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Nature genetics 17건

  1. [해외논문]   A rose on the garden fair   SCI SCIE


    Nature genetics v.50 no.6 ,pp. 769 - 769 , 2018 , 1061-4036 ,

    초록

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   The genomic floral language of rose   SCI SCIE

    Xu, Qing (State Forestry Administration Key Laboratory of Orchid Conservation and Utilization, College of Landscape Architecture, Fujian Agriculture and Forestry University, Fuzhou, China ) , Liu, Zhong-Jian (State Forestry Administration Key Laboratory of Orchid Conservation and Utilization, The Orchid Conservation and Research Center of Shenzhen, Shenzhen, China )
    Nature genetics v.50 no.6 ,pp. 770 - 771 , 2018 , 1061-4036 ,

    초록

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  3. [해외논문]   The Rosa genome provides new insights into the domestication of modern roses   SCI SCIE

    Raymond, Olivier (Laboratoire Reproduction et Développement des Plantes, Univ Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRA, Lyon, France ) , Gouzy, Jé (LIPM, Université) , rô (de Toulouse, INRA, CNRS, Castanet-Tolosan, France ) , me (Laboratoire Reproduction et Développement des Plantes, Univ Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRA, Lyon, France ) , Just, Jé (LIPM, Université) , ré (de Toulouse, INRA, CNRS, Castanet-Tolosan, France ) , my (Univ Lyon, Université) , Badouin, Hé (Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR5558, Villeurbanne, France ) , lè (Laboratoire Reproduction et Développement des Plantes, Univ Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRA, Lyon, France ) , ne (Institute of Plant Sciences Paris-Saclay (IPS2), CNRS, INRA, University Paris-Sud, University of Evry, University Paris-Diderot, Sorbonne Paris-Cite, University of Paris-Saclay, Orsay, France ) , Verdenaud, Marion (CEA–Institut de Biologie François Jacob, Genoscope, Evry, France ) , Lemainque, Arnaud (Laboratoire Reproduction et Développement des Plantes, Univ Ly) , Vergne, Philippe , Moja, Sandrine , Choisne, Nathalie , Pont, Caroline , Carrè , re, Sé , bastien , Caissard, Jean-Claude , Couloux, Arnaud , Cottret, Ludovic , Aury, Jean-Marc , Szé , csi, Judit , Latrasse, David , Madoui, Mohammed-Amin , Franç , ois, Lé , a , Fu, Xiaopeng , Yang, Shu-Hua , Dubois, Annick , Piola, Florence , Larrieu, Antoine , Perez, Magali , Labadie, Karine , Perrier, Lauriane , Govetto, Benjamin , Labrousse, Yoan , Villand, Priscilla , Bardoux, Claudia , Boltz, Vé , ronique , Lopez-Roques, Cé , line , Heitzler, Pascal , Vernoux, Teva , Vandenbussche, Michiel , Quesneville, Hadi , Boualem, Adnane , Bendahmane, Abdelhafid , Liu, Chang , Le Bris, Manuel , Salse, Jé , rô , me , Baudino, Sylvie , Benhamed, Moussa , Wincker, Patrick , Bendahmane, Mohammed
    Nature genetics v.50 no.6 ,pp. 772 - 777 , 2018 , 1061-4036 ,

    초록

    Roses have high cultural and economic importance as ornamental plants and in the perfume industry. We report the rose whole-genome sequencing and assembly and resequencing of major genotypes that contributed to rose domestication. We generated a homozygous genotype from a heterozygous diploid modern rose progenitor, Rosa chinensis ‘Old Blush’. Using single-molecule real-time sequencing and a meta-assembly approach, we obtained one of the most comprehensive plant genomes to date. Diversity analyses highlighted the mosaic origin of ‘La France’, one of the first hybrids combining the growth vigor of European species and the recurrent blooming of Chinese species. Genomic segments of Chinese ancestry identified new candidate genes for recurrent blooming. Reconstructing regulatory and secondary metabolism pathways allowed us to propose a model of interconnected regulation of scent and flower color. This genome provides a foundation for understanding the mechanisms governing rose traits and should accelerate improvement in roses, Rosaceae and ornamentals.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  4. [해외논문]   Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma   SCI SCIE

