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T : 목차정보

Journal of Korean medical science : JKMS 34건

  1. [국내논문]   The Medical Science Research and Development Supported by the Korea Science and Engineering Foundation  

    Min, Tae-Sun (Korea Science and Engineering Foundation (KOSEF), 180-1 Gajeong-dong, Yuseong-gu, Daejeon, Korea. ) , Han, Jin (Mitochondrial Signaling Laboratory, Department of Physiology and Biophysics, College of Medicine, Inje University, Busan, Korea. ) , Kim, Seong-Yong (Korea Institute of Geoscience and Mineral Resources, Daejeon, Korea. ) , Rhee, Byoung-Doo (Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea. ) , Kim, Myung-Suk (Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul, Korea.)
    Journal of Korean medical science : JKMS v.20 no.3 = no.103 ,pp. 345 - 354 , 2005 , 1011-8934 ,

    초록

    This study examined ways of promoting research in the medical sciences by evaluating trends in research funding, and the present status of research funding by the Korea Science and Engineering Foundation (KOSEF). This study analyzed statistics from KOSEF from 1978 to 2003 to examine support for research. In medical science field, group-based programs receive more funding than do individual-based programs. The proportion of research funds allocated to the medical sciences has increased markedly each year. Researchers in the medical sciences have submitted more articles to Science Citation Index (SCI) journals than to non-SCI journals, relative to other fields. Researchers supported by the Mission-Oriented Basic Grants program have published the majority of these papers, followed by those supported by the Programs for Leading Scientists, Regional Scientists, Leading Women Scientists, Young Scientists, and Promising Women Scientists, in that order. Funding by KOSEF reflects many decades of government support for research and development, the development and maintenance of necessary infrastructure, and the education and training of medical scientists.

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  2. [국내논문]   Genetic and Environmental Influences on Birthweight in a Sample of Korean Twins  

    Hur, Yoon-Mi (Neuroscience Research Institute, Medical Research Center, Seoul National University, College of Medicine, Seoul, Korea.)
    Journal of Korean medical science : JKMS v.20 no.3 = no.103 ,pp. 355 - 360 , 2005 , 1011-8934 ,

    초록

    This study is the first report of genetic and environmental influences on birthweight using Korean twins. The sample consisted of 255 monozygotic (MZ) and 178 dizygotic (DZ) twin pairs drawn from the Seoul Twin Family Study. Intraclass twin correlations were computed for the twins' birthweights obtained from parents (typically mothers) of the twins. To estimate genetic and shared and nonshared environmental influences on birthweight, standard univariate model-fitting analyses were performed using a software, Mx . For each gender, MZ twin correlations were higher than DZ twin correlations, suggesting existence of genetic influences on birthweight; however, DZ twin correlations were higher than half the MZ twin correlations, indicating that shared environmental factors are also important. For each zygosity, twin correlations were not significantly different between males and females, implicating that genes and environments that cause individual differences in birthweight may not vary between males and females. Model-fitting analyses based on the data pooled across gender yielded estimates of 17% for genetic, 60% for shared environmental, and 23% for nonshared environmental influences on birthweight.

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  3. [국내논문]   The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults  

    Shin, Min-Ho (Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Korea. ) , Kim, Hee Nam (Genomic Research Center of Hematopoietic Diseases, Chonnam National University Hospital, Gwangju, Korea. ) , Cui, Lian-Hua (Department of Preventive Medicine, Yanbian University Medical College, Yanbian, China. ) , Kweon, Sun-Seog (Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Korea. ) , Park, Kyeong-Soo (Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Korea. ) , Heo, Heon (Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Korea. ) , Nam, Hae-Sung (Department of Preventive Medicine, Chungnam University College of Medicine, Daejeon, Korea. ) , Jeong, Seul-Ki (Department of Neurology, Chonbuk National University Hospital, Jeonju, Korea. ) , Chung, Eun-Kyung (Department of Preventive Medicine, Chonnam National University College of Medicine, Chonnam National University Research Center of Medical Sciences, Gwangju, Korea. ) , Choi, Jin-Su (Department of Preventive Medicine, Chonnam National University College of Medicine, Chonnam Nationa)
    Journal of Korean medical science : JKMS v.20 no.3 = no.103 ,pp. 361 - 366 , 2005 , 1011-8934 ,

