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Osteoarthritis and cartilage 17건

  1. [해외논문]   Acknowledgement to Reviewers 2017   SCI SCIE

    Block, Joel
    Osteoarthritis and cartilage v.26 no.1 ,pp. iii - vii , 2018 , 1063-4584 ,

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  2. [해외논문]   Initiating pain in osteoarthritis (OA): is it the mast cell?   SCI SCIE

    Ioan-Facsinay, A. (Address correspondence and reprint requests to: A. Ioan-Facsinay, Department of Rheumatology, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands.)
    Osteoarthritis and cartilage v.26 no.1 ,pp. 1 - 3 , 2018 , 1063-4584 ,

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  3. [해외논문]   Pharmacological blockade of the WNT-beta-catenin signaling: a possible first-in-kind DMOAD   SCI SCIE

    Dell'Accio, F. (Address correspondence and reprint requests to: F. Dell'Accio, Queen Mary University of London, Centre for Experimental Medicine & Rheumatology, 2nd Floor, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, United Kingdom.)
    Osteoarthritis and cartilage v.26 no.1 ,pp. 4 - 6 , 2018 , 1063-4584 ,

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Hierarchical, imbalanced pro-inflammatory cytokine networks govern the pathogenesis of chronic arthropathies   SCI SCIE

    Livshits, G. (Address correspondence and reprint requests to: G. Livshits, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel.) , Kalinkovich, A.
    Osteoarthritis and cartilage v.26 no.1 ,pp. 7 - 17 , 2018 , 1063-4584 ,

    초록

    Summary Background Chronic inflammatory arthropathies, such as rheumatoid arthritis (RA), spondyloarthritis, including psoriatic arthritis (PsA), ankylosing spondyloarthritis (AS), osteoarthritis (OA), and intervertebral disc degenerative disease (DDD) constitute major public health problems that are anticipated to grow significantly as the human population ages. However, many aspects concerning the molecular mechanisms underlying their onset and progression remain unclear. Design This narrative review critically analyzes the molecular mechanisms underlying the inflammation-associated pathogenesis of the aforementioned joint diseases. This includes, in particular, the major role played by several key soluble factors (such as cytokines and the associated signaling pathways, designated as “fragile nodes”) produced by local cells and recruited to the joints' immune cells, whose elimination by specific drugs has dramatically improved the diseases' symptomatology and outcome in human clinical trials or in rodent arthritis models. Hypothesis and the aim of this review We hypothesize that the pathogenesis of chronic inflammatory arthropathies is governed by hierarchical, imbalanced pro-inflammatory cytokine networks (HIPICNs) (comprising a combination of fragile nodes) that are created during the development of both autoimmune (RA, PsA, and AS) and non-autoimmune (OA and DDD) disorders. The main aim of this review is to provide evidence that despite substantial pathobiological differences between these arthropathies, the HIPICNs created are quite common, thus justifying the merging of these disorders mechanistically and suggesting that these common mechanisms exist in the onset and progression of different joint diseases.

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  5. [해외논문]   A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee   SCI SCIE

    Deshmukh, V. (Samumed, LLC, San Diego, CA, USA ) , Hu, H. (Samumed, LLC, San Diego, CA, USA ) , Barroga, C. (Samumed, LLC, San Diego, CA, USA ) , Bossard, C. (Samumed, LLC, San Diego, CA, USA ) , KC, S. (Samumed, LLC, San Diego, CA, USA ) , Dellamary, L. (Samumed, LLC, San Diego, CA, USA ) , Stewart, J. (Samumed, LLC, San Diego, CA, USA ) , Chiu, K. (Samumed, LLC, San Diego, CA, USA ) , Ibanez, M. (Samumed, LLC, San Diego, CA, USA ) , Pedraza, M. (Samumed, LLC, San Diego, CA, USA ) , Seo, T. (Samumed, LLC, San Diego, CA, USA ) , Do, L. (Samumed, LLC, San Diego, CA, USA ) , Cho, S. (Samumed, LLC, San Diego, CA, USA ) , Cahiwat, J. (Samumed, LLC, San Diego, CA, USA ) , Tam, B. (Samumed, LLC, San Diego, CA, USA ) , Tambiah, J.R.S. (Samumed, LLC, San Diego, CA, USA ) , Hood, J. (Samumed, LLC, San Diego, CA, USA ) , Lane, N.E. (University of California, Davis, CA, USA ) , Yazici, Y. (Samumed, LLC, San Diego, CA, USA)
    Osteoarthritis and cartilage v.26 no.1 ,pp. 18 - 27 , 2018 , 1063-4584 ,

