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Archives of pharmacal research : a publication of ... 20건

  1. [국내논문]   Cholesterol gallstone formation in hypercholesterolemia.   SCOPUS

    Hwang, Eun Sook
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.32 no.9 ,pp. 1177 - 1178 , 2009 , 0253-6269 ,

    초록

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  2. [국내논문]   Structural Modification of 5,7-Dimethoxyflavone from Kaempferia parviflora and Biological Activities   SCOPUS

    Yenjai, Chavi (Natural Products Research Unit, Center for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University ) , Wanich, Suchana (Natural Products Research Unit, Center for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University ) , Pitchuanchom, Siripit (Natural Products Research Unit, Center for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University ) , Sripanidkulchai, Bungon (Division of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Khon Kaen University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.32 no.9 ,pp. 1179 - 1184 , 2009 , 0253-6269 ,

    초록

    5,7-Dimethoxyflavone, a major compound from Kaempferia parviflora, was used as a starting material for structural modification. Seven flavonoid derivatives have been synthesized from this flavone. Two new oxime derivatives 4 and 6 exhibited cytotoxicity against HepG2 cell line with $IC_{50}$ values of 36.38 and $25.34\;{\mu}g/mL$ , respectively, and against T47D cell line with $IC_{50}$ values of 41.66 and $22.94\;{\mu}g/mL$ , respectively. Compound 7 showed cytotoxicity against HepG2 and T47D cell lines with $IC_{50}$ values of 21.36 and $25.00\;{\mu}g/mL$ , respectively. Compounds 6 and 7 showed cytotoxicity nearly equal to the tamoxifen standard. In addition, oxime 6 exhibited antifungal activity against Candida albicans with an $IC_{50}$ value of $48.98\;{\mu}g/mL$ .

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  3. [국내논문]   Amino and Nitro Derivatives of 5,7-Dimethoxyflavone from Kaempferia parviflora and Cytotoxicity against KB Cell Line   SCOPUS

    Wanich, Suchana (Natural Products Research Unit, Center for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University ) , Yenjai, Chavi (Natural Products Research Unit, Center for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.32 no.9 ,pp. 1185 - 1189 , 2009 , 0253-6269 ,

    초록

    Structural modification of 5,7-dimethoxyflavone isolated from Kaempferia parviflora furnished two nitro and seven amino derivatives. Among these, six new (3, 5-6, 8-10) and three known (2, 4, 7) flavonoid derivatives were synthesized. All compounds were evaluated for cytotoxicity against KB cell line using colorimetric method. Compounds 6 and 8 exhibited strong cytotoxicity with $IC_{50}$ values of 6.80 and $5.84\;{\mu}g/mL$ , respectively.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  4. [국내논문]   Analgesic, Antipyretic, Anti-Inflammatory and Toxic Effects of Andrographolide Derivatives in Experimental Animals   SCOPUS

    Suebsasana, Supawadee (Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University ) , Pongnaratorn, Panicha (Department of Pharmacology, Faculty of Medicine, Khon Kaen University ) , Sattayasai, Jintana (Department of Pharmacology, Faculty of Medicine, Khon Kaen University ) , Arkaravichien, Tarinee (Department of Pharmacology, Faculty of Medicine, Khon Kaen University ) , Tiamkao, Siriporn (Department of Pharmacology, Faculty of Medicine, Khon Kaen University ) , Aromdee, Chantana (Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.32 no.9 ,pp. 1191 - 1200 , 2009 , 0253-6269 ,

    초록

    Andrographolide (1) and 14-deoxy-11,12-didehydroandrographolide (2) are active constituents of Andrographis paniculata (Burm. f.), family Acanthaceae. A. paniculata extracts are reported to have antiviral, antipyretic, immunostimulant and anticancer activities. In this study, 1 and its 14-acetyl- (4) and 3,19-isopropylidenyl- (3) derivatives, as well as 2 and its 3,19-dipalmitoyl-derivative (5), were intraperitoneally tested for their analgesic, antipyretic, anti-inflammatory and acute toxicity effects in animal models. Analgesic effects were tested in mice using hot plate and writhing tests to distinguish the central and peripheral effects, respectively. The results showed that, at 4 mg/kg, all tested substances have significant analgesic effects, and the highest potency was seen with 3, 4 and 5. Increasing the dose of 3 and 5 to 8 mg/kg did not increase the analgesic effect. In the writhing test, 3 and 5, but not 1, showed significant results. In a baker's yeast-induced fever model, 3 and 5 significantly reduced rats' rectal temperature (p

