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Microbiological research 9건

  1. [해외논문]   Editorial Board   SCIE SCOPUS


    Microbiological research v.209 ,pp. ii - ii , 2018 , 0944-5013 ,

    초록

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  2. [해외논문]   Biocontrol activity of surfactin A purified from Bacillus NH-100 and NH-217 against rice bakanae disease   SCIE SCOPUS

    Sarwar, Ambrin (Department of Biosciences, Faculty of Sciences, COMSATS Institute of Information Technology (CIIT), Park Road, Islamabad, Pakistan ) , Hassan, Muhammad Nadeem (Department of Biosciences, Faculty of Sciences, COMSATS Institute of Information Technology (CIIT), Park Road, Islamabad, Pakistan ) , Imran, Muhammad (Department of Biosciences, Faculty of Sciences, COMSATS Institute of Information Technology (CIIT), Park Road, Islamabad, Pakistan ) , Iqbal, Mazhar (Health Biotechnology Division, National Institute for Biotechnology & Genetic Engineering, NIBGE, Faisalabad, Pakistan ) , Majeed, Saima (Health Biotechnology Division, National Institute for Biotechnology & Genetic Engineering, NIBGE, Faisalabad, Pakistan ) , Brader, Gü (Center for Health & Bioresources, Bioresources Unit, AIT Austrian Institute of Technology GmbH, AIT, Konrad Lorenz Strasse 24, Tulln A-3430, Austria ) , nter (Center for Health & Bioresources, Bioresources Unit, AIT Austrian Institute of Technology GmbH, AIT, Konrad Lorenz Strasse 24, Tulln A-3430, Austria ) , Sessitsch, Angela (Department of Biosciences, Faculty of Sciences, COMSATS I) , Hafeez, Fauzia Yusuf
    Microbiological research v.209 ,pp. 1 - 13 , 2018 , 0944-5013 ,

    초록

    Abstract The potential of the Bacillus genus to antagonize phytopathogens is associated with the production of cyclic lipopeptides. Depending upon the type of lipopeptide, they may serve as biocontrol agents that are eco-friendly alternatives to chemical fertilizers. This study evaluates the biocontrol activity of surfactin-producing Bacillus (SPB) strains NH-100 and NH-217 and purified surfactin A from these strains against rice bakanae disease. Biologically active surfactin fractions were purified by HPLC, and surfactin A variants with chain lengths from C12 to C16 were confirmed by LCMS-ESI. In hemolytic assays, a positive correlation between surfactin A production and halo zone formation was observed. The purified surfactin A had strong antifungal activity against Fusarium oxysporum, F. moniliforme, F. solani , Trichoderma atroviride and T. reesei. Maximum fungal growth suppression (84%) was recorded at 2000 ppm against F. moniliforme . Surfactin A retained antifungal activity at different pH levels (5–9) and temperatures (20, 50 and 121 °C). Hydroponic and pot experiments were conducted to determine the biocontrol activity of SPB strains and the purified surfactin A from these strains on Super Basmati rice. Surfactin production in the rice rhizosphere was detected by LCMS-ESI at early growth stages in hydroponics experiments inoculated with SPB strains. However, the maximum yield was observed with a consortium of SPB strains (T4) and purified surfactin A (T5) treatments in the pot experiment. The outcomes of the present study revealed that surfactin A significantly reduced rice bakanae disease by up to 80%. These findings suggest that purified surfactin A could be an effective biocontrol agent against bakanae disease in rice and should be incorporated into strategies for disease management.

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  3. [해외논문]   Transcriptional control of the phenol hydroxylase gene phe of Corynebacterium glutamicum by the AraC-type regulator PheR   SCIE SCOPUS

    Chen, Can (Institute of Food and Drug Inspection, College of Life Science and Agronomy, Zhoukou Normal University, Zhoukou, Henan 466001, China ) , Zhang, Yaoling (Agricultural Scientific Research Institute in Hanzhong City, Hanzhong, Shaanxi 723000, China ) , Xu, Lei (Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, China ) , Zhu, Kaixiang (Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, China ) , Feng, Yanyan (Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, China ) , Pan, Junfeng (Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, China ) , Si, Meiru (Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 7) , Zhang, Lei , Shen, Xihui
    Microbiological research v.209 ,pp. 14 - 20 , 2018 , 0944-5013 ,

