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저널/프로시딩 상세정보

권호별목차 / 소장처보기

H : 소장처정보

T : 목차정보

Journal of Korean medical science : JKMS 13건

  1. [국내논문]   Factors associated with intrafamilial transmission of hepatitis B virus infection in Korea.  

    Kim, Y. S. , Ahn, Y. O.
    Journal of Korean medical science : JKMS v.8 no.6 ,pp. 395 - 404 , 1993 , 1011-8934 ,

    초록

    Epidemiologic and serologic data on 137 household contacts of 51 chronic carriers of HBsAg and 111 household contacts of 38 controls who were negative for serologic markers of hepatitis B virus (HBV) were obtained from March 1990 to August 1991. Using this data, possible routes of intrafamilial transmission of hepatitis B virus among household contacts of chronic carriers of hepatitis B surface antigen (HBsAg) were evaluated and analyzed. The HBsAg prevalence among the household contacts of carriers was 14. 1% (95% CI 7.8-24.0) compared to 0.0% (95% CI 0.0-7.0) among those of controls (P

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  2. [국내논문]   Distribution of Borrelia burgdorferi specific antibody among patients with juvenile rheumatoid arthritis in Korea.  

    Oh, S. H. , Song, Y. H. , Yoo, D. H. , Kim, S. Y. , Lee, H.
    Journal of Korean medical science : JKMS v.8 no.6 ,pp. 405 - 412 , 1993 , 1011-8934 ,

    초록

    Lyme disease, a multi-systemic infection occurring worldwide, has yet to be reported in Korea, although the spirochete B. burgdorferi, known as the causative organism of the disease, has recently been isolated from the vector tick Ixodes persulcatus in the region. To contribute to revealing whether Lyme disease exists in Korea or not, B. burgdorferi specific antibodies (IgG, IgM, and/or IgA) were measured by three individual enzyme-linked immunosorbent assays (ELISA) utilizing different antigens in 38 patients with juvenile rheumatoid arthritis (JRA) which shares a number of clinical features with Lyme arthritis. The antibody prevalence rates in patients with JRA were various depending on the antigens (21% of IgG and IgM antibodies to purified organisms, 0% for IgG antibody to purified native flagella, and 5% for IgG, IgM, and IgA antibodies to recombinant p39) and were not different compared to 39 controls (21%, 0%, and 0% respectively). The antibody prevalence rates compared in various subgroups of patients with JRA according to types of JRA, length of illness, age, and sex were not different. Comparing the three different antigens, the greatest number of positive responders were yielded by purified organisms followed by p39 and purified flagellin, however the possibility of nonspecificity with purified organisms remained. The data indicate that serologic tests using ELISA fail to illustrate Lyme disease among 38 patients with JRA in Korea.

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  3. [국내논문]   Phosphorylation of ribosomal protein S6 and its regulation during differentiation of human leukemic cells.  

    Kim, I. S. , Lee, S. B. , Cho, K. C.
    Journal of Korean medical science : JKMS v.8 no.6 ,pp. 413 - 419 , 1993 , 1011-8934 ,

    초록

    We attempted to study the role of protein tyrosine kinase (PTK) and protein kinase C (PKC) in the cascade of phosphorylation of ribosomal protein S6 during differentiation of leukemic cells (HL-60, THP-1, and RWLeu-4). Neither activation nor inhibition of colony stimulating factor-1 (CSF-1) receptor's PTK activity with CSF-1 or genistein respectively affected the phosphorylation of S6. However, vanadate which is a protein tyrosine phosphatase (PTP) inhibitor showed enhancement of S6 phosphorylation. Dimethylsulfoxide which does not affect either PTK or PKC demonstrated no change in S6 phosphorylation. PKC activation by acute 12-0-tetradecanoyl phorbol-13-acetate (TPA) treatment induced monocytic differentiation and S6 phosphorylation. Surprisingly, the more prominent phosphorylation of S6 protein was observed in PKC-depleted cells by prolonged TPA treatment. Our results suggest that PTK/PTP play a lesser role in S6 phosphorylation of HL-60 cells than PKC does. In addition, two different mechanisms seem to be involved in TPA-induced S6 phosphorylation during HL-60 differentiation: PKC activation by acute TPA treatment and PKC depletion which may lead to the synthesis of some endogenous protein responsible for the differentiation by chronic TPA treatment.