    Khawaja, Anthony P. (NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK ) , Cooke Bailey, Jessica N. (Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK ) , Wareham, Nicholas J. (Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA ) , Scott, Robert A. (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK ) , Simcoe, Mark (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK ) , Igo Jr, Robert P. (Department of Ophthalmology, King's College London, St. Thomas' Hospital, London, UK ) , Song, Yeunjoo E. (Department of Twin Research & Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK ) , Wojciechowski, Robert (Department of Population and Quantitative Health S) , Cheng, Ching-Yu , Khaw, Peng T. , Pasquale, Louis R. , Haines, Jonathan L. , Foster, Paul J. , Wiggs, Janey L. , Hammond, Chris J. , Hysi, Pirro G.
    Nature genetics v.50 no.6 ,pp. 778 - 782 , 2018 , 1061-4036 ,

    초록

    Glaucoma is the leading cause of irreversible blindness globally 1 . Despite its gravity, the disease is frequently undiagnosed in the community 2 . Raised intraocular pressure (IOP) is the most important risk factor for primary open-angle glaucoma (POAG) 3,4 . Here we present a meta-analysis of 139,555 European participants, which identified 112 genomic loci associated with IOP, 68 of which are novel. These loci suggest a strong role for angiopoietin-receptor tyrosine kinase signaling, lipid metabolism, mitochondrial function and developmental processes underlying risk for elevated IOP. In addition, 48 of these loci were nominally associated with glaucoma in an independent cohort, 14 of which were significant at a Bonferroni-corrected threshold. Regression-based glaucoma-prediction models had an area under the receiver operating characteristic curve (AUROC) of 0.76 in US NEIGHBORHOOD study participants and 0.74 in independent glaucoma cases from the UK Biobank. Genetic-prediction models for POAG offer an opportunity to target screening and timely therapy to individuals most at risk.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  5. [해외논문]   3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk   SCI SCIE

    Park, Hyun Jung (Division of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA ) , Ji, Ping (Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA ) , Kim, Soyeon (Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA ) , Xia, Zheng (Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA ) , Rodriguez, Benjamin (Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA ) , Li, Lei (Division of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA ) , Su, Jianzhong (Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA ) , Chen, Kaifu (Division of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA ) , Masamha, Chioniso P. (Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA ) , Baillat, David (Division of Biostatistics, Dan L Duncan Cancer Center, Bay) , Fontes-Garfias, Camila R. , Shyu, Ann-Bin , Neilson, Joel R. , Wagner, Eric J. , Li, Wei
    Nature genetics v.50 no.6 ,pp. 783 - 789 , 2018 , 1061-4036 ,

    초록

    Widespread mRNA 3′ UTR shortening through alternative polyadenylation 1 promotes tumor growth in vivo 2 . A prevailing hypothesis is that it induces proto-oncogene expression in cis through escaping microRNA-mediated repression. Here we report a surprising enrichment of 3′UTR shortening among transcripts that are predicted to act as competing-endogenous RNAs (ceRNAs) for tumor-suppressor genes. Our model-based analysis of the trans effect of 3′ UTR shortening (MAT3UTR) reveals a significant role in altering ceRNA expression. MAT3UTR predicts many trans-targets of 3′ UTR shortening, including PTEN, a crucial tumor-suppressor gene 3 involved in ceRNA crosstalk 4 with nine 3′UTR-shortening genes, including EPS15 and NFIA. Knockdown of NUDT21, a master 3′ UTR-shortening regulator 2 , represses tumor-suppressor genes such as PHF6 and LARP1 in trans in a miRNA-dependent manner. Together, the results of our analysis suggest a major role of 3′ UTR shortening in repressing tumor-suppressor genes in trans by disrupting ceRNA crosstalk, rather than inducing proto-oncogenes in cis.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  6. [해외논문]   The fecal metabolome as a functional readout of the gut microbiome   SCI SCIE

