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저널/프로시딩 상세정보

권호별목차 / 소장처보기

H : 소장처정보

T : 목차정보

Journal of Korean medical science : JKMS 13건

  1. [국내논문]   Clinical study on death in BehCet's disease.  

    Park, K. D. , Bang, D. , Lee, E. S. , Lee, S. H. , Lee, S.
    Journal of Korean medical science : JKMS v.8 no.4 ,pp. 241 - 245 , 1993 , 1011-8934 ,

    초록

    We were able to identify 7 patients who died of BehCet's disease, among 2,200 patients registered at the BehCet's Disease Specialty Clinic of Severance Hospital from November 1983 to October 1992. Six were male and one female. Age of death was 31 to 55 years with the mean age of 39.1. The age of onset was 24 to 54 years with the mean age of 32.6. The mean duration of illness was 6.5 years. The most frequent initial symptom was oral ulcer, with the most common type being the incomplete type in Shimizu's classification. Positive pathergy tests were found in all the 5 patients in whom the test was performed out of 7 patients. Various modalities of treatments such as oral steroid, colchicine, azathioprine, colectomy, and pacemaker insertion were attempted without outstanding therapeutic effects. The causes of death were gastrointestinal bleeding, bowel perforation, superior and inferior vena cava syndrome, aortic regurgitation, cerebrovascular disease, sepsis, and lung abscess.

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  2. [국내논문]   A complete remission can be achieved despite persistence of abnormal bone marrow promyelocytes in acute promyelocytic leukemia--experience in 2 patients.  

    Kim, S. W. , Lee, K. H. , Lee, J. S. , Suh, C. , Ahn, M. J. , Kim, S. W. , Chi, H. S. , Kim, S. H.
    Journal of Korean medical science : JKMS v.8 no.4 ,pp. 246 - 250 , 1993 , 1011-8934 ,

    초록

    Acute promyelocytic leukemia (APL) is a distinct subset of acute myeloid leukemia (AML) and is distinguished from other subsets of AML by its distinctive morphology, specific chromosomal abnormality, associated consumptive coagulopathy, and response to treatment. Interestingly, patients with APL frequently enter complete remission without undergoing a characteristic period of bone marrow hypoplasia. In two cases in this report, complete remission was achieved without bone marrow hypoplasia without further additional course of chemotherapy despite the appearance of persistent malignant cells in the bone marrow after first induction chemotherapy. During the period of treatment, severe coagulopathy occurred in both cases but resolved as the patients entered into remission. Remission in patients with APL may occur even when induction therapy fails to cause marrow hypoplasia or to eradicate replicative cells. To avoid unnecessary exposure to toxic therapy, caution should be exercised in assessing the adequacy of remission induction treatment.

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  3. [국내논문]   Pharmacokinetic comparison of two valproic acid formulations--a plain and a controlled release enteric-coated tablets.  

    Rha, J. H. , Jang, I. J. , Lee, K. H. , Chong, W. S. , Shin, S. G. , Lee, N. , Myung, H. J.
    Journal of Korean medical science : JKMS v.8 no.4 ,pp. 251 - 256 , 1993 , 1011-8934 ,

    초록

    We investigated the single- and multiple dose pharmacokinetics of a new controlled-release formulation (Orfil retard enteric coated tablet) of valproic acid in comparison with those of the plain tablet as a reference. Twelve healthy volunteers were given each formulation of 300 mg in the single-dose study. In the steady-state multiple-dose study, twelve epileptic patients received 1200 mg/day of the reference drug (300 mg 9 AM, 300 mg 3 PM, 600 mg 9 PM) and the test formulation (600 mg 9 AM, 600 mg 9 PM) with at least one week interval in cross-over manner. The AUC values of the test controlled release formulation were 91.7% (95% confidence interval: 78.4-100.4%) of the reference drug in the single-dose study and 98.2% (95% confidence interval: 86.2%-109.9%) in the steady-state study. The AUC's of the two formulations were not significantly different by ANOVA test. The Cmax and Tmax values of the test formulation were significantly different from the values of the reference in single-(Tmax: 158.4%, Cmax: 52.5% of the reference) and multiple-dose study (Tmax: 153.5% of the reference). The MRT values of the test formulation were also significantly greater (129.4% of the reference) in the single-dose study. Regarding the controlled-release characteristics of the test formulation, fluctuation index and percentage fluctuation of the twice a day dosage regimen of the test formulation were comparable with those of the thrice a day dosage regimen of the conventional tablet. Area deviation was even smaller in the test regimen of the controlled release formulation.(ABSTRACT TRUNCATED AT 250 WORDS)

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  4. [국내논문]   Detection of chromosome aberrations in interphase nuclei using fluorescence in situ hybridization technique.  

