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Neurobiology of learning and memory 29건

  1. [해외논문]   Editorial Board   SCI SCIE SSCI


    Neurobiology of learning and memory v.145 ,pp. IFC - IFC , 2017 , 1074-7427 ,

    초록

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  2. [해외논문]   Editorial Board  


    Neurobiology of learning and memory v.145 ,pp. IFC , 2017 , 1074-7427 ,

    초록

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  3. [해외논문]   Histamine regulates memory consolidation   SCI SCIE SSCI

    Passani, Maria Beatrice (Dipartimento di Scienze della Salute, Università) , Benetti, Fernando (di Firenze, Viale G. Pieraccini 6, 50139 Firenze, Italy ) , Blandina, Patrizio (Department of Physiology, Federal University of Rio Grande do Sul, (UFRGS), Rua Sarmento Leite, 500, Porto Alegre 90050-170, Brazil ) , Furini, Cristiane R.G. (Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Sezione di Farmacologia e Tossicologia, Università) , de Carvalho Myskiw, Jociane (di Firenze, Viale G. Pieraccini 6, 50139 Firenze, Italy ) , Izquierdo, Ivan (Memory Center, Brain Institute of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, 6690 –)
    Neurobiology of learning and memory v.145 ,pp. 1 - 6 , 2017 , 1074-7427 ,

    초록

    Abstract Recent findings have reasserted the role of histamine in the regulation of memory consolidation first proposed in 1986 in an inhibitory avoidance task in rats. They indicate that histamine is indeed a major regulator of memory consolidation in various tasks, through H2 receptors in the dorsal hippocampus and through H3 receptors in the basolateral amygdala, depending on the task. In the object recognition task, the memory enhancing effect is mediated by the three receptors (H1, H2, H3) in the dorsal hippocampus. In social recognition, the consolidation effect is mediated by H2 receptors in both amygdala and dorsal hippocampus. Data have suggested, in addition, influences on retrieval; this has been best studied in the dorsal hippocampus in step-down inhibitory avoidance task. Depending on the recent history of the conditioned stimulus (i.e., whether it has been recently reinforced or not), histamine acts on hippocampal H1 receptors, facilitating retrieval, or on H2 receptors, inhibiting it. Highlights Histamine regulates memory consolidation. Histamine facilitates the consolidation of extinction. Retrieval requires histamine H1 receptors in dorsal hippocampus. Histamine attenuates the cognitive impairing effects of early postnatal maternal deprivation.

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    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  4. [해외논문]   Investigating the role of dopamine receptor- and parvalbumin-expressing cells in extinction of conditioned fear   SCI SCIE SSCI

    Madsen, Heather B. (Corresponding author at: Behavioural Neuroscience Division, The Florey Institute of Neuroscience and Mental Health, Kenneth Myer Building, 30 Royal Pde, Parkville, VIC 3052, Australia.) , Guerin, Alexandre A. , Kim, Jee Hyun
    Neurobiology of learning and memory v.145 ,pp. 7 - 17 , 2017 , 1074-7427 ,

    초록

    Abstract The present study examined the pattern of activation of neurons that express dopamine receptors 1 and 2 (D1R and D2R), and parvalbumin (PV) in mice that underwent extinction of a fear memory. Adult male transgenic mice expressing D1R or D2R tagged with green fluorescent protein (GFP) were conditioned with 6 tone-shock pairings. The following day they were randomly divided into one of four experimental groups: extinction, retrieval, context or handled. Extinction groups were exposed to 45 tone presentations, retrieval groups were exposed to 5 tone presentations and the context groups were exposed to the chamber without any tones. Ninety minutes following their assigned treatment, mice were perfused and brain tissue processed for Fos/GFP/PV immunohistochemistry. Quantification of immunoreactivity revealed that extinction resulted in changes in the infralimbic cortex including increased Fos expression and a decrease in the number of D2R+ cells compared to all other groups. Conversely, fear memory retrieval resulted in increased activation of D2R+ cells in the prelimbic cortex compared to all other groups. Additional changes were observed in the extinction and retrieval groups that were different to the handled group, but not to the context group, which highlights that there is overlapping neurocircuitry between extinction and retrieval of fear memory, as well as with context exposure. These results provide novel insights into the roles of specific dopamine receptor subtypes, which will be valuable for informing future research that aims to strengthen extinction learning via dopaminergic mechanisms. Highlights Extinction increased Fos+ and decreased D2R+ cells in the infralimbic cortex. Fear retrieval increased Fos labeling of D2R+ cells in the prelimbic cortex. Context exposure, retrieval, and extinction display overlapping neural activation.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  5. [해외논문]   Brief periods of NREM sleep do not promote early offline gains but subsequent on-task performance in motor skill learning   SCI SCIE SSCI

