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Parkinsonism & related disorders 26건

  1. [해외논문]   Editorial Board   SCIE


    Parkinsonism & related disorders v.52 ,pp. i - i , 2018 , 1353-8020 ,

    초록

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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    Fig. 1 이미지
  2. [해외논문]   Consensus for the measurement of the camptocormia angle in the standing patient   SCIE

    Margraf, Nils G. (Department of Neurology, UKSH, Christian-Albrechts University Kiel, Germany ) , Wolke, Robin (Department of Neurology, UKSH, Christian-Albrechts University Kiel, Germany ) , Granert, Oliver (Department of Neurology, UKSH, Christian-Albrechts University Kiel, Germany ) , Berardelli, Alfredo (Department of Human Neuroscience, Sapienza, University of Rome and IRCCS NEUROMED, Pozzilli, Italy ) , Bloem, Bastian R. (Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Nijmegen, The Netherlands ) , Djaldetti, Ruth (Department of Neurology, Movement Disorder Unit, Rabin Medical Center, Petach Tiqva and the Sackler Faculty of Medicine, Ramat Aviv, Tel Aviv, Israel ) , Espay, Alberto J. (Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA ) , Fasano, Alfonso (Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada ) , Furusawa, Yoshihiko (National Center of Neurology & Psychiatry, Tokyo, Japan ) , Giladi, Nir (Neurologica) , Hallett, Mark , Jankovic, Joseph , Murata, Miho , Tinazzi, Michele , Volkmann, Jens , Berg, Daniela , Deuschl, Gü , nther
    Parkinsonism & related disorders v.52 ,pp. 1 - 5 , 2018 , 1353-8020 ,

    초록

    Abstract Introduction Camptocormia is characterized by a pathological forward flexion of the trunk, which is reversible when lying and worsened by standing and walking. So far there is no consensus on how to measure the angle of flexion, and studies therefore give differing results. Harmonization is needed for both research and clinical practice. Orthopedic measures are not useful for this purpose. Methods Two expert raters independently analyzed the photographs of 39 Parkinson patients with camptocormia while standing. They used four different methods to determine the camptocormia angle. The results were compared statistically. An international Consensus Group reviewed the results and drafted recommendations. Results The four methods yielded camptocormia angles that differed by up to 50% in the same patient. Inter-rater reliability and test-retest reliability also differed, but were satisfactory to excellent. Conclusion This Consensus Group concluded that two of the methods qualified as reliable measures of the trunk angles in standing patients based on their clinimetric properties. They propose that the ‘total camptocomia angle’ be the angle between the line from the lateral malleolus to the L5 spinous process and the line between the L5 spinous process and the spinous process of C7. They also propose that the ‘upper camptocormia angle’ be the angle of the lines between the vertebral fulcrum to the spinous processes of L5 and C7, respectively. An app is provided on the web for these measurements (http://www.neurologie.uni-kiel.de/de/axial-posturale-stoerungen/camptoapp). Highlights There is no agreement on how to measure the camptocormia angle. Therefore studies on camptocormia are not comparable. In this paper four different methods of angle assessment were empirically evaluated regarding reliability and face validity. A consensus could be reached to measure a total camptocormia angle and an upper camptocormia angle. Apps are available to measure these angles (http://www.neurologie.uni-kiel.de/de/axial-posturale-stoerungen/camptoapp).

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  3. [해외논문]   Camptocormia: a consensus for grading on a curve   SCIE

    Factor, Stewart A.
    Parkinsonism & related disorders v.52 ,pp. 6 - 6 , 2018 , 1353-8020 ,