    초록

    Abstract Corynebacterium glutamicum can degrade phenol by a meta-cleavage pathway, which depends on ncgl2588 ( phe ) of the phe operon encoding phenol hydroxylase. An additional gene, ncgl2587 ( pheR ), is located upstream of phe . The pheR encodes an AraC/XylR-type regulator protein with 377 amino acid residues and is transcribed in the same direction as phe . Disruption of pheR by homologous recombination resulted in the accumulation of phenol in C. glutamicum . PheR demonstrates a low type of constitutive expression where phenol induces phe expression. PheR shares 75% sequence identity with AraC-type regulator of Corynebacterium lubricantis and 37 conserved residues, characteristic of AraC family, were located. A constructed pK18 mobsacB-P phe :lacZ transcriptional fusion plasmid was transformed into the wild-type, Δ pheR , and Δ pheR + strains, and the results indicated that PheR activates the expression of phe encoding phenol hydroxylase. Electrophoretic mobility shift assay (EMSA) demonstrated a direct interaction of PheR with the phe promoter region and binding site of PheR on the P phe was located 109-bp upstream of phe , as indicated by foot printing analysis. Our research provides deep insight into PheR expression and its regulatory function on Phe in C. glutamicum .

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  4. [해외논문]   Plant growth promoting bacteria as an alternative strategy for salt tolerance in plants: A review   SCIE SCOPUS

    Numan, Muhammad (Department of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan ) , Bashir, Samina (Department of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan ) , Khan, Yasmin (Department of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan ) , Mumtaz, Roqayya (Department of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan ) , Shinwari, Zabta Khan (Qarshi Research International and Vice Chancellor of Qarshi University, Lahore, Pakistan ) , Khan, Abdul Latif (UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, P.O. Box 33, Birkatal Al Mauz, Nizwa 616, Oman ) , Khan, Ajmal (UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, P.O. Box 33, Birkatal Al Mauz, Nizwa 616, Oman ) , AL-Harrasi, Ahmed (UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, P.O. Box 33, Birkatal Al Mauz, Nizwa 616, Oman)
    Microbiological research v.209 ,pp. 21 - 32 , 2018 , 0944-5013 ,

    초록

    Abstract Approximately 5.2 billion hectare agriculture land are affected by erosion, salinity and soil degradation. Salinity stress has significantly affecting the fertile lands, and therefore possesses a huge impact on the agriculture and economy of a country. Salt stress has severe effects on the growth and development of plants as well as reducing its yield. Plants are inherently equipped with stress tolerance ability to responds the specific type of stress. Plants retained specific mechanisms for salt stress mitigation, such as hormonal stimulation, ion exchange, antioxidant enzymes and activation of signaling cascades on their metabolic and genetic frontiers that sooth the stressed condition. Additional to the plant inherent mechanisms, certain plant growth promoting bacteria (PGPB) also have specialized mechanism that play key role for salt stress tolerance and plant growth promotion. These bacteria triggers plants to produce different plant growth hormones like auxin, cytokinine and gibberellin as well as volatile organic compounds. These bacteria also produces growth regulators like siderophore, which fix nitrogen, solubilize organic and inorganic phosphate. Considering the importance of PGPB in compensation of salt tolerance in plants, the present study has reviewed the different aspect and mechanism of bacteria that play key role in promoting plants growth and yield. It can be concluded that PGPB can be used as a cost effective and economical tool for salinity tolerance and growth promotion in plants. Graphical abstract [DISPLAY OMISSION]

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  5. [해외논문]   Physiologically distinct subpopulations formed in Escherichia coli cultures in response to heat shock   SCIE SCOPUS

    Bruhn-Olszewska, Boż (Corresponding author.) , ena , Szczepaniak, Paweł , Matuszewska, Ewelina , Kuczyń , ska-Wiś , nik, Dorota , Stojowska-Swę , drzyń , ska, Karolina , Moruno Algara, Marí , a , Laskowska, Ewa
    Microbiological research v.209 ,pp. 33 - 42 , 2018 , 0944-5013 ,

    초록

    Abstract Bacteria can form heterogeneous populations containing phenotypic variants of genetically identical cells. The heterogeneity of populations can be considered a bet-hedging strategy allowing adaptation to unknown environmental changes – at least some individual subpopulations or cells might be able to withstand future adverse conditions. Using Percoll gradient centrifugation, we demonstrated that in an Escherichia coli culture exposed to heat shock at 50 °C, two physiologically distinct subpopulations were formed. A high-density subpopulation (HD 50 ) demonstrated continued growth immediately after its transfer to LB medium, whereas the growth of a low-density subpopulation (LD 50 ) was considerably postponed. The LD 50 subpopulation contained mainly viable but non-culturable bacteria and exhibited higher tolerance to sublethal concentrations of antibiotics or H 2 O 2 than HD 50 cells. The levels of aggregated proteins and main molecular chaperones were comparable in both subpopulations; however, a decreased number of ribosomes and a significant increase in protein oxidation were observed in the LD 50 subpopulation as compared with the HD 50 subpopulation. Interestingly, under anaerobic heat stress, the formation of the HD 50 subpopulation was decreased and culturability of the LD 50 subpopulation was significantly increased. In both subpopulations the level of protein aggregates formed under anaerobic and aerobic heat stress was comparable. We concluded that the formation of protein aggregates was independent of oxidative damage induced by heat stress, and that oxidative stress and not protein aggregation limited growth and caused loss of LD 50 culturability. Our results indicate that heat stress induces the formation of distinct subpopulations differing in their ability to grow under standard and stress conditions.

