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H : 소장처정보

T : 목차정보

Journal of Korean medical science : JKMS 34건

  1. [국내논문]   Attitudes and Reported Practice for Obesity Management in Korea After Introduction of Anti-obesity Agents  

    Park, Hye Soon (Department of Family Medicine, University of Ulsan College of Medicine, Seoul, Korea. ) , Park, Jee-Young (Department of Family Medicine, University of Ulsan College of Medicine, Seoul, Korea. ) , Cho, Hong-Jun (Department of Family Medicine, University of Ulsan College of Medicine, Seoul, Korea.)
    Journal of Korean medical science : JKMS v.20 no.1 = no.101 ,pp. 1 - 6 , 2005 , 1011-8934 ,

    초록

    This study aimed to evaluate current clinical assessments and management of obesity in the primary care setting in Korea since anti-obesity agents have become available. A questionnaire was sent to eligible primary care physicians selected from a national probability sample in two specialties: family physicians and internists. Of 939 randomly selected physicians, 452 (48.1%) replied. We found that 51.8% of physicians were aware of the definition of obesity, and 33.8% were aware of the definition of abdominal obesity proposed by Asia-Pacific guideline. When evaluating apparently obese patients, 50.0% of respondents measured body mass index (BMI) and 20.4% measured waist circumference. Fewer than 50% of physicians measured blood glucose or lipid profiles, both of which are risk factors for obesity. About 47.3% of physicians prescribed an anti-obesity medication without allowing sufficient time for nonpharmacologic therapy to take effect, and 68.8% of physicians prescribed anti-obesity medications to patients that requested them regardless of obesity status. The majority of respondents did not appropriately evaluate obesity and its risk factors, and were readily susceptible to prescribing anti-obesity medications. Our findings suggest that primary care physicians in Korea need additional education on obesity and its management.

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  2. [국내논문]   Does Waist Indicate Dyslipidemia better than BMI in Korean Adult Population?  

    Jeong, Seul-Ki (Department of Neurology, Chonbuk National Unversity School of Medicine, Jeonju, Korea. ) , Seo, Man-Wook (Department of Neurology, Chonbuk National Unversity School of Medicine, Jeonju, Korea. ) , Kim, Young-Hyun (Department of Neurology, Chonbuk National Unversity School of Medicine, Jeonju, Korea. ) , Kweon, Sun-Seog (Department of Preventive Medicine, Seonam University School of Medicine, Namwon, Korea. ) , Nam, Hae-Sung (Department of Preventive Medicine, Chungnam National University School of Medicine, Daejeon, Korea.)
    Journal of Korean medical science : JKMS v.20 no.1 = no.101 ,pp. 7 - 12 , 2005 , 1011-8934 ,

    초록

    Obesity is an independent and modifiable risk factor for cardiovascular disease, and known as a core of the metabolic syndrome. Obesity has been largely diagnosed based upon anthrompometric measurements like waist circumference (WC) and body mass index (BMI). We sought to determine associations between anthropometric measurements and dyslipidemia in a community adult sample composed of 1,032 community residents (356 men, 676 women) aged 50 yr and over in Namwon, Korea. Blood tests for lipid profiles, including total cholesterol (TC) and HDL cholesterol (HDL) were performed, and dyslipidemia was defined as TC/HDL greater than 4. Anthropometric measurements included WC, waist-to-height ratio (WHtR), waist-to-hip ratio, and BMI. All anthropometric measures were categorized into quartiles and evaluated for associations with dyslipidemia. TC/HDL showed the significant associations with the anthropometric measures, independently of potential confounders. In women, increases of obesity indexes by quartile analyses showed linear increases of odds ratios for dyslipidemia ( p values

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  3. [국내논문]   Chronic Hypoxia Alters Vasoconstrictive Responses of Femoral Artery in the Fetal Sheep  

    Kim, Yoon Ha (Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea. ) , Veille, Jean-Claude (Albany Medical College, Albany, New York 12208, U.S.A. ) , Cho, Moon Kyoung (Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea. ) , Kang, Myoung Seon (Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea. ) , Kim, Cheol Hong (Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea. ) , Song, Tae-Bok (Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea. ) , Figueroa, Jorge P. (Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, U.S.A.)
    Journal of Korean medical science : JKMS v.20 no.1 = no.101 ,pp. 13 - 19 , 2005 , 1011-8934 ,

