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International journal of cardiology 55건

  1. [해외논문]   Editorial Board  


    International journal of cardiology v.267 ,pp. IFC , 2018 , 0167-5273 ,

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  2. [해외논문]   Editorial Board  


    International journal of cardiology v.267 ,pp. IFC - IFC , 2018 , 0167-5273 ,

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Increased risk of myocardial infarction with dabigatran etexilate: fact or fiction? A critical meta-analysis of over 580,000 patients from integrating randomized controlled trials and real-world studies  

    Wei, An-Hua (Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China ) , Gu, Zhi-Chun (Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China ) , Zhang, Chi (Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China ) , Ding, Yu-Feng (Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China ) , Liu, Dong (Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China ) , Li, Juan (Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China ) , Liu, Xiao-Yan (Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China ) , Lin, Hou-Wen (Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China ) , Pu, Jun (Depa)
    International journal of cardiology v.267 ,pp. 1 - 7 , 2018 , 0167-5273 ,

    초록

    Abstract Background The question of whether the use of dabigatran etexilate is associated with a high risk of myocardial infarction (MI) remains unanswered owing to the lack of critical evidences. Methods A comprehensive search of databases (Medline, Embase, Cochrane Library databases, and ClinicalTrials.gov Website) was performed for RCTs that reported MI events and observational nationwide database studies that reported adjusted hazard ratio (HR) with dabigatran treatment. Summary HRs and 95% confidence intervals (95% CI) were calculated using random-effects models. Cumulative meta-analysis was conducted for evaluating the results as a continuum, and subgroup analyses were undertaken on the basis of study type, indication, controls, and dosage. Results Finally, 24 studies including 588,047 patients (44,856 patients in 14 RCTs and 543,191 patients in 10 observational database studies) met the inclusion criteria, among which 222,352 (37.8%) patients receiving dabigatran and 365,695 (62.2%) patients receiving placebo/other anticoagulants. In comparison to controls, no significant association was detected between the use of dabigatran and the higher risk of MI (HR: 0.97, 95% CI: 0.87–1.06; I 2 for heterogeneity: 26.3%, P = 0.089). The results were consistent across the key subgroups (indication, controls, and dosage, P interaction > 0.05 for each), with the exception of study type (RCTs or database studies, P interaction = 0.046). C 0.046). Cumulative meta-analysis was not suggestive of a temporal trend in the effect of dabigatran on MI. Conclusions This meta-analysis confirms a low risk of MI in patients exposed to dabigatran, which seems to be validated when pooling over 580,000 patients from RCTs and real-world studies. Highlights Previous evidence of MI risk with dabigatran is derived mainly from the RE-LY trial. High-quality observational studies can provide crucial evidence especially when there are gaps in evidence from RCTs In fact, dabigatran does not increase the risk of MI.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   An ordinal prediction model of the diagnosis of non-obstructive coronary artery and multi-vessel disease in the CARDIIGAN cohort  

    Edlinger, Michael (Department of Medical Statistics, Informatics, and Health Economics, Medical University Innsbruck, Austria ) , Dö (University Clinic of Internal Medicine III - Cardiology and Angiology, Medical University Innsbruck, Austria ) , rler, Jakob (Department of Medical Statistics, Informatics, and Health Economics, Medical University Innsbruck, Austria ) , Ulmer, Hanno (University Clinic of Internal Medicine III - Cardiology and Angiology, Medical University Innsbruck, Austria ) , Wanitschek, Maria (Department of Public Health, Erasmus University Medical Centre, Rotterdam, The Netherlands ) , Steyerberg, Ewout W. (Department of Cardiology and Karl Landsteiner Institute for Interdisciplinary Science, Rehabilitation Centre Münster in Tyrol, Austria ) , Alber, Hannes F. (Department of Biomedical Data Sciences, Leiden University Medical Centre, The Netherlands) , Van Calster, Ben
    International journal of cardiology v.267 ,pp. 8 - 12 , 2018 , 0167-5273 ,

