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Archives of pharmacal research : a publication of ... 21건

  1. [국내논문]   Inhibitory Effects of Ginseng Total Saponins on Hypoxia-induced Dysfunction and Injuries of Cultured Astrocytes  

    Seong, Yeon-Hee (College of Veterinary Medicine ) , Kim, Hack-Seang (College of Pharmacy, Chungbuk National University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.20 no.2 ,pp. 103 - 109 , 1997 , 0253-6269 ,

    초록

    The effects of ginseng total saponins (GTS) on hypoxic damage of primary cultures of astrocytes were studied. Hypoxia was created by placing cultures in an air tight chamber that was flushed with 95% $N_2/5%CO_2$ for 15 min before being sealed. Cultures showed evidence of significant cell injury after 24 h of hypoxia (increased lactate dehydrogenase (LDH) content in the culture medium, cell swelling and decreased glutamate uptake and protein content). Addition of GTS (0.1, 0.3 mg/ml) to the cultures during the exposure to hypoxic conditions produced dose-dependent inhibition of the LDH efflux. GTS (0.1, 0.3 mg/ml) also produced significant inhibition of the increased cell volume of astrocytes measured by $[^3H]$ O-methyl-D-glucose uptake under the hypoxic conditions. Decreased glutamate uptake and protein content was inhibited by GTS. These data suggest that GTS prevents astrocytic cell injury induced by severe hypoxia in vitro.

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  2. [국내논문]   Cytotoxic activities of various fractions extracted from some pharmaceutical insect relatives  

    Huang, Yao-Ge (College of Chinese Medicinal Materials, Jilin Agricultural University ) , Kang, Jong-Koo (College of Veterinary Medicine, Chungbuk National University ) , Liu, Ren-Song (College of Chinese Medicinal Materials, Jilin Agricultural University ) , Oh, Ki-Wan (College of Pharmacy, Chungbuk National University ) , Nam, Chun-Ja (College of Veterinary Medicine, Chungbuk National University ) , Kim, Hack-Seang (College of Pharmacy, Chungbuk University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.20 no.2 ,pp. 110 - 114 , 1997 , 0253-6269 ,

    초록

    This research was performed to screen the cytotoxic activities of some pharmaceutical insect relatives. Cytotoxic activities of total extract and fractions of hexane, ethyl acetate, methanol, water and boiling water were extracted from four pharmaceutical insect relatives: the Chinese gall, the cicada slough, the hornet nest and the batryticated silkworm. These extracts were investigated against the cancer cell lines of L1210, P388 and SNU-1 in vitro tests. Results showed that, ED, , against the cancer cell lines of L1210, P388 and SNU-1 were 0.55, 0.50, and $0.83{\mu}g/ml$ in the ethyl acetate fraction from the Chinese gall; 1.07, 2.19, and $2.24{\mu}g/ml$ in the ethyl acetate fraction, 1.51, 1.26, and $1.45{\mu}g/ml$ in the water fraction and 1.48, 2.29, and $1.29{\mu}g/ml$ in the boiling water fraction from the cicada slough; 3.31, 2.00, and $6.61\mug/ml$ in the water fraction from the hornet nest and 13.80, 19.95, and $31.62{\mu}g/ml$ in the hexane fraction and 33.88, 21.88, and $25.12{\mu}g/ml$ in the ethyl acetate fraction from the batryticated silkworm, respectively. All of the fractions mentioned above showed high cytotoxic activities and could be suggested for further studies in vivo tests.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [국내논문]   I269S Mutation in horse liver alcohol dehydrogenase S isoenzyme and its reactivity for steroids and retinoids  

    Ryu, Ji Won , Lee, Kang Man
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.20 no.2 ,pp. 115 - 121 , 1997 , 0253-6269 ,