    초록

    Summary Objectives Osteoarthritis (OA) is a degenerative disease characterized by loss of cartilage and increased subchondral bone within synovial joints. Wnt signaling affects the pathogenesis of OA as this pathway modulates both the differentiation of osteoblasts and chondrocytes, and production of catabolic proteases. A novel small-molecule Wnt pathway inhibitor, SM04690, was evaluated in a series of in vitro and in vivo animal studies to determine its effects on chondrogenesis, cartilage protection and synovial-lined joint pathology. Design A high-throughput screen was performed using a cell-based reporter assay for Wnt pathway activity to develop a small molecule designated SM04690. Its properties were evaluated in bone-marrow-derived human mesenchymal stem cells (hMSCs) to assess chondrocyte differentiation and effects on cartilage catabolism by immunocytochemistry and gene expression, and glycosaminoglycan breakdown. In vivo effects of SM04690 on Wnt signaling, cartilage regeneration and protection were measured using biochemical and histopathological techniques in a rodent acute cruciate ligament tear and partial medial meniscectomy (ACLT + pMMx) OA model. Results SM04690 induced hMSC differentiation into mature, functional chondrocytes and decreased cartilage catabolic marker levels compared to vehicle. A single SM04690 intra-articular (IA) injection was efficacious in a rodent OA model, with increased cartilage thickness, evidence for cartilage regeneration, and protection from cartilage catabolism observed, resulting in significantly improved Osteoarthritis Research Society International (OARSI) histology scores and biomarkers, compared to vehicle. Conclusions SM04690 induced chondrogenesis and appeared to inhibit joint destruction in a rat OA model, and is a candidate for a potential disease modifying therapy for OA.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  6. [해외논문]   One year effectiveness of neuromuscular exercise compared with instruction in analgesic use on knee function in patients with early knee osteoarthritis: the EXERPHARMA randomized trial   SCI SCIE

    Holsgaard-Larsen, A. (Orthopaedic Research Unit, Department of Orthopaedics and Traumatology, Odense University Hospital, Department of Clinical Research, University of Southern Denmark, Odense, Denmark ) , Christensen, R. (Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark ) , Clausen, B. (Research Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark ) , Søndergaard, J. (Research Unit for General Practice, Institute of Public Health, University of Southern Denmark, Odense, Denmark ) , Andriacchi, T.P. (Department of Mechanical Engineering, Stanford University, Stanford, CA, USA ) , Roos, E.M. (Research Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark)
    Osteoarthritis and cartilage v.26 no.1 ,pp. 28 - 33 , 2018 , 1063-4584 ,

    초록

    Summary Objective To test long-term effectiveness of neuromuscular exercise (NEMEX) with instructions in optimized pharmacological treatment (PHARMA) on activities of daily living (ADL) in patients with early knee osteoarthritis. Design 12-months follow-up from a randomized controlled trial. Participants with mild-to-moderate medial tibiofemoral knee osteoarthritis were randomly allocated to 8 weeks NEMEX or PHARMA. The primary outcome measure was the ADL-subscale of the Knee Injury and Osteoarthritis Outcome Score (KOOS). Secondary outcome measures included the other four KOOS-subscales, the University of California Activity Score (UCLA) and the European Quality of Life-5 Dimensions. Results Ninety-three patients (57% women, 58 ± 8 years, body mass index 27 ± 4 kg/m 2 ) were randomized to NEMEX ( n = 47) or PHARMA group ( n = 46) with data from 85% being available at 12-months follow-up. Good compliance was achieved for 49% of the participants in NEMEX (≥12 sessions) and 7% in PHARMA (half the daily dose of acetaminophen/NSAIDs ≥ 28 days). Within-group improvements in NEMEX were considered to be clinically relevant (≥10 points) for all KOOS-subscales, except Sport/Rec whereas, no between-groups difference in the primary outcome KOOS ADL (3.6 [−2.1 to 9.2]; P = 0.216 ) was observed. For KOOS Symptoms, a statistically significant difference of 7.6 points (2.6–12.7; P = 0.004 ) was observed in favor of NEMEX with 47% improving ≥10 points. Conclusions No difference in improvement in difficulty with ADL was observed. NEMEX improved knee symptoms to a greater extent with half of patients reporting clinically relevant improvements. ClinicalTrials.gov Identifier NCT01638962 (July 3, 2012). Ethical committee S-20110153

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  7. [해외논문]   Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA)   SCI SCIE

