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Archives of pharmacal research : a publication of ... 22건

  1. [국내논문]   Signal Transduction Network Leading to COX-2 Induction: A Road Map in Search of Cancer Chemopreventives  

    Surh Young-Joon (National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University ) , Kundu Joydeb Kumar (National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.28 no.1 ,pp. 1 - 15 , 2005 , 0253-6269 ,

    초록

    Cancer is still a major global health concern even after an everlasting strive in conquering this dread disease. Emphasis is now given to chemoprevention to reduce the risk of cancer and also to improve the quality of life among cancer afflicted individuals. Recent progress in molecular biology of cancer has identified key components of the cellular signaling network, whose functional abnormality results in undesired alterations in cellular homeostasis, creating a cellular microenvironment that favors premalignant and malignant transformation. Multiple lines of evidence suggest an elevated expression of cyclooxygenase-2 (COX-2) is causally linked to cancer. In response to oxidative/pro-inflammatory stimuli, turning on unusual signaling arrays mediated through diverse classes of kinases and transcription factors results in aberrant expression of COX-2. Population-based as well as laboratory studies have explored a broad spectrum of chemopreventive agents including selective COX-2 inhibitors and a wide variety of anti-inflammatory phytochemicals, which have been shown to target cellular signaling molecules as underlying mechanisms of chemoprevention. Thus, unraveling signaling pathways regulating aberrant COX-2 expression and targeted blocking of one or more components of those signal cascades may be exploited in searching chemopreventive agents in the future.

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  2. [국내논문]   Synthesis and Conformational Study of 2-Trityloxymethyltet­rahydrofurans as Key Intermediates for Antiviral Nucleosides  

    Choi Hye-Young (College of Pharmacy, Sookmyung Women's University ) , Kim Hee-Doo (College of Pharmacy, Sookmyung Women's University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.28 no.1 ,pp. 16 - 21 , 2005 , 0253-6269 ,

    초록

    We wanted to elucidate the reason why the trityloxymethyl substituent in $\gamma$ -trityloxymethyl- $\gamma$ ­butyrolactone takes a sterically unfavorable specific conformation, and so we synthesized 5-trityloxymethyldihydrofuran-3-one, 3-(trityloxymethyl)-4-butanolide and 2-trityloxymethyl- tetrahy­drofuran and we then analyzed their conformation by $^{1}H-NMR$ analysis.

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  3. [국내논문]   Antioxidant Activity of Anthraquinones and Flavonoids from Flower of Reynoutria sachalinensis   피인용횟수: 8

    Zhang Xinfeng (College of Pharmacy, Chungnam National University ) , Thuong Phuong Thien (College of Pharmacy, Chungnam National University ) , Jin WenYi (College of Pharmacy, Chungnam National University ) , Su Nguyen Duy (College of Pharmacy, Chungnam National University ) , Sok Dai Eun (College of Pharmacy, Chungnam National University ) , Bae KiHwan (College of Pharmacy, Chungnam National University ) , Kang Sam Sik (National Products Research Institute, Seoul National University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.28 no.1 ,pp. 22 - 27 , 2005 , 0253-6269 ,

    초록

    Bioassay-guided fractionation of methanol extract of Reynoutria sachalinensis flower using DPPH assay has led to the isolation of three anthraquinones and three flavonoids. Their structures were identified as emodin (1), emodin-8-O- $\beta$ -D-glucopyranoside (2), physcion-8-O- $\beta$ -D­glucopyranoside (3), quercetin-3-O- $\alpha$ -L-arabinofuranoside (4), quercetin-3-O- $\beta$ -D-galactopyra­noside (5), and quercetin-3-O- $\beta$ -D-glucuronopyranoside (6) by comparing their physicochemical and spectral data with those published in literatures. All isolated compounds were evaluated for antioxidant activities with free radical 1, 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging, superoxide radical scavenging and $Cu^{2+}$ -mediated low density lipoprotein (LDL) oxidation assay. The results demonstrated that three flavonoids, 4, 5, and 6 had remarkable antioxidant activities with the $IC_{50}$ values of 64.3, 54.7, and 46.2 ${\mu}M$ (DPPH scavenging), the $IC_{50}$ values of 6.0, 6.7, and $4.4{\mu}M$ (superoxide radical scavenging) and the $IC_{50}$ values of 3.8, 3.2, and 5.4 ${\mu}M$ against LDL oxidation, respectively.

