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The Korean journal of internal medicine : KJIM 16건

  1. [국내논문]   Comparison of the Clinical Features of Apical Hypertrophic Cardiomyopathy Versus Asymmetric Septal Hypertrophy in Korea  

    Yang, Hyun Suk (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Song, Jae-Kwan (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Song, Jong-Min (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Kang, Duk-Hyun (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Lee, Cheol Whan (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Hong, Myeong-Ki (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Kim, Jae-Joong (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Park, Seong-Wook (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Park, Seung-Jung (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.)
    The Korean journal of internal medicine : KJIM v.20 no.2 ,pp. 111 - 115 , 2005 , 1226-3303 ,

    초록

    Background We sought to test whether patients with apical hypertrophic cardiomyopathy (APH) have different clinical features compared to those with typical asymmetric septal hypertrophy (ASH). Methods Among 32,534 patients who underwent routine echocardiography at Asan Medical Center from January 2000 to December 2001, 305 patients (0.9%), who were finally diagnosed with hypertrophic cardiomyopathy (HCMP), were evaluated. The type of HCMP was classified according to the echocardiographic findings. Results ASH was the most frequent type (n=160, 53%, group I), and APH was the second most frequent (n=91, 30%, group II). Mean age (60.8±10 vs. 48.2±14 years, p p = 0.022) were significantly higher in group II than in group I. Family history of HCMP (4.4% vs. 0% p = 0.043) and sudden cardiac death (8.8% vs. 1.1% p = 0.014) was more prevalent in group I. During the follow-up period of 32.0± 37.2 months, cardiac events occurred at a significantly higher rate in group I (25.5% vs. 8.8%, p = 0.003). Conclusion APH comprises a significant proportion of HCMP in Korea and patients with APH show different clinical features compared to those with ASH.

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  2. [국내논문]   High frequency of microsatellite instability in intestinal-type gastric cancer in Korean patients.  

    Choe, Won Hyuk , Lee, Sun-Young , Lee, Jun Haeng , Shim, Sang Goon , Kim, Young-Ho , Rhee, Poong-Lyul , Rhee, Jong Chul , Ki, Chang-Seok , Kim, Jong-Won , Song, Sang Yong , Kim, Jae J
    The Korean journal of internal medicine : KJIM v.20 no.2 ,pp. 116 - 122 , 2005 , 1226-3303 ,

    초록

    Although there have been some reports on microsatellite alterations in gastric cancer, findings are inconsistent regarding the associations between histological classification and microsatellite instability (MSI). In the present study, we attempted to determine whether Lauren's histological subtypes are related with MSI status.

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  3. [국내논문]   The Effects of Methylene Blue on Hemodynamic Parameters and Cytokine Levels in Refractory Septic Shock  

    Park, Byung-Kyu (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Shim, Tae-Sun (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Lim, Chae-Man (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Lee, Sang-Do (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Kim, Woo-Sung (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Kim, Dong-Soon (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Kim, Won-Dong (Division of Pulmonary and Critical) , Koh, Younsuck
    The Korean journal of internal medicine : KJIM v.20 no.2 ,pp. 123 - 128 , 2005 , 1226-3303 ,

    초록

    Background/Aims Endogenous nitric oxide (NO) induces the peripheral vasodilation via the activation of guanylate cyclase in patients with septic shock. The purpose of this study was to assess the acute effects of methylene blue (MB), which is an inhibitor of guanylate cyclase, on the hemodynamics and on the production of pro-inflammatory cytokines and nitric oxide (NO) in patients with refractory septic shock. Methods Twenty consecutive patients with refractory septic shock, which was defined as shock refractory to a dopamine infusion of more than 20 μg/kg/min with the appropriate use of antibiotics and adequate volume replacement, received MB infusion of 1 mg/kg intravenously. The hemodynamic and respiratory variables were measured at baseline, 30, 60 and 120 min after an infusion of MB (1 mg/kg). The blood levels of NO, IL-1, IL-10 and TNF-α were measured at baseline, 30 and 120 min after MB infusion. Results The administration of MB induced an increase in the systemic vascular resistance (SVR) that resulted in an increase of the mean arterial pressure (MAP) in patients with refractory septic shock, and this was without a decrease in cardiac output. The administered MB induced an increase in pulmonary vascular resistance (PVR) that resulted in an increase of pulmonary arterial pressure (PAP), without any deterioration of gas exchange. However, the increases in SVR and PVR were not associated with the alteration of endogenous production of NO, IL-1, IL-10 and TNF-α. Conclusion MB transiently elevated the MAP by increasing the SVR without altering the endogenous productions of NO, IL-1, IL-10 and TNF-α during the study period in patients with refractory septic shock.

