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International journal of cardiology 58건

  1. [해외논문]   Editorial Board  


    International journal of cardiology v.250 ,pp. IFC , 2018 , 0167-5273 ,

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  2. [해외논문]   Editorial Board   SCI SCIE


    International journal of cardiology v.250 ,pp. IFC - IFC , 2018 , 0167-5273 ,

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Stethoscope: A short autobiography   SCI SCIE

    Singh, V.P.
    International journal of cardiology v.250 ,pp. 1 - 3 , 2018 , 0167-5273 ,

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Abnormal coronary vasoreactivity in transient left ventricular apical ballooning (tako-tsubo) syndrome   SCI SCIE

    Verna, Edoardo (Corresponding author at: Ospedale di Circolo e Fondazione Macchi, University of Insubria, Varese, Italy.) , Provasoli, Stefano , Ghiringhelli, Sergio , Morandi, Fabrizio , Salerno-Uriarte, Jorge
    International journal of cardiology v.250 ,pp. 4 - 10 , 2018 , 0167-5273 ,

    초록

    Abstract Background The exact etiology and pathophysiologic mechanisms of tako-tsubo syndrome (TTS) remain controversial. Objective To further evaluate the abnormal coronary vasoreactivity and its possible anatomical substrate in TTS. Methods We studied 47 patients (46 women; age 67±12years) who underwent diagnostic cardiac catheterization and evaluation of coronary vasoreactivity by sequential acetylcholine (Ach), nitroglycerine and adenosine testing with angiographic and intracoronary pressure-Doppler flow monitoring. Coronary artery wall morphology was also evaluated by intravascular ultrasound (IVUS) imaging in 45 vessels of 43 patients. Results Abnormal coronary vasoconstriction to Ach stimulation was elicited in 40 patients (85%) involving the LAD artery and its branches in 39 (83%). Abnormal microvascular function was seen in 39 (83%) patients. Overall, hyperemic microvascular resistance index (HMR) was higher and Doppler coronary flow velocity reserve (CFVR) was lower in the LAD artery territory as compared to the reference territories (2.64±1.23 vs 2.05±0.56; p=0.008 and 1.95±0.7 vs 2.3±0.6; p=0.018, respectively). IVUS revealed no plaque rupture, dissection or thrombosis but occult plaque formation and myocardial bridging were found as a possible anatomical substrate of endothelial dysfunction in 67% and 48.8% patients respectively. Conclusions A global failure of coronary vasomotor function was demonstrated in most TTS patients. These findings implicate abnormal vasoconstrictive response to the activation of the sympathetic system as a potential mechanism involved in the pathogenesis of myocardial stunning in TTS. Perspectives Competency in medical knowledge : Abnormal coronary vasoconstriction secondary to endothelial dysfunction may actively contribute to the clinical manifestation of acute coronary syndromes in patients with non-obstructive coronary disease. Translational outlook 1 : TTS patients reveal a global failure of vasomotor function with both vasoconstrictive response to acetylcholine and increased hyperemic microvascular resistances in the territory of myocardial stunning. They may also show occult coronary atherosclerosis and myocardial bridging as the anatomic substrates of endothelial dysfunction. Translational outlook 2 : The cardiac phenotype of TTS includes a high prevalence of coronary vasomotor disturbances. These findings implicate abnormal vasoconstrictive response to the activation of the sympathetic system as a potential mechanism involved in the pathogenesis of TTS in post-menopausal women. Thus, a systematic evaluation of coronary vasoreactivity could better characterize the syndrome. Graphical abstract Diagrammatic illustration of the normal adaptation of coronary blood flow in response to sympathetic and neuro-humoral activation (A) and of the consequences of impaired flow-mediated coronary vasodilation under catecholamine overflow in the presence of coronary artery diseases and other conditions (see text). [DISPLAY OMISSION]

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Comprehensive assessment of sex hormones in Takotsubo syndrome   SCI SCIE