    초록

    Abstract Introduction Camptocormia is characterized by a pathological forward flexion of the trunk, which is reversible when lying and worsened by standing and walking. So far there is no consensus on how to measure the angle of flexion, and studies therefore give differing results. Harmonization is needed for both research and clinical practice. Orthopedic measures are not useful for this purpose. Methods Two expert raters independently analyzed the photographs of 39 Parkinson patients with camptocormia while standing. They used four different methods to determine the camptocormia angle. The results were compared statistically. An international Consensus Group reviewed the results and drafted recommendations. Results The four methods yielded camptocormia angles that differed by up to 50% in the same patient. Inter-rater reliability and test-retest reliability also differed, but were satisfactory to excellent. Conclusion This Consensus Group concluded that two of the methods qualified as reliable measures of the trunk angles in standing patients based on their clinimetric properties. They propose that the ‘total camptocomia angle’ be the angle between the line from the lateral malleolus to the L5 spinous process and the line between the L5 spinous process and the spinous process of C7. They also propose that the ‘upper camptocormia angle’ be the angle of the lines between the vertebral fulcrum to the spinous processes of L5 and C7, respectively. An app is provided on the web for these measurements (http://www.neurologie.uni-kiel.de/de/axial-posturale-stoerungen/camptoapp). Highlights There is no agreement on how to measure the camptocormia angle. Therefore studies on camptocormia are not comparable. In this paper four different methods of angle assessment were empirically evaluated regarding reliability and face validity. A consensus could be reached to measure a total camptocormia angle and an upper camptocormia angle. Apps are available to measure these angles (http://www.neurologie.uni-kiel.de/de/axial-posturale-stoerungen/camptoapp).

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Freezing of gait: Promising avenues for future treatment   SCIE

    Gilat, Moran (Parkinson's Disease Research Clinic, Brain and Mind Centre, The University of Sydney, NSW, Australia ) , Lí (Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Department of Neurology, Nijmegen, The Netherlands ) , gia Silva de Lima, Ana (Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Department of Neurology, Nijmegen, The Netherlands ) , Bloem, Bastiaan R. (Parkinson's Disease Research Clinic, Brain and Mind Centre, The University of Sydney, NSW, Australia ) , Shine, James M. (Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Department of Rehabilitation, Nijmegen, The Netherlands ) , Nonnekes, Jorik (Parkinson's Disease Research Clinic, Brain and Mind Centre, The University of Sydney, NSW, Australia) , Lewis, Simon J.G.
    Parkinsonism & related disorders v.52 ,pp. 7 - 16 , 2018 , 1353-8020 ,

    초록

    Abstract Freezing of gait is a devastating symptom of Parkinson's disease and other forms of parkinsonism. It poses a major burden on both patients and their families, as freezing often leads to falls, fall-related injuries and a loss of independence. Treating freezing of gait is difficult for a variety of reasons: it has a paroxysmal and unpredictable nature; a multifaceted pathophysiology, with an interplay between motor elements (disturbed stepping mechanisms) and non-motor elements (cognitive decline, anxiety); and a complex (and likely heterogeneous) underlying neural substrate, involving multiple failing neural networks. In recent years, advances in translational neuroscience have offered new insights into the pathophysiology underlying freezing. Furthermore, the mechanisms behind the effectiveness of available treatments (or lack thereof) are better understood. Driven by these concepts, researchers and clinicians have begun to improve currently available treatment options, and develop new and better treatment methods. Here, we evaluate the range of pharmacological (i.e. closed-looped approaches), surgical (i.e. multi-target and adaptive deep brain and spinal cord stimulation) and behavioural (i.e. biofeedback and cueing on demand) treatment options that are under development, and propose novel avenues that are likely to play a crucial role in the clinical management of freezing of gait in the near future. The outcomes of this review suggest that the successful future management of freezing of gait will require individualized treatments that can be implemented in an on-demand manner in response to imminent freezing. With this review we hope to guide much-needed advances in treating this devastating symptom of Parkinson's disease. Highlights A better understanding of the aetiology of FOG allows for improved treatments. Promising pharmacological, surgical and behavioural treatments of FOG are described. Future FOG management requires personalized and on-demand strategies to treatment.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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    Fig. 1 이미지
  5. [해외논문]   The placebo effect on resting tremor in Parkinson's disease: an electrophysiological study   SCIE

