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Peptides 22건

  1. [해외논문]   The International Neuropeptide society pages   SCI SCIE


    Peptides v.88 ,pp. I - II , 2017 , 0196-9781 ,

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   Gayle & Richard Olson prize pages   SCI SCIE


    Peptides v.88 ,pp. III - IV , 2017 , 0196-9781 ,

    초록

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    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   IFC (editorial board)   SCI SCIE


    Peptides v.88 ,pp. IFC - IFC , 2017 , 0196-9781 ,

    초록

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    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  4. [해외논문]   IFC (editorial board)  


    Peptides v.88 ,pp. IFC , 2017 , 0196-9781 ,

    초록

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

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  5. [해외논문]   Cardiovascular effects of exogenous adrenomedullin and CGRP in Ramp and Calcrl deficient mice   SCI SCIE

    Pawlak, J.B. (Department of Cell Biology and Physiology, 111 Mason Farm Rd., 6312B MBRB CB# 7545, The University of North Carolina, Chapel Hill, NC 27599, USA ) , Wetzel-Strong, S.E. (Department of Cell Biology and Physiology, 111 Mason Farm Rd., 6312B MBRB CB# 7545, The University of North Carolina, Chapel Hill, NC 27599, USA ) , Dunn, M.K. (Ferring Research Institute, Inc., 4245 Sorrento Valley Blvd., San Diego, CA 92121, USA ) , Caron, K.M. (Department of Cell Biology and Physiology, 111 Mason Farm Rd., 6312B MBRB CB# 7545, The University of North Carolina, Chapel Hill, NC 27599, USA)
    Peptides v.88 ,pp. 1 - 7 , 2017 , 0196-9781 ,

    초록

    Abstract Adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) are potent vasodilator peptides and serve as ligands for the G-protein coupled receptor (GPCR) calcitonin receptor-like receptor (CLR/ Calcrl ). Three GPCR accessory proteins called receptor activity-modifying proteins (RAMPs) modify the ligand binding affinity of the receptor such that the CLR/RAMP1 heterodimer preferably binds CGRP, while CLR/RAMP2 and CLR/RAMP3 have a stronger affinity for AM. Here we determine the contribution of each of the three RAMPs to blood pressure control in response to exogenous AM and CGRP by measuring the blood pressure of mice with genetic reduction or deletion of the receptor components. Thus, the cardiovascular response of Ramp1 −/− , Ramp2 +/− , Ramp3 −/− , Ramp1 −/− / Ramp3 −/− double-knockout (dKO), and Calcrl +/− mice to AM and CGRP were compared to wildtype mice. While under anesthesia, Ramp1 −/− male mice had significantly higher basal blood pressure than wildtype males; a difference which was not present in female mice. Additionally, anesthetized Ramp1 −/− , Ramp3 −/− , and Calcrl +/− male mice exhibited significantly higher basal blood pressure than females of the same genotype. The hypotensive response to intravenously injected AM was greatly attenuated in Ramp1 −/− mice, and to a lesser extent in Ramp3 −/− and Calcrl +/− mice. However, Ramp1 −/− / Ramp3 −/− dKO mice retained some hypotensive response to AM. These results suggest that the hypotensive effect of AM is primarily mediated through the CLR/RAMP1 heterodimer, but that AM signaling via CLR/RAMP2 and CLR/RAMP3 also contributes to some hypotensive action. On the other hand, CGRP’s hypotensive activity seems to be predominantly through the CLR/RAMP1 heterodimer. With this knowledge, therapeutic AM or CGRP peptides could be designed to cause less hypotension while maintaining canonical receptor-RAMP mediated signaling. Highlights Ramp1 −/− male mice have higher basal blood pressure while under anesthesia. Ramp1 −/− , Ramp3 −/− , and Calcrl +/− males have higher basal blood pressure than females. Hypotension via bolus infusion of AM or CGRP is attenuated in Ramp1 −/− mice. Some AM-induced hypotension is attenuated in Ramp3 −/− and Calcrl +/− mice.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  6. [해외논문]   The anti-tumor effects of the recombinant toxin protein rLj-RGD3 from Lampetra japonica on pancreatic carcinoma Panc-1 cells in nude mice   SCI SCIE