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [국내논문]   Design, Synthesis, and Biological Evaluation of Phenylpropanamides as Novel Transient Receptor Potential Valnilloid 1 Antagonists   SCOPUS

    Li, Fu-Nan (College of Pharmacy, Seoul National University ) , Kim, Nam-Jung (College of Pharmacy, Seoul National University ) , Nam, Yeon-Hee (College of Pharmacy, Seoul National University ) , Kim, Seung-Hee (College of Pharmacy, Seoul National University ) , Seo, Seung-Yong (College of Pharmacy, Woosuk University ) , Jeong, Yeon-Su (Amorepacific R&D Center ) , Kim, Sun-Young (Amorepacific R&D Center ) , Park, Young-Ho (Amorepacific R&D Center ) , Suh, Young-Ger (College of Pharmacy, Seoul National University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.32 no.9 ,pp. 1201 - 1210 , 2009 , 0253-6269 ,

    초록

    Synthesis and structure-activity relationship of N-benzyl-3-phenylpropanamides as transient receptor potential vanilloid 1 (TRPV1) antagonists are described. A variety of substituents such as halide, ester, nitro, and alkyl groups at 2 or 3-position of 4-(methylsulfonylamino) benzyl unit were examined. These compounds exhibited potent $^{45}Ca^{2+}$ uptake inhibition in rat DRG neuron via TRPV1 blockade. Especially compound 28c, has been identified as a potent antagonist with $IC_{50}$ of 38 nM.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [국내논문]   2-Hydroxydiplopterol, A New Cytotoxic Pentacyclic Triterpenoid from the Halotolerant Fungus Aspergillus variecolor B-17   SCOPUS

    Wang, Wen-Liang (Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China,Key Laboratory of Systematic Mycology and Lichenology, and Center for Bioenergy and Industrial Biotechnology, Institute of Microbiology, Chinese Academy of Sciences ) , Liu, Pei-Pei (Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China ) , Zhang, Ya-Peng (Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China ) , Li, Jing (Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China ) , Tao, Hong-Wen (Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China ) , Gu, Qian-Qun (Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China ) , Zhu, Wei-Ming (Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharm)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.32 no.9 ,pp. 1211 - 1214 , 2009 , 0253-6269 ,

    초록

    A new hopane type pentacyclic triterpenoid, 2-hydroxydiplopterol (1) has been isolated from the metabolites produced by the halotolerant fungal strain Aspergillus variecolor B-17. The structure of 1 was determined by spectroscopic methods and single crystal X-Ray diffraction analysis. 2-Hydroxydiplopterol (1) exhibited cytotoxicity against K562 cells with an $IC_{50}$ value of $22\;{\mu}M$ .

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [국내논문]   Chemical Constituents from the Leaves of Ilex paraguariensis Inhibit Human Neutrophil Elastase   SCOPUS 피인용횟수: 1

    Xu, Guang-Hua (Korea Research Institute of Bioscience and Biotechnology ) , Kim, Young-Hee (Korea Research Institute of Bioscience and Biotechnology ) , Choo, Soo-Jin (Korea Research Institute of Bioscience and Biotechnology ) , Ryoo, In-Ja (Korea Research Institute of Bioscience and Biotechnology ) , Yoo, Jae-Kuk (Han Kook Shin Yak ) , Ahn, Jong-Seog (Korea Research Institute of Bioscience and Biotechnology ) , Yoo, Ick-Dong (Korea Research Institute of Bioscience and Biotechnology)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.32 no.9 ,pp. 1215 - 1220 , 2009 , 0253-6269 ,

    초록

    Human neutrophil elastase (HNE), a serine protease with broad target specificity, is the only enzyme responsible for the degradation of elastin which is an insoluble elastic fibrous protein in animal connective tissue. Biologically, elastase activity significantly increased with age, which results in a reduced skin elasticity and in the appearance of wrinkles or stretchmarks. In the course of our screening program for HNE inhibitors from natural source, the MeOH extract of Ilex paraguariensis leaves showed strong HNE inhibitory effect. Bioassay-guided fractionation led to the isolation of a new pyrrole alkaloid (1), along with seventeen known compounds (2-18) from the MeOH extract of Ilex paraguariensis leaves, and their chemical structures were elucidated on the basis of spectroscopic analysis. All isolated compounds were evaluated for HNE inhibitory activity, and the result demonstrated that dicaffeoylquinic acid derivatives (12, 13, 14, 15 and 16) and flavonoids (8 and 17) exhibited potent HNE inhibitory activity with $IC_{50}$ values ranging from 1.4 to $7.3\;{\mu}M$ .