    Zierer, Jonas (Department for Twin Research & Genetic Epidemiology, King's College London, London, UK ) , Jackson, Matthew A. (Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany ) , Kastenmü (Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA ) , ller, Gabi (Department for Twin Research & Genetic Epidemiology, King's College London, London, UK ) , Mangino, Massimo (Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany ) , Long, Tao (Department for Twin Research & Genetic Epidemiology, King's College London, London, UK ) , Telenti, Amalio (NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK ) , Mohney, Robert P. (Human Longevity, Inc, San Diego, CA, USA ) , Small, Kerrin S. (Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA ) , Bell, Jordana T. (Human Longevity, Inc, San Diego, CA, USA ) , Steves, Claire J. (Metabolon, Inc, Durham, NC, USA ) , Valdes, Ana M. (Department for Twin Research & Genet) , Spector, Tim D. , Menni, Cristina
    Nature genetics v.50 no.6 ,pp. 790 - 795 , 2018 , 1061-4036 ,

    초록

    The human gut microbiome plays a key role in human health 1 , but 16S characterization lacks quantitative functional annotation 2 . The fecal metabolome provides a functional readout of microbial activity and can be used as an intermediate phenotype mediating host–microbiome interactions 3 . In this comprehensive description of the fecal metabolome, examining 1,116 metabolites from 786 individuals from a population-based twin study (TwinsUK), the fecal metabolome was found to be only modestly influenced by host genetics (heritability (H 2 ) = 17.9%). One replicated locus at the NAT2 gene was associated with fecal metabolic traits. The fecal metabolome largely reflects gut microbial composition, explaining on average 67.7% (±18.8%) of its variance. It is strongly associated with visceral-fat mass, thereby illustrating potential mechanisms underlying the well-established microbial influence on abdominal obesity. Fecal metabolic profiling thus is a novel tool to explore links among microbiome composition, host phenotypes, and heritable complex traits.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  7. [해외논문]   Resequencing of 243 diploid cotton accessions based on an updated A genome identifies the genetic basis of key agronomic traits   SCI SCIE

    Du, Xiongming (Research Base, Anyang Institute of Technology, State Key Laboratory of Cotton Biology, Anyang, China ) , Huang, Gai (Institute of Cotton Research of the Chinese Academy of Agricultural Sciences, Anyang, China ) , He, Shoupu (State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China ) , Yang, Zhaoen (Institute for Advanced Studies and College of Life Sciences, Wuhan University, Wuhan, China ) , Sun, Gaofei (Institute of Cotton Research of the Chinese Academy of Agricultural Sciences, Anyang, China ) , Ma, Xiongfeng (Institute of Cotton Research of the Chinese Academy of Agricultural Sciences, Anyang, China ) , Li, Nan (Research Base, Anyang Institute of Technology, State Key Laboratory of Cotton Biology, Anyang, China ) , Zhang, Xueyan (Institute of Cotton Research of the Chinese Academy of Agricultural Sciences, Anyang, China ) , Sun, Junling (Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China ) , Liu, Min (Institute of Cotton Research of the Chine) , Jia, Yinhua , Pan, Zhaoe , Gong, Wenfang , Liu, Zhaohui , Zhu, Heqin , Ma, Lei , Liu, Fuyan , Yang, Daigang , Wang, Fan , Fan, Wei , Gong, Qian , Peng, Zhen , Wang, Liru , Wang, Xiaoyang , Xu, Shuangjiao , Shang, Haihong , Lu, Cairui , Zheng, Hongkun , Huang, Sanwen , Lin, Tao , Zhu, Yuxian , Li, Fuguang
    Nature genetics v.50 no.6 ,pp. 796 - 802 , 2018 , 1061-4036 ,

    초록

    The ancestors of Gossypium arboreum and Gossypium herbaceum provided the A subgenome for the modern cultivated allotetraploid cotton. Here, we upgraded the G. arboreum genome assembly by integrating different technologies. We resequenced 243 G. arboreum and G. herbaceum accessions to generate a map of genome variations and found that they are equally diverged from Gossypium raimondii. Independent analysis suggested that Chinese G. arboreum originated in South China and was subsequently introduced to the Yangtze and Yellow River regions. Most accessions with domestication-related traits experienced geographic isolation. Genome-wide association study (GWAS) identified 98 significant peak associations for 11 agronomically important traits in G. arboreum. A nonsynonymous substitution (cysteine-to-arginine substitution) of GaKASIII seems to confer substantial fatty acid composition (C16:0 and C16:1) changes in cotton seeds. Resistance to fusarium wilt disease is associated with activation of GaGSTF9 expression. Our work represents a major step toward understanding the evolution of the A genome of cotton.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  8. [해외논문]   Resequencing a core collection of upland cotton identifies genomic variation and loci influencing fiber quality and yield   SCI SCIE