    Barbagallo, Gaetano (Institute of Neurology, University “Magna Graecia”, Catanzaro, Italy ) , Nisticò (Neuroimaging Unit, IBFM, National Research Council, Catanzaro, Italy ) , , Rita (Biotecnomed, S.C.aR.L, Catanzaro, Italy ) , Vescio, Basilio (Neuroimaging Unit, IBFM, National Research Council, Catanzaro, Italy ) , Cerasa, Antonio (Neuroimaging Unit, IBFM, National Research Council, Catanzaro, Italy ) , Olivadese, Giuseppe (Neuroimaging Unit, IBFM, National Research Council, Catanzaro, Italy ) , Nigro, Salvatore (Neuroimaging Unit, IBFM, National Research Council, Catanzaro, Italy ) , Crasà (Institute of Neurology, University “Magna Graecia”, Catanzaro, Italy ) , , Marianna (Neuroimaging Unit, IBFM, National Research Council, Catanzaro, Italy ) , Quattrone, Andrea (Institute of Neurology, University “Magna Graecia”, Catanzaro, Italy ) , Bianco, Maria Giovanna (Biotecnomed, S.C.aR.L, Catanzaro, Italy ) , Morelli, Maurizio (Neuroimaging Unit, IBFM, National Research Council, Catanzaro, Italy ) , Augimeri, Antonio (Neuroimaging Unit, IBFM, National Research Council, Catanzaro, Italy ) , Salsone, Maria (Neuroimaging Unit, IBFM, National Research Council, Catanzaro, Italy ) , Novellino, Fabiana (Institute of Neurology, University “Magna Graecia) , Nicoletti, Giuseppe , Arabia, Gennarina , Quattrone, Aldo
    Parkinsonism & related disorders v.52 ,pp. 17 - 23 , 2018 , 1353-8020 ,

    초록

    Abstract Introduction The aim of our study was to investigate the effect of apomorphine and placebo on resting tremor in tremor-dominant Parkinson's disease (tPD) patients. Methods Fifteen tPD patients were enrolled. Each patient underwent two treatments on two consecutive days: on day one the patients received a subcutaneous injection of placebo, while on day two they received apomorphine. On each day, the patients underwent three electrophysiological recording sessions: T0, T1, and T2: before, 30 min, and 60 min after the treatment respectively. Electrophysiological changes in tremor amplitude were evaluated using a triaxial accelerometer. Results Placebo was effective in improving resting tremor in all tPD patients (p = 0.009) at T1, but not at T2. Eight out of 15 tPD patients (53.3%) responded to placebo with an at least 70% reduction in tremor amplitude compared to the basal condition (responders). By contrast, seven out of 15 tPD patients (46.7%) did not show any variation in tremor amplitude after placebo administration (non-responders). Apomorphine induced a marked reduction in tremor amplitude at 30 min and 60 min in all investigated tPD patients. Of note, the decrease in tremor amplitude in placebo responders was similar to that achieved with dopaminergic stimulation induced by apomorphine. Conclusions Our study demonstrates that placebo was very effective in reducing resting tremor in about half of patients with tPD. The decrease in tremor amplitude in placebo responders was similar to that induced by apomorphine. The cerebral mechanisms underlying the placebo effect on resting tremor need further investigations. Highlights Rigidity and bradykinesia in PD can improve after placebo administration. Whether resting tremor also can show a placebo-induced improvement is still debated. Accelerometric tremor modifications in tPD were studied after placebo and apomorphine. Placebo was effective in reducing resting tremor in about half of patients with tPD. Tremor improvement in placebo responders was similar to that induced by apomorphine.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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    Fig. 1 이미지
  6. [해외논문]   Unaffected first-degree relatives of essential tremor cases have more imbalance than age-matched control subjects   SCIE

    Louis, Elan D. (Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA ) , Meyers, James H. (Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA ) , Cristal, Ashley D. (Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA ) , Hickman, Ruby (Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA ) , Factor-Litvak, Pam (Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA)
    Parkinsonism & related disorders v.52 ,pp. 24 - 29 , 2018 , 1353-8020 ,