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  6. [해외논문]   Heat stress-induced reactive oxygen species participate in the regulation of HSP expression, hyphal branching and ganoderic acid biosynthesis in Ganoderma lucidum   SCIE SCOPUS

    Liu, Rui (Corresponding author at: College of Life Sciences, Nanjing Agricultural University, No. 1 Weigang, Nanjing, Jiangsu 210095, People′s Republic of China.) , Zhang, Xue , Ren, Ang , Shi, Deng-Ke , Shi, Liang , Zhu, Jing , Yu, Han-Shou , Zhao, Ming-Wen
    Microbiological research v.209 ,pp. 43 - 54 , 2018 , 0944-5013 ,

    초록

    Abstract Heat stress (HS) is an important environmental factor that affects the growth and metabolism of edible fungi, but the molecular mechanism of the heat stress response (HSR) remains unclear. We previously reported that HS treatment increased the length between two hyphal branches and induced the accumulation of ganoderic acid biosynthesis and the gene expression of heat shock proteins (HSPs) in Ganoderma lucidum . In this study, we found that HS induced a significant increase in the cytosolic ROS concentration, and exogenously added ROS scavengers NAC, VC and NADPH oxidase (Nox) inhibitor DPI reduce the cytosolic ROS accumulation in G. lucidum . In addition, the phenomena of the increased gene expression and increased length between the two hyphal branches and the accumulation of GA biosynthesis induced by HS were mitigated. Furthermore, we investigated the effects of HS on Nox-silenced strains (NoxABi-10, NoxABi-11 and NoxRi-4, NoxRi-7) and found that the level of ROS concentration was lower than that in wild-type (WT) strains treated with HS. Additionally, Nox silenced strains reduced the HS-induced increase in HSP expression, the length between two hyphal branches and GA biosynthesis compared with the WT strain. These data indicate that HS-induced ROS participate in the regulation of HSP expression, hyphal branching and ganoderic acid biosynthesis in G. lucidum . In addition, these findings identified potential pathways linking ROS networks to HSR, physiological and metabolic processes in fungi and provide a valuable reference for studying the role of ROS in HSR, mycelium growth and secondary metabolites.

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  7. [해외논문]   Phospholipases play multiple cellular roles including growth, stress tolerance, sexual development, and virulence in fungi   SCIE SCOPUS

    Barman, Ananya (Corresponding author.) , Gohain, Dibakar , Bora, Utpal , Tamuli, Ranjan
    Microbiological research v.209 ,pp. 55 - 69 , 2018 , 0944-5013 ,

    초록

    Abstract Phospholipases are ubiquitous enzymes that hydrolyze phospholipids. Based on the cleavage site of the ester linkage in the substrate phospholipids, phospholipases are classified into four major types, phospholipase A (PLA), phospholipase B (PLB), phospholipase C (PLC), and phospholipase D (PLD), which are further classified into various subtypes. Phospholipases hydrolyze phospholipids into various signaling products including phosphatidic acid (PA), diacylglycerol (DAG), free fatty acids (FFAs), and lyso-phospholipids (LPLs). These signaling products regulate numerous processes such as cytoskeletal dynamics, growth, homeostasis, membrane remodeling, nutrient acquisition, secretion, signal transduction, stress tolerance, sexual development, and virulence in various organisms including fungi. Due to these key cellular roles, phospholipases are also promising targets in diagnostic and therapeutic applications. In this review, we discuss current knowledge about the cellular roles of different classes of phospholipases in fungi.