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  4. [국내논문]   Clinical Aspects of Pregnancy and Delivery in Patients with Chronic Idiopathic Thrombocytopenic Purpura (ITP)  

    Won, Young-Woong (Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. ) , Moon, Won (Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. ) , Yun, Yeong-Seop (Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. ) , Oh, Ho-Suk (Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. ) , Choi, Jung-Hye (Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. ) , Lee, Young-Yeul (Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. ) , Kim, In-Soon (Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. ) , Choi, Il-Young (Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. ) , Ahn, Myung-Ju (Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.)
    The Korean journal of internal medicine : KJIM v.20 no.2 ,pp. 129 - 134 , 2005 , 1226-3303 ,

    초록

    Background Idiopathic thrombocytopenic purpura (ITP) is a condition that often develops in young women and, consequently, physicians should frequently manage and monitor pregnant patients with this disorder. Methods We reviewed the charts of 30 women with chronic ITP delivered in 31 pregnancies from January 1995 to December 2003. Results Fifteen patients were diagnosed with ITP before pregnancy and sixteen patients were diagnosed during pregnancy. The mean platelet counts before pregnancy, during pregnancy, and at delivery were 70,040/mm 3 , 83,960/mm 3 , and 62,680/mm 3 , respectively. The symptoms of hemostatic impairment were not noted in most of the pregnancies (77%, 24/31). During pregnancy and at delivery, most of the women (61%, 19/31) received various kinds of treatment to raise platelet counts. At delivery, the most commonly used therapy was platelet transfusion (48.4%, 15/31). Seven pregnancies (22.6%) were treated with corticosteroids during pregnancy and at delivery. Five pregnancies (16.1%) were treated with IV IgG during pregnancy and at delivery. Fifteen deliveries (51.7%) were performed by cesarean section and fourteen (48.3%) with vaginal delivery. Bleeding was uncommon at delivery. There were no cases of infants with any clinical signs of hemorrhage. Conclusion Our current results suggest that ITP in pregnancy can proceed safely with low hemorrhagic risk in both infants and mothers, and that mothers with ITP can deliver healthy infants without serious hemorrhagic complications

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  5. [국내논문]   The Efficacy of Paclitaxel and Cisplatin Combination Chemotherapy for the Treatment of Metastatic or Recurrent Gastric Cancer: a Multicenter Phase II Study  

    Shin, Sang Joon (Division of Oncology-Hematology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. ) , Chun, Sung Ho (Division of Oncology-Hematology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. ) , Kim, Kyeong Ok (Division of Oncology-Hematology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. ) , Kim, Min Kyoung (Division of Oncology-Hematology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. ) , Lee, Kyung Hee (Division of Oncology-Hematology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. ) , Hyun, Myung Soo (Division of Oncology-Hematology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. ) , Bae, Sung Hwa (Department of Internal Medicine, Daegu Catholic University Hospital, Daegu, Korea. ) , Ryoo, Hun Mo (Department of Internal Medicine, Daegu Catholic University Hospital, Daegu, Korea. ) , Do, Young Rok (Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. ) , Kwon, Ki Young (Dep) , Song, Hong Suk
    The Korean journal of internal medicine : KJIM v.20 no.2 ,pp. 135 - 140 , 2005 , 1226-3303 ,

    초록

    Background Although many treatments for advanced gastric cancer have been developed, only poor treatment results have generally been obtained. We performed a prospective study on the combination chemotherapy of paclitaxel and cisplatin (PC). The primary objectives of the study were elucidating the disease response and evaluating the drug regimen's safety. Methods Patients with metastatic or recurrent gastric cancer received intravenous paclitaxel 175 mg/m 2 , and cisplatin 70 mg/m 2 on day 1. This cycle was repeated every 3 weeks. Results From January 2000 to March 2004, 37 patients from 3 different hospitals were enrolled in this study. A total of 135 treatment cycles (median: 3 cycles) were administered. The responses were evaluable in 34 patients; 24 patients received this regimen as their first-line treatment for metastatic cancer and the other patients received it as their second-line treatment for recurrent cancer. The objective response rate (RR) was 26.5% (95% CI: 11.7-41.3) with two complete responses, and stable disease was observed in 41.1% of the patients. Importantly, an RR of 33.3% (95% CI: 0.6-66.0) was achieved for the eight patients who received this regimen as a first-line treatment. The median follow up duration was 14 months for all the patients, and the median time to progression was 6 months (95% CI: 1.9-10.2). The overall survival time was 8.9 months (95% CI: 7.0-11.0) with a 1-year survival rate of 18.7% (95% CI: 5.6-31.8). The most common toxicity was neutropenia. Conclusion PC exhibited promising activity against gastric cancer for the previously untreated patients as a first-line treatment with an acceptable toxicity profile.

