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H : 소장처정보

T : 목차정보

한국독성학회지 = The Korean journal of toxicology 22건

  1. [국내논문]   발암과정에서 염증의 역할  

    이병무 (성균관대학교 약학대학 독성학 교실 ) , 이지은 (성균관대학교 약학대학 독성학 교실 ) , 김태정 (성균관대학교 약학대학 독성학 교실 ) , 조홍태 (성균관대학교 약학대학 독성학 교실)
    한국독성학회지 = The Korean journal of toxicology v.13 no.1/2 ,pp. 1 - 21 , 1997 , 0258-2368 ,

    초록

    염증반응이란 우리 신체에 외부 물질이 침입했을 경우 대처하는 정상적인 현상이다. 외부에서 물리, 화학, 생물학적 물질에 노출되었을 경우 혈관이 팽창하고, 비특이적 면역반응이 시작된다. Selectin, integrin, immunoglobulin superfamily와 같은 adhesion molecule에 의해 macrophage 및 neutrophil과 같은 leukocyte의 반응을 촉진하기 위해 exudation이 일어나고 침입 부위에 모여 hyperemia가 발생된다.(Govan 등, 1995)

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  2. [국내논문]   랫드의 간압발생과정에서 홍삼의 항암효과와 자연살해세포의   피인용횟수: 1

    강경선 (서울대학교 수의과대학 공중보건학교실 ) , 이영순 (서울대학교 수의과대학 공중보건학교실)
    한국독성학회지 = The Korean journal of toxicology v.13 no.1/2 ,pp. 23 - 27 , 1997 , 0258-2368 ,

    초록

    This study was performed to examine the anti-cancer effect of Red Ginseng in the DENGalN-PH-induced hepatic tumor model system in rats. One hundred of male SPF Sprague-Dawley rats(6weeks old) were randomly divided into five groups. Rats in groups 1, 2, 3, and 4 were administered to diethylnitrosamine intraperitoneally 200 mg/kg body weight for the caner initiation. Rats in group 5 were given to saline as a control. On two weeks after cancer initiation, rats in groups 1 and 3 were fed on diet containing 0.01% of acethylaminofiuorene(AAF) which is strong cancer-promotor for 6 weeks, while rats in groups 2 and 4 were fed on water containing 0.05% of phenobarbital which is weak cancer.promotor for 6 weeks. Rats in groups 1 and 2 were treated with diet containing 3% of Red Ginseng for six weeks(from 9th week till 15th week after cancer initiation). Rats in all groups were necropsied time-sequencially at 8, 15, and 36 weeks. The hepatic lesions of rat treated with carcinogens expressed glutathione S-transferase placental form(GST-P) at 8 week. The GST-P positive foci of rats treated with AAF were larger than that of any other rats, while the GST-P positive foci of rats treated with AAF and red ginseng were significantly decreased. This anti-cancer effect of Red ginseng might be involved in the enhacement of natural killer cell activity. To know whether there is direct relationship between Red Ginseng and natural killer cell activity, the activity of natural killer cell was examined after treatment AAF, AAF+Red ginseng and Red ginseng only, respectively. Comparing with natural killer cell activity in AAF-treated group, natural killer cell activity was significantly activated in AAF+ Red ginseng-treated group. This indicated that Red ginseng might enhance natural killer activity after treatment carcinogen in rats. These results suggested that Red ginseng might have a cancer prevention ability by promoting natural killer cell activity during hepatocarclnogenesis.

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  3. [국내논문]   랫드에서 cyclophosphamide에 의해 유발된 흉선세포의 apoptosis  

    구현옥 , 권창희 , 조준형 , 정상희 , 박신자 , 김윤배 , 양재만 , 이영순
    한국독성학회지 = The Korean journal of toxicology v.13 no.1/2 ,pp. 39 - 48 , 1997 , 0258-2368 ,