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  4. [국내논문]   Histopathologic and ultrastructural findings of photocoagulation lesions produced by transpupillary diode laser in the rabbit retina.  

    Cho, H. K. , Park, Y. W. , Kim, Y. J. , Shyn, K. H.
    Journal of Korean medical science : JKMS v.8 no.6 ,pp. 420 - 430 , 1993 , 1011-8934 ,

    초록

    Transpupillary retinal photocoagulations were performed on ten eyes of five pigmented rabbits using a diode laser (Nidek Co., LTD, Aichi, Japan) emitting infrared radiation at 800 nm wavelength. A histological and an ultrastructural study on the treated eyes were done at 1, 3, 5, and 7 days after retinal photocoagulations. The purpose of this study was to observe the sequential changes in the retina and the choroid following transpupillary diode laser retinal photocoagulations at the parameters of laser power which produced a grayish white retinal discoloration with distinct white center. It seemed that the lesion was grade 3 retinal photocoagulation by Tso et al's classification. It appeared that the parameters necessary to produce grade 3 photocoagulation lesions were 160 mW power, and 0.2 second duration at 200 microns size. In general, with an agreement to other reports, histologic study of the diode laser lesions showed that the outer retina was damaged more severely than the inner retina. However, on day 1 after laser treatment, the alterations were more profound in the inner retina than in the outer retina and an occasional swelling of the axons in the nerve fiber layer was observed on the ultrastructural study. The results observed have not been found in other previous studies and suggest that the inner retina might be injured directly by 800 nm wavelength diode laser radiations. Thus we could conclude that 800 nm wavelength diode radiation might be absorbed by melanin pigment and also by other chromophores contained in inner retinal tissues. Further studies must follow to verify the laser-tissue interactions in diode laser retinal photocoagulations.

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  5. [국내논문]   Reticular network of the human thymus.  

    Yu, E. , Lee, I.
    Journal of Korean medical science : JKMS v.8 no.6 ,pp. 431 - 436 , 1993 , 1011-8934 ,

    초록

    To investigate the development of the reticular network of the thymus with aging and under pathologic conditions, we performed reticulin stains on the following samples; 5 fetal thymi (22 to 33 weeks of gestational age) and 35 postnatal thymi (less than 1 month to 33 years of age). The latter included 1 hyperplastic thymus, 4 pathologically involuted thymi and 1 physiologically involuted thymus as well as 29 normal thymi. Reticulin fibers were invariably seen along the capsule and interlobular septae of all the thymi. In fetal thymi, reticulin fibers circumscribed only cortical blood vessels and Hassall's corpuscles. Postnatal thymi from the children aged less than 1 month showed discontinuous reticulin fibers along the blood vessels of the corticomedullary junction. With aging, the amount of reticulin fibers increased and formed a "fibroreticular network(FRN)" from the branching point of the interlobular septae along the corticomedullary junction. It completely circumscribed the outer medulla in fully developed thymi. In the hyperplastic thymus, the reticular network retained its original structure. Both pathologically and physiologically involuted thymi revealed irregularly collapsed reticulin fibers. These findings suggest that the reticular network of the thymus consists of FRNs as well as capsule and interlobular septae and matures with aging before involution.

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  6. [국내논문]   Pathologic study of mice infected with Rickettsia tsutsugamushi R19 strain.  

    Hwang, T. S. , Chu, Y. C. , Kim, Y. B. , Lim, B. U. , Kang, J. S.
    Journal of Korean medical science : JKMS v.8 no.6 ,pp. 437 - 445 , 1993 , 1011-8934 ,

    초록

    Scrub typhus, an acute febrile infectious disease caused by R. tsutsugamushi, has been reported from various parts of the far east and pacific rim of Asia including Korea. It is well known that all human pathogenic rickettsia share an affinity to endothelial cells of the small blood vessels and evoke vascular inflammation variably associated with a rash, microthrombi, and hemorrhage. We infected the ICR mice by inoculating sublethal doses of R. tsutsugamushi R19 strain intraperitoneally and observed the pathologic changes by time sequence. The histopathologic features of experimentally induced scrub typhus in the mice were generally nonspecific interstitial inflammations characterized by interstitial pneumonitis, periportal inflammation, multifocal hepatic necrosis, interstitial nephritis, sinusoidal engorgement, and lymphohistiocytic cell infiltration in lymph nodes and spleen. Contrary to the general features of other rickettsial diseases, the pathologic process of scrub typhus experimentally induced by R. tsutsugamushi R19 strain mainly involved the interstitial connective tissue but not the blood vessels.