    Maier, Jonathan G. (Department of Psychiatry and Psychotherapy, Medical Center –) , Piosczyk, Hannah (University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany ) , Holz, Johannes (Department of Psychiatry and Psychotherapy, Medical Center –) , Landmann, Nina (University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany ) , Deschler, Christoph (Department of Psychiatry and Psychotherapy, Medical Center –) , Frase, Lukas (University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany ) , Kuhn, Marion (Department of Psychiatry and Psychotherapy, Medical Center –) , Klö (University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany ) , ppel, Stefan (Department of Psychiatry and Psychotherapy, Medical Center –) , Spiegelhalder, Kai (University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany ) , Sterr, Annette (Department of Psychiatry and Psychotherapy, Medical Center –) , Riemann, Dieter (University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany ) , Feige, Bernd (Department of Psychiatry and Psychotherapy, Medical Center) , Voderholzer, Ulrich , Nissen, Christoph
    Neurobiology of learning and memory v.145 ,pp. 18 - 27 , 2017 , 1074-7427 ,

    초록

    Abstract Sleep modulates motor learning, but its detailed impact on performance curves remains to be fully characterized. This study aimed to further determine the impact of brief daytime periods of NREM sleep on ‘offline’ (task discontinuation after initial training) and ‘on-task’ (performance within the test session) changes in motor skill performance (finger tapping task). In a mixed design (combined parallel group and repeated measures) sleep laboratory study ( n = 17 ‘active’ wake vs. sleep, n = 19 ‘passive’ wake vs. sleep), performance curves were assessed prior to and after a 90min period containing either sleep, active or passive wakefulness. We observed a highly significant, but state- (that is, sleep/wake)-independent early offline gain and improved on-task performance after sleep in comparison to wakefulness. Exploratory curve fitting suggested that the observed sleep effect most likely emerged from an interaction of training-induced improvement and detrimental ‘time-on-task’ processes, such as fatigue. Our results indicate that brief periods of NREM sleep do not promote early offline gains but subsequent on-task performance in motor skill learning. Highlights Sleep modulates motor learning. Brief periods of NREM sleep do not promote early offline gains in motor learning. Brief periods of NREM sleep improve subsequent on-task performance in motor learning. Our findings inform the optimization of sleep-wake schedules for motor performance. Future work is needed to clarify sleep’s impact on training-induced performance gains. Future work is needed to specify sleep’s impact on detrimental on-task processes.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  6. [해외논문]   CA1 inactivation impairs episodic-like memory in rats   SCI SCIE SSCI

    Drieskens, Davi Carvalho (Memory and Cognition Studies Laboratory, Department of Psychology, Universidade Federal da Paraíba, João Pessoa, PB, Brazil ) , Neves, Lí (Memory and Cognition Studies Laboratory, Department of Psychology, Universidade Federal da Paraíba, João Pessoa, PB, Brazil ) , via Rodrigues (Memory and Cognition Studies Laboratory, Department of Psychology, Universidade Federal da Paraíba, João Pessoa, PB, Brazil ) , Pugliane, Karen Cristina (Memory and Cognition Studies Laboratory, Department of Psychology, Universidade Federal da Paraíba, João Pessoa, PB, Brazil ) , de Souza, Ingrid Brasilino Montenegro Bento (Behavioral Neuroscience Laboratory, Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, SP, Brazil ) , Lima, Á (Memory and Cognition Studies Laboratory, Department of Psychology, Universidade Federal da Paraíba, João Pessoa, PB, Brazil ) , lvaro da Costa (Laboratory of Neuroscience and Bioprospecting of Natural Products, Department of Biosciences, Universidade Federal de São Paulo, Santos, SP, Brazil ) , Salvadori, Mirian Graciela da Silva Stiebbe (Behavi) , Ribeiro, Alessandra Mussi , Silva, Regina Helena , Barbosa, Flá , vio Freitas
    Neurobiology of learning and memory v.145 ,pp. 28 - 33 , 2017 , 1074-7427 ,

