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Archives of medical research 12건

  1. [해외논문]   Table of Contents   SCI SCIE


    Archives of medical research v.48 no.5 ,pp. A2 - A2 , 2017 , 0188-4409 ,

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  2. [해외논문]   Instructions for Authors   SCI SCIE


    Archives of medical research v.48 no.5 ,pp. A3 - A5 , 2017 , 0188-4409 ,

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  3. [해외논문]   Editorial Board   SCI SCIE


    Archives of medical research v.48 no.5 ,pp. A1 - A1 , 2017 , 0188-4409 ,

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  4. [해외논문]   Understanding the Biology of Thermogenic Fat: Is Browning A New Approach to the Treatment of Obesity?   SCI SCIE

    Vargas-Castillo, Ariana (Address reprint requests to: Armando R. Tovar, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Depto. Fisiología de la Nutrición, Av. Vasco de Quiroga No.15, Col. Belisario Domínguez Sección XVI, Ciudad de México, 14080, México) , Fuentes-Romero, Rebeca (Phone and FAX: (+52) (55) 5655-3038) , Rodriguez-Lopez, Leonardo A. , Torres, Nimbe , Tovar, Armando R.
    Archives of medical research v.48 no.5 ,pp. 401 - 413 , 2017 , 0188-4409 ,

    초록

    Obesity is characterized by an excess of white adipose tissue (WAT). Recent evidence has demonstrated that WAT can change its phenotype to a brown-like adipose tissue known as beige/brite adipose tissue. This transition is characterized by an increase in thermogenic capacity mediated by uncoupling protein 1 (UCP1). This browning process is a potential new target for treating obesity. The aim of this review is to integrate the different mechanisms by which beige/brite adipocytes are formed and to describe the physiological, pharmacological and nutritional inducers that can promote browning. An additional aim is to show evidence of how some of these inducers can be used as potential therapeutic agents against obesity and its comorbidities. This review shows the importance of brown and beige/brite adipose tissue and the mechanisms of their formation. Particularly, the two theories of beige/brite adipocyte origin are discussed: de novo differentiation and transdifferentiation. The gene markers that identify these types of adipocytes and the involvement of microRNAs in the epigenetic regulation of the browning process is also discussed. Additionally, we describe the transcriptional control of UCP1 expression by some of the inducers of browning. Furthermore, we describe in detail how some bioactive dietary compounds can induce browning and their subsequent beneficial health effects. The evidence suggests that browning is a new potential strategy for the treatment of obesity and obesity-associated metabolic disorders.

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  5. [해외논문]   Maternal Micronutrients, Omega-3 Fatty Acids and Gene Expression of Angiogenic and Inflammatory Markers in Pregnancy Induced Hypertension Rats   SCI SCIE

    Kemse, Nisha (Address reprint requests to: Sadhana Joshi, Dr, Scientist “G” Head, Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune Satara Road, Pune 411043, India) , Sundrani, Deepali (Phone: (020) 24366920) , Kale, Anvita (FAX: (020) 24379013) , Joshi, Sadhana
    Archives of medical research v.48 no.5 ,pp. 414 - 422 , 2017 , 0188-4409 ,

    초록

    Background and Aims Preeclampsia is a disorder of pregnancy and is associated with inflammation and altered angiogenesis. The present study examines the effect of micronutrient and omega-3 fatty acid supplementation (individual, as well as combined) on genes involved in inflammation and angiogenesis, as well as global DNA methylation levels in a pregnancy induced hypertension (PIH) rat model. Methods Pregnant Wistar rats were randomly assigned to six dietary groups: control, PIH (Pregnancy induced hypertension) Induced; PIH Induced with micronutrient supplements with vitamin B 12 (PIHB), folate (PIHF), omega-3 fatty acid (PIHO), and combined supplementation (PIHC) (micronutrients and omega-3 fatty acids). Half the dams were dissected on 20 d of gestation to collect placental tissue, and half were allowed to deliver normally on 22 d of gestation and were assigned to a postnatal control diet. The offspring were dissected at 3 month of age. Results PIH induction increased the mRNA levels of the pro inflammatory cytokine IL-6 ( p p p 12 and omega-3 fatty acids improved placental IL-10 levels and decreased TNF-α levels in offspring livers. Conclusion Our data indicate that a combined supplementation of vitamin B 12 , folic acid and omega-3 fatty acid was useful for the better management of preeclampsia in an animal model.