    Song, H. G. , Choi, S. O. , Kang, I. B.
    Journal of Korean medical science : JKMS v.8 no.4 ,pp. 257 - 261 , 1993 , 1011-8934 ,

    초록

    We report here several experiences of interphase cytogenetics, using fluorescence in situ hybridization (FISH) technique, for the detection of chromosome aberrations. FISH, using alpha satellite specific probes of 18, X, Y chromosomes, was done in interphase nuclei from peripheral blood of patients with Edwards' syndrome, Klinefelter's syndrome and Turner's syndrome with healthy male and female controls, respectively. The distributions of fluorescent signals in 100 interphase nuclei were well correlated with metaphase findings. Nowadays FISH plays an increasingly important role in a variety of research areas, including cytogenetics, prenatal diagnosis, tumor biology, gene amplification and gene mapping.

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  5. [국내논문]   Apolipoprotein E genotypes of normal and hyperlipidemic subjects.  

    Kim, Y. S. , Paeng, J. R. , Woo, J. T. , Kim, S. W. , Yang, I. M. , Kim, J. W. , Kim, K. W. , Choi, Y. K.
    Journal of Korean medical science : JKMS v.8 no.4 ,pp. 262 - 266 , 1993 , 1011-8934 ,

    초록

    Apolipoprotein E (apo E) plays a role in the regulation of the lipid metabolism of humans. Apo E, 229 amino acid polypeptide, is classified into three major isoform (E2, E3, E4) according to the differences of amino acid in position 112 and 158. In the normal population apo E3 isoform is most prevalent and apo E2 or E4 is frequently associated with hyperlipoproteinemia. To find out the frequency of apo E isoform distribution in the Korean population, apo E genotyping was performed. After amplification of apoE gene by polymerase chain reaction (PCR), restriction isotyping was done by cleavage with restriction enzyme Hha I and polyacrylamide gel electrophoresis. The apo E allele frequency in 73 normal subjects was 4.8% for E2, 84.9% for E3 and 10.3% for E4. In diabetic patient with hyperlipoproteinemia, the frequency of apo E allele was 6.3% for E2, 81.0% for E3 and 12.7% for E4. There was no significant difference in apo E isoform distribution between diabetics and normal populations. But in patients with cardiovascular disease with hyperlipidemia, the apo E4 allele frequency was significantly higher than normal (20.0% vs 10.3%, p

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  6. [국내논문]   Trends in radiation therapy facilities-1986 to 1991.  

    Park, C. I. , Yoo, S. Y.
    Journal of Korean medical science : JKMS v.8 no.4 ,pp. 267 - 270 , 1993 , 1011-8934 ,

    초록

    The Korean Society of Therapeutic Radiology has periodically conducted a national survey on the status of radiation therapy facilities in Korea. This paper summarized survey data on the status of radiation therapy facilities, manpower, megavoltage equipments, patient load, types of procedures performed and characteristics of the patients treated.

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  7. [국내논문]   A comparative study on aberrations of chromosome 17 and proliferating cell fraction in lung cancer.  

    Lee, K. J. , Lee, M. S. , Kim, J. O. , Kim, S. Y.
    Journal of Korean medical science : JKMS v.8 no.4 ,pp. 271 - 280 , 1993 , 1011-8934 ,

    초록

    To better understand the relationship between specific chromosome changes found in human lung tumors and their phenotypic consequences a the tissue level, an in situ hybridization (ISH) procedure of chromosome 17 and immunohistochemistry of proliferating cell nuclear antigen (PCNA) were done. The deparaffinized sections were stained with pericentromeric probes for chromosome 17 and an immunohistochemical study of a monoclonal antibody against PCNA were performed. The numbers of chromosome signals were than compared with the positivity of PCNA expression. The mean numbers of chromosome were 1.62 in normal lymphocytes and 2.48 in lung cancer cells. Tumors showed a high mean positivity of PCNA of 43.4%. Mean PCNA expression was higher in squamous carcinomas than in adenocarcinomas (p

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  8. [국내논문]   Epidemiology of cerebrovascular disease in Korea--a Collaborative Study, 1989-1990. Korean Neurological Association.  