    Mö (Department of Cardiology, Angiology and Intensive Care Medicine, Medical Clinic II, University Heart Center Lübeck, Lübeck, Germany ) , ller, Christian (Department of Cardiology, Angiology and Intensive Care Medicine, Medical Clinic II, University Heart Center Lübeck, Lübeck, Germany ) , Stiermaier, Thomas (Department of Experimental and Clinical Endocrinology, Medical Clinic I, University Medical Center Lübeck, Lübeck, Germany ) , Brabant, Georg (Department of Cardiology, Angiology and Intensive Care Medicine, Medical Clinic II, University Heart Center Lübeck, Lübeck, Germany ) , Graf, Tobias (Department of Internal Medicine-Cardiology, University of Leipzig-Heart Center, Leipzig, Germany ) , Thiele, Holger (Department of Cardiology, Angiology and Intensive Care Medicine, Medical Clinic II, University Heart Center Lübeck, Lübeck, Germany) , Eitel, Ingo
    International journal of cardiology v.250 ,pp. 11 - 15 , 2018 , 0167-5273 ,

    초록

    Abstract Background The detailed pathomechanism of Takotsubo syndrome (TS) is still elusive. Due to the predominance of postmenopausal females, a potential role of sex hormones has been suggested. However, the limited available data are contradictory. The aim of this study was to comprehensively assess the role of sex hormone levels in a large cohort of TS patients. Methods Serum samples of 57 female TS patients and 57 female patients with myocardial infarction (MI), matched for age (±2years) and repolarization disturbances were analyzed for estradiol (E2), estrone (E1), testosterone and androstenedione using liquid chromatography-tandem mass spectrometry. Results There was no difference concerning the concentrations of E1 [pmol/l (IQR): 89.1 (62.5, 132.0) vs. 98.8 (63.3, 156.0), p = 0,441], testosterone [nmol/l (IQR): 0.67 (0.46, 1.00) vs. 0.80 (0.49, 1.08), p = 0.382] and androstenedione [nmol/l (IQR): 2.03 (1.57, 3.11) vs. 2.98 (1.48, 5.27), p = 0.244] between female TS and MI patients. Regarding E2, the majority of patients demonstrated concentrations below the detection limit of 30pmol/l (TS: n = 41/54, 75.9%; MI: n = 32/53, 60.4%; p = 0.078). The remaining individuals with detectable E2 concentrations did not show a significant difference between TS and MI patients [pmol/l (IQR): 40.5 (33.0, 53.3) vs. 54.1 (37.9, 60.9); p = 0.20]. Conclusions Altered sex hormone levels, especially an estradiol deficiency, could not be identified as a risk factor for TS.

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  6. [해외논문]   International standardization of diagnostic criteria for microvascular angina   SCI SCIE

    Ong, Peter (Department of Cardiology, Robert-Bosch-Krankenhaus, Stuttgart, Germany ) , Camici, Paolo G. (Vita Salute University and San Raffaele Hospital, Milan, Italy ) , Beltrame, John F. (The Queen Elizabeth Hospital Discipline of Medicine, University of Adelaide, Central Adelaide Local Health Network, Adelaide, South Australia, Australia ) , Crea, Filippo (Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy ) , Shimokawa, Hiroaki (Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan ) , Sechtem, Udo (Department of Cardiology, Robert-Bosch-Krankenhaus, Stuttgart, Germany ) , Kaski, Juan Carlos (Cardiovascular and Cell Sciences Research Institute, St George's, University of London, London, UK ) , Bairey Merz, C. Noel (Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA)
    International journal of cardiology v.250 ,pp. 16 - 20 , 2018 , 0167-5273 ,

