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The Korean journal of internal medicine : KJIM 20건

  1. [국내논문]   Prognostic Significance of Immunohistochemical Expression of p53 and Retinoblastoma Gene Protein (pRB) in Curatively Resected Gastric Cancer  

    Song, Hong Suk (Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. ) , Kim, In Ho (Department of General Surgery, Keimyung University School of Medicine, Daegu, Korea. ) , Sohn, Soo Sang (Department of General Surgery, Keimyung University School of Medicine, Daegu, Korea. ) , Kwon, Kun Young (Department of Pathology, Keimyung University School of Medicine, Daegu, Korea. ) , Lee, Won Sik (Department of Internal Medicine, Fatima Hospital, Daegu, Korea.)
    The Korean journal of internal medicine : KJIM v.20 no.1 ,pp. 1 - 7 , 2005 , 1226-3303 ,

    초록

    Background The aim of this study was to determine the prognostic significance of the expression of p 53 and retinoblastoma (Rb) gene products in cases of curatively resected gastric adenocarcinoma, by immunohistochemical analysis. Methods Between January 1996 and December 2001, 736 curatively resected gastric cancer patients underwent immunohistochemical staining for p 53 or Rb proteins (pRb), and we retrospectively analyzed the correlation of our results with the clinical outcomes of these cases. Results High levels of expression of p 53 (>25% p 53-positive cells) and Rb (>50% Rb-positive cells) proteins were detected in 40.1% and 43.7% of cases, respectively. Tubular type was found to frequently exhibit higher levels of p 53 expression (high expression in 44.2%) than signet ring cell type (high expression in 26.0%) ( p = 0.042). The incidence of vascular invasion was lower in the high pRb expressors (43.2%) than in the pRb low expressors (56.8%), but this was not a statistically significant discrepancy ( p = 0.063). Preoperative CEA levels were found to be low in high pRb expressors: initial CEA level in the high pRb expressors was 2.31±3.30 ng/mL, and was 5.18±24.80 ng/mL in the low pRb expressors ( p = 0.033). Tumor depth and node metastasis were both independent of the levels of expression of p 53 and Rb proteins. The seven-year overall survival rate and relapse-free survival rates of patients were 87.2% and 75.7%, respectively. Multivariate Cox regression analysis indicated that tumor stage, tumor size, patient age and pRb expression were the significant prognostic factors with regard to overall survival, and tumor stage and age were both significant factors with regard to relapse-free survival. Conclusion Immunohistochemical staining of retinoblastoma gene products was an independent prognostic factor for the prediction of overall survival in curatively resected gastric cancer patients.

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  2. [국내논문]   Long-term Predictive Factors of Major Adverse Cardiac Events in Patients with Acute Myocardial Infarction Complicated by Cardiogenic Shock  

    Bae, Eun Hui (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea. ) , Lim, Sang Yup (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea. ) , Jeong, Myung Ho (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea. ) , Park, Hyung Wook (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea. ) , Lim, Ji Hyun (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea. ) , Hong, Young Joon (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea. ) , Kim, Weon (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, K) , Kim, Ju Han , Cho, Jeong Gwan , Ahn, Young Keun , Park, Jong Chun , Suh, Soon Pal , Ahn, Byoung Hee , Kim, Sang Hyung , Kang, Jung Chaee
    The Korean journal of internal medicine : KJIM v.20 no.1 ,pp. 8 - 14 , 2005 , 1226-3303 ,

    초록

    Background Cardiogenic shock (CS) after acute myocardial infarction (AMI) develops in 5~10% of patients and it is associated with high mortality. The aim of this study is to assess the predictive factors of mortality for patients with AMI and CS. Methods Two hundred fifty five AMI patients with CS (the mean age was 66.0±11.0 years, M:F=156:99) out of 1,268 AMI patients who admitted at Chonnam National University Hospital between July 2000 and June 2002 were analyzed according to the clinical characteristics, coronary angiographic findings and MACE during admission and for the 1-year clinical follow-up. Results Among the enrolled patients, 129 patients survived without MACE (Group I, mean age 64.2±10.6 years, M:F=76:53), and 126 patients had MACE (Group II, mean age 68.1±10.0 years, M:F=80:46) during admission or during the 1-year follow-up period. There were significant differences in age between the Groups I and II (64.2±10.6 vs. 68.1±11.0 years, respectively, p = 0.004) and the previous MI history (0 vs. 17.4%, respectively, p p p = 0.017, 3.8±0.48 vs. 9.9±1.21 mg/dL, p p = 0.004). In-hospital death was associated with low Thrombolysis In Myocardial Infarction (TIMI) flow after coronary revascularization. Conclusion Old age, a previous MI history, high Tn and CRP, low EF and LMSL are associated with higher MACE for patients with AMI and CS. Coronary revascularization with TIMI 3 flow lowers the in-hospital mortality.