    초록

    Abstract Episodic memory was initially believed to be unique to humans. However, studies demonstrate that nonhuman species discriminate items based on the triad what, where and when . Here we addressed the role of the dorsal hippocampal subfield CA1 in an integrative what-where-when task in Wistar rats. We performed bilateral inactivation of dorsal CA1 with the GABA A agonist muscimol previously to the task. As expected, sham-operated animals recollected an integrative memory for objects (what), their places (where) and temporal order (when). However, the inactivation of CA1 impaired the performance of the three components of episodic-like memory. In addition, total time of objects exploration and distance traveled were not different between groups, indicating that rats had similar levels of motivation, thus, alterations in exploration does not account for impaired locomotor performance. Altogether, our data provides evidence that CA1 plays an important role in episodic-like memory. Highlights Rats recollected an integrated episodic-like memory. Rats hippocampus was bilaterally inactivated with muscimol previously to the task. The inactivation of CA1 impaired the recollection of episodic-like memory. Our data provides evidence that CA1 plays an essential role in episodic-like memory.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  7. [해외논문]   The effect of mild acute stress during memory consolidation on emotional recognition memory   SCI SCIE SSCI

    Corbett, Brittany (Corresponding author.) , Weinberg, Lisa , Duarte, Audrey
    Neurobiology of learning and memory v.145 ,pp. 34 - 44 , 2017 , 1074-7427 ,

    초록

    Abstract Stress during consolidation improves recognition memory performance. Generally, this memory benefit is greater for emotionally arousing stimuli than neutral stimuli. The strength of the stressor also plays a role in memory performance, with memory performance improving up to a moderate level of stress and thereafter worsening. As our daily stressors are generally minimal in strength, we chose to induce mild acute stress to determine its effect on memory performance. In the current study, we investigated if mild acute stress during consolidation improves memory performance for emotionally arousing images. To investigate this, we had participants encode highly arousing negative, minimally arousing negative, and neutral images. We induced stress using the Montreal Imaging Stress Task (MIST) in half of the participants and a control task to the other half of the participants directly after encoding (i.e. during consolidation) and tested recognition 48h later. We found no difference in memory performance between the stress and control group. We found a graded pattern among confidence, with responders in the stress group having the least amount of confidence in their hits and controls having the most. Across groups, we found highly arousing negative images were better remembered than minimally arousing negative or neutral images. Although stress did not affect memory accuracy, responders, as defined by cortisol reactivity, were less confident in their decisions. Our results suggest that the daily stressors humans experience, regardless of their emotional affect, do not have adverse effects on memory. Highlights Across groups, highly arousing negative images are better remembered than minimally arousing negative or neutral images. Mild acute stress does not affect emotional memory performance. Cortisol reactivity affects memory confidence. Our daily stressors do not have an adverse effect on memory.

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    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  8. [해외논문]   An autonomous, automated and mobile device to concurrently assess several cognitive functions in group-living non-human primates   SCI SCIE SSCI

    Fizet, Jonas (Université) , Rimele, Adam (de Strasbourg, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), F-67000 Strasbourg, France ) , Pebayle, Thierry (Centre de Primatologie de l'Université) , Cassel, Jean-Christophe (de Strasbourg, Niederhausbergen, France ) , Kelche, Christian (Centre d'Investigation Neurocognitive et Neurophysiologique (UMS 3489), Université) , Meunier, Hé (de Strasbourg/CNRS, Strasbourg, France ) , lè (Université) , ne (de Strasbourg, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), F-67000 Strasbourg, France )
    Neurobiology of learning and memory v.145 ,pp. 45 - 58 , 2017 , 1074-7427 ,

    초록

    Abstract Research methods in cognitive neuroscience using non-human primates have undergone notable changes over the last decades. Recently, several research groups have described freely accessible devices equipped with a touchscreen interface. Two characteristics of such systems are of particular interest: some apparatuses include automated identification of subjects, while others are mobile. Here, we designed, tested and validated an experimental system that, for the first time, combine automatization and mobility. Moreover, our system allows autonomous learning and testing of cognitive performance in group-living subjects, including follow-up assessments. The mobile apparatus is designed to be available 24h a day, 7days a week, in a typical confined primate breeding and housing facility. Here we present as proof of concept, the results of two pilot studies. We report that rhesus macaques ( Macaca mulatta ) learned the tasks rapidly and achieved high-level of stable performance. Approaches of this kind should be developed for future pharmacological and biomedical studies in non-human primates. Highlights We present a tool to concurrently assess several cognitive functions in primates. This experimental system combines automatization and mobility. This system allows testing cognitive performance in group-living subjects. Using this device, macaques learned several cognitive tasks rapidly. Macaques showed high and stable performances thanks to this innovative tool.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  9. [해외논문]   Network oscillatory activity driven by context memory processing is differently regulated by glutamatergic and cholinergic neurotransmission   SCI SCIE SSCI