    초록

    The aim of this study was to determine the effects of polymorphisms in the apolipoprotein E gene ( APOE ) on lipid levels in Korean adults and to investigate the interactions between these polymorphisms and environmental factors in determining lipid levels. We performed a cross-sectional study of 1,900 subjects (668 men and 1,232 women; 45-74 yr old) in Namwon, Korea, in 2004. APOE polymorphisms were determined by polymerase chain reaction and restriction enzyme analysis. Carriers of the APOE*E2 ( E2 ) allele had significantly lower total cholesterol and low-density lipoprotein cholesterol (LDL-C) concentrations than did carriers of the APOE*E3 ( E3 ) or APOE*E4 ( E4 ) alleles, regardless of gender. The APOE allele type had significant effect on high-density lipoprotein cholesterol (HDL-C) and triglyceride levels in women, but not in men. The effect of APOE allele type on HDL-C levels was modified by age in women. In addition, in men, the effect of APOE allele type on triglyceride levels was modified by smoking. These findings highlight the important effect of gene-environment interactions on lipid levels.

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  4. [국내논문]   Polymorphisms of High-Affinity IgE Receptor and Histamine-Related Genes in Patients with ASA-Induced Urticaria/Angioedema  

    Choi, Jeong-Hee (Department of Pulmonology and Allergy, Bundang Jesaeng General Hospital, Seongnam, Korea. ) , Kim, Seung-Hyun (Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea. ) , Suh, Chang-Hee (Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea. ) , Nahm, Dong-Ho (Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea. ) , Park, Hae-Sim (Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea.)
    Journal of Korean medical science : JKMS v.20 no.3 = no.103 ,pp. 367 - 372 , 2005 , 1011-8934 ,

    초록

    The pathogenic mechanism of ASA-induced urticaria/angioedema (AIU) is still poorly understood, but it has been known that histamine releasing by cutaneous mast cell activation is considered to be an important role. Considering the importance of histamine in AIU, we speculated that a genetic abnormality of histamine-related genes such as a high-affinity IgE receptor, a metabolic enzyme of histamines and histamine receptors, may be involved in the development of AIU. Enrolled in the study were 110 patients with AIU, 53 patients without ASA hypersensitivity who had various drug allergies presenting as exanthematous skin symptoms, and 99 normal healthy controls (NC). Eleven single nucleotide polymorphisms (SNPs) of the β chain of the high-affinity IgE receptor (FCER1B) and three histamine-related genes-histamine N-methyltransferase (HNMT), histamine H1 receptor (HRH1), histamine H2 receptor (HRH2)-were screened using the SNP-IT assay based on a single base extension method. No significant differences were observed in allele and genotype frequencies, and haplotype frequencies of all the SNPs of FCER1B, HNMT, HRH1, and HRH2 among the three groups ( p >0.05, respectively). These results suggest that the polymorphisms of FCER1B and the three histamine-related genes may not contribute to the development of AIU phenotype in the Korean population.

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  5. [국내논문]   Distribution of the Ankle-Brachial Index and Associated Cardiovascular Risk Factors in a Population of Middle-Aged and Elderly Koreans  

    Kweon, Sun-Seog (Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Korea. ) , Shin, Min-Ho (Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Korea. ) , Park, Kyeong-Soo (Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Korea. ) , Nam, Hae-Sung (Department of Preventive Medicine, Chungnam University College of Medicine, Daejeon, Korea. ) , Jeong, Seul-Ki (Department of Neurology, Chonbuk National University Hospital, Jeonju, Korea. ) , Ryu, So-Yeon (Department of Preventive Medicine, Chosun University College of Medicine, Gwangju, Korea. ) , Chung, Eun-Kyung (Department of Preventive Medicine, Chonnam National University College of Medicine, Chonnam National University Research Center of Medical Sciences, Gwangju, Korea. ) , Choi, Jin-Su (Department of Preventive Medicine, Chonnam National University College of Medicine, Chonnam National University Research Center of Medical Sciences, Gwangju, Korea.)
    Journal of Korean medical science : JKMS v.20 no.3 = no.103 ,pp. 373 - 378 , 2005 , 1011-8934 ,