    Wang, Yue (Department of Pharmacology, Dalian Medical University, Dalian, Liaoning Province 116044, China ) , Zheng, Yuanyuan (School of Life Sciences, Liaoning Normal University, Dalian, Liaoning Province 116029, China ) , Tu, Zuoyu (Department of Pharmacology, Dalian Medical University, Dalian, Liaoning Province 116044, China ) , Dai, Yongguo (Department of Pharmacology, Dalian Medical University, Dalian, Liaoning Province 116044, China ) , Xu, Hong (Department of Pharmacology, Dalian Medical University, Dalian, Liaoning Province 116044, China ) , Lv, Li (Department of Pharmacology, Dalian Medical University, Dalian, Liaoning Province 116044, China ) , Wang, Jihong (School of Life Sciences, Liaoning Normal University, Dalian, Liaoning Province 116029, China)
    Peptides v.88 ,pp. 8 - 17 , 2017 , 0196-9781 ,

    초록

    Abstract Recombinant Lampetra japonica RGD peptide (rLj-RGD3) is a soluble toxin protein with three RGD (Arg-Gly-Asp) motifs and a molecular weight of 13.5kDa. The aim of this study was to investigate the effects and mechanisms of rLj-RGD3 on tumor growth and survival in pancreatic carcinoma Panc-1 cell-bearing mice. A Panc-1 human pancreatic carcinoma-bearing nude mouse model was successfully generated, and the animals were treated with different doses of rLj-RGD3 for 3 weeks. The volume and weight of the subcutaneous tumors, the survival of the nude mice, histopathological changes, the intratumoral MVD, the number of apoptotic Panc-1 cells, and apoptosis-related proteins and gene expressions were determined. rLj-RGD3 significantly decreased the tumor volumes and weights, and the maximum tumor volume and weight IR values were 53.2% (p Highlights rLj-RGD3 is a new recombinant RGD-toxin protein with 3 RGD motifs and is secreted from the buccal glands of Lampetra japonica . rLj-RGD3 suppresses human pancreatic carcinoma Panc-1 cell-derived tumors in nude mice. rLj-RGD3 exhibits pro-apoptotic effects that are regulated by the intrinsic apoptotic pathway. The effect of rLj-RGD3 on anti-angiogenesis is mediated via the FAK/PI3K/Akt signaling pathway.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  7. [해외논문]   In vivo digestomics of milk proteins in human milk and infant formula using a suckling rat pup model   SCI SCIE

    Wada, Yasuaki (Department of Nutrition, University of California, Davis, One Shields Ave., Davis, CA 95616, USA ) , Phinney, Brett S. (Genome Center Proteomics Core Facility, University of California, Davis, 451 E. Health Sciences Dr., Davis, CA 95616, USA ) , Weber, Darren (Genome Center Proteomics Core Facility, University of California, Davis, 451 E. Health Sciences Dr., Davis, CA 95616, USA ) , Lö (Department of Nutrition, University of California, Davis, One Shields Ave., Davis, CA 95616, USA) , nnerdal, Bo
    Peptides v.88 ,pp. 18 - 31 , 2017 , 0196-9781 ,