    Ma, Zhiying (North China Key Laboratory for Crop Germplasm Resources of Education Ministry, Hebei Agricultural University, Baoding, China. mzhy@hebau.edu.cn ) , He, Shoupu (State Key Laboratory of Cotton Biology, Institute of Cotton Research of the Chinese Academy of Agricultural Sciences, Anyang, China ) , Wang, Xingfen (North China Key Laboratory for Crop Germplasm Resources of Education Ministry, Hebei Agricultural University, Baoding, China. cotton@hebau.edu.cn ) , Sun, Junling (State Key Laboratory of Cotton Biology, Institute of Cotton Research of the Chinese Academy of Agricultural Sciences, Anyang, China ) , Zhang, Yan (North China Key Laboratory for Crop Germplasm Resources of Education Ministry, Hebei Agricultural University, Baoding, China ) , Zhang, Guiyin (North China Key Laboratory for Crop Germplasm Resources of Education Ministry, Hebei Agricultural University, Baoding, China ) , Wu, Liqiang (North China Key Laboratory for Crop Germplasm Resources of Education Ministry, Hebei Agricultural University, Baoding, China ) , Li, Zhikun (North China Key Laboratory for Crop Germplasm Resources o) , Liu, Zhihao , Sun, Gaofei , Yan, Yuanyuan , Jia, Yinhua , Yang, Jun , Pan, Zhaoe , Gu, Qishen , Li, Xueyuan , Sun, Zhengwen , Dai, Panhong , Liu, Zhengwen , Gong, Wenfang , Wu, Jinhua , Wang, Mi , Liu, Hengwei , Feng, Keyun , Ke, Huifeng , Wang, Junduo , Lan, Hongyu , Wang, Guoning , Peng, Jun , Wang, Nan , Wang, Liru , Pang, Baoyin , Peng, Zhen , Li, Ruiqiang , Tian, Shilin , Du, Xiongming
    Nature genetics v.50 no.6 ,pp. 803 - 813 , 2018 , 1061-4036 ,

    초록

    Upland cotton is the most important natural-fiber crop. The genomic variation of diverse germplasms and alleles underpinning fiber quality and yield should be extensively explored. Here, we resequenced a core collection comprising 419 accessions with 6.55-fold coverage depth and identified approximately 3.66 million SNPs for evaluating the genomic variation. We performed phenotyping across 12 environments and conducted genome-wide association study of 13 fiber-related traits. 7,383 unique SNPs were significantly associated with these traits and were located within or near 4,820 genes; more associated loci were detected for fiber quality than fiber yield, and more fiber genes were detected in the D than the A subgenome. Several previously undescribed causal genes for days to flowering, fiber length, and fiber strength were identified. Phenotypic selection for these traits increased the frequency of elite alleles during domestication and breeding. These results provide targets for molecular selection and genetic manipulation in cotton improvement.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Analysis of the androgen receptor–regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression   SCI SCIE

