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저널/프로시딩 상세정보

권호별목차 / 소장처보기

H : 소장처정보

T : 목차정보

Korean journal of ophthalmology : KJO 11건

  1. [국내논문]   The effect of dichlorotriazinyl aminofluorescein on human keratocytes in vitro.  

    Wee, W R , Rofougaran, R , Pakkar, A , Hayashi, S , McDonnell, P J
    Korean journal of ophthalmology : KJO v.10 no.2 ,pp. 63 - 67 , 1996 , 1011-8942 ,

    초록

    Dichlorotriazinyl aminofluorescein (DTAF) has been used to stain corneal stromal collagen as part of in vivo animal experiments for many years. Toxicity of this drug, if present, might alter the observed wound healing. To determine if this drug has any deleterious effect on keratocytes, we evaluated it in vitro. Human keratocytes prepared in 24-well plates were exposed to varying concentrations of DTAF (10(-4), 10(-3), 10(-2), 1, 10, 10(2) micrograms/ml). Exposure times of 1 hour and 24 hours at each concentration of DTAF were evaluated. The cell number was measured 1 and 3 days after initiation of exposure to DTAF using a Coulter counter. Keratocyte proliferation was not affected by 1-hour exposure to DTAF, but keratocyte proliferation measured 3 days after initiation of exposure to DTAF for 24 hours was inhibited in a dose-dependent manner (p = 0.02) and was significantly inhibited at concentrations of 10 and 100 micrograms/ml (p

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  2. [국내논문]   Effect of topically applied Na-hyaluronan on experimental corneal alkali wound healing.  

    Chung, J H , Kim, H J , Fagerholmb, P , Cho, B C
    Korean journal of ophthalmology : KJO v.10 no.2 ,pp. 68 - 75 , 1996 , 1011-8942 ,

    초록

    The effect of topically applied 1% sodium hyaluronate (Na-HA) on the healing of a standardized corneal alkali wound was studied. The healing of the epithelium, stroma, and endothelium was evaluated separately, using quantitative methods. Central corneal alkali wound was produced in one eye of the rabbits by applying a 5.5-mm round filter paper, soaked in 1 N NaOH, for 60 seconds. 1% Na-HA in the treatment group and phosphate buffered saline (PBS) in the control group were given topically 4 times per day for 2 days, 1- and 3-weeks. Epithelial and endothelial healing was assessed morphometrically from standardized photographs and micrographs, respectively. Stromal healing was determined by counting polymorphonuclear leukocytes (PMN) and keratocytes in the central and marginal wound areas. A positive healing influence was observed in the epithelium. In stromal healing, 1% Na-HA treated corneas showed less PMNs and more keratocytes than the control group, suggesting that topically applied 1% Na-HA may suppress the stromal PMN infiltration and enhance the keratocyte repopulation during corneal alkali wound healing. However, no significant difference was found in morphometric evaluation of endothelial healing between the two groups.

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  3. [국내논문]   Ultrastructure of surgically excised subfoveal neovascular membranes.  

    Kim, K S , Oh, J S , Kwak, J S
    Korean journal of ophthalmology : KJO v.10 no.2 ,pp. 76 - 81 , 1996 , 1011-8942 ,

    초록

    We studied the ultrastructural features of four consecutive subfoveal neovascular membranes (SFNM) associated with age-related macular degeneration. Cellular components of the membranes included retinal pigment epithelial (RPE) cells, endothelium-lined vascular channels, macrophages, myofibroblasts, fibrocytes, glial cells, erythrocytes, and lymphocytes. Extracellular interstitial constituents included collagen fibrils, basal laminar deposits, fibrin and young elastic fibrils. These findings show that SFNMs consist of various cells originating from surrounding tissues and vessels. Among these RPE cells and macrophages are the main cellular components and in conjunction with various extracellular matrix, especially collagen, may play an important role in the formation and maintenance of the membranes.

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  4. [국내논문]   Degradation of phagosomes and diurnal changes of lysosomes in rabbit retinal pigment epithelium.  