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  3. [국내논문]   The Effects of QRS Duration and Pacing Sites on the Acute Hemodynamic Changes during Right Ventricular Pacing  

    Hong, Young Joon (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea. ) , Yang, Bo Ra (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea. ) , Sim, Doo Seon (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea. ) , Lim, Sang Yup (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea. ) , Lee, Sang Hyun (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea. ) , Lim, Ji Hyun (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea. ) , Kim, Han Gyun (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, K) , Park, Ok Young , Kim, Ju Han , Kim, Weon , Kim, Nam Ho , Ahn, Young Keun , Jeong, Myung Ho , Cho, Jeong Gwan , Park, Jong Chun , Kang, Jung Chaee
    The Korean journal of internal medicine : KJIM v.20 no.1 ,pp. 15 - 20 , 2005 , 1226-3303 ,

    초록

    Background Has been reported that patients exhibiting prolonged paced QRS duration tend to have more serious heart disease, and the paced QRS duration can be an effective indicator of impaired left ventricular function. However, the acute and chronic hemodynamic effects of paced QRS duration and pacing sites during right ventricular (RV) pacing remain unknown. Methods A total of 14 patients who underwent electrophysiologic study for paroxysmal supraventricular tachycardia were examined. RV pacing was performed at 10 different sites with cycle lengths of 600 ms and 500 ms utilizing a 6-7F deflectable quadripolar electrode catheter. Systolic, diastolic, and mean blood pressures during pacing were measured once the blood pressure was stabilized. Results During RV pacing, blood pressures (systolic/diastolic/mean) decreased. The change of post-pacing QRS duration and pre-pacing the systolic blood pressure (SBP) were greater in the group with paced QRS duration. The differences overall were greater than 140 ms. The SBP decrease during pacing was larger in the group exhibiting paced QRS duration of greater than 140 ms. The SBP decrease during pacing showed relation to QRS duration during pacing ( r = 0.500, p = 0.001), the change of QRS duration post-pacing ( r = 0.426, p = 0.001), and SBP during sinus rhythm ( r = 0.342, p = 0.001) on linear correlation analysis. The pacing site, on the other hand, did not affect acute hemodynamic changes during pacing. Conclusion Ventricular pacing of less than 40 ms at the area of paced QRS duration is recommended.

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  4. [국내논문]   Terminal QRS Complex Distortion on the Admission Electrocardiogram in Anterior Acute Myocardial Infarction and Association with Residual Flow and Infarct Size after Primary Angioplasty  

    Yang, Hyun Suk (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. ) , Lee, Cheol Whan (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. ) , Hong, Myeong-Ki (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. ) , Moon, Dae-Hyuk (Department of Nuclear Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. ) , Kim, Young-Hak (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. ) , Lee, Sang-Gon (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. ) , Han, Ki-Hoon (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. ) , Kim, Jae-Joong (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. ) , Park, Seong-Wook (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. ) , Park, Seung-Jung (De)
    The Korean journal of internal medicine : KJIM v.20 no.1 ,pp. 21 - 25 , 2005 , 1226-3303 ,

    초록

    Background Terminal QRS complex distortion on admission is a simple and reliable predictor of infarct size in patients with acute myocardial infarction (AMI). It is uncertain, however, whether this reflects reduced myocardial perfusion of the infarct area and a larger area of the myocardium at risk. This study was conducted to investigate whether terminal QRS distortion complex on admission is a reliable predictor of reduced residual flow and a larger area of the myocardium at risk compared to patients who are admitted without a terminal QRS distortion. Methods We evaluated the relationship between terminal QRS complex distortion and residual flow to the infarct zone and risk area in 46 anterior AMI patients undergoing primary angioplasty. 99m Tc-sestamibi imaging was performed at baseline and 5-9 days after angioplasty. The study population was divided into those with (Group I, n=16) and without (Group II, n=30) terminal QRS complex distortion. Results Baseline characteristics were similar between the two groups. The area of the myocardium at risk was higher in Group I (59.9±15.3%) than in Group II (48.6±13.7%, p p p Conclusion Terminal QRS complex distortion seems to be associated with less residual flow to the infarct zone, a larger risk area and greater infarct size in patients with anterior AMI.