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  8. [해외논문]   Phosphorylation of PppA at threonine 253 controls T6SS2 expression and bacterial killing capacity in the marine pathogen Vibrio alginolyticus   SCIE SCOPUS

    Yang, Zhen (State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China ) , Wang, Xuetong (State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China ) , Xu, Wensheng (Food Science and Engineering College, Beijing University of Agriculture, Beijing 102206, China ) , Zhou, Mian (State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China ) , Zhang, Yuanxing (State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China ) , Ma, Yue (State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China ) , Wang, Qiyao (State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China)
    Microbiological research v.209 ,pp. 70 - 78 , 2018 , 0944-5013 ,

    초록

    Abstract Type VI secretion systems (T6SSs) are multi-protein secretory nano-machines that mediate inter-bacterial competition. Vibrio alginolyticus is an abundant gram-negative marine bacterium that efficiently kills other bacteria with its T6SS2. The V. alginolyticus T6SS2 gene cluster encodes a phosphatase, PppA, and a type II membrane-spanning Hanks-type threonine kinase, PpkA2, which have been implicated in the activation of T6S. Meanwhile, T6SS2 gene expression is under the control of quorum sensing. However, the role of PppA in T6SS2 activity is unclear. Here, our phosphoproteomic screen identified PppA as a novel PpkA2 substrate. Phosphorylation at threonine 253 (T253) of PppA is not conserved in other bacteria, suggesting that PppA may play a unique role in T6SS2 activation in V. alginolyticus . Interestingly, PppA phosphatase activity was modulated by the cognate kinase PpkA2, which implied that a homeostasis is required for optimal T6S activity. PppA and phosphorylation of PppA at T253 are important for T6S activity and T6SS2-mediated bacterial killing. Moreover, PppA and the phosphorylation of PppA are also essential for the expression of LuxR, the master regulator of quorum sensing, thus augmenting T6SS2 expression. Collectively, our data demonstrated that phosphorylation of PppA at T253 controls the activity of T6SS2, thereby enhancing the competitive fitness of V. alginolyticus .

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  9. [해외논문]   Antidiabetic “gliptins” affect biofilm formation by Streptococcus mutans   SCIE SCOPUS

    De, Arpan (School of Pharmacy, University of Camerino, 62032, Camerino, Italy ) , Pompilio, Arianna (Department of Medical, Oral and Biotechnological Sciences, School of Medicine, “G. d'Annunzio” University of Chieti-Pescara, 66100, Chieti, Italy ) , Francis, Jenifer (Department of Applied Sciences, Faculty of Health & Life Sciences, Northumbria University, NE1 8ST, Newcastle upon Tyne, UK ) , Sutcliffe, Iain C. (Department of Applied Sciences, Faculty of Health & Life Sciences, Northumbria University, NE1 8ST, Newcastle upon Tyne, UK ) , Black, Gary W. (Department of Applied Sciences, Faculty of Health & Life Sciences, Northumbria University, NE1 8ST, Newcastle upon Tyne, UK ) , Lupidi, Giulio (School of Pharmacy, University of Camerino, 62032, Camerino, Italy ) , Petrelli, Dezemona (School of Biosciences and Veterinary Medicine, University of Camerino, 62032, Camerino, Italy ) , Vitali, Luca A. (School of Pharmacy, University of Camerino, 62032, Camerino, Italy)
    Microbiological research v.209 ,pp. 79 - 85 , 2018 , 0944-5013 ,

    초록

    Abstract Streptococcus mutans , a dental caries causing odontopathogen, produces X-prolyl dipeptidyl peptidase (Sm-XPDAP, encoded by pepX ), a serine protease known to have a nutritional role. Considering the potential of proteases as therapeutic targets in pathogens, this study was primarily aimed at investigating the role of Sm-XPDAP in contributing to virulence-related traits. Dipeptidyl peptidase (DPP IV), an XPDAP analogous enzyme found in mammalian tissues,is a well known therapeutic target in Type II diabetes. Based on the hypothesis that gliptins, commonly used as anti-human-DPP IV drugs, may affect bacterial growth upon inhibition of Sm-XPDAP, we have determined their ex vivo antimicrobial and anti-biofilm activity towards S. mutans . All three DPP IV drugs tested reduced biofilm formation as determined by crystal violet staining. To link the observed biofilm inhibition to the human-DPP IV analogue present in S. mutans UA159, a pepX isogenic mutant was generated. In addition to reduced biofilm formation, CLSM studies of the biofilm formed by the pepX isogenic mutant showed these were comparable to those formed in the presence of saxagliptin, suggesting a probable role of this enzyme in biofilm formation by S. mutans UA159. The effects of both pepX deletion and DPP IV drugs on the proteome were studied using LC–MS/MS. Overall, this study highlights the potential of Sm-XPDAP as a novel anti-biofilm target and suggests a template molecule to synthesize lead compounds effective against this enzyme.

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    Fig. 1 이미지

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