    초록

    Abstract Standardization of diagnostic criteria for ischemic symptoms due to coronary microvascular dysfunction (CMD) is needed for further investigation of patients presenting with anginal chest pain consistent with “microvascular angina” (MVA). At the annual Coronary Vasomotion Disorders International Study Group (COVADIS) Summits held in August 2014 and 2015, the following criteria were agreed upon for the investigative diagnosis of microvascular angina: (1) presence of symptoms suggestive of myocardial ischemia; (2) objective documentation of myocardial ischemia, as assessed by currently available techniques; (3) absence of obstructive CAD ( 0.80) (4) confirmation of a reduced coronary blood flow reserve and/or inducible microvascular spasm. These standardized criteria provide an investigative structure for mechanistic, diagnostic, prognostic and clinical trial studies aimed at developing an evidence base needed for guidelines in this growing patient population. Standardized criteria will facilitate microvascular angina registries and recruitment of suitable patients into clinical trials. Mechanistic research will also benefit from the implementation of standardized diagnostic criteria for MVA.

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  7. [해외논문]   Chronic lower-dose relaxin administration protects from arrhythmia in experimental myocardial infarction due to anti-inflammatory and anti-fibrotic properties   SCI SCIE

    Beiert, Thomas (Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany ) , Knappe, Vincent (Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany ) , Tiyerili, Vedat (Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany ) , Stö (Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany ) , ckigt, Florian (Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany ) , Effelsberg, Verena (Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany ) , Linhart, Markus (Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany ) , Steinmetz, Martin (Department of Internal Medicine I, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany ) , Klein, Sabine (Department of Internal Medicine I, Univer) , Schierwagen, Robert , Trebicka, Jonel , Roell, Wilhelm , Nickenig, Georg , Schrickel, Jan W. , Andrié , , René , P.
    International journal of cardiology v.250 ,pp. 21 - 28 , 2018 , 0167-5273 ,

    초록

    Abstract Background The peptide hormone relaxin-2 (RLX) exerts beneficial effects during myocardial ischemia, but functional data on lower-dose RLX in myocardial infarction (MI) is lacking. Therefore, we investigated the impact of 75μg/kg/d RLX treatment on electrical vulnerability and left ventricular function in a mouse model of MI. Methods and results Standardized cryoinfarction of the left anterior ventricular wall was performed in mice. A two week treatment period with vehicle or RLX via subcutaneously implanted osmotic minipumps was started immediately after MI. The relaxin receptor RXFP1 was expressed on ventricular/atrial cardiomyocytes, myofibroblasts, macrophages and endothelial but not vascular smooth muscle cells of small coronary vessels. RLX treatment resulted in a significant reduction of ventricular tachycardia inducibility (vehicle: 91%, RLX: 18%, p p = 0.04). Interestingly, scar formation was attenuated by RLX with decreased transcript expression of connective tissue growth factor. Transcript levels of the pro-inflammatory cytokines interleukin-6 and interleukin-1β were upregulated in hearts of vehicle treated animals compared to mice without MI. Application of RLX attenuated this inflammatory response. In addition, macrophage infiltration was reduced in the borderzone of RLX treated mice. Conclusion Treatment with lower-dose RLX in mice prevents post-infarction ventricular tachycardia due to attenuation of scar formation and cardiac inflammation. Therefore, RLX could be evaluated as new therapeutic option in the treatment of MI.

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  8. [해외논문]   Effects of renal denervation on coronary flow reserve and forearm dilation capacity in patients with treatment-resistant hypertension. A randomized, double-blinded, sham-controlled clinical trial   SCI SCIE

    Engholm, Morten (Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark ) , Bertelsen, Jannik B. (Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark ) , Mathiassen, Ole N. (Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark ) , Bøtker, Hans E. (Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark ) , Vase, Henrik (Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark ) , Peters, Christian D. (Department of Nephrology, Aarhus University Hospital, Aarhus, Denmark ) , Bech, Jesper N. (University Clinic in Nephrology and Hypertension, Holstebro Hospital, Holstebro, Denmark ) , Buus, Niels H. (Department of Nephrology, Aarhus University Hospital, Aarhus, Denmark ) , Schroeder, Anne P. (Department of Cardiology, Viborg Hospital, Viborg ) , Rickers, Hans (Department of Cardiology, Randers Hospital, Randers, Denmark ) , Hansen, Klavs W. (Department of Internal Medicine, Silkeborg Hospital, Silkeborg, Denmark ) , Poulsen, Per L. (Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark ) , Kaltoft, Anne (Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark ) , Christensen, Kent L. (Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark)
    International journal of cardiology v.250 ,pp. 29 - 34 , 2018 , 0167-5273 ,