    Kim, I T , Kwak, J S
    Korean journal of ophthalmology : KJO v.10 no.2 ,pp. 82 - 91 , 1996 , 1011-8942 ,

    초록

    Diurnal changes of lysosomes including ultrastructural changes of phagosomes and acid phosphatase reactions in phagosomes, as well as diurnal biochemical changes in cathepsin D activity, were studied in the retinal pigment epithelium (RPE) of the rabbit. The rabbit was maintained on a natural light-dark cycle over seven days in fall and was sacrificed at various times during the day and night. The number of lysosomes or phagosomes in the RPE was the highest at 1.5 hours after exposure to sunlight (8:00 AM), and thereafter decreased with time. Three types of phagosomes were observed and acid phosphatase reactions were different in each type of phagosome; the fresh phagosomes were negative or positive, lamellar bodies positive, and dense bodies partially positive. The biochemical activity of cathepsin D was the highest at 8:00 AM, and this was consistent with the time of peak in phagocytic activity in the RPE. This report shows that phagocytic activity in the RPE occurred in the early stage after exposure to sunlight, and that fresh phagosomes were sequentially degraded to lamellar or dense bodies. Cathepsin D activity also increased, and this was consistent with the phagocytic activity in the RPE.

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  5. [국내논문]   The outcome of cryotherapy for retinopathy of prematurity (ROP) according to ROP location.  

    Khwarg, S I , Yu, H G , Yu, Y S
    Korean journal of ophthalmology : KJO v.10 no.2 ,pp. 92 - 96 , 1996 , 1011-8942 ,

    초록

    Cryotherapy has been shown to be an effective treatment for retinopathy of prematurity (ROP) stage 3+. However, the outcome of cryotherapy is less favorable in zone 1 ROP than in zone 2 ROP. We suspected whether there may be differences in the outcomes of cryotherapy if the zone of ROP is further divided. So we reviewed the records of 85 premature infants (145 eyes) who had undergone cryotherapy for ROP. The frequencies of favorable outcome were 42.9% of 14 eyes (zone 1), 78.9% of 38 eyes (posterior zone 2), 92.9% of 70 eyes (mid zone 2), and 100.0% of 23 eyes (anterior zone 2), respectively (p

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  6. [국내논문]   Incidence of ptosis following trabeculectomy: a comparative study.  

    Song, M S , Shin, D H , Spoor, T C
    Korean journal of ophthalmology : KJO v.10 no.2 ,pp. 97 - 103 , 1996 , 1011-8942 ,

    초록

    The occurrence of ptosis after trabeculectomy has been a common postoperative complication. Many factors have been implicated in the development of postoperative ptosis. The purpose of this study was to investigate the incidence of ptosis following trabeculectomy and whether or not it was influenced by combined cataract surgery, type of conjunctival flap, and previous intraocular surgery. We reviewed 386 eyes of 386 patients who underwent either trabeculectomy alone or trabeculectomy combined with cataract surgery, with greater than 6 month follow-up. Ptosis occurred in 10.7% (18 of 150 eyes) after trabeculectomy alone and in 12.7% (30 of 236 eyes) after trabeculectomy with combined cataract surgery (p = 0.96). The incidence of ptosis was 12.3% (10 of 81 eyes) after limbus-based conjunctival flap and 12.5% (38 of 305 eyes) after fornix-based conjunctival flap (p = 0.98). There was no significant difference in the incidence of ptosis between primary surgery eyes (12.5%, 34 of 273 eyes) and secondary surgery eyes (12.4%, 14 of 113 eyes) (p = 0.97). The incidence of ptosis after trabeculectomy was about 12% overall and not significantly influenced by combined cataract surgery, type of conjunctival flap or previous ocular surgery.

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  7. [국내논문]   Comparative study of intraocular pressure change after cataract surgery: phacoemulsification and extracapsular cataract extraction.  

