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Reviews in medical virology 8건

  1. [해외논문]   RNA epitranscriptomics: Regulation of infection of RNA and DNA viruses by N6‐methyladenosine (m6A)  

    Tan, Brandon (Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA) , Gao, Shou‐ (Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA) , Jiang
    Reviews in medical virology v.28 no.4 ,pp. e1983 , 2018 , 1052-9276 ,

    초록

    Summary N 6 ‐methyladenosine (m 6 A) was discovered 4 decades ago. However, the functions of m 6 A and the cellular machinery that regulates its changes have just been revealed in the last few years. m 6 A is an abundant internal mRNA modification on cellular RNA and is implicated in diverse cellular functions. Recent works have demonstrated the presence of m 6 A in the genomes of RNA viruses and transcripts of a DNA virus with either a proviral or antiviral role. Here, we first summarize what is known about the m 6 A “writers,” “erasers,” “readers,” and “antireaders” as well as the role of m 6 A in mRNA metabolism. We then review how the replications of numerous viruses are enhanced and restricted by m 6 A with emphasis on the oncogenic DNA virus, Kaposi sarcoma–associated herpesvirus (KSHV), whose m 6 A epitranscriptome was recently mapped. In the context of KSHV, m 6 A and the reader protein YTHDF2 acts as an antiviral mechanism during viral lytic replication. During viral latency, KSHV alters m 6 A on genes that are implicated in cellular transformation and viral latency. Lastly, we discuss future studies that are important to further delineate the functions of m 6 A in KSHV latent and lytic replication and KSHV‐induced oncogenesis.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  2. [해외논문]   Definitions for warning signs and signs of severe dengue according to the WHO 2009 classification: Systematic review of literature  

    Morra, Mostafa Ebraheem (Faculty of Medicine, Alazhar University, Cairo, Egypt) , Altibi, Ahmed M.A. (Faculty of Medicine, University of Jordan, Amman, Jordan) , Iqtadar, Somia (Faculty of Medicine, King Edward Medical University, Lahore, Pakistan) , Minh, Le Huu Nhat (University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam) , Elawady, Sameh Samir (Faculty of Medicine, Tanta University, Tanta, Egypt) , Hallab, Asma (Sorbonne Universités, Université) , Elshafay, Abdelrahman (Pierre et Marie Curie (UPMC), Paris 06, France) , Omer, Omer Abedlbagi (Faculty of Medicine, Alazhar University, Cairo, Egypt) , Iraqi, Ahmed (Faculty of Medicine, University of Gezira, Wad Madani, Sudan) , Adhikari, Purushottam (Cairo University Hospital, Giza, Egypt) , Labib, Jonair Hussein (Gandaki Medical College, Pokhara, Nepal) , Elhusseiny, Khaled Mosaad , Elgebaly, Ahmed , Yacoub, Sophie , Huong, Le Thi Minh , Hirayama, Kenji , Huy, Nguyen Tien
    Reviews in medical virology v.28 no.4 ,pp. e1979 , 2018 , 1052-9276 ,

    초록

    Summary Since warning signs and signs of severe dengue are defined differently between studies, we conducted a systematic review on how researchers defined these signs. We conducted an electronic search in Scopus to identify relevant articles, using key words including dengue, “warning signs,” “severe dengue,” and “classification.” A total of 491 articles were identified through this search strategy and were subsequently screened by 2 independent reviewers for definitions of any of the warning or severe signs in the 2009 WHO dengue classification. We included all original articles published in English after 2009, classifying dengue by the 2009 WHO classification or providing the additional definition or criterion of warning signs and severity (besides the information of 2009 WHO). Analysis of the extracted data from 44 articles showed wide variations among definitions and cutoff values used by physicians to classify patients diagnosed with dengue infection. The establishment of clear definitions for warning signs and severity is essential to prevent unnecessary hospitalization and harmonizing the interpretation and comparability of epidemiological studies dedicated to dengue infection.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Cytomegalovirus vaccine: timing is important  

    Griffiths, P.D.
    Reviews in medical virology v.28 no.4 ,pp. e1986 , 2018 , 1052-9276 ,

    초록

    Summary Since warning signs and signs of severe dengue are defined differently between studies, we conducted a systematic review on how researchers defined these signs. We conducted an electronic search in Scopus to identify relevant articles, using key words including dengue, “warning signs,” “severe dengue,” and “classification.” A total of 491 articles were identified through this search strategy and were subsequently screened by 2 independent reviewers for definitions of any of the warning or severe signs in the 2009 WHO dengue classification. We included all original articles published in English after 2009, classifying dengue by the 2009 WHO classification or providing the additional definition or criterion of warning signs and severity (besides the information of 2009 WHO). Analysis of the extracted data from 44 articles showed wide variations among definitions and cutoff values used by physicians to classify patients diagnosed with dengue infection. The establishment of clear definitions for warning signs and severity is essential to prevent unnecessary hospitalization and harmonizing the interpretation and comparability of epidemiological studies dedicated to dengue infection.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Peering into the HIV reservoir  

    Garcí (Instituto de Investigación Sanitaria‐Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS‐FJD, UAM), Madrid, Spain) , a, Marcial (Vall d'Hebron Research Institute, Barcelona, Spain) , Buzó (Instituto de Investigación Sanitaria‐Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS‐FJD, UAM), Madrid, Spain) , n, Marí (Instituto de Investigación Sanitaria‐Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS‐FJD, UAM), Madrid, Spain) , a J. , Benito, José , M. , Ralló , n, Norma
    Reviews in medical virology v.28 no.4 ,pp. e1981 , 2018 , 1052-9276 ,