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  5. [국내논문]   Correlation Between Levels of N-terminal Pro-B-Type Natriuretic Peptide and Degrees of Heart Failure  

    Song, Bong Geun (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Center, Seoul, Korea. ) , Jeon, Eun Seok (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Center, Seoul, Korea. ) , Kim, Yong Hoon (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Center, Seoul, Korea. ) , Kang, Min Kyung (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Center, Seoul, Korea. ) , Doh, Joon Hyung (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Center, Seoul, Korea. ) , Kim, Phil Ho (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Center, Seoul, Korea. ) , Ahn, Seok Jin (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Ce) , Oh, Hye Lim , Kim, Hyun-Joong , Sung, Ji Dong , Lee, Sang Chol , Gwon, Hyeon Cheol , Kim, June Soo , Kim, Duk-Kyung , Lee, Sang Hoon , Hong, Kyung Pyo , Park, Jeong Euy , Lee, Soo Youn , Lee, Jong Koo
    The Korean journal of internal medicine : KJIM v.20 no.1 ,pp. 26 - 32 , 2005 , 1226-3303 ,

    초록

    Background The N-terminal fragment of pro Brain Natriuretic Peptide (NT-pro BNP) is a neuro-hormone synthesized in the cardiac ventricles in response to increased wall tension. The purpose of this study was to assess the correlation between the NT-pro BNP levels and the New York Heart Association function class (NYHA Fc) of dyspnea and echocardiographic findings for the patients who visited our cardiology departments. Methods From October, 2002 to April, 2003, serum NT-pro BNP levels were measured in 348 patients who visited the Samsung Medical Center and the Jong Koo Lee Heart Clinic. Results The NT-pro BNP levels were increased with the progression of NYHA Fc of dyspnea ( p p p p p p p p = 0.017), the left ventricular internal dimension as well as the decrease in the ejection fraction ( p Conclusion The NT-pro BNP levels were positively correlated with the NYHA Fc of dyspnea and the systolic dysfunction for the patients who visited our cardiology departments. A 300 pg/mL value for the NT-pro BNP cut-off point appears to be a sensitive level to differentiate dyspnea originating from an ailing heart or not for the patients who visited our cardiology departments.

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  6. [국내논문]   Overweight and Effect of Hormone Replacement Therapy on Lipid Profiles in Postmenopausal Women  

    Ko, Hong Sook (Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. ) , Kim, Chee Jeong (Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. ) , Ryu, Wang Seong (Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.)
    The Korean journal of internal medicine : KJIM v.20 no.1 ,pp. 33 - 39 , 2005 , 1226-3303 ,

    초록

    Background Many experimental and observational studies have suggested that hormone replacement therapy (HRT) in postmenopausal women is cardioprotective. However, the results of randomized controlled trials have been discouraging. We attempted to evaluate the influence of overweight, a frequent risk factor for coronary artery disease, on the lipid-modifying effects of HRT. Methods A total of 345 postmenopausal women were divided into 2 groups according to body mass index (BMI): the control group; BMI 2 (n=248) and the overweight group; BMI≥25 Kg/m 2 (n=97). All women received either 0.625 mg conjugated equine estrogen (CEE)(n=139), CEE plus 5 mg medroxyprogesterone acetate (MPA)(n=97) or CEE plus 10 mg MPA (n=109). Lipid profiles were measured before and 12 months after HRT. Results In both the control and overweight groups, HRT reduced low density lipoprotein cholesterol (LDL-C) ( p = 0.000 and p = 0.000 respectively) and lipoprotein (a) [Lp(a)] levels ( p = 0.000 and p = 0.000 respectively) and raised high density lipoprotein cholesterol (HDL-C) levels ( p = 0.000 and p = 0.002 respectively). However, the elevation of the HDL-C level was higher in the control group than in overweight group (17.5% vs. 10.4%, p = 0.015), and this was significant after adjusting for changes in body weights ( p = 0.016). There were no differences in the reduction of LDL-C ( p = 0.20) and Lp(a) ( p = 0.09) levels between the two groups. Conclusion HRT had less favorable effects on HDL-C levels in overweight postmenopausal women than in women with normal body weight. This finding may be partially associated with no cardioprotective effect of HRT in postmenopausal patients at a high risk due to multiple risk factors including obesity.