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  4. [국내논문]   Inhibitory Constituents against Cyclooxygenases from Aralia cordata Thunb   피인용횟수: 14

    Dang Nguyen Hai (College of Pharmacy, Chungnam National University ) , Zhang XinFeng (College of Pharmacy, Chungnam National University ) , Zheng MingShan (College of Pharmacy, Chungnam National University ) , Son Kun Ho (Department of Food and Nutrition, Andong National University ) , Chang Hyeun Wook (College of Pharmacy, Yeungnam University ) , Kim Hyun Pyo (College of Pharmacy, Kangwon National University ) , Bae KiHwan (College of Pharmacy, Chungnam National University ) , Kang Sam Sik (Natural Products Research Institute and College of Pharmacy, Seoul National University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.28 no.1 ,pp. 28 - 33 , 2005 , 0253-6269 ,

    초록

    Seven diterpenes, four polyacetylenes, a lipid glycerol, and two sterols were isolated from the methylene chloride fraction of the root of Aralia cordata. Their chemical structures were determined as (-)-pimara-8(14), 15-dien-19-oic acid (2), pimaric acid (3), (-)-kaur-16-en-19-oic acid (4), 17-hydroxy-ent-kaur-15-en-19-oic acid (9), $7{\alpha}$ -hydroxy-(-)-pimara-8(14), 15-dien-19-oic acid (10), $16\alpha$ , 17 -dihydroxy-(-)-kauran-19-oic acid (11), 16-hydroxy-17-isovaleroyloxy-ent-kauran-19­oic acid (12), falcarindiol (5), dehydrofalcarindiol (6), dehydrofalcarindiol-8-acetate (7), falcarin­diol-8-acetate (8), alpha-mono palmitin (13), stigmasterol (1), and daucosterol (14) by the spectral evidences. These compounds were tested with COX-1 and COX-2 inhibition assays. This study found that compounds 2, 4, 5, 6, 7, 8, and 10 inhibited COX-1 dependent conversion of the exogenous arachidonic acid to $PGE_2$ in a dose-dependent manner with $IC_{50}$ values of $134.2{\mu}M$ , $121.6{\mu}M$ , $170{\mu}M$ , $50.4{\mu}M$ , $11.7{\mu}M$ , $99.6{\mu}M$ , and $69.6{\mu}M$ , respectively. But, most of these compounds weakly inhibited COX-2 dependent $PGE_2$ generation. Among them, only compound 4 showed relatively significant inhibitory activity $(IC_{50}\;:\;127.6{\mu}M)$ .

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  5. [국내논문]   A New Antipsychotic Effective Neolignan from Firmiana simplex  

    Son Yeon Kyoung (Natural Products Research Institute Seoul National University ) , Lee Ming Hong (Natural Products Research Institute Seoul National University ) , Han Yong Nam (Natural Products Research Institute, College of Pharmacy, Seoul National University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.28 no.1 ,pp. 34 - 38 , 2005 , 0253-6269 ,

    초록

    A new neolignan, named simplidin was isolated from the n-butanol extract of stem of Firmiana simplex, together with six known compounds, scopoletin (1), syrigaresinol (2), aquillochin (3), nitidanin (4), tamarixetin 3-rhamnoside (6), and quercitrin (7). On the basis of spectral and chemical evidence, simplidin (5) was determined to be rel-(7R, 8R)-4, 5, 9, 9'-tetrahydroxy-3,3'­dimethoxy-7-O-5', 8-O-4'-neolignan. All the six compounds were also isolated for the first time from this plant.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [국내논문]   Antitumor and Antiinflammatory Constituents from Celtis sinensis   피인용횟수: 1

    Kim Dae Keun (College of Pharmacy, Woosuk University ) , Lim Jong Pil (College of Pharmacy, Woosuk University ) , Kim Jin Wook (College of Pharmacy, Woosuk University ) , Park Hee Wook (College of Pharmacy, Woosuk University ) , Eun Jae Soon (College of Pharmacy, Woosuk University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.28 no.1 ,pp. 39 - 43 , 2005 , 0253-6269 ,

    초록

    Eight compounds were isolated from the methanolic extract of the twigs of Celtis sinensis through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as two triterpenoids, germanicol and epifriedelanol, two amide compounds, trans-N-caffeoyltyramine and cis-N-coumaroyltyramine, two lignan glycoside, pinoresinol glycoside and pinoresinol rutinoside, and two steroids by spectroscopic analysis.

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  7. [국내논문]   Hepatoprotective Constituents of Cudrania tricuspidata   피인용횟수: 5

    Tian Yu-Hua (College of Pharmacy and Phytofermentation Research Center, Wonkwang university ) , Kim Hyun-Chul (College of Pharmacy and Phytofermentation Research Center, Wonkwang university ) , Cui Jiong-Mo (College of Medicine, Yanbian University ) , Kim Youn-Chul (College of Pharmacy and Phytofermentation Research Center, Wonkwang university)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.28 no.1 ,pp. 44 - 48 , 2005 , 0253-6269 ,

    초록

    Phytochemical investigation of the MeOH extract of the root barks of Cudrania tricuspidata Bureau (Moraceae), as guided by hepatoprotective activity in vitro, furnished four isoprenylated xanthones, cudratricusxanthone A (1), cudraxanthone L (2), cudratricusxanthone E (3), and macluraxanthone B (4). All of these compounds showed the significant hepatoprotective effect on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Compounds 1, 2, and 4 also exhibited the significant hepatoprotective effect on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.