    Kim, J W
    Korean journal of ophthalmology : KJO v.10 no.2 ,pp. 104 - 108 , 1996 , 1011-8942 ,

    초록

    A randomized prospective study was performed to evaluate intraocular pressure (IOP) change after extracapsular cataract extraction (ECCE) or phacoemulsification and aspiration (PEA) with implantation of posterior chamber intraocular lens in otherwise normal cataract patients. IOP was measured preoperatively and postoperatively at up to 6 months. There was a mean fall in pressure of 1.1mmHg (5.72%) in the ECCE group (15 eyes) and of 0.6mmHg (4.16%) in the PEA group (24 eyes) after 6 months. The decrease in mean IOP was significant at 2 months in the PEA group and at 4 to 6 months in the ECCE group, but there was no statistically significant difference between the two groups during the follow-up periods (p

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  8. [국내논문]   Magnitude of decrease in intraocular pressure depends upon intensity of exercise.  

    Qureshi, I A , Xi, X R , Huang, Y B , Wu, X D
    Korean journal of ophthalmology : KJO v.10 no.2 ,pp. 109 - 115 , 1996 , 1011-8942 ,

    초록

    The present study was planned to investigate the relationship between the magnitude of intraocular pressure (IOP) reduction after short-duration exercise and the intensity, duration and quantity of exercise in healthy subjects. Twenty-five healthy, sedentary male of the same age group, performed exercises at the levels of 80%, 60%, and 40% maximum heart rate (HRmax) for 15 minutes, 80% HRmax for 7.5 minutes, 60% HRmax for 10 minutes, and 40% HRmax for 30 minutes. IOP was measured with the Goldmann applanation tonometer. The IOP reduction at 5 minutes after 15 minutes of exercising at 80% HRmax, 60% HRmax, and 40% HRmax were 4.7 +/- 0.9, 3.5 +/- 0.7, and 0.9 +/- 0.4 mmHg, respectively. At five minutes, after exercising 7.5 minutes at 80% HRmax, 10 minutes at 60% HRmax, and 30 minutes at 40% HRmax, IOP reduced by 4.5 +/- 0.7, 3.3 +/- 0.9, and 2.9 +/- 1.1 mmHg, respectively. This study concludes that intensity of exercise seems responsible for the magnitude of the initial IOP decrease after short-term exercise. Furthermore, it seems that other factors such as duration of exercise or quantity of exercise, blood pressures, body mass index are not related to the amount of the initial fall in IOP.

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  9. [국내논문]   Clinical evaluation of corneal diseases associated with floppy eyelid syndrome.  

    Lee, W J , Kim, J C , Shyn, K H
    Korean journal of ophthalmology : KJO v.10 no.2 ,pp. 116 - 121 , 1996 , 1011-8942 ,

    초록

    We examined 18 cases of floppy eyelid syndrome, first reported in the Orient, in patients ranging in age from 11 to 55 years (mean 24 years); 16 were men and two were women. In contrast to previous reports in which almost all patients were obese men, only three of our patients were mildly obese. The most common abnormal corneal finding was punctate epithelial keratopathy (five patients-28%). Keratoconus was detectable in three patients (17%) overall; it was bilateral in one case and unilateral in two. Other miscellaneous corneal findings were corneal astigmatism and corneal opacity. In two cases, we found a familial tendency to skin hyperextensibility and joint hypermobility, and in one case, floppy eyelid syndrome developed after pars plana vitrectomy. The pathogenesis of the syndrome is still unknown, but our findings suggest that the more important pathogenetic risk factors are not obesity and sleeping pattern, but genetic collagen and/or elastin abnormality.

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  10. [국내논문]   Carbon monoxide poisoning as an epigenetic factor for Leber's hereditary optic neuropathy.  

    Hwang, J M , Park, H W
    Korean journal of ophthalmology : KJO v.10 no.2 ,pp. 122 - 123 , 1996 , 1011-8942 ,

    초록

    A 45-year-old Korean woman visited our hospital complaining of poor vision after carbon monoxide (CO) poisoning. We have confirmed the presence of a point mutation at position 11778 in the ND4 gene of mitochondrial DNA. This case suggests that CO poisoning may precipitate the clinical expression of Leber's hereditary optic neuropathy (LHON). To our knowledge, this would be the first case report of clinical expression of LHON precipitated by CO poisoning.

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