In the present study on the anti-inflammatory effect of Korean propolis, it was extracted with ethanol, and used as a test material. The $LD_{50}$ value with the oral administration of ethanolic extract of Korean propolis (EEKP) was higher than 2g/kg in mice. The oral administration of the propolis extract (100mg/kg) significantly inhibited the development of hind paw edema induced by carrageenin in rats. the oral pretreatment of the propolis extract markedly inhibited the increase in vascular permeability and the number of writhing induced by acetic acetic acid in mice. Propolis extract, 50 and 100 mg/kg p.o. per day for 7 days, produced a significant inhibitory effect on granuloma and exudate formation in rats. This inhibitory effect was enhanced with the concomitant use of prednisolone (2.5 mg/kg). These results suggest that Korean propolis apparently has a strong anti-inflammatory activity.

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  2. [국내논문]   Establishment of Doxorubicin-resistant Subline Derived from HCT15 Human Colorectal Cancer Cells   피인용횟수: 2

    Choi, Sang-Un (Pharmaceutical Screening Team, Korea Research Institute of Chemical Technology ) , Kim, Nam-Young (Pharmaceutical Screening Team, Korea Reserch Institute of Chemical Technology ) , Choi, Eun-Jung (Pharmaceutical Screening Team, Korea Reserach Insitute of Chemical Technology ) , Kim, Kwang-Hee (Pharmaceutical Screening Team, Korea Research Institute of Chemical Technology ) , Lee, Chong-Ock (Pharmaceutical Screening Team, Korea Research Institute of Chemical Technology)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.5 ,pp. 342 - 347 , 1996 , 0253-6269 ,

    초록

    Doxorubicin, one of the clinically most useful anticancer agents, is used alone or in combination with other drugs against a wide variety of tumors, recently. But cancer cells developed resistance to this agent in many ways. This resistance is an important limiting factor of doxorubicin for anticancer drug. We newly established doxorubicin-resistant HCT15/CL02 subline from parental HCT15 human adenocarcinoma colon cancer cells. HCT15/CL02 revealed resistance to doxorubicin about 85-fold of its parental cells, and it also revealed cross-resistance to actinomycin D, etoposide and vinblastine but not to displatin and tamoxifen. And verapamil, a reversal agent of multidrug-resistance (MDR) by P-glycoprotein, elevated the cytotoxicity of doxorubicin against both HCT15 and GCT15/CL02 cells. But the relative resistant rate was not reduced. Verapamil had no effects on the tosicity of cisplatin to the both cell lines. These results indicate that HCT15/CL02 cells have some functionally complex mechanisms for MDR.

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  3. [국내논문]   The Effect of Aspalatone, a New Antithrombotic Agent, on the Specific Activity of Antioxidant Enzyme in the Rat Blood  

    Kim, Chin (Bukwang Pharmaceutical Ind., Co. ) , Koo, Chang-Hui (Bukwang Pharmaceutical Ind., Co. ) , Choi, Dong-Young (College of Pharmacy, Kangwon National University ) , Cho, Yong-Joon (College of Pharmacy, Kangwon National University ) , Choi, Jae-Ho (College of Pharmacy, Kangwon National University ) , Im, Doo-Hyeon (College of Pharmacy, Kangwon National Univeristy ) , Jhoo, Wang-Kee (College of Pharmacy, Kangwon National University ) , Kim, Hyoung-Chun (College of Pharmacy, Kangwon national University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.5 ,pp. 348 - 352 , 1996 , 0253-6269 ,

    초록

    The antioxidant efficacy of aspalatone, a new antithrombotic agent, has been recognized in the neurotoxic model and in the cardiotoxic model in proliminary studies. We examined the specific activity of antiosidnat enzyme in the rat blood following administrations of aspirin, maltol, aspirin together with maltol, salicylmaltol (major metabolite of aspalatone) and aspalatone, respectively. Our assessment showed that salicylmaltol, maltol, aspalatone enhanced antiperoxidative activity. In addition, neither aspirin nor combination of aspirin and maltol, showed any significant effect on the activity of antioxidant enzyme. Because $H_{2}$$O_{2}$ accumulation may stimulate the thrombogenesis in blood, the result suggests that the induction of blood antiperoxidative activity produced by aspalatone may have beneficial effects on the thrombogenesis.