    Kraus, V.B. (Duke University School of Medicine, Durham, NC, USA ) , Conaghan, P.G. (Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, UK ) , Aazami, H.A. (Hope Clinical Research, Canoga Park, CA, USA ) , Mehra, P. (Artemis Institute for Clinical Research, San Diego, CA, USA ) , Kivitz, A.J. (Altoona Center for Clinical Research, Duncansville, PA, USA ) , Lufkin, J. (Flexion Therapeutics, Inc., Burlington, MA, USA ) , Hauben, J. (Flexion Therapeutics, Inc., Burlington, MA, USA ) , Johnson, J.R. (Summit Analytical, Inc., Cary, NC, USA ) , Bodick, N. (Flexion Therapeutics, Inc., Burlington, MA, USA)
    Osteoarthritis and cartilage v.26 no.1 ,pp. 34 - 42 , 2018 , 1063-4584 ,

    초록

    Summary Objective Intra-articular (IA) corticosteroids relieve osteoarthritis (OA) pain, but rapid absorption into systemic circulation may limit efficacy and produce untoward effects. We compared the pharmacokinetics (PK) of IA triamcinolone acetonide (TA) delivered as an extended-release, microsphere-based formulation (FX006) vs a crystalline suspension (TAcs) in knee OA patients. Method This Phase 2 open-label study sequentially enrolled 81 patients who received a single IA injection of FX006 (5 mL, 32 mg delivered dose, N = 63) or TAcs (1 mL, 40 mg, N = 18). Synovial fluid (SF) aspiration was attempted in each patient at baseline and one post-IA-injection visit (FX006: Week 1, Week 6, Week 12, Week 16 or Week 20; TAcs: Week 6). Blood was collected at baseline and multiple post-injection times. TA concentrations (validated LC-MS/MS, geometric means (GMs)), PK (non-compartmental analysis models), and adverse events (AEs) were assessed. Results SF TA concentrations following FX006 were quantifiable through Week 12 (pg/mL: 231,328.9 at Week 1; 3590.0 at Week 6; 290.6 at Week 12); post-TAcs, only two of eight patients had quantifiable SF TA at Week 6 (7.7 pg/mL). Following FX006, plasma TA gradually increased to peak (836.4 pg/mL) over 24 h and slowly declined to Conclusion In knee OA patients, microsphere-based TA delivery via a single IA injection prolonged SF joint residency, diminished peak plasma levels, and thus reduced systemic TA exposure relative to TAcs.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  8. [해외논문]   Implementing core NICE guidelines for osteoarthritis in primary care with a model consultation (MOSAICS): a cluster randomised controlled trial   SCI SCIE

    Dziedzic, K.S. (Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK ) , Healey, E.L. (Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK ) , Porcheret, M. (Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK ) , Afolabi, E.K. (Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK ) , Lewis, M. (Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK ) , Morden, A. (School of Social and Community Medicine, University of Bristol, Gloucestershire, UK ) , Jinks, C. (Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK ) , McHugh, G.A. (Sc) , Ryan, S. , Finney, A. , Main, C. , Edwards, J.J. , Paskins, Z. , Pushpa-Rajah, A. , Hay, E.M.
    Osteoarthritis and cartilage v.26 no.1 ,pp. 43 - 53 , 2018 , 1063-4584 ,

    초록

    Summary Objective To determine the effectiveness of a model osteoarthritis consultation, compared with usual care, on physical function and uptake of National Institute for Health and Care Excellence (NICE) osteoarthritis recommendations, in adults ≥45 years consulting with peripheral joint pain in UK general practice. Method Two-arm cluster-randomised controlled trial with baseline health survey. Eight general practices in England. Participants: 525 adults ≥45 years consulting for peripheral joint pain, amongst 28,443 population survey recipients. Four intervention practices delivered the model osteoarthritis consultation to patients consulting with peripheral joint pain; four control practices continued usual care. The primary clinical outcome of the trial was the SF-12 physical component score (PCS) at 6 months; the main secondary outcome was uptake of NICE core recommendations by 6 months, measured by osteoarthritis quality indicators. A Linear Mixed Model was used to analyse clinical outcome data (SF-12 PCS). Differences in quality indicator outcomes were assessed using logistic regression. Results 525 eligible participants were enrolled (mean age 67.3 years, SD 10.5; 59.6% female): 288 from intervention and 237 from control practices. There were no statistically significant differences in SF-12 PCS: mean difference at the 6-month primary endpoint was −0.37 (95% CI −2.32, 1.57). Uptake of core NICE recommendations by 6 months was statistically significantly higher in the intervention arm compared with control: e.g., increased written exercise information, 20.5% (7.9, 28.3). Conclusion Whilst uptake of core NICE recommendations was increased, there was no evidence of benefit of this intervention, as delivered in this pragmatic randomised trial, on the primary outcome of physical functioning at 6 months. Trial registration ISRCTN06984617.