    초록

    Abstract Background Endophenotypes are measurable clinical characteristics that may be present in individuals with increased risk for disease (e.g., unaffected family members). Endophenotypes are useful; they may clarify diagnosis in genetic studies and foster the development of animal models. In recent years, problems with balance and mild gait ataxia have been associated with essential tremor (ET). We compared gait and balance of first-degree relatives of ET cases (FD-ET) to that of age-matched controls (Co). Methods One-hundred-ninety FD-ET and 68 Co, none of whom reported tremor or were diagnosed with ET, underwent a standardized assessment of gait and balance. Results FD-ET reported more near-falls in the past year (p = 0.015) and lower balance confidence according to the Activities of Balance Confidence (ABC-6) Scale (p = 0.03). The specific ABC-6 items for which FD-ET reported lower balance confidence than Co were being bumped into by people while walking (p = 0.006) and walking outside on icy sidewalks (p = 0.007). On videotaped neurological examination, FD-ET were able to stand in the tandem position for fewer seconds than were Co (p = 0.048). The differences between FD-ET and Co, although statistically significant, were clinically mild. Conclusion FD-ET reported more near-falls in the past year and a reduction in balance confidence; additionally, ability to maintain tandem stance was impaired compared to Co. These data suggest a more pervasive abnormality of cerebellar dysfunction than previously conceived, extending beyond ET cases themselves and manifesting in mild form in their unaffected family members. Highlights We studied gait and balance in unaffected first-degree relatives of ET cases. Unaffected first-degree relatives of ET cases reported more near-falls than controls. They also reported a reduction in balance confidence. Their ability to maintain tandem stance was impaired compared to controls. Mild cerebellar dysfunction extends beyond ET cases to their unaffected relatives.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  7. [해외논문]   Decreased interhemispheric homotopic connectivity in Parkinson's disease patients with freezing of gait: A resting state fMRI study   SCIE

    Li, Junyi (Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, China ) , Yuan, Yongsheng (Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, China ) , Wang, Min (Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, China ) , Zhang, Jiejin (Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, China ) , Zhang, Li (Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, China ) , Jiang, Siming (Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, China ) , Wang, Xixi (Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, China ) , Ding, Jian (Department of Neurology, The First Affiliated Hospital of Nanj) , Zhang, Kezhong
    Parkinsonism & related disorders v.52 ,pp. 30 - 36 , 2018 , 1353-8020 ,

    초록

    Abstract Introduction Freezing of gait is a common complaint in patients with Parkinson's disease (PD). However, the neural bases of freezing of gait in PD remain uncertain. Existing studies on PD patients with freezing of gait (PD-FOG+) have reported damage of the corpus callosum, the largest commissural bundle of the brain. Thus, in this study we explored homotopic connectivity to investigate FOG-related interehemispheric alterations Methods A total of 21 PD-FOG + patients, 33 PD patients without freezing of gait (PD-FOG-), and 24 matched healthy controls were recruited. All PD patients were evaluated via the FOG questionnaire (FOGQ) and all subjects had a resting state functional magnetic resonance imaging (rs-fMRI) scan. The pattern of the homotopic connectivity was measured with the voxel-mirrored homotopic connectivity (VMHC) approach. Result The PD-FOG + patients showed decreased VMHC values in the inferior parietal lobe (IPL) compared to both PD-FOG-patients and healthy controls. In PD-FOG + patients, the mean VMHC values in the IPL were negatively correlated with the FOGQ scores. Receiver operating characteristic curves analyses revealed that the VMHC in the IPL had discriminatory function distinguishing PD-FOG + patients from PD-FOG-patients or healthy controls. Conclusion Decreased VMHC values of PD-FOG + patients relative to PD-FOG- and healthy controls in IPL maybe a unique feature for PD-FOG+ and it may have the ability to separate PD-FOG + patients from PD-FOG- and healthy controls. Highlights Altered VMHC values may have the ability to separate PD-FOG + patients. Freezing of gait is associated with incoordination of interhemispheric connectivity. Uncoordinated control of gait and cognitive may result to freezing of gait.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   Combined measurement of plasma cystatin C and low-density lipoprotein cholesterol: A valuable tool for evaluating progressive supranuclear palsy   SCIE