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  4. [국내논문]   Norfloxacin Resistance Mechanism of E. coli 11 and E. coli 101-Clinical Isolates of Escherichia coli in Korea  

    Kim, Kyung-Soon (Department of Biology, Seoul Women's University ) , Lee, Soon-Deuk (Department of biology, Seoul Women's Univeristy ) , Lee, Yeon-Hee (Department of Biology, Seoul Women's University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.5 ,pp. 353 - 358 , 1996 , 0253-6269 ,

    초록

    E. coli 11 and E. coli 101, clinical isolates of Escherichia coli were resistant to various quinolones, especially MICs to norfloxacin of both strains were higher than 100 mg/ml. In the presence of carbonyl cyanide m-chlorophenylhydrazone, a proton gradient uncoupler, norfloxacin uptake in both strains was increased, suggesting that an efflux system play an important role in the norfloxacin resistance. Outer membrane proteins of the susceptible and resistant strains which could affect the route of norfloxacin entry into cells were different. When quinolone resistance determining region(QRDR) of gyrA was amplified using PCR and cut with Hinf I, QRDR in the susceptible strain yielded two fragments while QRDRs in E. coli 11 and E. coli 101 yielded only one uncut fragment. When DNA sequence of QRDR was analyzed, there were two mutations as Ser-83 and Asp-87 in both resistant strains. these residues were changed to Leu-83 and Asn-87, respectively. These results showed that the norfloxacin resistance of E. coli 11 and E. coli 101 was resulted from multiple changes-an altered DNA gyrase A subunit, a change in route of drug entry, and reduction in quinolone concentration inside cells due to an efflux system.

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  5. [국내논문]   Pharmacokinetics of LB20304, a New Fluoroquinolone, in Rats and Dogs  

    Seo, Mi-Kyeong (LG Chem Biotech Research Institute ) , Lee, Sun-Hwa (LG Chem Biotech Research Institute ) , Choi, Yun-Jeong (LG Chem Biotech Research Institute ) , Jeong, Yi-Na (LG Chem Biotech Research Institute ) , Lee, Sung-Hack (LG Chem Biotech Research Institute ) , Kim, In-Chull (LG Chem Biotech Research Institute ) , Lee, Yong-Hee (LG Chem Biotech Research Institute)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.5 ,pp. 359 - 367 , 1996 , 0253-6269 ,

    초록

    The pharmacokinetics of LB20304 was investigated following intravenous (IV) and oral administration to rats and dogs. Additionally, in vitro metabolism and serum protein binding studies were also conducted. The total body clearance, apparent volume of distribution, terminal half-life, and extent of bioavailability were 21.8 ml/min/kg, 2265 ml/kg, 93.6 min, and 30.8% for rats; and 7.95 ml/min/kg, 4144 ml/kg, 363 min, and 81.1% for dogs, respectively. LB20304 was stable in the liver microsome containing NADPH generating system and its serum protein binding was 58.5-65.8% for rats, 19.1-29.6% for dogs, and 56.9-59.6% for humans. Its tissue concentration levels in lever, stomach, small intestine, and kidney were 9.5 to 26.1 times greater than plasma level, but the concentration in testis was quite low and that in brain was negligible in rats. The 48 hr urinary recovery of the dose was 44% for IV dosing and 14% for oral dosing, shereas the 48 hr biliary recovery of the dose was 6.4% for IV dosing and 4.5% for oral dosing in rats. In summary, the pharmacokinetic properties of LB20304 were characterized by its good oral absorption, long plasma half-life, and good tissue distribution.

