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Behavioural brain research 29건

  1. [해외논문]   Full title with Editorial board members   SCI SCIE


    Behavioural brain research v.321 ,pp. iii - iii , 2017 , 0166-4328 ,

    초록

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   Pre-treatment with nimodipine and 7.5% hypertonic saline protects aged rats against postoperative cognitive dysfunction via inhibiting hippocampal neuronal apoptosis   SCI SCIE

    Qi, Zhang (Corresponding author.) , Tianbao, Yuan , Yanan, Li , Xi, Xin , Jinhua, He , Qiujun, Wang
    Behavioural brain research v.321 ,pp. 1 - 7 , 2017 , 0166-4328 ,

    초록

    Abstract Objective This study aimed to investigate the effects of pre-treatment with nimodipine and 7.5% hypertonic saline (HS) on postoperative cognitive dysfunction (POCD) in aged rats. Methods Healthy Sprague-Dawley aged rats were randomly assigned into 4 groups: POCD group, nimodipine group, HS group, and nimodipine+HS group. Rats in POCD group received normal saline injection and then splenectomy 30min later under 1.8% isoflurane inhalation for 2h. In remaining groups, rats received injection of 1mg/kg nimodipine (i.p) and/or 4ml/kg 7.5% HS (i.v) and then splenectomy. Morris water maze test was performed before and after surgery. The hippocampus was harvested for the detection of neuronal apoptosis rate (AR), cytoplasmic calcium ([Ca 2+ ] i ), Bcl-2 and Bax mRNA expression and hippocampal neuronal ultrastructure. Results When compared with POCD group, the latency to escape, neuronal AR, [Ca 2+ ] i , Bax mRNA expression and Bax/Bcl-2 ratio reduced dramatically, but the times of crossing the platform and Bcl-2 mRNA expression increased significantly ( P 2+ ] i , Bax mRNA expression and Bax/Bcl-2 ratio reduced markedly, but the times of crossing the platform and Bcl-2 mRNA expression increased significantly in nimodipine+HS group as compared to nimodipine group and NS group ( P Conclusion Pre-treatment with both nimodipine and 7.5% HS exerts better protective effects, which is related to the inhibition of hippocampal neuronal apoptosis.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

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  3. [해외논문]   Adenosine A2A receptor deletion affects social behaviors and anxiety in mice: Involvement of anterior cingulate cortex and amygdala   SCI SCIE

    Ló (Àrea de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, 12071 Castelló, Spain ) , pez-Cruz, Laura (Àrea de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, 12071 Castelló, Spain ) , Carbó (Àrea de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, 12071 Castelló, Spain ) , -Gas, Maria (Àrea de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, 12071 Castelló, Spain ) , Pardo, Marta (Grup de Recerca en Neurobiologia del Comportament (GReNeC), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Hospital del Mar Medical Research Institute (IMIM), Dr. Aiguader 88, 08003 Barcelona, Spain ) , Bayarri, Pilar (Universite Libre de Bruxelles, IRIBHM, Campus Erasme, CP602, route de Lennik 808, 1070 Bruxelles, Belgium ) , Valverde, Olga (Department of Psychology, University of Connecticut, Storrs, CT, 06269-1020, USA ) , Ledent, Catherine (Àrea de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, 12071 Castelló, Spain) , Salamone, John D. , Correa, Mercè
    Behavioural brain research v.321 ,pp. 8 - 17 , 2017 , 0166-4328 ,