    초록

    The Doppler ankle-brachial pressure index (ABI) is an objective and efficient tool that can be used to determine the presence and severity of peripheral arterial disease in the lower extremities. The ABI value is inversely associated with other cardiovascular risk factors. To date, there have been no studies of the distribution of ABI in Korea. We performed a cross-sectional study of 1,943 subjects (681 men and 1,262 women; 45-74 yr old) in Namwon, Korea. The prevalence of a low ABI ( p

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  6. [국내논문]   Relations of Plasma High-Sensitivity C-Reactive Protein to Various Cardiovascular Risk Factors  

    Ryu, So Yeon (Department of Preventive Medicine, Chosun University College of Medicine, Gwangju, Korea. ) , Lee, Young Sun (Department of Public Health, Graduate School of Chosun University, Gwangju, Korea. ) , Park, Jong (Department of Preventive Medicine, Chosun University College of Medicine, Gwangju, Korea. ) , Kang, Myeng Geun (Department of Preventive Medicine, Chosun University College of Medicine, Gwangju, Korea. ) , Kim, Ki Soon (Department of Preventive Medicine, Chosun University College of Medicine, Gwangju, Korea.)
    Journal of Korean medical science : JKMS v.20 no.3 = no.103 ,pp. 379 - 383 , 2005 , 1011-8934 ,

    초록

    This study was performed to evaluate the relation of high-sensitivity C-reactive protein (hsCRP) with several cardiovascular risk factors such as age, blood pressure, smoking habit and serum lipids, body mass index, blood glucose, regular exercise, alcohol drinking, white blood cell counts in a cross-sectional survey. Plasma hsCRP was measured by immunoturbidimetry in 202 subjects, aged over 50 yr, who participated in health-check survey in a rural area of Jeollanamdo, Korea. Plasma hsCRP level was 1.9±3.0 mg/dL. There were significant associations between hsCRP levels and age, white blood cell counts, blood glucose, diastolic blood pressure, HDL-cholesterol, body mass index and smoking status. In stepwise multivariate regression analysis, white blood cell counts, age, blood glucose, smoking status and body mass index were independent correlates of hsCRP levels. In conclusion, plasma hsCRP levels were associated with several cardiovascular risk factors, and these data are compatible with the hypothesis that CRP levels may be a marker for preclinical cardiovascular disease. Further what we need now are prospective studies to evaluate the association of C-reactive protein concentrations with subsequent cardiac events.

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  7. [국내논문]   Relationship between Dendritic Cells and Activated Eosinophils in Induced Sputum of Asthmatics  

    Koh, Youngil I. (Department of Allergy, Chonnam National University Medical School and Research Institute of Medical Science, Gwangju, Korea. ) , Lee, Jee-Bum (Department of Dermatology, Chonnam National University Medical School and Research Institute of Medical Science, Gwangju, Korea. ) , Lee, Se-Ryeon (Department of Allergy, Chonnam National University Medical School and Research Institute of Medical Science, Gwangju, Korea. ) , Ji, Seung-Gyu (Department of Allergy, Chonnam National University Medical School and Research Institute of Medical Science, Gwangju, Korea. ) , Choi, Inseon S. (Department of Allergy, Chonnam National University Medical School and Research Institute of Medical Science, Gwangju, Korea.)
    Journal of Korean medical science : JKMS v.20 no.3 = no.103 ,pp. 384 - 389 , 2005 , 1011-8934 ,

    초록

    It has been suggested that dendritic cells (DCs) are critical antigen presenting cells for eosinophilic airway inflammation in a mouse model of asthma, and cysteinyl leukotrienes may play a role in DC trafficking in asthmatics. We investigated whether the number of DCs is increased in the induced sputum of both atopic and nonatopic asthmatics and is related to activated eosinophil count in the sputum. Sputum was induced by inhalation of hypertonic saline in 9 atopic and 12 nonatopic asthmatics and 10 nonatopic normal controls, and differential cell counts were performed. DCs and activated eosinophils were identified by immunocytochemistry with monoclonal antibodies (anti-CD1a and EG2, respectively). There were significantly higher percentages of eosinophils, EG2+ cells, and CD1a+ DC in the sputum of atopic and nonatopic asthmatics compared with normal controls, respectively. In asthmatics, the percentage of CD1a+ DC was significantly correlated with that of EG2+ cells ( Rs =0 0.62, p = 0.004). We demonstrated that the increased number of DCs was evident in the induced sputum of both atopic and nonatopic asthmatics, and the DC number was related to the activated eosinophil count, which suggests that DCs may contribute to the ongoing eosinophilic inflammation in asthmatic airways, and vice versa.