    초록

    Highlights An ordinal diagnostic tool is proposed based on routinely obtained information. Assessment of individual probabilities of various coronary artery disease categories. Treatment depends on disease severity, unnecessary angiographies might be prevented.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Improvement in quality indicators using NCDR® registries: First international experience  

    de Barros e Silva, Pedro Gabriel Melo (Hospital TotalCor, São Paulo, Brazil ) , Ribeiro, Henrique Barbosa (Hospital TotalCor, São Paulo, Brazil ) , Lopes, Renato Delascio (Duke Clinical Research Institute, Durham, NC, USA ) , Macedo, Thiago Andrade (Hospital TotalCor, São Paulo, Brazil ) , Conejo, Fabio (Hospital TotalCor, São Paulo, Brazil ) , do Amaral Baruzzi, Antô (Hospital TotalCor, São Paulo, Brazil ) , nio Clá (Hospital TotalCor, São Paulo, Brazil ) , udio (Hospital TotalCor, São Paulo, Brazil ) , Okada, Mariana Yumi (Hospital TotalCor, São Paulo, Brazil ) , Garcia, Jose Carlos Teixeira (Hospital TotalCor, São Paulo, Brazil ) , Rodrigues, Marcelo Jamus (Hospital TotalCor, São Paulo, Brazil) , Furlan, Valter , Ribeiro, Expedito E.
    International journal of cardiology v.267 ,pp. 13 - 15 , 2018 , 0167-5273 ,

    초록

    Abstract Background The National Cardiovascular Data Registry (NCDR?) Database is commonly used for quality-improvement initiatives in North America, but little is known about the application of this tool in other regions of the world. Methods All consecutive patients admitted due to myocardial infarction (MI) and/or undergoing percutaneous coronary intervention (PCI) from January 2012 until December 2015 in a Brazilian private cardiovascular hospital were included respectively in ACTION REGISTRY?-GWTG™ and CathPCI Registry?. Meetings including all hospital staff were performed quarterly to discuss every NCDR? report. Quality improvement initiatives were developed based on the reports which were also used for evaluation of changes after the interventions. The following indicators were considered a priority 1) Door-to-ECG and door-to-balloon (D2B) times; 2) PCI appropriateness; 3) length of stay; 4) delivery of guideline-based medication. Changes in the quality of care with respect to the over time were assessed using linear and logistic regression for continuous and binary outcomes, respectively. Results A total of 1.382 patients were included in the ACTION REGISTRY?-GWTG™ and 3.179 patients in the CathPCI Registry?. In the ACTION registry, the overall AMI performance composite of quality indicators improved along the 4 years from 95.0% to 99.6% (p for trend Conclusion The present novel experience using the NCDR? registries as benchmarks to guide quality-improvement programs in an international site was associated with improvement in quality indicators. Highlights National Cardiovascular Data Registry (NCDR?) is a well-known quality-improvement tool. The utility of this tool in outside North America is unknown. The report of an international site in NCDR showed an improvement in medical care. The results indicate promising application of international registries in different countries.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Clinical and coronary haemodynamic determinants of recurrent chest pain in patients without obstructive coronary artery disease — A pilot study  

    Sheikh, Abdul R. (Discipline of Medicine, University of Adelaide, Adelaide, South Australia 5005, Australia ) , Zeitz, Christopher J. (Discipline of Medicine, University of Adelaide, Adelaide, South Australia 5005, Australia ) , Rajendran, Sharmalar (Discipline of Medicine, University of Adelaide, Adelaide, South Australia 5005, Australia ) , Di Fiore, David P. (Discipline of Medicine, University of Adelaide, Adelaide, South Australia 5005, Australia ) , Tavella, Rosanna (Discipline of Medicine, University of Adelaide, Adelaide, South Australia 5005, Australia ) , Beltrame, John F. (Discipline of Medicine, University of Adelaide, Adelaide, South Australia 5005, Australia)
    International journal of cardiology v.267 ,pp. 16 - 21 , 2018 , 0167-5273 ,