    초록

    The purpose of this study was to determine if mild hypoxia alters the responsiveness to vasoactive agents in the renal and the femoral arteries in the fetal sheep. Ten pregnant sheep were operated under halothane anesthesia at 116 to 124 days' gestation. A maternal tracheal catheter was placed for infusing compressed air (control group, n=5) or nitrogen (hypoxia group, n=5) starting on post operative day 6 and maintained for 5 days. Femoral and renal arteries were harvested from the fetus to study the constriction response to phenylephrine (PE 10 -9 to 10 -5 mol/L). To determine the involvement of nitric oxide as a modulator of vessel constriction, N-nitro-L-arginine methyl ester (L-NAME) was used at a concentration of 10 -4 mol/L in parallel chambers. In the hypoxia group, maternal Pao 2 significantly decreased from a baseline of 110.4±1.4 to 80.5±1.6 (mmHg, p 2 significantly decreased from a baseline of 20.9±0.3 to 15.5±0.1 (mmHg, p 50 in the absence (6.0±1.1 vs. 27.0±4.1) of L-NAME of femoral arteries. However, there were no significant differences in PE maximal response and EC 50 in the absence and presence of L-NAME of renal arteries. We concluded that mild chronic hypoxia seems to increase the fetal femoral artery response to PE, but not in the fetal renal artery. This observation is consistent with a redistribution of cardiac output away from the carcass.

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  4. [국내논문]   New Parameters for Left Ventricular Function in Atrial Fibrillation: Based on the Relationship between RR Interval and Performance  

    Ko, Hong Sook (Division of Cardiology, Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. ) , Kim, Chee Jeong (Division of Cardiology, Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. ) , Ryu, Wang Seong (Division of Cardiology, Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.)
    Journal of Korean medical science : JKMS v.20 no.1 = no.101 ,pp. 20 - 25 , 2005 , 1011-8934 ,

    초록

    This study was designed to obtain new parameters representing left ventricular (LV) function independent of irregular RR intervals in atrial fibrillation (AF). AF patients were divided into Normal (n=9) and LV Dysfunction (n=9) groups. The relations between LV outflow peak ejection velocity (Vpe) and preceding (RR-1) or pre-preceding RR intervals (RR-2) were obtained using logarithmic equations, from which the squared correlation coefficient (r 2 ), slope, Vpe at RR-1 or RR-2=1 sec (Vpe-1), and the ratio of slope to Vpe-1 (Slope/Vpe-1) were calculated. Among the parameters between RR-1 and Vpe, Slope/Vpe-1 was higher in LV Dysfunction group than in Normal group ( p = 0.05). When only coordinates with RR-1 from 0.6 to 1 sec were included, Slope/Vpe-1 ( p = 0.001) was higher in LV Dysfunction group than in Normal group. Among the parameters between RR-2 and Vpe, Slope/Vpe-1, slope, and r 2 were different between the two groups. In multivariate analysis, Slope/Vpe-1 between RR-2 and Vpe was only independent parameter. However, Slope/Vpe-1 between RR-1 and Vpe in the coordinates with RR-1 from 0.6 to 1 sec had the highest discriminating power. New parameters derived from the relations between RR intervals and LV performance might be useful to evaluate LV function quantitatively in AF.

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  5. [국내논문]   Prevalence of and Risk Factors for Atrial Fibrillation in Korean Adults Older than 40 Years  

    Jeong, Joon Hoon (Division of Cardiology, Department of Internal Medicine, Wallace Memorial Baptist Hospital, Busan, Korea.)
    Journal of Korean medical science : JKMS v.20 no.1 = no.101 ,pp. 26 - 30 , 2005 , 1011-8934 ,

    초록

    Atrial fibrillation (AF) is a common arrhythmia that is a potent independent risk factor for stroke. The incidence of AF increase with age and most affected people have underlying cardiac disease. This study aimed to describe the prevalence of and risk factors for AF in Korean. In this study, 14,540 adults (male 6,573/female 7,967) ≥40 yr old received screening test for general health between April 2000 and December 2000. Participants answered questionnaires and underwent examinations that included blood pressure, electrocardiogram (ECG), total cholesterol, and fasting glucose. Data analysis was done by SPSS 10.0 for Windows. The prevalence of AF was 0.7% in people older than 40 yr and 2.1% in those older than 65 yr. The prevalence in men was 1.2% and women was 0.4% in people older than 40 yr. The prevalence in men was 3.3% and women was 1.1% in people older than 65 yr. Approximately 56.6% of individuals with AF are older than 65 yr. The prevalence of AF was higher at all age group in men than in women. Also, the prevalence of AF was highest in people older than 80 yr. In univariate analysis, male sex, old age (≥65 yr), hypertension, diabetes mellitus, left ventricular hypertrophy in ECG, stroke, and cardiac disease were associated with an increased risk of AF. In multivariate analysis, however, risk factors of AF were male (odds ratio, OR 4.1; 95% confidence interval [CI] : 2.6 to 6.5; p = 0.000), old age (OR 5.3; 95% CI:3.5 to 7.9; p = 0.000), and cardiac disease (OR 19.8; 95% CI:12.3 to 31.8; p = 0.000). In this study, the most potent risk factors of AF was cardiac disease.