    Weng, Ruihui (Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China ) , Wei, Xiaobo (Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China ) , Yu, Bin (Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, China ) , Zhu, Shuzhen (Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China ) , Yang, Xiaohua (Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China ) , Xie, Fen (Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China ) , Zhang, Mahui (Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China ) , Jiang, Ying (Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China ) , Feng, Zhong-Ping (Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada ) , Sun, Hong-Shuo (Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada ) , Xia, Ying (Shanghai Key Laboratory of) , Jin, Kunlin , Chan, Piu , Wang, Qing , Gao, Xiaoya
    Parkinsonism & related disorders v.52 ,pp. 37 - 42 , 2018 , 1353-8020 ,

    초록

    Abstract Introduction Progressive supranuclear palsy (PSP) was previously thought as a cause of atypical Parkinsonism. Although Cystatin C (Cys C) and low-density cholesterol lipoprotein-C (LDL-C) are known to play critical roles in Parkinsonism, it is unknown whether they can be used as markers to distinguish PSP patients from healthy subjects and to determine disease severity. Methods We conducted a cross-sectional study to determine plasma Cys C/HDL/LDL-C levels of 40 patients with PSP and 40 healthy age-matched controls. An extended battery of motor and neuropsychological tests, including the PSP-Rating Scale (PSPRS), the Non-Motor Symptoms Scale (NMSS), Geriatric Depression Scale (GDS) and Mini-Mental State Examination (MMSE), was used to evaluate the disease severity. Receiver operating characteristic (ROC) curves were adopted to assess the prognostic accuracy of Cys C/LDL-C levels in distinguishing PSP from healthy subjects. Results Patients with PSP exhibited significantly higher plasma levels of Cys C and lower LDL-C. The levels of plasma Cys C were positively and inversely correlated with the PSPRS/NMSS and MMSE scores, respectively. The LDL-C/HDL-C ratio was positively associated with PSPRS/NMSS and GDS scores. The ROC curve for the combination of Cys C and LDL-C yielded a better accuracy for distinguishing PSP from healthy subjects than the separate curves for each parameter. Conclusions Plasma Cys C and LDL-C may be valuable screening tools for differentiating PSP from healthy subjects; while they could be useful for the PSP intensifies and severity evaluation. A better understanding of Cys C and LDL-C may yield insights into the pathogenesis of PSP. Highlights Higher plasma Cys C levels in patients with PSP than in healthy controls. Lower plasma LDL-C levels in patients with PSP than in healthy controls. Significantly positive correlation of Cys C/LDL-C/HDL-C ratio in PSP patients. Better discrimination between PSP patients and healthy subjects by the ROC curve of combined measurement of Cys C and LDL-C.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  9. [해외논문]   Eye movement parameters and cognitive functions in Parkinson's disease patients without dementia   SCIE

    Wong, Oscar WH (Department of Psychiatry, Tai Po Hospital, Hong Kong SAR ) , Chan, Anne YY (Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR ) , Wong, Adrian (Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR ) , Lau, Claire KY (Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR ) , Yeung, Jonas HM (Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong SAR ) , Mok, Vincent CT (Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR ) , Lam, Linda CW (Department of Psychiatry, The Chinese University of Hong Kong, Tai Po Hospital, G/F, Multi-centre Building, 9 Chuen On Road, Tai Po, Hong Kong SAR ) , Chan, Sandra (Department of Psychiatry, The Chinese University of Hong Kong, Tai Po Hospital, G/F, Multi-centre Building, 9 Chuen On Road, Tai Po, Hong Kong SAR)
    Parkinsonism & related disorders v.52 ,pp. 43 - 48 , 2018 , 1353-8020 ,