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  7. [국내논문]   Effect of IgA Aggregates on Transforming Growth Factor-β1 Production in Human Mesangial Cells and the Intraglomerular Expression of Transforming Growth Factor-β1 in Patients with IgA Nephropathy  

    Han, Sang-Youb (Department of Internal Medicine, Inje University College of Medicine, Go-yang, Korea. ) , Ihm, Chun-Gyoo (Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, Korea. ) , Cha, Dae-Ryong (Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea. ) , Kang, Young-Sun (Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea. ) , Han, Kum-Hyun (Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea. ) , Kim, Hyoung-Kyu (Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea. ) , Han, Jee-Young (Department of Pathology, College of Medicine, Inha University, Incheon, Korea.)
    The Korean journal of internal medicine : KJIM v.20 no.1 ,pp. 40 - 47 , 2005 , 1226-3303 ,

    초록

    Background Transforming growth factor-β (TGF-β) stimulates renal fibrosis in various renal diseases including IgA nephropathy. Methods We examined whether immunoglobulin A (IgA) stimulated TGF-β1 synthesis in human mesangial cells (MCs), and whether this effect was mediated through the protein kinase C (PKC) pathway. We measured the intraglomerular TGF-β1 mRNA expression by using competitive RT-PCR, and this was compared with various parameters in IgA nephropathy patients. Results The IgA aggregate increased the TGF-β1 mRNA expression in MCs, while this expression was not affected by the culture media or IgG aggregate. Phorbol 12-myristate 13-acetate and calphostin C did not influence the TGF-β1 mRNA expression that was increased by the IgA aggregate. Intraglomerular TGF-β1 mRNA expression was significantly correlated with creatinine clearance (r=-0.764, p = 0.027), daily proteinuria (r=0.781, p = 0.022), serum creatinine (r=0.884, p = 0.004), and tubulointerstitial changes (r=0.809, p = 0.015). Glomerular TGF-β1 mRNA expression was associated with an increased tendency for glomerulosclerosis (r=0.646, p = 0.084). After 4 years, patients with a high expression of intraglomerular TGF-β1 mRNA showed a tendency for an decrease of their renal function. Conclusion The IgA aggregate increased TGF-β1 mRNA expression in MCs, and this was independent of the PKC pathway. The evaluation of intraglomerular TGF-β1 mRNA expression could be useful in predicting the progression of IgA nephropathy.

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  8. [국내논문]   Diabcare Asia 2001 - Korea : Country Report on Outcome Data and Analysis  

    Rhee, Sang Youl (Department of Endocrinology and Metabolism, School of Medicine, Kyung Hee University, Seoul, Korea. ) , Kim, Young Seol (Department of Endocrinology and Metabolism, School of Medicine, Kyung Hee University, Seoul, Korea. ) , Oh, Seungjoon (Department of Endocrinology and Metabolism, School of Medicine, Kyung Hee University, Seoul, Korea. ) , Choi, Woong Hwan (Department of Endocrinology and Metabolism, Hanyang University College of Medicine, Seoul, Korea. ) , Park, Jong Eun (Park's IM Clinic, Seoul, Korea. ) , Jeong, Woo Jin (Jeong's IM Clinic, Seoul, Korea.)
    The Korean journal of internal medicine : KJIM v.20 no.1 ,pp. 48 - 54 , 2005 , 1226-3303 ,

    초록

    Background The Diabcare-Asia study was designed for the purpose of describing diabetes control and management, and late complication status in the diabetic population. Methods From the 1 st of July 2001 to the 1 st of September 2001, data from 1170 diabetic patients were collected in 21 centers (one university hospital and 20 clinics located in Seoul and in Gyeonggi, Korea), and blood samples were collected for centralized HbA1c measurements. Results Only 16.8% of patients at the clinics reported self-monitoring their blood glucose. The mean HbA 1c was 7.3±1.4% at the hospital and 7.5±1.5% at the clinics, and the mean fasting plasma glucose (FPG) levels were 7.0±3.3 mmol/L at the hospital and 7.9±2.5 mmol/L at the clinics. About 40% of patients had a HbA 1c and FPG above the normal upper limits. Screening for microalbuminuria was rarely performed. The available data represents only about 0.9% of the patients at the hospital and 12.3% of the patients at the clinics. Nephropathy (serum creatinine >2 mg/dL) was found in 0.8% of the patients at the hospital and in 3.4% of the patients at the clinics. Retinopathy and neuropathy were commonly reported diabetic complications. The prevalence of other severe late complications was relatively low. Conclusion The data revealed suboptimal glycemic control in about 40% of patients.