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  6. [해외논문]   Hemin Reduces HMGB1 Release by UVB in an AMPK/HO-1-dependent Pathway in Human Keratinocytes HaCaT Cells   SCI SCIE

    Park, Eun Jung (Department of Pharmacology and Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, Republic of Korea ) , Kim, Young Min (Department of Pharmacology and Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, Republic of Korea ) , Chang, Ki Churl (Department of Pharmacology and Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, Republic of Korea)
    Archives of medical research v.48 no.5 ,pp. 423 - 431 , 2017 , 0188-4409 ,

    초록

    Background and Aims High mobility group box 1 (HMGB1) plays an important role as a pro-inflammatory cytokine that regulates inflammation in various diseases. We hypothesized that hemin might reduce HMGB1 release through the induction of HO-1 in UVB-induced HaCaTs. Methods The effects of hemin on the release of HMGB1 in UVB exposure were evaluated. The mechanisms were investigated using various signal inhibitors and small interfering RNA techniques. Results Treatment with hemin inhibited reactive oxygen species (ROS) in UVB-induced HaCaTs in a dose-dependent manner. HMGB1 release by UVB was significantly reduced by hemin, N-acetyl-cysteine and DPI (NADPH oxidase inhibitor). Hemin increased HO-1 induction followed by phosphorylation of AMPK in a time- and dose-dependent manner. Additionally, hemin significantly increased the NAD + /NADH ratio in HaCaTs. The inhibitory effects of UVB-induced HMGB1 release by hemin were significantly reversed not only with pharmacological inhibitors of AMPK (compound c) or HO-1 (ZnPPIX) but also through transfection of small interfering RNAs (siRNAs) for AMPK or HO-1. Interestingly, hemin decreased phosphor-AMPK expression by HO-1 siRNA transfection, but it failed to induce HO-1 in AMPK siRNA-transfected cells, which suggested that HO-1 was involved in AMPK activation by hemin in HaCaT. Moreover, recombinant HMGB1 induced Snail and inhibited E-Cadherin in HaCaTs, whereas hemin reversed those effects through rHMGB1. Conclusions It is concluded that the increased activity of HO-1/AMPK and scavenging ROS are, at least in part, responsible for the inhibition of UVB-induced HMGB1 release in keratinocyte HaCaTs. Therefore, hemin may be a useful agent for preventing UVB-induced skin cancer. Graphical Abstract [DISPLAY OMISSION]

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  7. [해외논문]   Effect of Native and Minimally Modified Low-density Lipoprotein on the Activation of Monocyte Subsets   SCI SCIE

    Blanco-Favela, Francisco (Unidad de Investigación Médica en Inmunología, Unidad Médica de Alta Especialidad, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México ) , Espinosa-Luna, José (Unidad de Investigación Médica en Inmunología, Unidad Médica de Alta Especialidad, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México ) , Esteban (Unidad de Investigación Médica en Inmunología, Unidad Médica de Alta Especialidad, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México ) , Chá (Coordinación de Educación en Salud, Instituto Mexicano del Seguro Social, Ciudad de México, México ) , vez-Rueda, Adriana Karina (Unidad de Investigación Médica en Inmunología, Unidad Médica) , Madrid-Miller, Alejandra , Chá , vez-Sá , nchez, Luis
    Archives of medical research v.48 no.5 ,pp. 432 - 440 , 2017 , 0188-4409 ,

