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H : 소장처정보

T : 목차정보

한국독성학회지 = The Korean journal of toxicology 20건

  1. [국내논문]   한국산 생약으로부터 항암물질의 개발(제4보) 소엽 부탄올 가용분획의 항암활성   피인용횟수: 1

    최규은 (원광대학교 자연과학대학 화학과 ) , 곽정숙 (목포전문대학 치위생과 ) , 김영옥 (원광대학교 자연과학대학 화학과 ) , 백승화 (원광대학교 자연과학대학 화학과 ) , 한두석 (원광대학교 치과대학 구강해부학실)
    한국독성학회지 = The Korean journal of toxicology v.13 no.4 ,pp. 311 - 316 , 1997 , 0258-2368 ,

    초록

    This study was carried out to develop antitumor effect of the n-butanol soluble fraction of Perilla frutescens on (KB cells) human oral epitheloid carcinoma cells. The cytotoxictty of methanollc extract of Perilla frutescens on KB cells was evaluated by 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide(MTT) assay. The antitumor activity of various fractions obtained from n-butanol soluble fraction of Perilla frutescens was evaluated in human oral epithelold carcinoma cells. The antitumor acavity of the n-butanol soluble fraction on human oral epitheloid carcinoma cells was evaluated by MTT assay of colorimetric method. The light microscopic study was carried out to observe morphological changes of cultured human oral epitheloid carcinoma cells. These results were obtained as follows; 1. The fractions 1,2 and 3 of the n-butanol soluble fraction of Perilla frutescens were shown significant antitumor activities. 2. The number of human oral epitheloid carcinoma cells were decreased and tend to form cell cluster by treatment with fractions 1,2,3 and 4 of the n-butanol soluble fraction of Perilla frutescens. 3. The fraction 1 of the n-butanol soluble fraction of Perllla frutescens showed the highest antitumor activity on Perilla frutescens. It has been selected as a lead fraction for further examinations.

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  2. [국내논문]   새로운 합성 농약인 KH-502의 급성 지연성 신경독성 시험에 관한 연구  

    박재학 (서울대학교 수의과대학 실험동물의학교실 ) , 서광원 (서울대학교 수의과대학 공중보건학교실 ) , 남기환 (서울대학교 수의과대학 공중보건학교실 ) , 한상섭 (한국화학연구소 ) , 이영순 (서울대학교 수의과대학 공중보건학교실)
    한국독성학회지 = The Korean journal of toxicology v.13 no.4 ,pp. 317 - 322 , 1997 , 0258-2368 ,

    초록

    Acute delayed neurotoxicity of KH-502 [O.O-Diethyl O-(1-phenyyl-3-trifluoromethyl-5-pyrazoyl) thiophosphoric acid ester], an insecticide synthesized newly in Korea, was studied in White Leghorn hens. The doses were determined on the basis of preliminary $LD_{50}$ study. High, middle and low doses were determined to be 1123 mg/kg, 762 mg/kg and 518 mg/kg, respectively. The animals were pretreated with atropine (30 mg/kg) prior to administration of KH-502. The chemical was administrated at the first and 21st day of the study. As positive controls, animals were admlnistrated with triorthocresylphosphate (TOCP 1000 mg/kg and 500 mg/kg). Animals administrated with TOCP or KH-502 were sacrificed by perfusion-fixation at 21st and 42nd day of the study, respectively. The central and peripheral nerve tissues were routinely treated for microscopic observation. As results, eight, three, one, and one chickens died within 2 day after adminiatration with signs of cholinergic acute toxicity in high, middle low and TOCP dose-group (500 mg/kg), respectively. No abnormal clinical signs were observed in the survived chickens administrated with KH-502 in the duration of the study. The chickens in positive control groups showed ataxia and incoordination at the 14th day after administration of TOCP. From necropsy, macroscopic changes were not observed in all groups including positive control groups. Histopathologically, oxonal swelling with myelin loss, focal gliosis, distention around axonal space were observed in the spinal cords of the chickens administrated with TOCP 1000 mg/kg. The lesions were distinct in the dorsal and lateral funiculi of cervical spinal cord, in the lateral and ventral funiculi of thoracic spinal cord and in ventral funiculi of lumbosacral spinal cord. Axonal swelling and mlcrogliosis were infrequently observed in the chickens of other groups including negative control one. However, they were nonspecifically distributed in the spinal cords. In this study, we concluded that the new chemical, KH-502 did not have acute delayed neurotoxicity in White Leghorn hens.