    초록

    Cyclophosphamide(25, 50 or 100 mg/kg), orally administered to male Sprague-Dawley rats, caused a time- and dose-dependent thymic atrophy. In the light microscopic examination of the atrophic thymus, thymocytes with condensed or fragmented nucleus were multifocally observed in the cortical region, started to increase 8 hr after CPA treatment and reached to the maximal level at 16 hr, although such cells were not seen after 48 hr when the severe depletion of thymocytes were marked. In agarose gel electrophoresis to analyze the DNA changes, DNA extracted from atrophic thymus showed a oligonucleosomal laddering at the corresponding time to morphological changes. In an additional supportive experiment, thymocytes showing morphological changes, nuclear condensation or apoptotic body, exhibited a positive reaction to immunoperoxidase staining using in situ apoptosis detection kit. Separately, agarose gel electrophoresis of DNA from bone .marrow cells was performed to investigate the involvement of bone marrow cells in the process of thymocyte apoptosis. Although DNA laddering was slightly increased 2 and 4 hr after treatment, no clear correlation was inferred. Taken togather, it is concluded that thymocytes showing morphological changes in thymic atrophy induced by cyclophosphamide administration represent an apoptosis having biochemical nature of programmed cell death.

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  4. [국내논문]   특정지역에서 토양중 PCB의 분석과 인체노출량평가  

    이효민 (한국과학기술연구원 도핑콘트롤센터 ) , 박송자 (한국과학기술연구원 도핑콘트롤센터 ) , 김명수 (한국과학기술연구원 도핑콘트롤센터 ) , 윤은경 (한국과학기술연구원 도핑콘트롤센터 ) , 최시내 (한국과학기술연구원 도핑콘트롤센터 ) , 김선태 (한국과학기술연구원 특성분석센터 ) , 박종세 (식품의약품안전본부 독성연구소)
    한국독성학회지 = The Korean journal of toxicology v.13 no.1/2 ,pp. 49 - 54 , 1997 , 0258-2368 ,

    초록

    PCBs are classified as B2 (Probable human carcinogen) based on the induction of hepatocellular carcinomas in rats and mice from IRIS (Integrated Risk Information System). About 20 years ago, PCBs were phased out for electrical use in Korea, but PCBs were continuously used in the other field. Lately, there has been increasing concern on possible effects of contaminated soil to the other environment and human health. The purpose of this study is to determine PCBs level in soil at some site and to assess the human exposure doses according to exposure routes for people living within sites which expected to be exposed to PCBs. Pollution level of PCBs on the site was monitored using gas liquid chromatography. To assess the transport of PCBs in soil to plant and to air, various transfer factors(diffusion coefficient, bioconcentration factor etc.) were considered in simple calculations. To calculate the residential exposure doses by routes, some equations were considered using assumption value, which define inhalation, ingestion (soil, plant) and derreal uptake pathway. Computated results will be used as risk assessment information for human health evaluation on contaminated soil.

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  5. [국내논문]   감마선조사에 의한 당귀와 알로에의 위생화 및 안전성 평가  

    강일준 (한림대학교 식품영양학과 ) , 이수용 (한림대학교 환경,생명과학연구소 ) , 이상준 (강원대학교 농화학과 ) , 김광훈 (원광대학교 약학대학 ) , 이병훈 (원광대학교 약학대학)
    한국독성학회지 = The Korean journal of toxicology v.13 no.1/2 ,pp. 55 - 60 , 1997 , 0258-2368 ,

    초록

    Gamma irradiation was applied to Angelicae gigantis radix and Aloe to improve their hygienic quality. The effective dose of irradiation was 7 kGy in Angelicae gigantis radlx and 5 kGy in Aloe for the sterilization of all contaminated microorganisms tested. After 8 months of storage at room temperature, no growth of microorganisms was observed in the irradiated products. The safety of these products were evaluated by Salmonella typhimurium reversion assay and in vivo micronucleus assay using mouse bone marrow cells. They were negative in the bacterial reversion assay with S. typhimurium TA 98, TA100, TA1535 and TA1537. In the in vivo mouse micronucleus assay, they did not show any clastogenic effect at all doses tested. These results indicate that the gamma irradiation of Angelicae gigantis radix at 12 kGy and of Aloe at 10 kGy have no genotoxic effects under these experimental conditions.

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  6. [국내논문]   Protective Effect of Aminoglycosides and Their Combinations Against 2-Chloroethylethyl Sulfide Exposure  

    Kim, Yun-Bae ; Hur, Gyeung-Haeng ; Choi, Dae-Sung ; Shin, SungHo ; Cha, Seung-Hee ; Park, Yong-Keun ; Sok, Dai-Eun
    한국독성학회지 = The Korean journal of toxicology v.13 no.1/2 ,pp. 61 - 69 , 1997 , 0258-2368 ,