    초록

    Abstract Background Coronary haemodynamic testing frequently identifies abnormal pathophysiological parameters in patients with angina and non-obstructed coronaries on angiography (NoCAD) but the clinical utility of these measures has received limited attention. Objective This study aims to identify the clinical and coronary haemodynamic determinants of recurrent chest pain at one month in patients with NoCAD. Methods Patients with angina, NoCAD ( Provocative spasm testing with high dose IC-ACh boluses (25, 50 and 100 μg). Clinical and health status were assessed at baseline and one month. Results In the 49 NoCAD patients (78% female, mean age of 54 ± 11) undergoing comprehensive coronary haemodynamic testing, 33 (67%) continued to experience chest pain at one month. Determinants of recurrent chest pain on univariate analysis included baseline chest pain status or a HMR > 1.9. Multivariate logistic regression analysis identified frequent angina at baseline (OR: 68.9 [4.1, 1165.0], p = 0.003), previous unstable angina admission (OR: 43.9 [3.5, 547.9], p = 0.003) and a HMR > 1.9 (OR: 15.6 [2.1, 114.0], p = 0.007) as independent predictors of recurrent chest pain. Conclusion In this small pilot study, an abnormal HMR was the only coronary haemodynamic parameter that was a determinant of ongoing angina at short-term follow-up. Highlights Many patients with angina but no significant CAD or ischaemia, have abnormal coronary haemodynamic measures. Hyperaemic Microvascular Resistance index (HMR) is a determinant of ongoing angina at 30 days.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Natural history and predictors of mortality of patients with Takotsubo syndrome  

    Kim, Hyunsu (Department of Cardiovascular Disease, Mayo Clinic, Rochester, MN, USA ) , Senecal, Conor (Department of Cardiovascular Disease, Mayo Clinic, Rochester, MN, USA ) , Lewis, Bradley (Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA ) , Prasad, Abhiram (Department of Cardiovascular Disease, Mayo Clinic, Rochester, MN, USA ) , Rajiv, Gulati (Department of Cardiovascular Disease, Mayo Clinic, Rochester, MN, USA ) , Lerman, Lilach O. (Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA ) , Lerman, Amir (Department of Cardiovascular Disease, Mayo Clinic, Rochester, MN, USA)
    International journal of cardiology v.267 ,pp. 22 - 27 , 2018 , 0167-5273 ,

    초록

    Abstract Background Takotsubo syndrome is a unique transient cardiomyopathy. The pathogenesis, management, and long-term prognosis of Takotsubo syndrome are incompletely understood. The study was designed to evaluate the natural history and determinants of outcomes in patients with Takotsubo syndrome patients. Methods We analyzed 265 patients in the Mayo Clinic Takotsubo syndrome registry for clinical presentation, treatment, and long-term outcomes with a focus on identifying prognostic factors for mortality and recurrence. Results 95% of patients were women with a mean age of 70 ± 11.8 years. Among 257 patients discharged alive, there were 89 (34.6%) deaths, 18 (6.8%) non-fatal myocardial infarction, 12 (4.7%) cerebrovascular accidents and 23 (8.9%) re-hospitalization for heart failure over a mean follow-up of 5.8 ± 3.6 years. Only 4 (5%) patients died from cardiac causes. Cancer was the single leading cause of death. Overall 1-year survival rate was 94.2%. Independent prognostic predictors of mortality were a history of cancer (HR 2.004, 1.334–3.012, p = 0.004), physical stress as precipitating factors (HR 1.882, 1.256–2.822, p = 0.012), history of depression (HR 1.622, 1.085–2.425, p = 0.009) and increased age (HR 1.059, 1.037–1.081, p Conclusion The high mortality rate is related to non-cardiac co-morbidities such as cancer. Additional determinants include physical stressors, increased age, and history of depression. Use of beta-blockers and ACE inhibitors did not affect development, prognosis or recurrence. Highlights The prognosis of Takotsubo syndrome is not benign, shows poor outcomes. The prognosis is worse than age- and sex-matched the normal population. The important factor that determines the prognosis is underlying co-morbidity. Cancer is the most important factor affecting prognosis. Treatment with beta blockers and ACE inhibitors do not affect the prognosis.