    Journal of Korean medical science : JKMS v.8 no.4 ,pp. 281 - 289 , 1993 , 1011-8934 ,

    초록

    We present epidemiologic, etiologic, and clinical data for 3,021 patients with cerebrovascular disease admitted to the 17 regional hospital centers from all over Korea from 1989 to 1990. Each case was coded retrospectively into a computerized registry using a standard protocol. This study was conducted to provide baseline data on recent patterns on cerebrovascular disease in Korea and to evaluate any temporal trends compared with previous reports. It is the largest hospital-based study and gives a rough estimate of the current stroke profiles in Korea. Although there might be some selection bias in several hospitals, the distribution of cases by type of stroke was: thrombosis (27.2%), lacular infarction (11.2%), transient ischemic attack (3.0%), embolism (7.0%), intracerebral hemorrhage (31.4%), subarachnoid hemorrhage (18.0%), intraventricular hemorrhage (1.5%), and others (0.7%). The overall incidence rate of cerebral thrombotic strokes (41.1%) was higher than that of intracerebral hemorrhage (31.4%) which was the reverse in most of previous reports before 1980s. This study suggests a changing trend of stroke patterns in Korea and a multicenter prospective study using more complete registry protocols is required for an accurate evaluation.

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  9. [국내논문]   Case of difficult intubation overcome by the laryngeal mask airway.  

    Lee, C. M. , Yang, H. S.
    Journal of Korean medical science : JKMS v.8 no.4 ,pp. 290 - 292 , 1993 , 1011-8934 ,

    초록

    A case of difficult intubation is described in which the problem was overcome by use of the laryngeal mask airway (LMA). The patient had difficulty in mouth opening due to severe burn scar contracture around the mouth and limited access prevented tracheal intubation. The use of LMA is shown to have obviated the need for tracheal intubation in the case of a patient whose injuries would have made this technique difficult.

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  10. [국내논문]   Immunohistochemical detection of p53 protein, c-erbB-2 protein, epidermal growth factor receptor protein and proliferating cell nuclear antigen in gastric carcinoma.  

    Jang, W. I. , Yang, W. I. , Lee, C. I. , Kim, H. S. , Song, K. S. , Cho, M. Y. , Park, J. K. , Shim, Y. H.
    Journal of Korean medical science : JKMS v.8 no.4 ,pp. 293 - 304 , 1993 , 1011-8934 ,

    초록

    There is increasing evidence that genes involved in normal cell growth and differentiation (oncogenes) or genes that encode for growth factors are important in determining the development and biologic aggressiveness of gastric carcinoma. This study was undertaken to define the prognostic value of the overexpression of p53 protein, c-erbB-2 protein, EGFr protein and PCNA in gastric carcinomas. Using monoclonal antibodies, immunohistochemical studies were performed on formalin-fixed, paraffin-embedded tissue sections from 84 primary gastric carcinomas. Overall, 34% of gastric carcinomas had nuclear-staining for p53 protein, 34% of carcinomas membrane staining for the c-erbB-2 and 74% of carcinomas membrane and cytoplasmic staining for EGFr, showing distribution in a heterogeneous fashion. PCNA was expressed as Grade 2 and 3 in 75% of patients with gastric carcinomas. Both c-erbB-2 and p53 staining was significantly associated with high grade expression of PCNA. p53 staining tended to be associated with positive nodal status and metastasis, and c-erbB-2 staining with positive nodal status only. Multivariate analysis using the Cox model showed that overexpression of p53 protein, c-erbB-2 protein and PCNA was not an independent prognostic variable in gastric carcinoma. These results suggest that expressions of p53 and c-erbB-2 protein are heterogeneous and that p53 and c-erbB-2 overexpressions are significantly associated with high proliferative activity in gastric carcinoma.

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