    Miller, Adam M.P. (Department of Psychology, Cornell University, Ithaca, NY 14853, United States ) , Frick, Brendan J. (Department of Psychiatry and Behavioral Sciences, The Asher Center for the Study and Treatment of Depressive Disorders, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States ) , Smith, David M. (Department of Psychology, Cornell University, Ithaca, NY 14853, United States ) , Radulovic, Jelena (Department of Psychiatry and Behavioral Sciences, The Asher Center for the Study and Treatment of Depressive Disorders, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States ) , Corcoran, Kevin A. (Department of Psychiatry and Behavioral Sciences, The Asher Center for the Study and Treatment of Depressive Disorders, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States)
    Neurobiology of learning and memory v.145 ,pp. 59 - 66 , 2017 , 1074-7427 ,

    초록

    Abstract Memory retrieval requires coordinated intra- and inter-regional activity in networks of brain structures. Dysfunction of these networks and memory impairment are seen in many psychiatric disorders, but relatively little is known about how memory retrieval and memory failure are represented at the level of local and regional oscillatory activity. To address this question, we measured local field potentials (LFPs) from mice as they explored a novel context, retrieved memories for contextual fear conditioning, and after administration of two amnestic agents: the NMDA receptor antagonist MK-801 and muscarinic acetylcholine receptor antagonist scopolamine (SCOP). LFPs were simultaneously recorded from retrosplenial cortex (RSC), dorsal hippocampus (DH), and anterior cingulate cortex (ACC), which are involved in processing contextual memories, and analyzed for changes in intra-regional power and inter-regional peak coherence of oscillations across multiple frequency bands. Context encoding and memory retrieval sessions yielded similar patterns of changes across all three structures, including decreased delta power and increased theta peak coherence. Baseline effects of MK-801 and SCOP were primarily targeted to gamma oscillations, but in opposite directions. Both drugs also blocked memory retrieval, as indicated by reduced freezing when mice were returned to the conditioning context, but this common behavioral impairment was only associated with power and peak coherence disruptions after MK-801 treatment. These findings point to neural signatures for memory impairment, whose underlying mechanisms may serve as therapeutic targets for related psychiatric disorders. Highlights Network oscillatory activity during memory processing was investigated. Encoding and retrieval of context memory yielded similar activity patterns. Drugs that block memory retrieval caused distinct changes to activity patterns.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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    Fig. 1 이미지
  10. [해외논문]   Amnestic drugs in the odor span task: Effects of flunitrazepam, zolpidem and scopolamine   SCI SCIE SSCI

    Galizio, Mark (University of North Carolina Wilmington, United States ) , Mathews, Michael (University of North Carolina Wilmington, United States ) , Mason, Madeleine (University of North Carolina Wilmington, United States ) , Panoz-Brown, Danielle (University of North Carolina Wilmington, United States ) , Prichard, Ashley (University of North Carolina Wilmington, United States ) , Soto, Paul (Louisiana State University, United States)
    Neurobiology of learning and memory v.145 ,pp. 67 - 74 , 2017 , 1074-7427 ,

    초록

    Abstract The odor span task is an incrementing non-matching–to-sample procedure designed to provide an analysis of working memory capacity in rodents. The procedure takes place in an arena apparatus and rats are exposed to a series of odor stimuli in the form of scented lids with the selection of new stimuli reinforced. This procedure makes it possible to study drug effects as a function of the number of stimuli to remember. In the present study, the non-selective positive allosteric GABA A receptor modulator flunitrazepam impaired odor span performance at doses that did not affect a control odor discrimination. In contrast, the alpha-1 selective positive GABA A receptor modulator zolpidem and the cholinergic receptor antagonist scopolamine only impaired odor span at doses that produced more global impairment, including decreased accuracy in the control discrimination and increased response omissions in the both the odor span and control discrimination procedures. Even though the effects of flunitrazepam were selective to odor span performance, they did not depend on the number of stimuli to remember—the same degree of impairment occurred regardless of the memory load. These findings suggest that flunitrazepam interfered selectively with conditional discrimination performance rather than working memory and tentatively suggest that flunitrazepam’s selective effects in the odor span task relative to the control odor discrimination are mediated by one or more non-alpha1 GABA A receptor subtypes. Highlights The odor span task (OST) assesses rodent’s ability to remember multiple odor stimuli. Positive GABA A modulator flunitrazepam selectively impaired OST accuracy. However, flunitrazepam effects did not depend on the number of items to remember. Alpha-1 selective positive GABA A modulator zolpidem did not selectively impair OST accuracy. Cholinergic antagonist scopolamine did not selectively impair OST accuracy.

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