    초록

    Background In atherosclerosis, monocytes are essential and secrete pro-inflammatory cytokines in response to modified low-density lipoprotein (LDL). Human CD14 ++ CD16 − , CD14 ++ CD16 + and CD14 + CD16 ++ monocytes produce different cytokines. The objective of this research was to determine the number of monocyte subsets positives to cytokines in response to native (nLDL) and minimally modified LDL (mmLDL). Methods Human monocytes from healthy individuals were purified by negative selection and were stimulated with nLDL, mmLDL or LPS. Subsequently, human total monocytes were incubated with monoclonal antibodies specific for CD14 or both CD14 and CD16 to characterize total monocytes and monocyte subsets and with antibodies specific to anti-tumor necrosis factor (TNF)-α, anti-interleukin (IL)-6 and anti-IL-10. The number of cells positive for cytokines was determined and cells cultured with nLDL, mmLDL and LPS were compared with cells cultured only with culture medium. Results We found that nLDL does not induce in the total monocyte population or in the three monocyte subsets positives to cytokines. MmLDL induced in total monocytes positives to TNF-α and IL-6 as well as in both CD14 ++ CD16 + and CD14 + CD16 ++ and in CD14 ++ CD16 + monocytes, respectively. Moreover, total monocytes and the three monocyte subsets expressed few amounts of cells positives to IL-10 in response to mmLDL. Conclusion Our study demonstrated that nLDL did not induce cells positives to cytokines and that the CD14 ++ CD16 + and CD14 + CD16 ++ monocyte subsets could be the main sources of TNF-α and IL-6, respectively, in response to mmLDL, which promotes the development and progression of atherosclerotic plaque.

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  8. [해외논문]   Gender-Specific Association of Desacylated Ghrelin with Subclinical Atherosclerosis in the Metabolic Syndrome   SCI SCIE

    Zanetti, Michela (Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy ) , Gortan Cappellari, Gianluca (Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy ) , Semolic, Annamaria (Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy ) , Burekovic, Ismet (Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy ) , Fonda, Maurizio (Service for Diabetes and Metabolic Diseases, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy ) , Cattin, Luigi (Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy ) , Barazzoni, Rocco (Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy)
    Archives of medical research v.48 no.5 ,pp. 441 - 448 , 2017 , 0188-4409 ,

    초록

    Objective Ghrelin, a gastric hormone with pleiotropic effects modulates vascular function and may influence atherosclerosis. Plasma ghrelin is reduced in the metabolic syndrome (MS), which is also characterized by early atherosclerosis. Ghrelin circulates in acylated (AG) and desacylated (DAG) forms. Their relative impact and that of gender on subclinical atherosclerosis in MS is unknown. Aim of the Study To investigate potential associations of total, AG and DAG with carotid atherosclerosis and with gender in the MS. Methods Plasma total ghrelin, AG, DAG and carotid artery IMT (cIMT) were measured in 46 MS patients (NCEP-ATP III criteria, 22M/24F). Results Compared with males, females had higher ( p p p p p Conclusions These data indicate a negative independent association between DAG and cIMT in middle-aged women with the MS and suggest a gender-specific modulatory function of DAG in the development of atherosclerosis.

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  9. [해외논문]   Kidney Injury Molecule-1 Level is Associated with the Severity of Renal Interstitial Injury and Prognosis in Adult Henoch–SchOnlein Purpura Nephritis   SCI SCIE

    Zhang, Yuanyuan (Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China ) , Li, Aiju (Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, China ) , Wen, Jiliang (Department of Urology, the Second Hospital of Shandong University, Jinan, China ) , Zhen, Junhui (Department of Pathology, Qilu Hospital of Shandong University, Jinan, China ) , Hao, Qiufa (Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China ) , Zhang, Yidan (Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China ) , Hu, Zhao (Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China ) , Xiao, Xiaoyan (Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China)
    Archives of medical research v.48 no.5 ,pp. 449 - 458 , 2017 , 0188-4409 ,