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  6. [국내논문]   Prognostic factors influencing infection-related mortality in patients with acute leukemia in Korea.  

    Yoo, Jin-Hong , Choi, Su Mi , Lee, Dong-Gun , Choi, Jung-Hyun , Shin, Wan-Shik , Min, Woo-Sung , Kim, Chun-Choo
    Journal of Korean medical science : JKMS v.20 no.1 = no.101 ,pp. 31 - 35 , 2005 , 1011-8934 ,

    초록

    We retrospectively reviewed the medical records of 284 patients with neutropenic fever following chemotherapy for acute leukemia at the Catholic Hematopoietic Stem Cell Transplantation Center from January 1998 to December 1999, to identify prognostic factors for infection-related mortality. Twenty-eight patients died of infections. There was no difference in median age, gender ratio, or underlying disease between the dying and surviving groups. Bacteria were the main pathogens following chemotherapy, and Gram positive organisms predominated in the dying group. Pneumonia and sepsis were the main causes of death. There were 72 cases of invasive fungal infection and their mortality was 27.8%. Invasive fungal infection and previous history of fungal infection were independent prognostic factors for outcome. Recovery from neutropenia was the significant protective factor for mortality. In conclusion, the prognostic factors identified in this study could be useful for deciding on more intensive treatment for those patients at greater risk of death. To our knowledge, this is the first Korean study delineating prognostic factors in acute leukemic patients with infectious complications.

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  7. [국내논문]   Molecular Cytogenetic Analysis of Gene Rearrangements in Childhood Acute Lymphoblastic Leukemia  

    Woo, Hee Yeon (Department of Laboratory Medicine, Sungkyunkwan University, School of Medicine, Seoul, Korea. ) , Kim, Dae Won (Department of Laboratory Medicine, Sungkyunkwan University, School of Medicine, Seoul, Korea. ) , Park, Hyosoon (Department of Laboratory Medicine, Sungkyunkwan University, School of Medicine, Seoul, Korea. ) , Seong, Ki Woong (Department of Pediatric Oncology and Hematology, Sungkyunkwan University, School of Medicine, Seoul, Korea. ) , Koo, Hong Hoe (Department of Pediatric Oncology and Hematology, Sungkyunkwan University, School of Medicine, Seoul, Korea. ) , Kim, Sun Hee (Department of Laboratory Medicine, Sungkyunkwan University, School of Medicine, Seoul, Korea.)
    Journal of Korean medical science : JKMS v.20 no.1 = no.101 ,pp. 36 - 41 , 2005 , 1011-8934 ,

    초록

    The aims of this study were to estimate the incidences of BCR/ABL , MLL , TEL/AML1 rearrangements, and p16 deletions in childhood acute lymphoblastic leukemia (ALL), to identify new abnormalities, and to demonstrate the usefulness of interphase fluorescence in situ hybridization (FISH). We performed G-banding analysis and FISH using probes for BCR/ABL , MLL , TEL/AML1 rearrangements, and p16 deletions on 65 childhood ALL patients diagnosed and uniformly treated at a single hospital. Gene rearrangements were identified in 73.8% of the patients using the combination of G-banding and FISH, while the chromosomal abnormalities were identified in 49.2% using G-banding alone. Gene rearrangements were disclosed by FISH in 24 (72.7%) of 33 patients with normal karyotype or no mitotic cell in G-banding. Among the gene rearrangements detected by FISH, the most common gene rearrangement was p16 deletion (20.3%) and the incidences of others were 14.1% for TEL/AML1 , 11.3% for MLL , and 1.8% for BCR/ABL translocations. Infrequent or new aberrations such as AML1 amplification, MLL deletion, ABL deletion, and TEL/AML1 fusion with AML1 deletion were also observed. We established the rough incidences of gene rearrangements in childhood ALL, found new abnormalities and demonstrated the diagnostic capability of interphase FISH to identify cryptic chromosome aberrations.

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  8. [국내논문]   Effects of Particulate Matter (PM 10 ) on The Pulmonary Function of Middle-School Children  

    Kim, Jeong Hee (Department of Pediatrics, College of Medicine, Inha University, Incheon, Korea. ) , Lim, Dea Hyun (Department of Pediatrics, College of Medicine, Inha University, Incheon, Korea. ) , Kim, Ja Kyoung (Department of Pediatrics, College of Medicine, Kangwon University, Chunchon, Korea. ) , Jeong, Su Jin (Department of Pediatrics, College of Medicine, Pochon CHA University, Pochon, Korea. ) , Son, Byong Kwan (Department of Pediatrics, College of Medicine, Inha University, Incheon, Korea.)
    Journal of Korean medical science : JKMS v.20 no.1 = no.101 ,pp. 42 - 45 , 2005 , 1011-8934 ,