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [국내논문]   Novel Ceramides from Aerial Parts of Saussurea involucrata Kar. et. Kir.   SCOPUS

    Wu, Wei (Department of Phytochemistry, Shenyang Pharmaceutical University ) , Qu, Yang (Department of Phytochemistry, Shenyang Pharmaceutical University ) , Gao, Huiyuan (Department of Phytochemistry, Shenyang Pharmaceutical University ) , Yang, Jingyu (Department of Pharmacology, Shenyang Pharmaceutical University ) , Xu, Jianguo (Xinjiang Institute of Materia Medica ) , Wu, Lijun (Department of Phytochemistry, Shenyang Pharmaceutical University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.32 no.9 ,pp. 1221 - 1225 , 2009 , 0253-6269 ,

    초록

    Novel ceramides, together with nine known compounds were isolated from aerial parts of the Saussurea involucrata Kar. et. Kir. The novel structures were determined by spectroscopic methods and microscale chemical degradation. The ceramides showed appreciable cytotoxicity against three human tumor cell lines including human promyelocytic leukemia (HL-60), human melanoma (A375-S2) and human cervical carcinoma (HeLa) cell lines. The results suggested that this class of ceramides may have potential as an antitumor agent.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [국내논문]   A Cyclohexenone Derivative from Diaporthaceous Fungus PSU-H2   SCOPUS 피인용횟수: 1

    Sommart, Ubonta (Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University ) , Rukachaisirikul, Vatcharin (Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University ) , Sukpondma, Yaowapa (Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University ) , Phongpaichit, Souwalak (Department of Microbiology, Faculty of Science, Prince of Songkla University ) , Towatana, Nongporn Hutadilok (Department of Biochemistry, Faculty of Science, Prince of Songkla University ) , Graidist, Potchanapond (Department of Biomedical Sciences, Faculty of Medicine, Prince of Songkla University ) , Hajiwangoh, Zuboidah (Faculty of Science Technology and Agriculture, Yala Rojabhat University ) , Sakayaroj, Jariya (National Center for Genetic Engineering and Biotechnology (BIOTEC))
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.32 no.9 ,pp. 1227 - 1231 , 2009 , 0253-6269 ,

    초록

    One new cyclohexenone derivative (1) was isolated from Diaporthaceous fungus PSU-H2 together with six known compounds, dothiorelone A (2), dothiorelone C (3), 2,3-dihydromycoepoxydiene (4), (+)-mycoepoxydiene (5), deacetylmycoepoxydiene (6) and tyrosol (7). The structures were elucidated by spectroscopic methods. Their cytotoxic activity against human breast cancer cell line, MCF-7, was evaluated.

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  10. [국내논문]   Two New Acorane Sesquiterpenes from Illicium henryi   SCOPUS

    Song, Tai-Fa (Department of Phytochemistry, School of Pharmacy, Second Military Medical University ) , Zhang, Wei-Dong (Department of Phytochemistry, School of Pharmacy, Second Military Medical University ) , Xia, Xin-Hua (Department of Pharmaceutics, School of Pharmacy, Hunan University of TCM ) , Shen, Yun-Heng (Department of Phytochemistry, School of Pharmacy, Second Military Medical University ) , Liu, Chun-Mei (Department of Phytochemistry, School of Pharmacy, Second Military Medical University ) , Lin, Sheng (Department of Phytochemistry, School of Pharmacy, Second Military Medical University ) , Jin, Hui-Zi (School of Pharmacy, Shanghai Jiao Tong University ) , Li, Hui-Liang (Department of Phytochemistry, School of Pharmacy, Second Military Medical University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.32 no.9 ,pp. 1233 - 1236 , 2009 , 0253-6269 ,

    초록

    Two new acorane sesquiterpenes, 10-hydroxyacoronene (1) and $1{\beta}$ -isopropyl- $4{\beta}$ -methyl- $9{\beta}$ - hydroxy spiro[4.5]dec-6-en-8-one (2), one new natural product, 4-hydroxy-4, 6-dimethyl-1-tetralone (3), and one known acorane sesquiterpene, acoradiepoxide (4) were isolated from the twigs and leaves of Illicium henryi. The structures of the new compounds were elucidated primarily on the basis of analysis of spectroscopic data. In addition, the inhibitory effect on NO production of these compounds were tested. Compounds 1 and 4 exhibited slight inhibitory effects on NO production with $IC_{50}$ values of $82.4\;{\mu}g/mL$ and $76.5\;{\mu}g/mL$ , respectively.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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