    초록

    This research was performed to screen the cytotoxic activities of some pharmaceutical insect relatives. Cytotoxic activities of total extract and fractions of hexane, ethyl acetate, methanol, water and boiling water were extracted from four pharmaceutical insect relatives: the Chinese gall, the cicada slough, the hornet nest and the batryticated silkworm. These extracts were investigated against the cancer cell lines of L1210, P388 and SNU-1 in vitro tests. Results showed that, ED, , against the cancer cell lines of L1210, P388 and SNU-1 were 0.55, 0.50, and $0.83{\mu}g/ml$ in the ethyl acetate fraction from the Chinese gall; 1.07, 2.19, and $2.24{\mu}g/ml$ in the ethyl acetate fraction, 1.51, 1.26, and $1.45{\mu}g/ml$ in the water fraction and 1.48, 2.29, and $1.29{\mu}g/ml$ in the boiling water fraction from the cicada slough; 3.31, 2.00, and $6.61\mug/ml$ in the water fraction from the hornet nest and 13.80, 19.95, and $31.62{\mu}g/ml$ in the hexane fraction and 33.88, 21.88, and $25.12{\mu}g/ml$ in the ethyl acetate fraction from the batryticated silkworm, respectively. All of the fractions mentioned above showed high cytotoxic activities and could be suggested for further studies in vivo tests.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [국내논문]   1269S mutation in horse liver alcohol dehydrogenase S isoenzyme and its reactivity for steroids and retinoids  

    Ryu, Ji-Won (College of Pharmacy, Ewha Womans University ) , Lee, Kang-Man (College of Pharmacy, Ewha Womans University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.20 no.2 ,pp. 115 - 121 , 1997 , 0253-6269 ,

    초록

    Ile-269 in horse liver alcohol dehydrogenase isoenzyme S(HLADH-S) was mutated to serine by phosphorothioate-based site-directed mutagenesis in order to study the role of the residue in coenzyme binding. The specific activity of the mutant(1269S) enzyme to ethanol was increased 49-fold. All turnover numbers of 1269S enzyme toward 9 primary alcohols were increased. The mutant enzyme showed 3.6, 4.6, 11.6-fold higher catalytic efficiency for $5{\beta}$ -androstane-3, 17-dione, $5{\beta}$ -cholanic acid-3-one and retinal than wild-type, respectively. The reaction mechanism of 1269S enzyme was ordered bi bi as wild-type's. These results indicate that the hydrophobic interaction of Ile-269 residue with coenzyme plays an important role in dissociation of coenzyme from enzyme-coenzyme complex, which has been known as the rate limiting step of ADH reaction.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [국내논문]   Suppression of Anaphylactic Reaction in Murine by Siegesbeckia pubescens  

    Kim, Hyung-Min (College of Pharmacy, Wonkwang University ) , Kim, Chang-Young (College of Pharmacy, Wonkwang University ) , Kwon, Mun-Hyun (College of Oriental Medicine, Wonkwang, University ) , Shin, Tae-Yong (College of Pharmacy, Woosunk University ) , Lee, Eon-Jeong (College of Oriental Medicine, Wonkwang University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.20 no.2 ,pp. 122 - 127 , 1997 , 0253-6269 ,

    초록

    The aqueous extract of Siegesbeckia pubescens (SPAE) inhibited compound 48/80-induced systemic anaphylaxis 100% with the dose of 1.0, 0.5 mg/g body weight (BW) at 1 h before or 5 min, 10 min after intraperitoneal injection of compound 48/80. The passive cutaneous anaphylaxis (PCA) reaction also inhibited to 78.5% by oral administration of SPAE(1.0 mg/g BW). When SPAE pretreated on mice at concentrations ranging from 0.0001 to 1.0 mg/g BW, the serum histamine levels were reduced in a dose-dependent manner. Moreover, SPAE ( $100-800{\mu}g/ml) dose-dependently inhibited the histamine release from peritoneal mast cells (RPMC) by compound 48/80 $(5{\mu}g/ml)$ . Analysis by microscopic appearance observation revealed that SPAE $(500{\mu}g/ml) stabilized the RPMC membrane. Therefore, these findings indicate that SPAE inhibits anaphylactic reactions through stabilization of mast cell membrane.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [국내논문]   Immunological studies on the antitumor components of the basidiocarps ofAgrocybe cylindracea  