    초록

    Abstract Background Microvascular impairment is well documented in hypertension. We investigated the effect of renal sympathetic denervation (RDN) on cardiac and peripheral microvasculature in patients with treatment-resistant essential hypertension (TRH). Methods A randomized, single centre, double-blinded, sham-controlled clinical trial. Fifty-eight patients with TRH (ambulatory systolic BP (ASBP) ≥ 145mmHg) despite stable treatment were randomized to RDN or SHAM. RDN was performed with the unipolar Medtronic Flex catheter. Coronary flow reserve (CFR) and coronary- and forearm minimum vascular resistance (C-Rmin and F-Rmin) were determined using transthoracic Doppler echocardiography and F-Rmin with venous occlusion plethysmography at baseline and at six-months follow-up. Results RDN was performed with 5.3±0.2 lesions in the right renal artery and 5.4±0.2 lesions in the left. Baseline ASBP was 152±2mmHg (RDN, n=29) and 154±2mmHg (SHAM, n=29). Similar reductions in MAP were seen at follow up (−3.5±2.0 vs. −3.2±1.8, P=0.92). Baseline CFR was 2.9±0.1 (RDN) and 2.4±0.1 (SHAM), with no significant change at follow-up (0.2±0.2 vs. −0.1±0.2, P=0.57). C-Rmin was 1.9±0.3 (RDN) and 2.7±0.6 (SHAM) (mmHgmin/ml pr. 100g) and did not change significantly (0.3±0.5 vs. −0.4±0.8, P=0.48). F-Rmin was 3.6±0.2 (RDN) and 3.6±0.3 (SHAM) (mmHgmin/ml pr. 100ml tissue) and unchanged at follow-up (4.2±0.4 vs. 3.8±0.2, P=0.17). Left ventricular mass index was unchanged following RDN (−4±7 (RDN) vs. 3±5 (SHAM) (g/m 2 ) P=0.38). Conclusion The current study does not support positive effects of RDN on microvascular impairment in TRH.

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  9. [해외논문]   Short-term exposure to air pollutants increases the risk of ST elevation myocardial infarction and of infarct-related ventricular arrhythmias and mortality   SCI SCIE

    Bañ (Department of Cardiology, Vall d'Hebron Hospital, CIBERCV, Autonomous University of Barcelona, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain ) , eras, Jordi (Department of Cardiology, Vall d'Hebron Hospital, CIBERCV, Autonomous University of Barcelona, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain ) , Ferreira-Gonzá (CIBER de Epidemiología y Salud Pública (CIBERESP), Spain ) , lez, Ignacio (Department of Cardiology, Vall d'Hebron Hospital, CIBERCV, Autonomous University of Barcelona, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain ) , Marsal, Josep Ramon (Department of Cardiology, Vall d'Hebron Hospital, CIBERCV, Autonomous University of Barcelona, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain ) , Barrabé (Department of Cardiology, Vall d'Hebron Hospital, CIBERCV, Autonomous University of Barcelona, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain ) , s, José (Department of Cardiology, Vall d'Hebron Hospital, CIBERCV, Autonomous University of Barcelona, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain ) , A. (Department of Cardiol) , Ribera, Aida , Lidó , n, Rosa Maria , Domingo, Enric , Martí , , Gerard , Garcí , a-Dorado, David
    International journal of cardiology v.250 ,pp. 35 - 42 , 2018 , 0167-5273 ,