    초록

    Abstract Blockade of adenosine A 2A receptors can potentiate motivation to work for natural reinforcers such as food. Conspecific interaction is a potent natural reinforcer in social animals that can be manifested as preference for social exploration versus other sources of novel stimulation. Deficiencies in this type of motivated behavior (social withdrawal) have been seen in several pathologies such as autism and depression. However, the role of A 2A receptors in motivation for social interaction has not been widely explored. Social interaction paradigms evaluate the natural preference of animals for exploring other conspecifics, and the ability to differentiate between familiar versus novel ones. Anxiety is one of the factors that can induce avoidance of social interaction. In the present study, adenosine A 2A knockout (A 2A KO) and wild-type (WT) mice were assessed for social and anxiety-related behaviors. c-Fos immunoreactivity was evaluated as a measure of neuronal activation in brain areas involved in different aspects of motivation and emotional processes. Although A 2A KO mice showed an anxious profile, they displayed higher levels of sociability and were less sensitive to social novelty. WT mice displayed a typical pattern of social recognition 24h later, but not A 2A KO mice, which explored equally both conspecifics. There were no differences between strains in aggressiveness, perseverance or social odor preferences. c-Fos immunoreactivity in A 2A KO mice was higher in anterior cingulate and amygdala compared to WT mice. Thus, A 2A receptors appear to be potential targets for the improvement of pathologies related to social function. Highlights Blockade of adenosine A 2A receptors can potentiate motivation. A 2A KO mice showed anxiety but are more socially oriented. A 2A KO mice were less sensitive to social novelty. c-Fos in A 2A KO mice was higher in anterior cingulate and amygdala than in WT mice. A 2A receptors could be targets for pathologies such as autism and depression.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  4. [해외논문]   Neuronal expression of a thyroid hormone receptor α mutation alters mouse behaviour   SCI SCIE

    Richard, S. (IGFL, INRA, Univ. Lyon 1, CNRS, ENS Lyon, 69 007 France ) , Aguilera, N. (PBES, SFR Biosciences, INSERM, CNRS UMS3444, Univ. Lyon 1, ENS Lyon, France ) , Thé (CRNL, CNRS, Lyon, France ) , venet, M. (INSERM U846, Stem-cell and Brain Research Institute, Department of Chronobiology, University of Lyon 1, 69003 Lyon, France ) , Dkhissi-Benyahya, O. (IGFL, INRA, Univ. Lyon 1, CNRS, ENS Lyon, 69 007 France) , Flamant, F.
    Behavioural brain research v.321 ,pp. 18 - 27 , 2017 , 0166-4328 ,

    초록

    Abstract In humans, alterations in thyroid hormone signalling are associated with mood and anxiety disorders, but the neural mechanisms underlying such association are poorly understood. The present study investigates the involvement of neuronal thyroid hormone receptor α (TRα) in anxiety, using mouse genetics and Cre/loxP technology to specifically alter TRα signalling in neurons. We evaluated the behaviour of mice expressing a dominant negative, neuron-specific mutation of TRα ( TRα AMI /Cre3 mice), using the elevated-plus maze, light-dark box and open-field tests. In a first experiment, mice were housed individually, and the behaviour of TRα AMI /Cre3 mice differed significantly from that of control littermates in these 3 tests, suggesting heightened anxiety. In a second experiment, designed to evaluate the robustness of the results with the same 3 tests, mice were housed in groups. In these conditions, the behaviour of TRα AMI /Cre3 mice differed from that of control littermates only in the light-dark box. Thus, TRα AMI /Cre3 mice appear to be more likely to develop anxiety under stressful housing conditions than control mice. These results suggest that in adult mice, thyroid hormone signalling in neurons, via TRα, is involved in the control of anxiety behaviour. Highlights The role of central thyroid hormone receptors in emotional behaviour was assessed. A neuron-specific TRα mutation induced anxiety-like behaviour in mice. Stressful housing conditions potentiated the effects of the TRα mutation. We conclude that neuronal TRα signalling influences adult anxiety behaviour. Neuronal TRα thus constitutes a functional link between hypothyroidism and anxiety.

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    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  5. [해외논문]   Computational EEG modelling of decision making under ambiguity reveals spatio-temporal dynamics of outcome evaluation   SCI SCIE

    Jollans, Lee (School of Psychology, Trinity College Dublin, Dublin 2, Ireland ) , Whelan, Robert (School of Psychology, Trinity College Dublin, Dublin 2, Ireland ) , Venables, Louise (Department of Psychology, Swansea University, Singleton Campus, Swansea SA2 8PP, United Kingdom ) , Turnbull, Oliver H. (School of Psychology, Bangor University, Bangor, Gwynedd LL57 2DG, United Kingdom ) , Cella, Matteo (Department of Psychology, Swansea University, Singleton Campus, Swansea SA2 8PP, United Kingdom ) , Dymond, Simon (Department of Psychology, Swansea University, Singleton Campus, Swansea SA2 8PP, United Kingdom)
    Behavioural brain research v.321 ,pp. 28 - 35 , 2017 , 0166-4328 ,