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  8. [국내논문]   Immunobioloical Activity of a New Benzyl Benzoate from the Aerial Parts of Solidago virga-aurea var. gigantea   피인용횟수: 2

    Choi Sang Zin (Natural Products Laboratory, College of Pharmacy, SungkyunKwan University ) , Choi Sang Un (Korea Research Institute of Chemical Technology ) , Bae Seong Yun (Division of Immunophar-macology, College of Pharmacy, SungKyunKwan University ) , Pyo Suhk neung (Division of Immunophar-macology, College of Pharmacy, SungKyunKwan University ) , Lee Kang Ro (Natural Products Laboratory, College of Pharmacy, SungkyunKwan University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.28 no.1 ,pp. 49 - 54 , 2005 , 0253-6269 ,

    초록

    The chromatographic separation of the hexane soluble fraction of the methanol extract of the aerial parts of Solidago virga-aurea var. gigantea Mo. (Compositae) led to the isolation of a new benzylbenzoate (1) together with four known benzylbenzoates (2-5). Their structures were determined as 2-methoxybenzyl-2-hydroxybenzoate (1), benzyl-2-hydroxy-6-methoxy­benzoate (2), 2-methoxybenzyl-2,6-dimethoxybenzoate (3), 2-methoxybenzyl-2-methoxy-6­hydroxybenzoate (4), and benzyl-2,6-dimethoxybenzoate (5). Their structures were established by spectroscopic methods. Biological effects of compounds, 1 and 2, were investigated in vitro usingherapeutic agents by stimulating macrophage functions, with potential use in the treat­ mouse peritoneal macrophages. The benzylbenzoates (1 and 2) could serve as immunotherapeutic agents by stimulating macrophage functions, with potential use in the treatment of infectious diseases.

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  9. [국내논문]   Manassantin a and b isolated fromSaururus chinensis inhibit TNF-α-induced Cell adhesion molecule expression of human umbilical vein endothelial cells  

    Kwon, Oh Eok , Lee, Hyun Sun , Lee, Seung Woong , Chung, Mi Yeon , Bae, Ki Hwan , Rho, Mun-Chual , Kim, Young-Kook
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.28 no.1 ,pp. 55 - 60 , 2005 , 0253-6269 ,

    초록

    The chromatographic separation of the hexane soluble fraction of the methanol extract of the aerial parts of Solidago virga-aurea var. gigantea Mo. (Compositae) led to the isolation of a new benzylbenzoate (1) together with four known benzylbenzoates (2-5). Their structures were determined as 2-methoxybenzyl-2-hydroxybenzoate (1), benzyl-2-hydroxy-6-methoxy­benzoate (2), 2-methoxybenzyl-2,6-dimethoxybenzoate (3), 2-methoxybenzyl-2-methoxy-6­hydroxybenzoate (4), and benzyl-2,6-dimethoxybenzoate (5). Their structures were established by spectroscopic methods. Biological effects of compounds, 1 and 2, were investigated in vitro usingherapeutic agents by stimulating macrophage functions, with potential use in the treat­ mouse peritoneal macrophages. The benzylbenzoates (1 and 2) could serve as immunotherapeutic agents by stimulating macrophage functions, with potential use in the treatment of infectious diseases.

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  10. [국내논문]   Manassantin A and B Isolated from Saururus chinensis Inhibit $TNF-{\alpha}-Induced$ Cell Adhesion Molecule Expression of Human Umbilical Vein Endothelial Cells  

    Kwon Oh Eok (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology ) , Lee Hyun Sun (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology ) , Lee Seung Woong (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology ) , Chung Mi Yeon (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology ) , Bae Ki Hwan (College of Pharmacy, Chungnam National University ) , Rho Mun-Chual (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology ) , Kim Young-kook (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.28 no.1 ,pp. 55 - 60 , 2005 , 0253-6269 ,

    초록

    Leukocyte adhesion to the vascular endothelium is a critical initiating step in inflammation and atherosclerosis. We have herein studied the effect of manassantin A (1) and S (2), dineolignans, on interaction of THP-1 monocytic cells and human umbilical vein endothelial cells (HUVEC) and expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin in HUVEC. When HUVEC were pretreated with 1 and 2 followed by stimulation with $TNF-{\alpha}$ , adhesion of THP-1 cells to HUVEC decreased in dose-dependent manner with $IC_{50}$ values of 5 ng/mL and 7 ng/mL, respectively, without cytotoxicity. Also, 1 and 2 inhibited $TNF-{\alpha}-induceda$ up-regulation of ICAM-1, VCAM-1 and E-selectin. The present findings suggest that 1 and 2 prevent monocyte adhesion to HUVEC through the inhibition of ICAM-1, VCAM-1 and E-selectin expression stimulated by $TNF-\alpha$ , and may imply their usefulness for the prevention of atherosclerosis relevant to endothelial activation.

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