    초록

    Summary The main obstacle to HIV eradication is the establishment of a long‐term persistent HIV reservoir. Although several therapeutic approaches have been developed to reduce and eventually eliminate the HIV reservoir, only a few have achieved promising results. A better knowledge of the mechanisms involved in the establishment and maintenance of HIV reservoir is of utmost relevance for the design of new therapeutic strategies aimed at purging it with the ultimate goal of achieving HIV eradication or alternatively a functional cure. In this regard, it is also important to take a close look into the cellular HIV reservoirs other than resting memory CD4 T‐cells with key roles in reservoir maintenance that have been recently described. Unraveling the special characteristics of these HIV cellular compartments could aid us in designing new therapeutic strategies to deplete the latent HIV reservoir.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   A review on current status of antiviral siRNA  

    Qureshi, Abid (Biomedical Informatics Center, Sher‐i‐Kashmir Institute of Medical Sciences (SKIMS), Srinagar, India) , Tantray, Vaqar Gani (Biomedical Informatics Center, Sher‐i‐Kashmir Institute of Medical Sciences (SKIMS), Srinagar, India) , Kirmani, Altaf Rehman (Biomedical Informatics Center, Sher‐i‐Kashmir Institute of Medical Sciences (SKIMS), Srinagar, India) , Ahangar, Abdul Ghani (Biomedical Informatics Center, Sher‐i‐Kashmir Institute of Medical Sciences (SKIMS), Srinagar, India)
    Reviews in medical virology v.28 no.4 ,pp. e1976 , 2018 , 1052-9276 ,

    초록

    Summary Viral diseases like influenza, AIDS, hepatitis, and Ebola cause severe epidemics worldwide. Along with their resistant strains, new pathogenic viruses continue to be discovered so creating an ongoing need for new antiviral treatments. RNA interference is a cellular gene‐silencing phenomenon in which sequence‐specific degradation of target mRNA is achieved by means of complementary short interfering RNA (siRNA) molecules. Short interfering RNA technology affords a potential tractable strategy to combat viral pathogenesis because siRNAs are specific, easy to design, and can be directed against multiple strains of a virus by targeting their conserved gene regions. In this review, we briefly summarize the current status of siRNA therapy for representative examples from different virus families. In addition, other aspects like their design, delivery, medical significance, bioinformatics resources, and limitations are also discussed.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Hepatitis B virus (HBV) reactivation—The potential role of direct‐acting agents for hepatitis C virus (HCV)  

    Blackard, Jason T. (Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA) , Sherman, Kenneth E. (Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA)
    Reviews in medical virology v.28 no.4 ,pp. e1984 , 2018 , 1052-9276 ,

    초록

    Summary Hepatitis C virus (HCV) is known to inhibit hepatitis B virus (HBV) replication in patients with HBV/HCV coinfection. Reactivation of HBV in patients treated for HCV with direct‐acting agents (DAAs) has emerged recently as an important clinical consideration. A growing number of case reports and case series support the association between new HCV treatments and HBV reactivation. Yet, very little is known about the specific viral characteristics that facilitate reactivation as functional characterization of the reactivated HBV has been conducted only rarely. This review provides the most recent data on HBV reactivation in the context of DAA initiation and highlights the existing viral genomic data from reactivating viruses. Current functional studies of HBV reactivation are largely limited by the retrospective identification of cases, no standardization of genomic regions that are studied with respect to HBV reactivation, and the lack of inclusion of nonreactivating controls to establish specific viral mutations that are associated with HBV reactivation. Importantly, none of these sequencing studies included cases of HBV reactivation after initiation of DAAs. While new HCV treatments have revolutionized care for HCV infected patients, HBV reactivation will likely increase in frequency, as DAAs are more commonly prescribed. Pretreatment determination of HBV status and thoughtful management of HBV coinfections will be necessary and lead to improved patient safety and yield optimal treatment results.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Autophagy: The multi‐purpose bridge in viral infections and host cells  

    Abdoli, Asghar (Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran) , Alirezaei, Mehrdad (Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA) , Mehrbod, Parvaneh (Influenza and Other Respiratory Viruses Dept., Pasteur Institute of Iran, Tehran, Iran) , Forouzanfar, Faezeh (University of Strasbourg, EA7292, DHPI, Institute of Parasitology and Tropical Pathology Strasbourg, France)
    Reviews in medical virology v.28 no.4 ,pp. e1973 , 2018 , 1052-9276 ,

    초록

    Summary Autophagy signaling pathway is involved in cellular homeostasis, developmental processes, cellular stress responses, and immune pathways. The aim of this review is to summarize the relationship between autophagy and viruses. It is not possible to be fully comprehensive, or to provide a complete “overview of all viruses”. In this review, we will focus on the interaction of autophagy and viruses and survey how human viruses exploit multiple steps in the autophagy pathway to help viral propagation and escape immune response. We discuss the role that macroautophagy plays in cells infected with hepatitis C virus, hepatitis B virus, rotavirus gastroenteritis, immune cells infected with human immunodeficiency virus, and viral respiratory tract infections both influenza virus and coronavirus.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   Issue Information  


    Reviews in medical virology v.28 no.4 ,pp. e1948 , 2018 , 1052-9276 ,

    초록

    No abstract is available for this article.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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