    초록

    Abstract Complex human cognition, such as decision-making under ambiguity, is reflected in dynamic spatio-temporal activity in the brain. Here, we combined event-related potentials with computational modelling of the time course of decision-making and outcome evaluation during the Iowa Gambling Task. Measures of choice probability generated using the Prospect Valence Learning Delta (PVL-Delta) model, in addition to objective trial outcomes (outcome magnitude and valence), were applied as regressors in a general linear model of the EEG signal. The resulting three-dimensional spatio-temporal characterization of task-related neural dynamics demonstrated that outcome valence, outcome magnitude, and PVL-Delta choice probability were expressed in distinctly separate event related potentials. Our findings showed that the P3 component was associated with an experience-based measure of outcome expectancy. Highlights Complex human cognition is reflected in dynamic spatio-temporal activity. We combined event-related potentials with computational modelling. A general linear model created a three-dimensional map of neural dynamics.

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    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  6. [해외논문]   Behavioral characterization of female zinc transporter 3 (ZnT3) knockout mice   SCI SCIE

    Thackray, Sarah E. (Department of Psychology, University of Calgary, Calgary, Alberta, Canada ) , McAllister, Brendan B. (Department of Psychology, University of Calgary, Calgary, Alberta, Canada ) , Dyck, Richard H. (Department of Psychology, University of Calgary, Calgary, Alberta, Canada)
    Behavioural brain research v.321 ,pp. 36 - 49 , 2017 , 0166-4328 ,

    초록

    Abstract Zinc is an important element in all cells of the body, having structural, enzymatic, and regulatory functions. In some neurons, zinc is loaded into synaptic vesicles by zinc transporter 3 (ZnT3) and released into the synaptic cleft, where it can modulate neuronal function. ZnT3 knockout (KO) mice lack ZnT3 and thus lack synaptic zinc. Previous studies have examined the behavioral phenotype of ZnT3 KO mice, mostly using mixed-sex or male-only groups. In the present study we focused specifically on the behavior of female ZnT3 KO mice (2–3 months old). An extensive battery of tests was administered to assess sensorimotor and cognitive behaviours, as well as to examine for a possible schizophrenia-like phenotype. ZnT3 KO mice performed similarly to wild type controls in the majority of tests. However, they were less accurate in the skilled reach task, suggesting impaired skilled motor learning, and faster to descend a vertical pole. ZnT3 KO mice were also slower in the open field and made fewer chamber entries in the social preference test, suggesting decreased exploratory locomotion. No differences were observed in the Morris water task or fear conditioning test. This is the first study to show a behavioural phenotype specifically for female ZnT3 KO mice. Comparing our results to previous studies, it appears that there may be sex-specific effects of eliminating ZnT3. Female ZnT3 KO mice exhibit abnormalities in locomotion and at skilled motor learning, but we were unable to detect spatial or fear learning deficits previously described in male ZnT3 KO mice. Highlights Female ZnT3 KO mice do not show normal improvement over time at skilled reaching. Female ZnT3 KO mice show decreased exploratory locomotion. Female ZnT3 KO mice perform normally on many tests of motor skill and cognition. Female ZnT3 KO mice do not exhibit the same behavioural deficits previously found in male ZnT3 KO mice. It is critical to conduct behavioural testing on mice of both sexes whenever possible.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  7. [해외논문]   Young pigs exhibit differential exploratory behavior during novelty preference tasks in response to age, sex, and delay   SCI SCIE

    Fleming, Stephen A. (Piglet Nutrition & Cognition Laboratory, Department of Animal Sciences, University of Illinois, 1207 West Gregory Drive, Urbana, IL 61801, USA ) , Dilger, Ryan N. (Piglet Nutrition & Cognition Laboratory, Department of Animal Sciences, University of Illinois, 1207 West Gregory Drive, Urbana, IL 61801, USA)
    Behavioural brain research v.321 ,pp. 50 - 60 , 2017 , 0166-4328 ,