    Kim, Byong Kak , Hyun, Jin Won , Yoon, Jong Myung , Choi, Eung Chil
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.20 no.2 ,pp. 128 - 137 , 1997 , 0253-6269 ,

    초록

    The aqueous extract of Siegesbeckia pubescens (SPAE) inhibited compound 48/80-induced systemic anaphylaxis 100% with the dose of 1.0, 0.5 mg/g body weight (BW) at 1 h before or 5 min, 10 min after intraperitoneal injection of compound 48/80. The passive cutaneous anaphylaxis (PCA) reaction also inhibited to 78.5% by oral administration of SPAE(1.0 mg/g BW). When SPAE pretreated on mice at concentrations ranging from 0.0001 to 1.0 mg/g BW, the serum histamine levels were reduced in a dose-dependent manner. Moreover, SPAE ( $100-800{\mu}g/ml) dose-dependently inhibited the histamine release from peritoneal mast cells (RPMC) by compound 48/80 $(5{\mu}g/ml)$ . Analysis by microscopic appearance observation revealed that SPAE $(500{\mu}g/ml) stabilized the RPMC membrane. Therefore, these findings indicate that SPAE inhibits anaphylactic reactions through stabilization of mast cell membrane.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [국내논문]   Immunological Studies on the Antitumor Componets of the Basidiocarps of Agrocybe cylindracea  

    Kim, Byong-Kak (College of Pharmacy, Seoul National University ) , Hyun, Jin-won (College of Pharmacy, Seoul National University ) , Yoon, Jong-Myung (College of Pharmacy, Seoul National University ) , Choi, Eung-Chil (College of Pharmacy, Seoul National University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.20 no.2 ,pp. 128 - 137 , 1997 , 0253-6269 ,

    초록

    The effects of cylindan, a polysaccharide isolated from the basidiocarps of Agrocybe cylindracea, on murine sarcoma 180 tumor and murine immune cells were examined after intraperitoneal administration. Cylindan exhibited a marked life extension effect in mice against ascite forms of sarcoma 180 and Lewis lung carcinoma at a dose of 50 mg/kg/day, although it did not show any direct cytotoxicity against sarcoma 180, X5563, and MM46 murine tumor cells. Cylindan increased numbers of bone marrow stem cells as well as peritoneal exudate cells in flow cytometry using monoclonal antibodies. The tumor bearing mice group apparently showed the increase of macrophages and cytotoxic T lymphocytes in mouse spleen cells during the early stage of tumor growth. But during the later stage, the control group decreased immune cells and cylindan restored the decreased immune cells in the tumor bearing mice to the normal level. In non-specific immune response, cylindan stimulated the bacterial phagocytosis and acid phosphatase production in macrophages. It also activated components of the alternative complement pathway and natural killer activity against YAC-1 lymphoma. In number of plasma cells as token of stimulation of the differentiation of B lymphocytes. In cellular immunity, cylindan restored the depressed response of delayed type hypersensitivity in the tumor bearing mice to 60% of the normal level and increased the interleukin-2 (IL-2) responsiveness in the IL-2 dependent CTLL-2 cells. These results suggest that cylindan did not show direct cytotoxic effects on tumor cells but restored the decreased immune response of the tumor bearing mice.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [국내논문]   Synthesis and Structure-Activity Relationship Studies of 2,3-Dihydroimidazo[2,1-a]isoquinoline Analogs as Antitumor Agents  