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  8. [해외논문]   The risk for a first acute coronary syndrome in patients treated with different types of antidepressants: A population based nested case-control study  

    Almog, Ronit (Epidemiology Unit, Rambam Health Care Center, Israel ) , Carasso, Shemy (Cardiovascular Division, B Padeh Medical Center, Poriya, Lower Galilee 15208, Israel ) , Lavi, Idit (School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Israel ) , Amir, Offer (Cardiovascular Division, B Padeh Medical Center, Poriya, Lower Galilee 15208, Israel)
    International journal of cardiology v.267 ,pp. 28 - 34 , 2018 , 0167-5273 ,

    초록

    Abstract Background Tricyclic antidepressants (TCAs) are still used in 30% of anxiety/depression cases and have been related to increased cardiovascular risk. Newer serotonin/norepinephrine reuptake inhibitors (SSRI s /SNRI s ) safety remains conflicting. Our aim was to assess the risk of a first acute coronary syndrome (ACS) in patients treated by various types of antidepressants. Methods Study was a retrospective nested case-control of 40–80 years old northern-Israeli members of Clalit Health Services (CHS) during 1.1.2003–31.12.2013. Patients with severe psychiatric, cardiac or systemic diseases, or pre-enrollment antidepressants were excluded. Cases that had a first ACS during the study period were matched in 1:30 ratio with controls. The association between antidepressants use and ACS was tested by adjusted multivariable conditional logistic regression. Results The cohort included 535,315 individuals 128,550 of whom met the exclusion/inclusion criteria. 3391 Cases with first ACS, (incidence rate of 24.6/10,000 person years) were matched with 88,016 controls. ACS was not associated with use of either SSRI S /SNRI S or TCA s compared with no antidepressants use. However, treatment by SSRI S /SNRI S was associated with a 36% decreased risk ACS compared to TCA s , OR = 0. 64, 95%CI (0.43–0.95), p = 0.029. Age 40–64 years, male gender and metabolic syndrome associated with reduced risk of ACS among SSRI S /SNRI S compared to TCA s users. Conclusion In this study of patients without prior cardiovascular disease– neither antidepressant group imposed excess risk for ACS, compared to-no treatment. SSRIs treatment seemed safer compared to TCAs in regard of ACS. This study probably adds to our confidence of preferring SSRIs over TCAs in patients without prior cardiovascular disease. Highlights Population based retrospective study assessing risk of ACS with antidepressants Compared to no-treatment TCA and SSRI/SNRI treatment showed a similar risk for ACS. Compared to TCA, SSRI/SNRIs were associated with a 36% risk reduction for a 1st ACS.

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  9. [해외논문]   A narrative overview: Have clinical trials of PCI vs medical therapy addressed the right question?  

    Morrone, Doralisa (Christiana Care Health System, Newark, DE, USA ) , Marzilli, Mario (Surgery Pathology, Medical, Molecular and Critic Area Department-Cardiovascular Disease Section, Pisa University, Italy ) , Panico, Roberta Antonazzo (Surgery Pathology, Medical, Molecular and Critic Area Department-Cardiovascular Disease Section, Pisa University, Italy ) , Kolm, Paul (Christiana Care Health System, Newark, DE, USA ) , Weintraub, William S. (Christiana Care Health System, Newark, DE, USA)
    International journal of cardiology v.267 ,pp. 35 - 40 , 2018 , 0167-5273 ,

