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Neurobiology of learning and memory 8건

  1. [해외논문]   Editorial Board  


    Neurobiology of learning and memory v.146 ,pp. IFC , 2017 , 1074-7427 ,

    초록

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   Editorial Board   SCI SCIE SSCI


    Neurobiology of learning and memory v.146 ,pp. IFC - IFC , 2017 , 1074-7427 ,

    초록

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Differential effects of MDMA and cocaine on inhibitory avoidance and object recognition tests in rodents   SCI SCIE SSCI

    Garcí (Faculty of Psychology, European University of Valencia, General Elio, 8, 46010 Valencia, Spain ) , a-Pardo, Marí (Faculty of Dentistry, European University of Valencia, General Elio, 8, 46010 Valencia, Spain ) , a Pilar (Faculty of Psychology, University of Valencia, Av. Blasco Ibañez, 21, Spain) , De la Rubia Ortí , , Jose Enrique , Aguilar Calpe, Maria Asunció , n
    Neurobiology of learning and memory v.146 ,pp. 1 - 11 , 2017 , 1074-7427 ,

    초록

    Abstract Introduction Drug addiction continues being a major public problem faced by modern societies with different social, health and legal consequences for the consumers. Consumption of psychostimulants, like cocaine or MDMA (known as ecstasy) are highly prevalent and cognitive and memory impairments have been related with the abuse of these drugs. Aim The aim of this work was to review the most important data of the literature in the last 10 years about the effects of cocaine and MDMA on inhibitory avoidance and object recognition tests in rodents. Development: The object recognition and the inhibitory avoidance tests are popular procedures used to assess different types of memory. We compare the effects of cocaine and MDMA administration in these tests, taking in consideration different factors such as the period of life development of the animals (prenatal, adolescence and adult age), the presence of polydrug consumption or the role of environmental variables. Brain structures involved in the effects of cocaine and MDMA on memory are also described. Conclusions Cocaine and MDMA induced similar impairing effects on the object recognition test during critical periods of lifetime or after abstinence of prolonged consumption in adulthood. Deficits of inhibitory avoidance memory are observed only in adult rodents exposed to MDMA. Psychostimulant abuse is a potential factor to induce memory impairments and could facilitate the development of future neurodegenerative disorders. Highlights Cocaine does not alter passive avoidance task. Cocaine impairs recognition memory in critical phases of development or during abstinence in adulthood. Acute and chronic MDMA during adulthood induce an impairment in the passive avoidance test. MDMA exposure through lifetime impairs performance in the object recognition test. Cocaine and MDMA treatment can enhance the risk of developing neurodegenerative disorders.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Intra-nasal dopamine alleviates cognitive deficits in tgDISC1 rats which overexpress the human DISC1 gene   SCI SCIE SSCI

    Wang, An-Li (Center for Behavioral Neuroscience, Institute of Experimental Psychology, Heinrich Heine University Düsseldorf, Germany ) , Fazari, Benedetta (Center for Behavioral Neuroscience, Institute of Experimental Psychology, Heinrich Heine University Düsseldorf, Germany ) , Chao, Owen Y. (Center for Behavioral Neuroscience, Institute of Experimental Psychology, Heinrich Heine University Düsseldorf, Germany ) , Nikolaus, Susanne (Clinic of Nuclear Medicine, University Hospital Düsseldorf, Düsseldorf, Germany ) , Trossbach, Svenja V. (Department Neuropathology, Medical Faculty, Heinrich Heine University Düsseldorf, Germany ) , Korth, Carsten (Department Neuropathology, Medical Faculty, Heinrich Heine University Düsseldorf, Germany ) , Sialana, Fernando J. (Department of Pharmaceutical Chemistry, University of Vienna, 1090, Austria ) , Lubec, Gert (Department of Pharmaceutical Chemistry, University of Vienna, 1090, Austria ) , Huston, Joseph P. (Center for Behavioral Neuroscience, Institute of Experimental Psychology, Heinrich Heine University Düsseldorf, Germany ) , Mattern, Claudia (M et P Pharma AG, 6376 Emmetten, Switzerland ) , de Souza Silva, Maria Angelica (Cen)
    Neurobiology of learning and memory v.146 ,pp. 12 - 20 , 2017 , 1074-7427 ,