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  7. [국내논문]   Genetic study of hydatidiform moles by restriction fragment length polymorphisms (RFLPs) analysis.  

    Cho, S. , Kim, S. J.
    Journal of Korean medical science : JKMS v.8 no.6 ,pp. 446 - 452 , 1993 , 1011-8934 ,

    초록

    Twenty three hydatidiform moles (HMs) were studied using the techniques of "RFLPs" employing a minisatellite deoxyribonucleic acid probe. Among the 23 HMs, 17 were homozygous types resulting from a duplicated haploid sperm, and two were heterozygous types resulting from fertilization two independent sperms (dispermy). It was revealed that the four histopathologically diagnosed complete HMs (CHMs) were partial HMs (PHMs) with one maternal and 2 paternal chromosome contribution (diandry) or two maternal and 1 paternal alleles (digyny). The locus specific minisatellite probes were useful in classifying CHM into heterozygous and homozygous types as well as in diagnosing PHM. One heterozygous (50%) and 5 homozygous (29.4%) CHMs, and one PHM (25%) progressed to persistent gestational trophoblastic disease (p > 0.5).

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  8. [국내논문]   Optimal site of throat swab for the isolation of beta-hemolytic streptococci.  

    Kim, S. J.
    Journal of Korean medical science : JKMS v.8 no.6 ,pp. 453 - 457 , 1993 , 1011-8934 ,

    초록

    The optimal site for the isolation of beta-hemolytic streptococci (BHS) from throat cultures was investigated in 164 healthy elementary school children. All throat cultures were streaked onto duplicate blood agar plates (BAP), one of which was taken from the tonsillar fossae and the other from the posterior pharynx. BHS were isolated in cultures from 56 (34.2%) of the children. BHS were more frequently recovered from the tonsillar fossae than from the posterior pharynx (54 vs. 47; both sites, 45; tonsillar fossae only, 9; posterior pharynx only, 2; P

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  9. [국내논문]   Thymic carcinoid tumor combined with thymoma--neuroendocrine differentiation in thymoma?  

    Cho, K. J. , Ha, C. W. , Koh, J. S. , Zo, J. I. , Jang, J. J.
    Journal of Korean medical science : JKMS v.8 no.6 ,pp. 458 - 463 , 1993 , 1011-8934 ,

    초록

    A carcinoid tumor of the thymus combined with thymoma in a 62-year-old man is described. The mediastinal tumor had been present for 13 years and was associated with pure red cell aplasia. Carcinoid tumor occupied the central two-thirds of the tumor, consisting of nests and trabeculae of monotonous round cells, which ultrastructurally showed many intracytoplasmic dense-core granules. Typical spindle cell type thymoma surrounded the carcinoid area. Clinico-pathologic findings of this unique case suggested that the carcinoid tumor developed within a preexisting thymoma, illustrating a possibility of neuroendocrine differentiation of thymic epithelial cells.

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  10. [국내논문]   Hyperkalemia due to hyporeninemic hypoaldosteronism with liver cirrhosis and hypertension.  

    Kee, C. S. , Choi, J. W. , Chang, D. K. , Ahn, Y. H. , Kim, H. J.
    Journal of Korean medical science : JKMS v.8 no.6 ,pp. 464 - 470 , 1993 , 1011-8934 ,

    초록

    A 49-year-old man with liver cirrhosis and hypertension was found to have hyperkalemia out of a degree of renal insufficiency and metabolic acidosis with low to normal anion gap, aggravated by volume contraction with diarrhea and medications (captopril, spironolactone and atenolol) interfering with potassium homeostasis. Plasma renin activity and serum aldosterone levels of this patient on a regular diet after discontinuation of medications were very low compared to those of five other cirrhotic patients with normokalemia as controls. Also, the renin-aldosterone stimulation testing on this patient performed by sodium restricted diet and furosemide, upright position and by angiotensin converting enzyme inhibition (captopril, 50 mg) showed the blunted renin and aldosterone responses to each of these stimuli, almost no changes from baseline renin and aldosterone levels, it was concluded that the underlying defect responsible for hyperkalemia in this case was hyporeninemic hypoaldosteronism and this was aggravated by other factors or drugs affecting potassium homeostasis.

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