    초록

    Background and Aims Kidney injury molecule-1 (KIM-1) was identified the most highly upregulated protein in chronic kidney diseases and prolonged KIM-1 expression may be maladaptive. The present study was aimed to investigate urinary, renal and plasma KIM-1 levels and to analyze association between KIM-1 levels with clinical and pathological indexes in adult Henoch-SchOnlein purpura (HSP) patients. Methods Twenty healthy individuals, 20 HSP patients without nephritis and 35 HSP patients with nephritis were recruited. Urinary and plasma KIM-1 levels were determined by ELISA and Luminex, respectively. Renal KIM-1 expression was evaluated by immunohistochemistry. Results HSP patients with nephritis were characterized as elevated levels of urinary, renal and plasma KIM-1. Those with more severe tubular injury of renal biopsy tissues presented significantly higher urinary and renal KIM-1 levels compared to control and patients without nephritis. Urinary and renal levels of KIM-1 were positively correlated with blood urea nitrogen and proteinuria, while they were negatively correlated with eGFR at both baseline and after two years follow-up. Moreover, plasma KIM-1 levels were associated with blood urea nitrogen and proteinuria as well. Further univariate correlation analysis indicated urinary and renal KIM-1 levels were positively correlated with interstitial inflammation index and tubulointerstitial chronicity index. Only urinary KIM-1 levels were associated with interstitial inflammation index, tubulointerstitial chronicity index and extracapillary glomerular activity index, after logistic regression analysis. The area under the curve (AUC) for urinary KIM-1/Cr predicting progression of renal damage was significantly greater than the AUC for proteinuria. Conclusions This finding suggests that measurement of urinary and renal KIM-1 level may be helpful to evaluate severity of renal pathological damage and prognosis in adult HSP patients with nephritis.

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  10. [해외논문]   Comparative Assessment of Serum Adipokines Zinc-α2-glycoprotein and Adipose Triglyceride Lipase, and Cardiovascular Risk Factors Between Normal Weight and Obese Patients with Hemodialysis   SCI SCIE

    Hosseinzadeh-Attar, Mohammad Javad (Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran ) , Mahdavi-Mazdeh, Mitra (Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran ) , Yaseri, Mehdi (Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran ) , Zahed, Narges Sadat (Department of Nephrology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran ) , Alipoor, Elham (Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran)
    Archives of medical research v.48 no.5 ,pp. 459 - 466 , 2017 , 0188-4409 ,

    초록

    Background Little is known about the potential relationship of obesity, adipose tissue and novel adipokines with cardiometabolic risk factors in end-stage renal disease. Zinc-α2-glycoprotein (ZAG) and adipose triglyceride lipase (ATGL) are novel adipokines with proposed desirable effects on inflammation, and lipid and glucose metabolism. The aim of this study was to investigate serum concentrations of ZAG and ATGL, and the relationship of these adipokines with cardiovascular risk factors in normal weight (NW) and obese (OB) patients undergoing hemodialysis. Methods Patients with regular hemodialysis including 44 normal weight (18.5 2 ) and 44 obese (BMI≥30 kg/m 2 ) were enrolled. Serum lipid profile, high-sensitivity C-reactive protein (hsCRP) and nitric oxide metabolites along with ZAG and ATGL concentrations were assessed. Results ZAG concentrations were significantly lower in OB compared to NW group (100 ± 34 vs. 106 ± 31 ng/ml; p = 0.007). No significant difference was observed in ATGL between the two groups. A significant inverse correlation between ZAG and HDL ( r = ‒0.236, p = 0.048) and a marginal inverse correlation between ATGL and HDL ( r = ‒0.211, p = 0.078) were observed in all patients. ZAG had positive correlations with triglyceride/HDL ( r = 0.279, p = 0.019), cholesterol/HDL ( r = 0.319, p = 0.007), and LDL/HDL ( r = 0.26, p = 0.029) ratios. Among cardiovascular risk factors, only LDL/HDL ratio and hsCRP were significantly higher in OB patients ( p = 0.009 and p = 0.038, respectively). Conclusions Serum concentrations of ZAG, but not ATGL, were significantly lower in the OB group. It appears that obesity overrides the role of hemodialysis in determining ZAG concentration. In contrast, uremic condition might overshadow the role of obesity in determining levels of traditional cardiovascular risk factors.

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