    초록

    Abstract Human milk is the optimal mode of infant feeding for the first several months of life, and infant formulas serve as an alternative when breast-feeding is not possible. Milk proteins have a balanced amino acid composition and some of them provide beneficial bioactivities in their intact forms. They also encrypt a variety of bioactive peptides, possibly contributing to infant health and growth. However, there is limited knowledge of how milk proteins are digested in the gastrointestinal tract and bioactive peptides are released in infants. A peptidomic analysis was conducted to identify peptides released from milk proteins in human milk and infant formula, using a suckling rat pup model. Among the major milk proteins targeted, α-lactalbumin and β-casein in human milk, and β-lactoglobulin and β-casein in infant formula were the main sources of peptides, and these peptides covered large parts of the parental proteins’ sequences. Release of peptides was concentrated to specific regions, such as residues 70–92 of β-casein in human milk, residues 39–55 of β-lactoglobulin in infant formula, and residues 57–96 and 145–161 of β-CN in infant formula, where resistance to gastrointestinal digestion was suggested. In the context of bioactive peptides, release of fragments containing known bioactive peptides was confirmed, such as β-CN-derived opioid and antihypertensive peptides. It is therefore likely that these fragments are of biological significance in neonatal health and development. Highlights Suckling rat pups were intubated with human milk or infant formula, and milk protein-derived peptides formed in the intestine were analyzed. Release of peptides was concentrated to specific regions, suggesting their resistance to gastro intestinal digestion. Some of the bioactive peptides are likely of biological significance in neonatal health and development.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  8. [해외논문]   Phoenixin is negatively associated with anxiety in obese men   SCI SCIE

    Hofmann, Tobias (Charité) , Weibert, Elena (Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine) , Ahnis, Anne (Charité-Universitätsmedizin Berlin, Berlin, Germany ) , Elbelt, Ulf (Charité) , Rose, Matthias (Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine) , Klapp, Burghard F. (Charité-Universitätsmedizin Berlin, Berlin, Germany ) , Stengel, Andreas (Charité)
    Peptides v.88 ,pp. 32 - 36 , 2017 , 0196-9781 ,

    초록

    Abstract Phoenixin was recently identified in the rat hypothalamus and initially implicated in reproductive functions. A subsequent study described an anxiolytic effect of the peptide. The aim of the study was to investigate a possible association of circulating phoenixin with anxiety in humans. We therefore enrolled 68 inpatients with a broad spectrum of psychometrically measured anxiety (GAD-7). We investigated men since a menstrual cycle dependency of phoenixin has been assumed. Obese subjects were enrolled since they often report psychological comorbidities. In addition, we also assessed depressiveness (PHQ-9) and perceived stress (PSQ-20). Plasma phoenixin levels were measured using a commercial ELISA. First, we validated the ELISA kit performing a spike-and-recovery experiment showing a variance of 6.7±8.8% compared to the expected concentrations over the whole range of concentrations assessed, while a lower variation of 1.6±0.8% was observed in the linear range of the assay (0.07–2.1ng/ml). We detected phoenixin in the circulation of obese men at levels of 0.68±0.50ng/ml. These levels showed a negative association with anxiety scores ( r = −0.259, p = 0.043), while no additional associations with other psychometric parameters were observed. In summary, phoenixin is present in the human circulation and negatively associated with anxiety in obese men, a population often to report comorbid anxiety. Highlights Phoenixin is a recently discovered peptide initially implicated in reproduction. Phoenixin was also shown to have an anxiolytic effect in mice. Phoenixin is detectable in the circulation in humans. Phoenixin shows a negative association with anxiety in obese men. Phoenixin might be an interesting target in the treatment of anxiety disorders.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

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  9. [해외논문]   Chronic blockade of the AT2 receptor with PD123319 impairs insulin signaling in C57BL/6 mice   SCI SCIE

    Muñ (Corresponding author.) , oz, M.C. , Burghi, V. , Miquet, J.G. , Cervino, I.A. , Quiroga, D.T. , Mazziotta, L. , Dominici, F.P.
    Peptides v.88 ,pp. 37 - 45 , 2017 , 0196-9781 ,