    초록

    Abstract Background The relation between STEMI and air pollution (AP) is scant. We aimed to investigate the short term association between AP and the incidence of STEMI, and STEMI-related ventricular arrhythmias (VA) and mortality. Methods The study was carried out in the area of Barcelona from January 2010 to December 2011. Daily STEMI rates and incidence of STEMI-related VA and mortality were obtained prospectively. The corresponding daily levels of the main pollutants were recorded as well as the atmospheric variables. Three cohorts were defined in order to minimize exposure bias. The magnitude of association was estimated using a time-series design and was adjusted according to atmospheric variables. Results The daily rate of hospital admissions for STEMI was associated with increases in PM 2.5, PM 10, lead and NO2 concentrations. VA incidence and mortality were associated with increases in PM 2.5 and PM 10 concentrations. In the most specific cohort, BCN (Barcelona) Attended & Resident, STEMI incidence was associated with increases in PM 2.5 (1.009% per 10μg/m 3 ) and PM 10 concentrations (1.005% per 10μg/m 3 ). VA was associated with increases in PM 2.5 (1.021%) and PM 10 (1.015%) and mortality was associated with increases in PM 2.5 (1.083%) and PM 10 (1.045%). Conclusions Short-term exposure to high levels of PM 2.5 and PM 10 is associated with increased daily STEMI admissions and STEMI-related VA and mortality. Exposure to high levels of lead and NO2 is associated with increased daily STEMI admissions, and NO2 with higher mortality in STEMI patients.

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  10. [해외논문]   Predictive value of depression and anxiety for long-term mortality: differences in outcome between acute coronary syndrome and stable angina pectoris   SCI SCIE

    de Jager, Tom A.J. (Department of Cardiology, Thoraxcenter Erasmus Medical Centre, Rotterdam, The Netherlands ) , Dulfer, Karolijn (Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands ) , Radhoe, Sumant (Department of Cardiology, Thoraxcenter Erasmus Medical Centre, Rotterdam, The Netherlands ) , Bergmann, Michael J. (Department of Cardiology, Thoraxcenter Erasmus Medical Centre, Rotterdam, The Netherlands ) , Daemen, Joost (Department of Cardiology, Thoraxcenter Erasmus Medical Centre, Rotterdam, The Netherlands ) , van Domburg, Ron T. (Department of Cardiology, Thoraxcenter Erasmus Medical Centre, Rotterdam, The Netherlands ) , Lenzen, Mattie J. (Department of Cardiology, Thoraxcenter Erasmus Medical Centre, Rotterdam, The Netherlands ) , Utens, Elisabeth M.W.J. (Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands)
    International journal of cardiology v.250 ,pp. 43 - 48 , 2018 , 0167-5273 ,

    초록

    Abstract Background Since the early 2000s the treatment of choice for an acute myocardial infarction has moved from thrombolytic therapy to primary PCI (pPCI). As a result, the majority of patients undergoing PCI shifted from stable angina pectoris (SA) to acute coronary syndrome (ACS). Additionally the previously observed association between depression and anxiety and long-term outcome in patients who underwent a PCI may have been changed. The main objective of this study was to investigate the predictive value of depression and anxiety for 10-year mortality, in a cohort with post-PCI patients treated for SA versus patients treated for ACS. Methods This prospective single center cohort consists of a consecutive series of patients (n=528) treated with PCI. At 1month post-PCI, patients completed the Dutch version of the Hospital Anxiety and Depression Scale (HADS). Results After adjustment for baseline characteristics depression was associated with higher 10-year mortality post-PCI (HR 1.58 95% Confidence Interval [95% CI] 1.04–2.40). In the ACS population no association between depression and 10-year mortality was found (HR 1.05 95% CI 0.62–1.79), in contrast to the SA population (HR 1.97 95% CI 1.09–3.57). After additional adjustment for anxiety, depression was no longer associated with higher mortality. Conclusions Anxiety at baseline was associated with an increased 10-year mortality rate after PCI. Depression was also associated with higher 10-year mortality, however the association disappeared after additional adjustment for anxiety. This finding was more pronounced in patients presenting with SA as compared to those presenting with ACS, which might be a result of the increasing number of ACS patients treated with pPCI.

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