    Cheon, Seung-Hoon (College of Pharmacy, Chonnam National University ) , Park, Joon-Suck (College of Pharmacy, Chonnam National University ) , Jeong, Seon-Hee (College of Pharmacy, Chonnam National University ) , Chung, Byung-Ho (College of Pharmacy, Chonnam National University ) , Choi, Bo-Gil (College of Pharmacy, Chonnam National University ) , Cho, Won-Jae (College of Pharmacy, Chonnam National University ) , Kang, Boo-Hyon (Screening and Toxicology Research Center, Korea Research Institute of Chemical Technology ) , Lee, Chong-Ock (Screening and Toxicology Research Center, Korea Research Institute of Chemical Technology)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.20 no.2 ,pp. 138 - 143 , 1997 , 0253-6269 ,

    초록

    5-Aryl-2,3-dihydroimidazo[2,1-a]isoquinolines were reported to have strong antitumor activity and one of the derivatives such as $5-[4^{l}$ -(piperidinomethyl)phenyl]-2,3-dihydroimidazo[2,1-a] isoquinoline (1, SDZ 62-434) was found to be more effective than the clinical cytostatic agent edelfosine (2) in in vitro and in vivo assays. Currently SDZ 62-434 is in clinical trials in Europe. The structure-activity relationship studies of SDZ 62-434 showed that compounds with substitution on ring A were less active than the lead compound. Ring B in SDZ 62-434 was essential for the activity because compounds without B ring had no antitumor activity. Among the 3-arylisoquinolin-1-one derivatives, $3-[4^{I}$ -(piperidinomethyl)phenyl] substituted analog had no antitumor activity but simple phenyl substituted compound, such as 4, showed the most potent antitumor activity in various human tumor cell lines.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [국내논문]   A Novel Synthetic Method for 3-Hydroxyhomoisoflavanone  

    Jew, Sang-Sup (College of Pharmacy, Seoul National University ) , Kim, Hyun-Ah (College of Pharmacy, Seoul National University ) , Park, Hyeung-Geun (College of Pharmacy, Seoul National University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.20 no.2 ,pp. 144 - 147 , 1997 , 0253-6269 ,

    초록

    A novel synthetic method was developed for 3-hydroxyhomoisoflavanone. Treatment of aryllithium 14 to aldehyde 13 which was obtained from dihydroxylation of 10, followed by cycloetherification to give 3-hydroxyhomoisoflavanones.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  10. [국내논문]   Chlorogenic Acid, an Antioxidant Principle from the Aerial Parts of Artemisia iwayomogi that Acts on 1,1-Diphenyl-2-picrylhydrazyl Radical   피인용횟수: 1

    Kim, Soon-Shin (College of Pharmacy, Kyungsung University ) , Lee, Chung-Kyu (College of Pharmacy, Kyungsung University ) , Sam, Sik-Kang (Natural Products Research Institute, Seoul National University ) , Jung, Hyun-Ah (Department of Food and Life Science, Pukyong National University ) , Choi, Jae-Sue (Department of Food and Life Science, Pukyong National University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.20 no.2 ,pp. 148 - 154 , 1997 , 0253-6269 ,

    초록

    The antioxidant activity of Artemisia iwayomogi was determined by measuring the radical scavenging effect on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical. The methanol extract of A. iwayomogi showed strong antioxidant activity, and thus fractionated with several solvents. The antioxidant activity potential of the individual fraction was in the order of ethyl acetate > n-butanol > water > chloroform > n-hexane fraction. The ethyl acetate and n-butanol soluble fractions exhibiting strong antioxidant activity were further purified by repeated sitica get and Sephadex LH-20 column chromatography. Antioxidant chlorogenic acid was isolated as one of the active principles from the n-butanol fraction, together with the inactive components, 1octacosanol, scopoletin, scopolin, apigenin $7, 4^{I}$ -di-O-methylether, luteolin $6, 3^{I}$ -di-O-methylether (jaceosidin), apigenin methylether (genkwanin), 2, 4-dihydroxy-6-methoxyacetophenone $4-O-{\beta}-$ D-glucopyranoside and quebrachitol. The antioxidant activity of chlorogenic acid was comparable to that of L-ascorbic acid, which is a well known antioxidant.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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