    초록

    Abstract The renin-angiotensin system modulates insulin action. Angiotensin type 1 receptor exerts a deleterious effects while the angiotensin type 2 receptor (AT2R) appears to have beneficial effects providing protection against insulin resistance and type 2 diabetes. Although recent reports indicate that agonism of AT2R ameliorates diabetes and insulin resistance, the phenotype of AT2R-knockout mice seems to be controversial relating this aspect. Thus, in this study we have explored the role of AT2R in the control of insulin action. To that end, C57Bl/6 mice were administered the synthetic AT2R antagonist PD123319 for 21days (10mg/kg/day ip); vehicle treated animals were used as control. Glucose tolerance, metabolic parameters, in vivo insulin signaling in main insulin-target tissues as well as levels of adiponectin, TNF-α, MCP-1 and IL-6 in adipose tissue were assessed. AT2R blockade with PD123319 induced a marginal effect on glucose homeostasis but an important reduction in the insulin-induced phosphorylation of the insulin receptor and Akt in both liver and adipose tissue. Insulin signaling in skeletal muscle remained unaltered after treatment with PD123319, which could explain the minimal effect on glucose homeostasis induced by PD123319. Our current results reinforce the notion that the AT2R has a physiological role in the conservation of insulin action. Highlights AT2R antagonism attenuated insulin signaling in both liver and adipose tissue. ERK 1/2 might participate in the attenuation of insulin signaling in the liver. Current results suggest a role for the AT2R in the control of insulin action.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  10. [해외논문]   A novel GLP-1 analog, a dimer of GLP-1 via covalent linkage by a lysine, prolongs the action of GLP-1 in the treatment of type 2 diabetes   SCI SCIE

    Pan, Yingying (School of Life Science, East China Normal University, Shanghai, China ) , Shi, Siwei (School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China ) , Lao, Xun (School of Life Science, East China Normal University, Shanghai, China ) , Zhang, Jinlong (School of Life Science, East China Normal University, Shanghai, China ) , Tan, Shiming (School of Life Science, East China Normal University, Shanghai, China ) , Wu, Zirong (School of Life Science, East China Normal University, Shanghai, China ) , Huang, Jing (School of Life Science, East China Normal University, Shanghai, China)
    Peptides v.88 ,pp. 46 - 54 , 2017 , 0196-9781 ,

    초록

    Abstract GLP-1 is an incretin hormone that can effectively lower blood glucose, however, the short time of biological activity and the side effect limit its therapeutic application. Many methods have been tried to optimize GLP-1 to extend its in vivo half-time, reduce its side effect and enhance its activity. Here we have chosen the idea to dimerize GLP-1 with a C-terminal lysine to form a new GLP-1 analog, DLG3312. We have explored the structure and the biological property of DLG3312, and the results indicated that DLG3312 not only remained the ability to activate the GLP-1R, but also strongly stimulated Min6 cell to secrete insulin. The in vivo bioactivities have been tested on two kinds of animal models, the STZ induced T2DM mice and the db/db mice, respectively. DLG3312 showed potent anti-diabetic ability in glucose tolerance assay and single-dose administration of DLG3312 could lower blood glucose for at least 10 hours. Long-term treatment with DLG3312 can reduce fasted blood glucose, decrease water consumption and food intake and significantly reduce the HbA1c level by 1.80% and 2.37% on STZ induced T2DM mice and the db/db mice, respectively. We also compared DLG3312 with liraglutide to investigate its integrated control of the type 2 diabetes. The results indicated that DLG3312 almost has the same effect as liraglutide but with a much simpler preparation process. In conclusion, we, by using C-terminal lysine as a linker, have synthesized a novel GLP-1 analog, DLG3312. With simplified preparation and improved physiological characterizations, DLG3312 could be considered as a promising candidate for the type 2 diabetes therapy. Highlights DLG3312 is a dimer of GLP-1 via covalent linkage by a lysine. DLG3312 remains the native GLP-1 bioactivity and exhibits strong stability in vitro. DLG3312 can efficiently reduce the blood glucose on type 2 diabetes mellitus model mice. The efficacy of DLG3312 in mice is similar to a long-acting marketed drug liragutide.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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