    초록

    It has been reported that the particulate matter under 10 μm (PM 10 ) has deleterious effects on respiratory health. The purpose of this study was to assess the influence of PM 10 upon normal children's lung function. The subjects were 368 middle school students in two areas of Incheon Metropolitan City. One (Incheon) is in the central city and the other (Ganghwa) is in the suburbs. Air pollution data in the vicinities of two participating schools were obtained from monthly report of air quality from Korean Ministry of Environment in 2000. Pulmonary function testing (PFT) was done two times, the first one in March and the second one in December with the same students. We analyzed the relationship between the PM 10 levels and pulmonary functions (FEV 1 , FVC) of the children. The monthly average of the PM 10 level between the two areas showed no significant difference (55.3 vs. 52.3 μg/m 3 ). In both regions, the difference of the PM 10 level between March and December was statistically significant (64 vs. 56 μg/m 3 in Incheon, 64 vs. 54 μg/m 3 in Ganghwa). The findings of the PFT values in March were significantly lower than those values found in December for both regions. In conclusion, we suggest that PM 10 has some adverse effect on the pulmonary function of normal children.

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  9. [국내논문]   Occupational asthma and rhinitis induced by a herbal medicine, Wonji (Polygala tenuifolia).  

    Park, Hye-Kyung , Jeon, Seong-Gyu , Kim, Tae-Bum , Kang, Hye-Ryun , Chang, Yoon-Seok , Kim, Yoon-Keun , Cho, Sang-Heon , Min, Kyung-Up , Kim, You-Young
    Journal of Korean medical science : JKMS v.20 no.1 = no.101 ,pp. 46 - 49 , 2005 , 1011-8934 ,

    초록

    Occupational asthma is induced by many agents, including herbal materials, that are exposed in working places. Although there are a few case reports for occupational allergy induced by herbal materials, there is none for that induced by Wonji (Polygala tenuifolia). This study was conducted to evaluate clinical characteristics and immunologic mechanism of Wonji-induced asthma in a exposed-worker. A patient who complained of asthma and rhinitis symptoms, and who had worked in a herbal manufacturing factory for 8 yr, underwent a skin prick test with crude extract of Wonji under the impression of occupational asthma induced by the agent. The patient had a strong positive response to the extract on the skin prick test. Allergen bronchial challenge to the extract demonstrated a typical dual response. Serum specific IgE level to the extract was higher in the patient than in healthy controls, and ELISA inhibition test revealed complete inhibition of IgE binding with the extract, but no inhibition with Der p 2 or mugwort extracts. Six IgE binding components to the extract (10, 25, 28, 36, 50, and 90 kDa) were detected using SDS-PAGE and immunoblot analysis. These findings suggest that Polygala tenuifolia, a herbal material, can induce IgE-mediated bronchoconstriction in exposed workers.

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  10. [국내논문]   Expression of CD99 in Pleomorphic Carcinomas of the Lung  

    Yoo, Seong-Ho (Department of Pathology and Xenotransplantation Research Center Seoul National University College of Medicine, Seoul, Korea. ) , Han, Jungho (Department of Pathology, Sungkyunkwan University School of Medicine, Seoul, Korea. ) , Kim, Tae Jin (Department of Pathology, Sungkyunkwan University School of Medicine, Seoul, Korea. ) , Chung, Doo Hyun (Department of Pathology and Xenotransplantation Research Center Seoul National University College of Medicine, Seoul, Korea.)
    Journal of Korean medical science : JKMS v.20 no.1 = no.101 ,pp. 50 - 55 , 2005 , 1011-8934 ,

    초록

    Pleomorphic carcinoma of the lung (PCL) is characterized by a mixture of sarcomatoid and carcinoma components, and a poor prognosis. However, no immunophenotype of tumor markers has been characterized in PCL. To charaterize the immunophenotype for CD99 in PCL, we performed an immunohistochemical evaluation of PCLs for thyroid transcription factor-1 (TTF-1), cytokeratin (CK) 7 and 20, and for CD99. CD99 was found to be expressed in both carcinomatous (47%) and sarcomatous components such as spindle cells (92%) and giant cells (57%). In the case of spindle cells, CK7 was expressed in 6 cases (46%) and TTF-1 in 2 cases (15%), whereas for giant cells CK7 was expressed in 8 cases (57%) and TTF-1 in one case (7%). However, CK20 was not expressed in either the carcinomatous or sarcomatous components in any case. Thus, CD99 was found to be widely expressed in both sarcomatous and carcinoma component in PCL. A clinicopathological analysis showed no direct correlation between the expression of CD99 and the clinical indices (stage, survival rate, invasion) of PCL.

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