    초록

    Abstract The Disrupted-in-Schizophrenia 1 (DISC1) gene has been associated with mental illnesses such as major depression and schizophrenia. The transgenic DISC1 (tgDISC1) rat, which overexpresses the human DISC1 gene, is known to exhibit deficient dopamine (DA) homeostasis. To ascertain whether the DISC1 gene also impacts cognitive functions, 14–15 months old male tgDISC1 rats and wild-type controls were subjected to the novel object preference (NOP) test and the object-based attention test (OBAT) in order to assess short-term memory (1 h), long-term memory (24 h), and attention. Results : The tgDISC1 group exhibited intact short-term memory, but deficient long-term-memory in the NOP test and deficient attention-related behavior in the OBAT. In a different group of tgDISC1 rats, 3 mg/kg intranasally applied dopamine (IN-DA) or its vehicle was applied prior to the NOP or the OBAT test. IN-DA reversed cognitive deficits in both the NOP and OBAT tests. In a further cohort of tgDISC1 rats, post-mortem levels of DA, noradrenaline, serotonin and acetylcholine were determined in a variety of brain regions. The tgDISC1 group had less DA in the neostriatum, hippocampus and amygdala, less acetylcholine in neostriatum, nucleus accumbens, hippocampus, and amygdala, more serotonin in the nucleus accumbens, and less serotonin and noradrenaline in the amygdala. Conclusions : Our findings show that DISC1 overexpression and misassembly is associated with deficits in long-term memory and attention-related behavior. Since behavioral impairments in tgDISC1 rats were reversed by IN-DA, DA deficiency may be a major cause for the behavioral deficits expressed in this model. Highlights Rats with overexpressed human DISC1 gene show object attention deficits. Rats with overexpressed human DISC1 gene show deficits in long-term object memory. Intranasal dopamine can recover these cognitive deficits. DISC1 overexpression causes changes in monoamines and acetylcholine systems.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Orexin/hypocretin treatment restores hippocampal-dependent memory in orexin-deficient mice   SCI SCIE SSCI

    Mavanji, Vijayakumar (Research Service, Veterans Affairs Health Care System, Minneapolis, MN 55417 USA ) , Butterick, Tammy A. (Research Service, Veterans Affairs Health Care System, Minneapolis, MN 55417 USA ) , Duffy, Cayla M. (Research Service, Veterans Affairs Health Care System, Minneapolis, MN 55417 USA ) , Nixon, Joshua P. (Research Service, Veterans Affairs Health Care System, Minneapolis, MN 55417 USA ) , Billington, Charles J. (Research Service, Veterans Affairs Health Care System, Minneapolis, MN 55417 USA ) , Kotz, Catherine M. (Research Service, Veterans Affairs Health Care System, Minneapolis, MN 55417 USA)
    Neurobiology of learning and memory v.146 ,pp. 21 - 30 , 2017 , 1074-7427 ,

    초록

    Abstract Orexin A is produced in neurons of the lateral, perifornical and dorsomedial regions of the lateral hypothalamic area, which then project widely throughout the central nervous system to regulate arousal state, sleep-wake architecture, energy homeostasis and cognitive processes. Disruption of orexin signaling leads to sleep disturbances and increased body mass index, but recent studies also indicate that orexin neuron activation improves learning and memory. We hypothesized that hippocampal orexin receptor activation improves memory. To test this idea, we obtained orexin/ataxin-3 (O/A3) mice, which become deficient in orexin neurons by about 12 weeks of age. We first measured hippocampal orexin receptor 1 (OX1R) gene expression and protein levels, then tested acquisition and consolidation of two-way active avoidance (TWAA) memory, a hippocampal-dependent learning and memory task. Finally, we determined if exogenous intra-hippocampal OXA treatment could reverse cognitive impairment (as determined by TWAA) in OA/3 mice. We showed that OX1R mRNA expression and protein levels were significantly elevated in O/A3 mice, indicating the potential for preserved orexin responsiveness. The O/A3 mice were significantly impaired in TWAA memory vs. control mice, but OXA treatment (both acute and chronic) reversed these memory deficits. These results demonstrate that orexin plays an important role in hippocampal-dependent consolidation of two-way active avoidance memory, and orexin replacement can rescue the cognitive impairment. Highlights Orexin 1 receptor expression is elevated in mice lacking orexin (O/A3 mice). O/A3 mice showed significant impairments in a two-way active avoidance memory task. Memory deficits in O/A3 mice were reversed by hippocampal orexin A treatment.

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    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  6. [해외논문]   Olfactory stimulation induces cerebellar vermis activation during sexual learning in male rats   SCI SCIE SSCI

    Herná (Doctorado en Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Ver., Mexico ) , ndez-Briones, Zuleyma Samaria (Centro de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Ver., Mexico ) , Garcí (Centro de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Ver., Mexico ) , a-Bañ (Centro de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Ver., Mexico ) , uelos, Paulina (Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Ver., Mexico ) , Herná (Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Ver., Mexico ) , ndez, Marí (Centro de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Ver., Mexico ) , a Elena (Centro de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Ver., Mexico ) , Ló (Centro de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Ver., Mexico) , pez, Marí , a-Leonor , Chacó , n, Armando Martí , nez , Carrillo, Porfirio , Coria-Avila, Genaro , Manzo, Jorge , Garcí , a, Luis Isauro
    Neurobiology of learning and memory v.146 ,pp. 31 - 36 , 2017 , 1074-7427 ,