    초록

    Abstract Novelty preference paradigms have been widely used to study recognition memory and its neural substrates. The piglet model continues to advance the study of neurodevelopment, and as such, tasks that use novelty preference will serve especially useful due to their translatable nature to humans. However, there has been little use of this behavioral paradigm in the pig, and previous studies using the novel object recognition paradigm in piglets have yielded inconsistent results. The current study was conducted to determine if piglets were capable of displaying a novelty preference. Herein a series of experiments were conducted using novel object recognition or location in 3- and 4-week-old piglets. In the novel object recognition task, piglets were able to discriminate between novel and sample objects after delays of 2min, 1h, 1 day, and 2 days (all P P P = 0.008) but not the 1-day delay ( P = 0.347). Furthermore, 4-week-old piglets and females tended to exhibit greater exploratory behavior compared with males. Such performance did not extend to novel location recognition tasks, as piglets were only able to discriminate between novel and sample locations after a short delay ( P >0.046). In conclusion, this study determined that piglets are able to perform the novel object and location recognition tasks at 3-to-4 weeks of age, however performance was dependent on sex, age, and delay.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  8. [해외논문]   Dopamine D1-like receptor in lateral habenula nucleus affects contextual fear memory and long-term potentiation in hippocampal CA1 in rats   SCI SCIE

    Chan, Jiangping (Corresponding authors at: Medical Faculty, Kunming University of Science and Technology, #727 South Jingming Road, Kunming, Yunnan 650550, China. ) , Guan, Xin (Corresponding authors at: Medical Faculty, Kunming University of Science and Technology, #727 South Jingming Road, Kunming, Yunnan 650550, China.) , Ni, Yiling , Luo, Lilu , Yang, Liqiang , Zhang, Pengyue , Zhang, Jichuan , Chen, Yanmei
    Behavioural brain research v.321 ,pp. 61 - 68 , 2017 , 0166-4328 ,

    초록

    Abstract The Lateral Habenula (LHb) plays an important role in emotion and cognition. Recent experiments suggest that LHb has functional interaction with the hippocampus and plays an important role in spatial learning. LHb is reciprocally connected with midbrain monoaminergic brain areas such as the ventral tegmental area (VTA). However, the role of dopamine type 1 receptor (D1R) in LHb in learning and memory is not clear yet. In the present study, D1R agonist or antagonist were administered bilaterally into the LHb in rats. We found that both D1R agonist and antagonist impaired the acquisition of contextual fear memory in rats. D1R agonist or antagonist also impaired long term potentiation (LTP) in hippocampal CA3-CA1 synapses in freely moving rats and attenuated learning induced phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) subunit 1 (GluA1) at Ser831 and Ser845 in hippocampus. Taken together, our results suggested that dysfunction of D1R in LHb affected the function of hippocampus. Highlights D1R agonist or antagonist in LHb impaired the acquisition of contextual fear memory in rats. D1R agonist or antagonist in LHb impaired long term potentiation (LTP) in hippocampal CA3-CA1 synapses. D1R agonist or antagonist in LHb attenuated learning induced phosphorylation of AMPAR subunit 1 (GluA1) at Ser831 and Ser845 in hippocampus. Dysfunction of D1R in LHb affected the function of hippocampus.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  9. [해외논문]   Assessment of mouse cognitive and anxiety-like behaviors and hippocampal inflammation following a repeated and intermittent paradoxical sleep deprivation procedure   SCI SCIE

    Yin, Mengmei (Department of Neurology, The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu 210029, China ) , Chen, Yali (Jiangsu Province, Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu, China ) , Zheng, Hui (Jiangsu Province, Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu, China ) , Pu, Tinglin (Jiangsu Province, Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu, China ) , Marshall, Charles (Department of Rehabilitation Sciences, University of Kentucky Center of Excellence in Rural Health, Hazard, KY, USA ) , Wu, Ting (Department of Neurology, The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu 210029, China ) , Xiao, Ming (Jiangsu Province, Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu, China)
    Behavioural brain research v.321 ,pp. 69 - 78 , 2017 , 0166-4328 ,