    Zhang, Yajia (Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA ) , Pitchiaya, Sethuramasundaram (Department of Pathology, University of Michigan, Ann Arbor, MI, USA ) , Cieś (Molecular and Cellular Pathology Program, University of Michigan, Ann Arbor, MI, USA ) , lik, Marcin (Department of Computational Medicine and Bioinformatics, Ann Arbor, MI, USA ) , Niknafs, Yashar S. (Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA ) , Tien, Jean C.-Y. (Department of Pathology, University of Michigan, Ann Arbor, MI, USA ) , Hosono, Yasuyuki (Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA ) , Iyer, Matthew K. (Department of Pathology, University of Michigan, Ann Arbor, MI, USA ) , Yazdani, Sahr (Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA ) , Subramaniam, Shruthi (Department of Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA ) , Shukla, Sudhanshu K. (Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA ) , Jiang, Xia (Department of Pathology, University of Michigan, Ann Arbor, MI, USA ) , Wang, Lisha (Michigan Cente) , Liu, Tzu-Ying , Uhl, Michael , Gawronski, Alexander R. , Qiao, Yuanyuan , Xiao, Lanbo , Dhanasekaran, Saravana M. , Juckette, Kristin M. , Kunju, Lakshmi P. , Cao, Xuhong , Patel, Utsav , Batish, Mona , Shukla, Girish C. , Paulsen, Michelle T. , Ljungman, Mats , Jiang, Hui , Mehra, Rohit , Backofen, Rolf , Sahinalp, Cenk S. , Freier, Susan M. , Watt, Andrew T. , Guo, Shuling , Wei, John T. , Feng, Felix Y. , Malik, Rohit , Chinnaiyan, Arul M.
    Nature genetics v.50 no.6 ,pp. 814 - 824 , 2018 , 1061-4036 ,

    초록

    The androgen receptor (AR) plays a critical role in the development of the normal prostate as well as prostate cancer. Using an integrative transcriptomic analysis of prostate cancer cell lines and tissues, we identified ARLNC1 (AR-regulated long noncoding RNA 1) as an important long noncoding RNA that is strongly associated with AR signaling in prostate cancer progression. Not only was ARLNC1 induced by the AR protein, but ARLNC1 stabilized the AR transcript via RNA–RNA interaction. ARLNC1 knockdown suppressed AR expression, global AR signaling and prostate cancer growth in vitro and in vivo. Taken together, these data support a role for ARLNC1 in maintaining a positive feedback loop that potentiates AR signaling during prostate cancer progression and identify ARLNC1 as a novel therapeutic target.

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  10. [해외논문]   Genetic identification of brain cell types underlying schizophrenia   SCI SCIE

    Skene, Nathan G. (Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden ) , Bryois, Julien (UCL Institute of Neurology, Queen Square, London, UK ) , Bakken, Trygve E. (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden ) , Breen, Gerome (Allen Institute for Brain Science, Seattle, WA, USA ) , Crowley, James J. (King's College London, Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, UK ) , Gaspar, Hé (National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, London, UK ) , lé (Department of Genetics, University of North Carolina, Chapel Hill, NC, USA ) , na A. (King's College London, Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, UK ) , Giusti-Rodriguez, Paola (National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, London, UK ;) , Hodge, Rebecca D. , Miller, Jeremy A. , Muñ , oz-Manchado, Ana B. , O'Donovan, Michael C. , Owen, Michael J. , Pardiñ , as, Antonio F. , Ryge, Jesper , Walters, James T. R. , Linnarsson, Sten , Lein, Ed S. , Sullivan, Patrick F. , Hjerling-Leffler, Jens
    Nature genetics v.50 no.6 ,pp. 825 - 833 , 2018 , 1061-4036 ,

    초록

    With few exceptions, the marked advances in knowledge about the genetic basis of schizophrenia have not converged on findings that can be confidently used for precise experimental modeling. By applying knowledge of the cellular taxonomy of the brain from single-cell RNA sequencing, we evaluated whether the genomic loci implicated in schizophrenia map onto specific brain cell types. We found that the common-variant genomic results consistently mapped to pyramidal cells, medium spiny neurons (MSNs) and certain interneurons, but far less consistently to embryonic, progenitor or glial cells. These enrichments were due to sets of genes that were specifically expressed in each of these cell types. We also found that many of the diverse gene sets previously associated with schizophrenia (genes involved in synaptic function, those encoding mRNAs that interact with FMRP, antipsychotic targets, etc.) generally implicated the same brain cell types. Our results suggest a parsimonious explanation: the common-variant genetic results for schizophrenia point at a limited set of neurons, and the gene sets point to the same cells. The genetic risk associated with MSNs did not overlap with that of glutamatergic pyramidal cells and interneurons, suggesting that different cell types have biologically distinct roles in schizophrenia.

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