    초록

    Abstract Background In RCTs about revascularization, the terms “coronary artery disease” and “ischemic heart disease” are sometimes used interchangeably. This can create confusion concerning inclusion and exclusion criteria, which may lead to uncertain results. Objective Our purpose is to investigate whether the study populations in randomized controlled trials (RCTs) which compared percutaneous coronary revascularization to medical therapy for stable ischemic heart disease specifically enrolled patients with demonstrable ischemia, and how many patients were included in trials with evidence of coronary atherosclerosis but without evidence of ischemia. Methods Trial published data were obtained from ACME I, ACME II, RITA I, RITA II, MASS I, MASS II, AVERT, ACIP, COURAGE and FAME2. Published data were used to calculate the number of patients included in the trials with a negative stress test but significant coronary artery stenosis and the number of patients excluded from the trials with a positive stress test or angina, but without significant coronary artery stenosis at the time of angiography. Results A total of 196,433 patients were screened between 1998 and 2011. Overall about 30% of patients were excluded if they did not meet the angiographic criteria, even though the presence of inducible ischemia or angina, and, about 20% of patients were included without inducible ischemia. Conclusion RCTs have contributed to the confusion between coronary artery disease and ischemic heart disease. This may limit the ability to interpret the results and apply them in practice. Highlights Ischemic Heart disease and CAD today are used interchangeably RCTs have contributed to this confusion limiting the ability to interpret results and apply them in practice The goal of SIHD should be to draw inferences from findings in the trial about the nature of the proper patient

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  10. [해외논문]   Predictors of poor clinical outcomes in patients with acute myocardial infarction and non-obstructed coronary arteries (MINOCA)  

    Ciliberti, Giuseppe (Cardiology and Arrhythmology Clinic, Marche Polytechnic University, University Hospital "Ospedali Riuniti", Ancona, Italy ) , Coiro, Stefano (Division of Cardiology, University of Perugia School of Medicine, Perugia, Italy ) , Tritto, Isabella (Division of Cardiology, University of Perugia School of Medicine, Perugia, Italy ) , Benedetti, Martina (Division of Cardiology, University of Perugia School of Medicine, Perugia, Italy ) , Guerra, Federico (Cardiology and Arrhythmology Clinic, Marche Polytechnic University, University Hospital "Ospedali Riuniti", Ancona, Italy ) , Del Pinto, Maurizio (Division of Cardiology, S. Maria della Misericordia Hospital, Perugia, Italy ) , Finocchiaro, Gherardo (Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, United Kingdom ) , Cavallini, Claudio (Division of Cardiology, S. Maria della Misericordia Hospital, Perugia, Italy ) , Capucci, Alessandro (Cardiology and Arrhythmology Clinic, Marche Polytechnic University, University Hospital "Ospedali Riuniti", Ancona, Italy ) , Kaski, Juan Carlos (Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, United Kingd) , Ambrosio, Giuseppe
    International journal of cardiology v.267 ,pp. 41 - 45 , 2018 , 0167-5273 ,

    초록

    Abstract Objective To assess the characteristics and prognosis of patients with myocardial infarction and non-obstructed coronary arteries (MINOCA). Methods MINOCA was defined as acute myocardial infarction (AMI) with angiographic coronary stenosis Results From January 2006 to December 2014, 7935 consecutive AMI patients were entered into our institutional database;150 (2%) were diagnosed as having MINOCA. At a median follow-up of 7.1 years the composite end-point (cardiovascular death, AMI or acute coronary syndrome, heart failure, stroke) occurred in 23 patients (17.4%). Survival analysis showed no differences between NCA versus MCAD ( p = 0.781). When assessed by distribution of CAD, group III had a lower event-free survival compared to group I and group II, respectively 54 ± 14%, 83 ± 4% and 90 ± 5% ( p = 0.001). In a multivariate model, only 3 vessel disease or LMS involvement (HR = 23.5, 95% CI 2.59–173.49, P = 0.001) and high C-reactive protein at hospital admission (HR = 1.47, 95% CI 1.06–2.07, P = 0.005) were significant predictors of the study composite endpoint. Conclusions In patients with MINOCA, the presence of NCA or 1–2 vessel MCAD was associated with better long-term clinical outcomes compared with patients with MCAD affecting 3 vessels or the LMS. Increased CRP concentrations on hospital admission were also a marker of worse clinical outcome during follow-up. Highlights MINOCA is a challenging working diagnosis. A new standard definition of MINOCA has recently been proposed. MINOCA patients with MCAD affecting 3 vessels and/or the LMS have a guarded prognosis. MINOCA patients with increased CRP levels may require more aggressive treatment. Systematic assessment of both number of coronary vessels showing MCAD and CRP levels may improve prognostic scores in MINOCA patients.

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