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  9. [해외논문]   Population-based prevalence of multiple radiographically-defined hip morphologies: the Johnston County Osteoarthritis Project   SCI SCIE

    Raveendran, R. (Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA ) , Stiller, J.L. (Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA ) , Alvarez, C. (Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA ) , Renner, J.B. (Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA ) , Schwartz, T.A. (Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA ) , Arden, N.K. (Arthritis Research UK Centre for Sport, Exercise, and Osteoarthritis, University of Oxford, Oxford, UK ) , Jordan, J.M. (Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA ) , Nelson, A.E. (Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA)
    Osteoarthritis and cartilage v.26 no.1 ,pp. 54 - 61 , 2018 , 1063-4584 ,

    초록

    Summary Objective To provide the first prevalence estimates of different radiographic hip morphologies relevant to dysplasia and femoroacetabular impingement in a well-characterized USA population-based cohort. Methods Cross-sectional data were from the baseline examination (1991–1997) of a large population-based prospective longitudinal cohort study (The Johnston County Osteoarthritis Project). HipMorf software (Oxford, UK) was used to assess hip morphology on anteroposterior (AP) pelvis radiographs. Weighted, sex-stratified prevalence estimates and 95% confidence intervals for four key hip morphologies (AP alpha angle, triangular index sign, lateral center edge angle (LCEA), and protrusio acetabula) were derived and further stratified by age, race and body mass index (BMI). Results A total of 5192 hips from 2596 individuals were included (31% African American, 43% male, mean age 63 years, mean BMI 29 kg/m 2 ). Cam morphology was seen in more than 25% of men and 10% of women. Mild dysplasia was present in about 1/3 of men and women, while pincer morphology was identified in 7% of men and 10% of women. Femoral side (cam) morphologies were more common and more frequently bilateral among men, while pincer morphologies were more common in women; mixed morphologies were infrequent. African-Americans were more likely to have protrusio acetabula than whites. Conclusion We report the first population-based prevalence estimates of radiographic hip morphologies relevant to femoroacetabular impingement (FAI) and dysplasia in the USA. These morphologies are very common, with ¼ men and 1/10 women having cam morphology, 1/3 of all adults having mild dysplasia, and 1/15 men and 1/10 women having pincer morphology in at least one hip.

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  10. [해외논문]   Where does meniscal damage progress most rapidly? An analysis using three-dimensional shape models on data from the Osteoarthritis Initiative   SCI SCIE

    Dube, B. (Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, UK ) , Bowes, M.A. (Imorphics Ltd, Kilburn House, Manchester, UK ) , Kingsbury, S.R. (Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, UK ) , Hensor, E.M.A. (Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, UK ) , Muzumdar, S. (Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, UK ) , Conaghan, P.G. (Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, UK)
    Osteoarthritis and cartilage v.26 no.1 ,pp. 62 - 71 , 2018 , 1063-4584 ,

    초록

    Summary Objectives Meniscal pathology is integral to knee osteoarthritis (OA) and its progression; it provides a progression biomarker and a potential treatment target. Magnetic resonance imaging (MRI) demonstrates large heterogeneity in meniscal damage; this structural complexity means measurement is difficult. The aim of this study was to apply novel 3D image analysis to determine which meniscal pathologies demonstrated most change during OA progression. Methods Knee images were selected from the progression cohort of the Osteoarthritis Initiative choosing participants with risk factors for medial OA progression. Medial and lateral menisci were manually segmented then analysed using a statistical shape model of the tibia as a reference surface. Responsiveness was assessed at 1 year using standardised response means (SRMs) for four constructs: meniscal volume, extrusion volume, thickness and tibial coverage; anatomical sub-regions of these constructs were also explored. Results Paired images from 86 participants (median age 61.5, 49% female, 56% obese) were included. Reliability of the novel meniscal measurements was very good intraclass correlation coefficients (ICCs all > 0.98). Meniscal volume and extrusion demonstrated no significant change. Moderate responsiveness was observed for medial meniscus thickness (SRM −0.35) and medial tibial coverage (SRM −0.36). No substantial change was seen for the lateral meniscus measures. Sub-region analysis did not improve responsiveness; while greater change was seen in the posterior medial compartment, it was associated with increased variance of the change. Conclusions The location of meniscal damage was consistently in the posterior medial region, and two measurements (thickness and tibial coverage) were most responsive. Meniscal measures should add to discriminatory power in OA progression assessment.

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