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  9. [국내논문]   Prevalence and Molecular Epidemiology of Vancomycin-Resistant Enterococci (VRE) Strains Isolated from Animals and Humans in Korea  

    Song, Joon Young (Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. ) , Hwang, In Sook (Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. ) , Eom, Joong Sik (Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. ) , Cheong, Hee Jin (Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. ) , Bae, Won Ki (Depatment of Microbiology, Seoul National University College of Veterinary Medicine, Seoul, Korea. ) , Park, Yong Ho (Depatment of Microbiology, Seoul National University College of Veterinary Medicine, Seoul, Korea. ) , Kim, Woo Joo (Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.)
    The Korean journal of internal medicine : KJIM v.20 no.1 ,pp. 55 - 62 , 2005 , 1226-3303 ,

    초록

    Background To assess the possibility of VRE transmission from animals to humans, we studied the prevalence of vancomycin-resistant enterococci (VRE) in farm animals, raw chicken meat, and healthy people. We then determined the molecular relatedness of VRE isolates between animals and humans in Korea. Methods We aimed to isolate VRE from 150 enterococci specimens of farm animals, 15 raw chicken meat samples, and stools from 200 healthy people. Species differentiation was done with conventional biochemical tests. Vancomycin resistance genotyping was done by polymerase chain reaction (PCR). Using the agar dilution method, antimicrobial susceptibility was tested for 8 antimicrobials and pulsed-field gel electrophoresis (PFGE) was done to evaluate the molecular relatedness of VRE isolates. Results The prevalence of VRE was 14.7% (22/150) in farm animal specimens, 1% (2/200) in healthy people, and 60% (9/15) in raw chicken meat. Of 22 animal VRE isolates, 1 vanA E. faecium , 15 vanC1 E. gallinarum , and 6 vanC2 E. casseliflavus were identified. All of the 9 VRE from raw chicken meat and all of the 20 clinical VRE strains were vanA E. faecium . However, in healthy people, only 2 vanC2 E. casseliflavus were isolated. These showed low-level resistance to vancomycin and susceptibility to teicoplanin. However, 9 VRE strains from raw chicken meat had high-level resistance to vancomycin (MIC 50,90 : >128 μg/mL), teicoplanin (MIC 50,90 : >128 μg/mL), ampicillin (MIC 50,90 : >128 μg/mL), erythromycin (MIC 50,90 : >128 μg/mL), and tetracycline (MIC 50,90 : 128/>128 μg/mL). Conclusion This study demonstrated little evidence of VRE colonization in healthy people despite high recovery of VRE among raw chicken meat. It is suggested that there is little evidence of VRE transmission from animals to healthy people. However, we assumed that there exists the possibility of VRE contamination during the processing of chicken meat.

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  10. [국내논문]   Visualization of Jejunal Bleeding by Capsule Endoscopy in a Case of Eosinophilic Enteritis  

    Kim, Nayoung (Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Korea. ) , Kim, Jin-Wook (Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Korea. ) , Hwang, Jin-Hyeok (Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Korea. ) , Lee, Dong Ho (Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Korea. ) , Lee, Hye Seung (Department of Pathology, Seoul National University Bundang Hospital, Seoungnam, Korea. ) , Lee, Kyoung Ho (Department of Radiology, Seoul National University Bundang Hospital, Seoungnam, Korea. ) , Kim, Sung-Won (Department of Surgery, Seoul National University Bundang Hospital, Seoungnam, Korea.)
    The Korean journal of internal medicine : KJIM v.20 no.1 ,pp. 63 - 67 , 2005 , 1226-3303 ,

    초록

    Eosinophilic enteritis is a rare disease characterized by tissue eosinophilia, which can affect different layers of bowel wall. Normally, the disease presents as colicky abdominal pain, and rarely as an acute intestinal obstruction or perforation. In this paper, we report a case of eosinophilic enteritis, hitherto unreported, presenting as an ileal obstruction, and followed by jejunal bleeding, which was visualized by capsule endoscopy. A 62-year-old man received a 15 cm single segmental ileal resection at a point 50 cm from the IC valve due to symptoms of obstruction, which were diagnosed as eosinophilic enteritis. Seventeen days after operation, intermittent abdominal pain occurred again, and subsided upon 30 mg per day treatment with prednisolone. Fourteen days after this pain attack, the patient exhibited hematochezia, in spite of continuous prednisolone treatment. Capsule endoscopy showed fresh blood spurting from the mid-to-distal jejunum, in the absence of any mass or ulcer. This hematochezia rapidly disappeared following a high-dose steroid injection, suggesting it was a manifestation of jejunal eosinophilic enteritis.

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