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  6. [국내논문]   Regulation of Proliferation of Mouse Bone Marrow-derived Mast Cells by Activated Fibroblasts  

    Park, Sung-Joo (Department of Microbiology and Immunology, Wonkwang University School of Medicine ) , Kim, Hyung-Ryong (College of Dentistry, Wonkwang University ) , Cho, Hye-Won (College of Dentistry, Wonkwang University ) , Kim, Hyung-Min (Department of Orientalpharmacy, College of Pharmacy, Wonkwang University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.5 ,pp. 368 - 373 , 1996 , 0253-6269 ,

    초록

    Nitric oxide (NO) is synthesized by various cells involved in inflammatory reactions and may then act on mast cells. In the present work, we attempted to clarify the role of this molecule on the proliferation of mouse bone marrow derived-mast cells (BMMC). Swiss 3T3 fibroblastsproduced nitrite ( $NO_{2}$ ) and nitrate ( $NO_{3}$ ) upon treatment with interferon ${\gamma}$ (IFN- ${\gamma}$ ). This formation was dependent of L-arginine and could be inhibited by the -L-arginine analogue $N^{G}$-monomethyl-L-arginine ( $N^{G}$MMA ). The effect of IFN-g was drastically invreased by cotreatment with tumor necrosis factor g(IFN-g). BMMC were maintained in vitro for as long as 30 days when cocultured with Swiss 3T3 fibroblasts. coculture with $N^{G}$MMA , significantly increased the number of BMMC. These results indicate that NO involves the inhibition of proliferation of BMMC when cocultured with Swiss 3T3 fibroblasts.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [국내논문]   The effect of chronic ethanol treatement and cold stress on catecholaminergic enzyme activity and mRNA in rat brain and adrenals  

    Lee, Yong-Kyu , Park, Dong H.
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.5 ,pp. 374 - 380 , 1996 , 0253-6269 ,

    초록

    Nitric oxide (NO) is synthesized by various cells involved in inflammatory reactions and may then act on mast cells. In the present work, we attempted to clarify the role of this molecule on the proliferation of mouse bone marrow derived-mast cells (BMMC). Swiss 3T3 fibroblastsproduced nitrite ( $NO_{2}$ ) and nitrate ( $NO_{3}$ ) upon treatment with interferon ${\gamma}$ (IFN- ${\gamma}$ ). This formation was dependent of L-arginine and could be inhibited by the -L-arginine analogue $N^{G}$-monomethyl-L-arginine ( $N^{G}$MMA ). The effect of IFN-g was drastically invreased by cotreatment with tumor necrosis factor g(IFN-g). BMMC were maintained in vitro for as long as 30 days when cocultured with Swiss 3T3 fibroblasts. coculture with $N^{G}$MMA , significantly increased the number of BMMC. These results indicate that NO involves the inhibition of proliferation of BMMC when cocultured with Swiss 3T3 fibroblasts.

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  8. [국내논문]   THe Effect of Chronic Ehronic Treatment and Cold stress on Catecholaminergic Enzyme activity and mRNA in Rat Brain and Adrenals  

    Lee, Yong-Kyu (Department of Food Engineering, Dongeseo University ) , Park, Dong-H (Department of Molecular Neurobiology Cornell Medical College)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.5 ,pp. 374 - 380 , 1996 , 0253-6269 ,

    초록

    Sprague-Dawley male rats (150 g) were chronically treated with 5 v/v % ethanol admixed with nutritionally complete liquid diet and fed ad libitum for 3 weeks. One half of each group was exposed to cold stress at 4 ^{\circ}C either for 24 h (for determination of mRNA by in situ hybridization) or for 48 h (for determination of enzyme activity). Chronic ethanol treatment (ethanol) did not affect tyrosine hydroxylase(TH) mRNA level in locus coeruleus(LC) of brain and adrenal medulla(AM) compared to controls. Cold stress showed strong increase of TH mRNA level in LC and AM compared to controls. Pretreated ethanol reduced the increased TH mRNA level by cold stress in LC and AM. Ethanol did not affect TH activity in LC and adenal glands(adrenals). Cold stress increased TH activity in LC but not in adrenals. Pretreated ethanol did not reduce the increased TH activity by cold stress in LC but this result was not shown in adrenals. Phenylethanolamine-N-methyltransferase(PNMT) activity in $C_{1}$ $C_{2}$ and adrenals increased only in ethanol treated group. THese results suggest that ethanol does not affect TH mRNA level and activity in LC and adrenals, but increases PNMT activity in $C_{1}$ $C_{2}$ and adrenals in normal rat. It is also suggested that pretreated ethanol reduces the magnitude of cold stress response, that is induction of TH mRNA in LC and AM, and does not reduce the protein activation of TH that is also cold stress response in LC.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [국내논문]   Different distribution of the α2 Na+, K+-ATPase isoform between rat atria and ventricles  