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  6. [국내논문]   Digitized QT dispersion by the Valsalva Maneuver in Hypertensive Patients  

    Yoon, Hee-Jeoung (Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. ) , Jin, Seung-Won (Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. ) , Lee, Jong-Min (Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. ) , Shin, Woo-Seung (Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. ) , Oh, Yong-Suk (Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. ) , Lee, Man-Young (Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. ) , Seung, Ki-Bae (Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. ) , Rho, Tai-Ho (Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea College of Medicine,) , Kim, Jae-Hyung , Hong, Soon-Jo , Choi, Kyu-Bo
    The Korean journal of internal medicine : KJIM v.20 no.2 ,pp. 141 - 145 , 2005 , 1226-3303 ,

    초록

    Background Hypertension is an important risk factor for sudden cardiac death, of which the incidence increases with increases in blood pressure. Prolonged QT dispersion has been identified to indicate increased risk of life-threatening ventricular arrhythmia and sudden cardiac death. In this study, QT dispersion was investigated in hypertensive patients during the strain phase of the Valsalva maneuver. Methods The study population included 75 subjects: 25 with normal blood pressure (Control), 25 with stage I hypertension (Group A), and 25 with stage II hypertension (Group B). Electrocardiography for QT dispersion was recorded at 25 mm/sec paper speeds before and during the Valsalva maneuver. Results The patients in Group B were significantly older than the controls ( p p p Conclusion The conditions that increase intrathoracic pressure may increase QT dispersion and severe hypertensive patients should avoid these conditions.

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  7. [국내논문]   Increased Expression of Glucocorticoid Receptorβ Messenger RNA in Patients with Ankylosing Spondylitis  

    Lee, Chang-Keun (Division of Allergy and Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Lee, Eun Young (Division of Allergy and Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Cho, You-Sook (Division of Allergy and Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Moon, Keun Ae (Asan Institute for Life Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Yoo, Bin (Division of Allergy and Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Moon, Hee-Bom (Division of Allergy and Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.)
    The Korean journal of internal medicine : KJIM v.20 no.2 ,pp. 146 - 151 , 2005 , 1226-3303 ,

    초록

    Background Glucocorticoids have been known to be less effective for treating ankylosing spondylitis (AS) patients than for treating rheumatoid arthritis (RA) patients. To elucidate the mechanisms underlying this phenomenon, we evaluated whether the glucocorticoid receptor (GR)β expression of the peripheral blood mononuclear cells (PBMCs) in patients with AS is increased compared with patients with RA. Methods PBMCs were isolated from the subjects of 3 study groups: the healthy controls (n=25), the RA patients (n=25), and the AS patients (n=25). All the subjects had never taken corticosteroids and the patients with RA or AS were newly diagnosed. The expression of GRβ messenger RNA (mRNA) was determined by reverse transcription of the total RNA, and this was followed by semi-quantitative polymerase chain reaction analysis (RT-PCR). Results The level of GRα mRNA expression was not different among three groups. GRβ mRNA expression of the AS patients (2.02 [range: 0.99-7.21], median [25 th -75 th percentiles]) was enhanced compared with that of the controls (0.78 [range: 0.43-1.62]) and the RA patients (0.98 [range: 0.79-1.18]). The level of GRβ mRNA expression was not related to the inflammatory markers or the disease activity score 28 for the RA patients, and it was not related to the Bath ankylosing spondylitis disease activity index for the AS patients. Conclusion The expression of GRβ mRNA, which is a dominant negative regulator for the glucocorticoid response, was increased in AS patients. The results suggest that the increased expression of GRβ mRNA may be related to the ineffectiveness of glucocorticoids for the treatment of AS.