    초록

    Abstract It has been reported that more than one fourth of the world’s population suffers from sleep problems. However, there is not a stable and reliable animal model to mimic the persistent and periodic features of sleep disorders, and correspondingly, the feasibility and effectiveness of repeated behavioral tests remains to be determined. In the present study, we repetitively, and intermittently, treated mice with 3days and 7days of paradoxical sleep deprivation (SD), using the modified multiple small-platforms-over-water method for 3 months. The behavioral results suggested that repeated open field and Y-maze tests are able to successfully detect anxiety-like behaviors and working memory dysfunction of the model mice. The Morris water maze test is not suitable for evaluating spatial learning ability following SD because the long-term utilization of the flower-pot method increases the familiarity of mice with the water environment. Moreover, neuroinflammation, microglial activation and neuronal apoptosis were observed in the hippocampus of model mice even recovery for 3 weeks later. This animal model and corresponding behavioral evaluation method will help to explore the pathogenesis and therapeutic strategies of chronic sleep disorders. Highlights A mouse model of intermittent and repetitive sleep deprivation has been established. The effects of paradoxical sleep deprivation on various behavioral tasks are examined. Neuroinflmmation and neuronal apoptosis endured for even 3 weeks after deprivation.

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    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

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  10. [해외논문]   Epigallocatechin-3-gallate promotes angiogenesis via up-regulation of Nfr2 signaling pathway in a mouse model of ischemic stroke   SCI SCIE

    Bai, Qian (Anesthesiology Department, The Second Affiliated Hospital of ZhengZhou University, China ) , Lyu, Zhipai (Anesthesiology Department, The Third Affiliated Hospital of Zhengzhou University, China ) , Yang, Xianhui (Anesthesiology Department, The Second Affiliated Hospital of ZhengZhou University, China ) , Pan, Zhenjie (Pharmacology Department, The Second Affiliated Hospital of ZhengZhou University, China ) , Lou, Jiyu (Neurology Department, The Second Affiliated Hospital of ZhengZhou University, China ) , Dong, Tieli (Anesthesiology Department, The Second Affiliated Hospital of ZhengZhou University, China)
    Behavioural brain research v.321 ,pp. 79 - 86 , 2017 , 0166-4328 ,

    초록

    Abstract Epigallocatechin-3-gallate (EGCG) is the major effective component of green tea and has been known as a potential anticancer drug because of its antioxidant and anti-angiogenic properties. EGCG has also been reported to have preventive effects against ischemic stroke via nuclear factor erythroid 2-related factor 2 (Nfr2) signaling pathway, but how EGCG affect angiogenesis after stroke remains unclear. In this study, we investigated whether EGCG treatment in the acute phase of ischemic stroke can promote angiogenesis in a mouse model of transient middle cerebral artery occlusion (MCAO). We assessed neurological function with modified neurologic severity score (mNSS) test, infarct volume by Nessl staining, angiogenesis and oxidative stress by immunofluorescence analysis, intravital lectin perfusion analysis, western blot analysis and enzyme-linked immunosorbent assay (ELISA). In order to explore the role of Nrf2 in the angiogenesis of MCAO+EGCG-treated mice, we used MAPK/ERK inhibitor PD98059 to block the activation of Nrf2. We found MCAO+EGCG-treated mice had better neurologic outcome, less infarct volume, more number of Ki67/CD31-positive vessels, higher vascular density, unregulated VEGF-VEGFR2 signaling pathway, increased Nrf2 expression and decreased oxidative stress than did MCAO+vehicle-treated mice. Blocking Nrf2 with PD98059 significantly reduced the expression of Nrf2, increased oxidative stress and abolished the angiogenic and neuroprotective effects of EGCG on MCAO mice. We conclude that EGCG treatment in the early stage of ischemic stroke can promote angiogenesis in MCAO mice, possibly via upregulation of Nrf2 signaling pathway.

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