    초록

    Exposure of splenocytes to 2-chloroethylethyl sulfide (CEES) resulted in the cell death, and the cytotoxicity of CEES was prevented by inhibitors of lysosomal hydrolases. Therefore, it has been postulated that the cytotoxicity of CEES may be partially due to the lysosomal labilization. This study, based on this mechanism, was undertaken to determine whether aminoglycoside antibiotics as inhibitors of lysosomal phospholipases and their combinations with other lysosome stabilizers can be useful as a treatment to reduce the CEES toxicity in mice. 2-Chloroethylethyl sulfide (20 mg/kg body weight) was injected ip into female ICR mice, and candidate compounds were administered ip before or after the CEES challenge. Kanamycin (40 mg/kg body weight) as effective as deferoxamine (100 mg/kg body weight) enhanced the survival rate after 5 days of intoxication from 10% of control to 50 - 60%. The most effective was found to be the combination of kanamycin, cycloheximide, deferoxamine and dextrose showing an almost full protection against 2LD50 of CEES. Consistent with the protection of the CEES toxicity, the decrease of body weight in mice intoxicated with CEES was effectively prevented by kanamycin or its combinations. It is suggested that kanamycin or its combination (kanamycin, cycloheximide, deferoxamine and dextrose) would be one of effective antidotes against the CEES poisoning in mice.

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  7. [국내논문]   Pentachlorophenol의 노출에 의한 사람 T-임파구의 hprt 유전자에서 돌연변이 빈도  

    윤병수 (경기대학교 생물학과 ) , 조명행 (서울대학교 수의과대학 ) , 김인규 (한국원자력연구소 방사선생체해석분야 ) , 박선영 (한국원자력연구소 방사선생체해석분야 ) , 이영순 (서울대학교 수의과대학)
    한국독성학회지 = The Korean journal of toxicology v.13 no.1/2 ,pp. 71 - 78 , 1997 , 0258-2368 ,

    초록

    The mutational effects of pentachlorophenol (PCP) on the hypoxanthine phosphoribosyl transf erase (hprt) locus in human T-cell were analysed by T-cell clonal assay in vitro. Cells were exposed for 24 hours at primary culture to 0~100 ppm (W/V) PCP in dimethyl sulfoxide. Treated cells were allowed at the same time to stimulate by phytohemagglutinin (PHA) and T-cell growth factor (TCGF) and then seeded in medium containing 6-thioguanine to select for hprt-negative routants. We have also defined the optimal condition for the determination of mutant frequency. The parameters investigated include survival counting, first and second subculture for clonal efficiency plating and mutant plating. Under the optimal conditions, mutant frequencies of high dose-treated cells were significantly higher than those of non-treated or low dose cells. The results indicated a clear dose-effect relationship and showed that mutant frequency in 50 ppm PCP treated cell was 4.31 $\times$ $10^{-5}$ (background, 8.32 $\times$ $10^{-6}$ ). Above data strongly suggest that hprt mutation assay can be used as a biomarker for the environmental risk assessment.

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  8. [국내논문]   자외선 B 파로 유도된 Hairless Mouse에서 타닌의 피부 독성 억제효과 및 Heat Shock Protein 70의 생성억제 효과  

    이세윤 (동덕여자대학교 종합약학연구소 ) , 이민경 (동덕여자대학교 약학과 ) , 장동덕 (동덕여자대학교 식품의약품안전본부 ) , 안령미 (동덕여자대학교 보건관리학과 ) , 안형수 (동덕여자대학교 약학과)
    한국독성학회지 = The Korean journal of toxicology v.13 no.1/2 ,pp. 79 - 86 , 1997 , 0258-2368 ,

    초록

    Inhibitory effects of tannic acid on skin toxicity and heat shock protein induced by UVB were investigated. Tannic acid was administered either topically or orally for 3 days to hairless mice, which were previously irradiated with UVB. UVB was found to cause skin erythema . However, the skin erythema was decreased when tannic acid was administered either topically or orally. The heat shock proteins, Hsp-78 kDa and 70 kDa, were induced by UVB irradiation, but the induction was decreased by treatment of tannic acid in both topically and orally administered groups. The hsp induction was more prominent in orally administered groups than in topically administerd groups. However, the difference between two groups was not statistically significant. The route of administrations, topical and oral, does not affect the activity of tannic acid. In the skin tissue observation, tannic acid regenerated the epithelial cells with 7-9 cell layers which were injured by UVB. In conclusion, tannic acid has an ability to protect against UVB irradiation and regenerate the skin.