    Lee, Jeung-Soo , Lee, Shin-Woong , Wallick, Earl T.
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.5 ,pp. 381 - 385 , 1996 , 0253-6269 ,

    초록

    Sprague-Dawley male rats (150 g) were chronically treated with 5 v/v % ethanol admixed with nutritionally complete liquid diet and fed ad libitum for 3 weeks. One half of each group was exposed to cold stress at 4 ^{\circ}C either for 24 h (for determination of mRNA by in situ hybridization) or for 48 h (for determination of enzyme activity). Chronic ethanol treatment (ethanol) did not affect tyrosine hydroxylase(TH) mRNA level in locus coeruleus(LC) of brain and adrenal medulla(AM) compared to controls. Cold stress showed strong increase of TH mRNA level in LC and AM compared to controls. Pretreated ethanol reduced the increased TH mRNA level by cold stress in LC and AM. Ethanol did not affect TH activity in LC and adenal glands(adrenals). Cold stress increased TH activity in LC but not in adrenals. Pretreated ethanol did not reduce the increased TH activity by cold stress in LC but this result was not shown in adrenals. Phenylethanolamine-N-methyltransferase(PNMT) activity in $C_{1}$ $C_{2}$ and adrenals increased only in ethanol treated group. THese results suggest that ethanol does not affect TH mRNA level and activity in LC and adrenals, but increases PNMT activity in $C_{1}$ $C_{2}$ and adrenals in normal rat. It is also suggested that pretreated ethanol reduces the magnitude of cold stress response, that is induction of TH mRNA in LC and AM, and does not reduce the protein activation of TH that is also cold stress response in LC.

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  10. [국내논문]   Different Distribution of the ${alpha}_{2},Na^+,K^+-ATPase lsoform between Rat Atria and Ventricles$  

    Lee, Jeung-Soo (Department of Food and Nutrition, Shinil Christian College ) , Lee, Shin-Woong (College of Pharmacy, Yeung-nam University ) , Wallick, Earl-T (Department of Pharmacology and Cell Biophysics, Univeristy of Cincinnati, College of Medicine)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.5 ,pp. 381 - 385 , 1996 , 0253-6269 ,

    초록

    Rat ventricles respond with a biphasic positive inotropic effect to ouabain, low-dose and high-dose effects but rat atria with only a monophasic high dose effect. In an effect to understand the difference in response to ouabain of two tissues between rat atria and ventricles the levels of the $a_{2}$ -isoform of the $Na^{+}$ , $K^{+}$ -ATPase which has higher affinity for ouabain than the $a_{1}$ -iso-form were determined by a $[^{3}H]$ ouabain binding assay. The yield of protein per gram wet weight was about 47 mg for atria and 100 mg for ventricles. The $K_{d}$ values of ouabain for the high-affinity ouabain binding site $(a_{2} -isoform)$ were nearly the same (230 nM) in the atria and ventricles. However, the numbers of the $a_{2}$ -isoform $(B_{max})$ per mg protein were approximately half in the atria. When the binding data were expressed in unit per gram tissue wet weight, the numbers of $a_{2}$ -isoform in the atria was about 25% of that in the ventricles. THese results demonstrate that the $a_{2}$ -isoform of the $Na^{+}$, $K^{+}$ -ATPase in the rat atria could be detected by $[^{3}H]$ ouabain binding assay and the levels of this isoform are too low to show the low-dose effect of ouabain.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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