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  8. [국내논문]   Pharaoh Ant ( Monomorium pharaonis ): Newly Identified Important Inhalant Allergens in Bronchial Asthma  

    Kim, Cheol-Woo (Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea. ) , Kim, Deok-In (Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea. ) , Choi, Soo-Young (Department of Internal Medicine, Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea. ) , Park, Jung-Won (Department of Internal Medicine, Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea. ) , Hong, Chein-Soo (Department of Internal Medicine, Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.)
    Journal of Korean medical science : JKMS v.20 no.3 = no.103 ,pp. 390 - 396 , 2005 , 1011-8934 ,

    초록

    The nonstinging house ant, Monomorium pharaonis (pharaoh ant), was recently identified as a cause of respiratory allergy. This study was performed to evaluate the extent of sensitization to pharaoh ant, and its clinical significance in asthmatic patients. We carried out skin prick tests in 318 patients with asthma. Specific IgE (sIgE) to pharaoh ant was measured by ELISA, and cross-reactivity was evaluated by ELISA inhibition tests. Bronchial provocation testing was performed using pharaoh ant extracts. Fifty-eight (18.2%) of 318 patients showed positive skin responses to pharaoh ant, and 25 (7.9%) had an isolated response to pharaoh ant. Positive skin responses to pharaoh ant were significantly higher among patients with non-atopic asthma than among those with atopic asthma (26.0% vs. 14.9%, p p

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [국내논문]   Scoring Method for Early Prediction of Neonatal Chronic Lung Disease Using Modified Respiratory Parameters  

    Kim, Young Don (Department of Pediatrics, University of Ulsan Hospital, Ulsan, Korea. ) , Kim, Ellen Ai-Rhan (Division of Neonatology, Department of Pediatrics, Asan Medical Center, University of Ulsan, Seoul, Korea. ) , Kim, Ki-Soo (Division of Neonatology, Department of Pediatrics, Asan Medical Center, University of Ulsan, Seoul, Korea. ) , Pi, Soo-Young (Division of Neonatology, Department of Pediatrics, Asan Medical Center, University of Ulsan, Seoul, Korea. ) , Kang, Weechang (Department of Information and Statistics, Daejun University, Daejun, Korea.)
    Journal of Korean medical science : JKMS v.20 no.3 = no.103 ,pp. 397 - 401 , 2005 , 1011-8934 ,

    초록

    In our previous study, we have demonstrated that peak inspiratory pressure over birth weight (PIP/kg) and mean airway pressure over birth weight (MAP/kg) were more significant risk factors for the development of neonatal chronic lung disease (CLD) than PIP and MAP. We aimed to develop a scoring method using the modified respiratory variables (SMUMRV) to predict CLD at early postnatal period. From 1997 to 1999, a retrospective review was performed for 197 infants 2 ), MAP/kg, modified oxygenation index and ventilatory mode were selected as parameters of SMUMRV. No significant differences of AUCs were found between the SMUMRV and the Yoder model. It is likely that our scoring method provides reliable values for predicting the development of CLD in very low birth weight infants.

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  10. [국내논문]   Lung Cancer Screening with Low-Dose Helical CT in Korea: Experiences at the Samsung Medical Center  

    Chong, Semin (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ) , Lee, Kyung Soo (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ) , Chung, Myung Jin (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ) , Kim, Tae Sung (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ) , Kim, Hojoong (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ) , Kwon, O Jung (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ) , Choi, Yoon-Ho (Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ) , Rhee, Chong H. (Center for)
    Journal of Korean medical science : JKMS v.20 no.3 = no.103 ,pp. 402 - 408 , 2005 , 1011-8934 ,

    초록

    To determine overall detection rates of lung cancer by low-dose CT (LDCT) screening and to compare histopathologic and imaging differences of detected cancers between high- and low-risk groups, this study included 6,406 asymptomatic Korean adults with ≥45 yr of age who underwent LDCT for lung cancer screening. All were classified into high- (≥20 pack-year smoking; 3,353) and low-risk (3,053; p p = 0.215). Therefore, LDCT screening help detect early stage of lung cancer in asymptomatic Korean population with detection rate of 0.36% on a population basis and may be useful for discovering early lung cancer in low-risk group as well as in high-risk group.

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