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  9. [국내논문]   Carbofuran이 NIH 3T3섬유모세포와 흰쥐의 신장에 미치는 영향과 Phenobarbital sodium의 보상효과에 관한 연구  

    한두석 (원광대학교 치과대학 구강해부학교실 ) , 임요섭 (원광대학교 농과대학 농화학과 ) , 한성수 (원광대학교 농과대학 농화학과)
    한국독성학회지 = The Korean journal of toxicology v.13 no.1/2 ,pp. 87 - 94 , 1997 , 0258-2368 ,

    초록

    This study was carried out to investigate toxicity of insecticide carbofuran and compensatory effects of phenobarbital sodium (PB) in vivo and in vitro. Sprague Dawley male rats were used as experimental animals and divided into carbofuran only administered group and simultaneous application group of carbofuran and PB. At 30 rain and 1, 3, 6, 12, 24, 48 and 96 hrs after each treatment, the animals were sacrificed by decapitation. Kidney were immediately removed, immersed in fixatives, and processed with routine method for light microscopic study. Paraffin sections were stained with H-E, PAM and PAS. $5.0\times 10^4$ cell/ml of NIH 3T3 fibroblast in each well of 24 multidish were cultured: After 24 hours, the cells were treated with solution of six groups; control group cultured in media only, carbofuran $MTT_50$ or $NR_50$ group cultured in the media containing carbofuran $MTT_50$ or $NR_50$ and four experimental groups cultured in the media containing carbofuran $NR_50$ plus various concentratins of PB. After the NIH 3T3 fibroblast of all groups were cultured in same condition for 48 hours, Tetrazolium MTT (MTT) and NR (neutral red) assay were performed to evaluate the cytotoxicity of cell organelles. Under the light microscope, atrophic change of renal corpuscles were frequently observed in 1 and 2 days after carbofuran treatment. The increase of the mesangium was apparent in 1 and 2 days after carbofuran treatment. Necrotic changes of the epithelium and loss of brush border of proximal tubules were most severe at 2 and 3 days after carbofuran treatment, respectively. In contrast, there were no evidences of the toxic effects on renal tissues at 48hrs in carbofuran-PB treated groups. Carbofuran $MTT_50$ and $NR_50$ were 78 $\mu M$ , 82.5 $\mu M$ respectively. MTT and NR quantities were significantly increased in carbofuran-PB 100 $\mu M$ treatment group and carbofuran-PB 100 $\mu M$ treatment group. On the basis of these results, it is obvious that PB has compensatory effects against carbofuran toxicity.

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  10. [국내논문]   Effects of Phenobarbital Pretreatment on Ethyl Carbamate-induced Embryotoxicity in Rats  

    Chung, Moon-Koo ; Jiang, Cheng-Zhe ; Kim, Jong-Choon ; Yun, Hyo-In ; Han, Sang-Seop ; Roh, Jung-Koo
    한국독성학회지 = The Korean journal of toxicology v.13 no.1/2 ,pp. 95 - 101 , 1997 , 0258-2368 ,

    초록

    Ethyl carbamate (EC) is a potent teratogen in rodents and is present at low concentration in fermented foods and alcohol beverages. It has been well hypothesized that some metabolic products are responsible for the teratogenic effects of the compound. In the present study, the effects of phenobarbital (PB) on EC-induced embryotoxicity were investigated in SD rats. Six groups were constructed: EC 300 (EC 300 mg/kg/day), EC 600 (EC 600 mg/kg/day), EC 600+PB (EC 600 mg/kg/day and PB 80 mg/kg/day), PB (PB 80 mg/kg/day), DR (dietary restriction, 8 g/day/rat) and a control group. Rats of the EC 600+PB group were pretreated with phenobarbital intraperitoneally for three days to induce cytochrome P450 enzymes, followed by oral administration of EC for two consecutive days. The incidence of fetal deaths in the EC 600+PB group was higher than that of the EC 600 group(42.7 vs. 14.3%). The incidence of fetal realformations in the EC 600+PB group was higher than that of the EC 600 group (external; 7.0 vs. 4.1%, visceral; 31.4 vs. 11.3%, skeletal; 11.1 vs. 6.5%). There was no embryotoxicity in the control, EC 300, PB and DR groups. These results show that the pretreatment with phenobarbital augments EC-induced embryotoxicity in rats, indicating an evidence that metabolic activation by cytochrome P450 may be the major pathway of EC to its embryotoxic forms.

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