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  8. [국내논문]   Comparison of Asthma Phenotypes Using Different Sensitizing Protocols in Mice  

    Chang, Yoon-Seok (Department of Internal Medicine, College of Medicine, Seoul National University Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea. ) , Kim, Yoon-Keun (Department of Internal Medicine, College of Medicine, Seoul National University Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea. ) , Bahn, Joon-Woo (Department of Internal Medicine, College of Medicine, Seoul National University Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea. ) , Kim, Sang-Heon (Department of Internal Medicine, College of Medicine, Seoul National University Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, and Clinical Research Institute, Seou) , Park, Heung-Woo , Kim, Tae-Bum , Cho, Sang-Heon , Min, Kyung-Up , Kim, You-Young
    The Korean journal of internal medicine : KJIM v.20 no.2 ,pp. 152 - 158 , 2005 , 1226-3303 ,

    초록

    Background Several methods have been reported to induce asthmatic reactions in mice but few studies have compared their efficiency. We evaluated the efficiency of the protocols frequently used in the literature. Methods BALB/c mice were sensitized to ovalbumin (OVA) by intraperitoneal injection; 1] Once a week for two weeks using OVA with alum (IPOA-2) or without (IPO-2), and provocation on days 28-30 by 1% OVA inhalation; 2] seven times for two weeks by OVA with alum (IPOA-7) or without (IPO-7) and provocation by 1% OVA inhalation on days 42-44. 3] Sensitization by 1% OVA inhalation for ten days (IHO-10) and provocation by 1% OVA inhalation on days 28-30. After the last challenge, airway hyperresponsiveness was measured with single chamber plethysmography 24 hours later and mice were sacrificed 48 hours later. Results Airway hyperresponsiveness, BALF eosinophilia, airway inflammation, and OVA-specific IgE and IgG1 production were effectively induced in IPOA-2, IPOA-7, and IPO-7. However, these phenotypes were not induced in IPO-2 (except for increased BALF eosinophils) or IHO-10 (except for an increased OVA-specific IgG1 level). Conclusion The intraperitoneal injections of OVA with alum once a week for two weeks proved to be the most efficient sensitization method of inducing an asthmatic reaction in mice.

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  9. [국내논문]   Kimura's Disease Involving Thoracic and Abdominal Lymph Nodes in a Hemodialysis Patient  

    Lee, Sik (Department of Internal Medicine, Chonbuk National University Medicial School, Jeonju, Korea. ) , Jung, Su Jin (Department of Internal Medicine, Chonbuk National University Medicial School, Jeonju, Korea. ) , Park, Sung Kwang (Department of Internal Medicine, Chonbuk National University Medicial School, Jeonju, Korea. ) , Kang, Kyung Pyo (Department of Internal Medicine, Chonbuk National University Medicial School, Jeonju, Korea. ) , Jang, Kyu Yun (Department of Pathology, Chonbuk National University Medicial School, Jeonju, Korea. ) , Kang, Myoung Jae (Department of Pathology, Chonbuk National University Medicial School, Jeonju, Korea. ) , Kim, Won (Department of Internal Medicine, Chonbuk National University Medicial School, Jeonju, Korea.)
    The Korean journal of internal medicine : KJIM v.20 no.2 ,pp. 159 - 162 , 2005 , 1226-3303 ,

    초록

    We report the first observed case of Kimura's disease occurring during hemodialysis, involving the thoracic and abdominal lymph nodes, which spontaneously resolved nearly completely after two months. Early diagnosis and recognition of Kimura's disease may spare both the patient and doctor from the need for unnecessary invasive diagnostic procedures. Therefore, we emphasize that we need to have a high index of suspicion regarding Kimura's disease.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  10. [국내논문]   Autoimmune Chronic Pancreatitis Relapsing Despite the Maintenance Dose of Steroid  

    Pyun, Dae Keun (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Choi, Won Beom (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Kim, Myung Hwan (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Yun, Jae Pil (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Lee, Sang Su (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Seo, Dong Wan (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ) , Lee, Sung Koo (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.)
    The Korean journal of internal medicine : KJIM v.20 no.2 ,pp. 163 - 167 , 2005 , 1226-3303 ,

    초록

    Autoimmune chronic pancreatitis is a disease characterized by diffuse swelling of the pancreas, irregular narrowing of the main pancreatic duct and elevated levels of serum IgG, and lymphoplasmacytic infiltration is observed on histologic examination. Steroid therapy can dramatically reverse the clinical symptoms and the histologic and radiologic findings. It is known that recurrence is very rare after successful steroid treatment. Furthermore, there have not yet been any reports about a case that relapsed during maintenance therapy with low dose steroid. We experienced a rare case of autoimmune chronic pancreatitis that relapsed despite maintenance therapy with low-dose steroid, and the patient again responded to high-dose steroid.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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