    초록

    Abstract Background Cognitive deficits and eye movement abnormalities have been demonstrated to be detectable early clinical manifestations of Parkinson's disease. Understanding the relationship between these phenotypes may yield insight into the underlying anatomical pathways, assisting in the search for simple non-invasive markers of early neurodegeneration. Objective To explore the correlations between eye movement parameters with multi-domain cognitive functions in patients suffering from Parkinson's disease without dementia. Method This is a cross-sectional case-control study of Parkinson's disease patients without dementia. Participants underwent global and domain-specific cognitive tests and an eye-tracking visual search task to characterize eye movement parameters. Results 62 Chinese Parkinson's disease patients without dementia and 62 sex-, age- and education-matched controls were recruited. The disease group performed worse in multiple cognitive tasks and exhibited a smaller saccadic amplitude. Negative correlations between the eye fixation duration and performance in semantic verbal fluency, verbal and visual recognition memory tasks were observed, though there was no moderation effect on the correlations due to the presence of Parkinson's disease. A common cholinergic deficit in the temporal and parietal regions may account for the observed correlations. The lack of association with predominantly frontal-executive tasks may suggest specificity of these correlations. Conclusion Prolonged visual fixation duration is correlated with poorer performance in semantic verbal fluency, verbal and visual recognition memory tasks in Parkinson's disease patients without dementia, although these correlations are not specific. The clinical utility of eye movement parameters as an early marker for cognitive decline in Parkinson's disease warrants further exploration in longitudinal studies. Highlights Parkinson's disease is associated with cognitive & eye movement abnormalities. Their relationship is unknown but could be informative to the degenerative process. Prolonged visual fixation correlates negatively several cognitive functions. A posterior cortical acetylcholine deficit may underlie these associations. Eye-tracking as a surrogate for cognitive impairment worth further investigation.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  10. [해외논문]   Gender-specific effect of uric acid on resting-state functional networks in de novo Parkinson's disease   SCIE

    Lee, Yoonju (Department of Neurology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemungu, Seoul 03722, South Korea ) , Park, Yeong-Hun (Department of Biomedical Engineering, Hanyang University, 222 Wangsimni-ro, Sungdong-gu, Seoul 04763, South Korea ) , Lee, Jae Jung (Department of Neurology, Inje University College of Medicine, Ilsan Paik Hospital, 170 Juhwa-ro, Ilsanseo-gu, Goyang 10380, South Korea ) , Sohn, Young H. (Department of Neurology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemungu, Seoul 03722, South Korea ) , Lee, Jong-Min (Department of Biomedical Engineering, Hanyang University, 222 Wangsimni-ro, Sungdong-gu, Seoul 04763, South Korea ) , Lee, Phil Hyu (Department of Neurology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemungu, Seoul 03722, South Korea)
    Parkinsonism & related disorders v.52 ,pp. 49 - 54 , 2018 , 1353-8020 ,

    초록

    Abstract Introduction The pattern of resting-state networks is influenced by several factors besides the underlying pathological changes of Parkinson's disease (PD). Uric acid (UA), as an antioxidant, has a neuroprotective property against PD-related microenvironment; however, this effect would be gender-specific. We aimed to evaluate a gender-sensitive resting-state networks (RSN) according to the UA level in drug naIve de novo patients with PD to elucidate the role of antioxidant in cortical functional networks of PD. Methods This study enrolled 135 de novo patients with PD underwent functional magnetic resonance imaging (MRI). Based on the distribution, the serum UA level was stratified into tertiles in the PD patients by gender. With a seed-based approach, we investigated the pattern of RSN within the dorsal attention network (DAN), executive control network (ECN), and default mode network (DMN). Results Interaction analysis showed a significant interaction between the lowest (PD-L-UA) and the highest UA level (PD-H-UA) groups according to gender within the DAN, ECN, and DMN. Compared to the control subjects, male patients with PD-H-UA had higher cortical functional connectivity (FC), while female patients had lower cortical FC regardless of UA level within all seeds. In a direct comparison, male patients with PD-H-UA had increased FC than did those with PD-L-UA. However, there was no significant difference in FC between PD-L-UA and PD-H-UA in female PD patients. Conclusions These data suggest that RSN might be closely and gender-specifically associated with the status of serum UA in de novo PD patients. Highlights We present fMRI data from 135 drug naIve de novo patients with PD. Male patients with higher UA levels had higher corticalfunctional connectivity. In contrast, female patients had lower functional networks regardless of UA level. Serum UA might influence RSN closely and gender-specifically in PD patients.

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