    초록

    Abstract The cerebellum is a complex structure mainly recognized for its participation in motor activity and balance, and less understood for its role in olfactory processing. Herein, we assessed Fos immunoreactivity (Fos-IR) in the cerebellar vermis following exposure to different odors during sexual training in male rats. Males were allowed to copulate for either one, three or five sessions. One day after the corresponding session they were exposed during 60 min to woodshaving that was either: clean (Control), sprayed with almond scent (Alm) or from cages of sexually receptive females (RF). The vermis of the cerebellum was removed, cut in sagittal sections and analyzed for Fos-IR to infer activation. Our results showed that the cerebellum responded with more Fos-IR in the Alm and RF groups as compared to Control. More copulatory sessions resulted in more odor-induced Fos-IR, especially in the RF group. Accordingly, we discuss possible mechanisms on how the cerebellum mediates processing of both unconditioned and conditioned odors, and how sexual experience accelerates such process. Highlights Olfactory stimulation with odorants activates the cerebellar vermis. Olfactory stimulation increases in Fos-IR at the cerebellum as sexual experience is gained. In sexual experienced males, exposure to Receptive Female stimuli resulted in highest Fos-IR. During acquisition of sexual experience change the Fos-IR magnitude in control group.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Possible positive effect of the APOE ε2 allele on cognition in early to mid-adult life   SCI SCIE SSCI

    Sinclair, Lindsey I. (School of Social and Community Medicine, University of Bristol, Oakfield House, Bristol BS8 2BN, UK ) , Pleydell-Pearce, Christopher W. (School of Experimental Psychology, University of Bristol, The Priory Road Complex, Priory Road, Bristol BS8 1TU, UK ) , Day, Ian N.M. (School of Social and Community Medicine, University of Bristol, Oakfield House, Bristol BS8 2BN, UK)
    Neurobiology of learning and memory v.146 ,pp. 37 - 46 , 2017 , 1074-7427 ,

    초록

    Abstract Background ε4 allele possession is associated with an increased risk of Alzheimer’s disease. Its effects earlier in life are less well understood. Previous studies have reported both detrimental effects and a lack of effect on cognition outside dementia. We used genotype based recall from the ALSPAC study to investigate whether APOE genotype influences cognition in earlier adult life. Methods We invited all individuals with the rarer ε22 or ε44 genotypes and equal numbers of those with ε32, ε33 or ε34 APOE genotypes (total n invited = 1936, ages 23–67). Participants were screened for dementia using the Addenbrooke’s Cognitive Examination Revised (ACE-R). Participants were asked to complete a 3 h battery of neuropsychological tests covering a range of cognitive domains. The primary outcome was performance on the Rey Auditory Verbal Learning Test (RAVLT). Transformation of variables was used where required to permit parametric testing. As genotypes are unlikely to be confounded unadjusted analyses were performed. Results 114 participants were recruited to the study (39 ε33, 27 ε34, 15 ε44, 26 ε32 & 7 ε22). ε4+ participants had higher scores on the cognitive failures questionnaire (10 point increase, p = 0.006) but no deficits on objective cognitive testing. ε2 carriers had slightly better episodic memory performance (p = 0.016), slightly improved n-back accuracy and better executive functioning (trails A&B, p = 0.005). Conclusions It is intriguing that the ε2+ group performed better as this group have a lower risk of Alzheimer’s disease. Most previous studies have analysed as ε4/non ε4 so may have missed this effect. Highlights E4 carriers self reported more memory problems, but no objective differences found. E2 carriers performed slightly better on episodic memory test. E2 carriers were faster in a test of executive function.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  8. [해외논문]   Persistent, generalized hypersensitivity of olfactory bulb interneurons after olfactory fear generalization   SCI SCIE SSCI

    Kass, Marley D. (Corresponding author.) , McGann, John P.
    Neurobiology of learning and memory v.146 ,pp. 47 - 57 , 2017 , 1074-7427 ,

    초록

    Abstract Generalization of fear from previously threatening stimuli to novel but related stimuli can be beneficial, but if fear overgeneralizes to inappropriate situations it can produce maladaptive behaviors and contribute to pathological anxiety. Appropriate fear learning can selectively facilitate early sensory processing of threat-predictive stimuli, but it is unknown if fear generalization has similarly generalized neurosensory consequences. We performed in vivo optical neurophysiology to visualize odor-evoked neural activity in populations of periglomerular interneurons in the olfactory bulb 1 day before, 1 day after, and 1 month after each mouse underwent an olfactory fear conditioning paradigm designed to promote generalized fear of odors. Behavioral and neurophysiological changes were assessed in response to a panel of odors that varied in similarity to the threat-predictive odor at each time point. After conditioning, all odors evoked similar levels of freezing behavior, regardless of similarity to the threat-predictive odor. Freezing significantly correlated with large changes in odor-evoked periglomerular cell activity, including a robust, generalized facilitation of the response to all odors, broadened odor tuning, and increased neural responses to lower odor concentrations. These generalized effects occurred within 24 h of a single conditioning session, persisted for at least 1 month, and were detectable even in the first moments of the brain’s response to odors. The finding that generalized fear includes altered early sensory processing of not only the threat-predictive stimulus but also novel though categorically-similar stimuli may have important implications for the etiology and treatment of anxiety disorders with sensory sequelae. Highlights Olfactory fear learning facilitated odor-evoked periglomerular (PG) cell activity. Strength of learned fear correlated with degree of PG response enhancement ( r = 0.7). Generalized fear across odors paralleled generalized enhancement of PG activity. Plasticity occurred within 24 h of learning and persisted for at least 1 month. These findings have implications for anxiety disorders with sensory sequelae.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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