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  3. [국내논문]   렛드와 마우스에서 Ag-Os(수처리제)의 급성 독성  

    이용규 (동서대학교 식품공학과 ) , 신춘환 (동서대학교 환경공학과)
    한국독성학회지 = The Korean journal of toxicology v.13 no.4 ,pp. 323 - 325 , 1997 , 0258-2368 ,

    초록

    Ag-Os, water treatment agent, was administered orally to ICR mice and Sprague-Dawley rats to investigate the acute oral toxicity. $LD_{50}$ values were above 5 g/kg, 2,000 fold higher than the expected concentration in water, in both species with oral administration. There were also no differences in body weight changes, clinical signs and atopsy findings between all treated groups and control group. Therefore, it was concluded that Ag-Os is a very safe compound.

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  4. [국내논문]   Protective Effect of Several Korean Edible Plants on Galactosamine-induced Hepatic Damage in Rats  

    Ha, Young-Duck ; Lee, In-Seon
    한국독성학회지 = The Korean journal of toxicology v.13 no.4 ,pp. 327 - 330 , 1997 , 0258-2368 ,

    초록

    Hepatitis, liver cirrhosis and liver cancer caused by viral infection are among the most prevalent causes of death in Korea. Several medicines have been in use despite their nonsatisfactory effects on these disease. Some herbal medicines put to use recently have not shown beneficial effects, either. This paper evaluates the effects of extracts from 10 traditional Korean herbal medicines on rats with hepatic damage induced by galactosamine. Rubus coreanus showed an anti-inflammatory effect as shown on the data of activities of serum transaminases.

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  5. [국내논문]   원방우황청심원의 랫드 최기형성에 관한 연구  

    한순영 (식품의약품안전본부 독성연구소 ) , 박귀례 (식품의약품안전본부 독성연구소 ) , 신재호 (식품의약품안전본부 독성연구소 ) , 김판기 (식품의약품안전본부 독성연구소 ) , 권석철 (식품의약품안전본부 독성연구소 ) , 장성재 (식품의약품안전본부 독성연구소)
    한국독성학회지 = The Korean journal of toxicology v.13 no.4 ,pp. 331 - 338 , 1997 , 0258-2368 ,

    초록

    A teratogenic study on Original Woo-Whang-Chung-Sim-Won was carried out in SpragueDawley rats. Original Woo-Whang-Chung-Sim-Won suspended in distilled water was administered to pregnant dams by oral gavage during organogenesis period (from 7th to 17th day of gestation) at daily doses of 1/9, 1/3 and I pill/kg. About two-thirds of dams were sacrificed at 20th day of gestation to scrutinize the pregnant performances and fetal development, and the remaining dams were allowed to deliver. The growth, reflex, behaviour and reproductive function of F1 offsprings were examined. There was no treatment-related difference in body weight, food consumption and necropy findings of dams. No gross, skeletal and visceral abnormalities was observed in F1 fetuses from dams treated with Original Woo-Whang-Chung-Sim-Won. F1 offsprings did not show any treatment-related difference in growth, reflex, behaviour and reproductive peuformance. At caesarean section of F1 dams, no growth retardation and gross abnormality was observed in F2 fetuses. In conclusion, Original Woo-Whang-Chung-Sim-Won did not show any potential teratogenic activity in rats.

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  6. [국내논문]   Induction of Microsomal Epoxide Hydrolase, rGSTA2, rGSTA3/5, and rGSTM1 by Disulfiram, but not by Diethyldithiocarbamate, a Reduced Form of Disulfiram  

    Kim, Sang-Geon ; Kim, Hye-Jung
    한국독성학회지 = The Korean journal of toxicology v.13 no.4 ,pp. 339 - 347 , 1997 , 0258-2368 ,

    초록

    Disulfiram (DSF) and diethyldithiocarbamate (DDC), a reduced form of DSF, protect the liver against toxicant-induced injury through inhibition of cytochrome P450 2E1. The effect of DSF and DDC on the levels of major hepatic microsomal epoxide hydrolase (mEH) and glutathione S-transferase (GST) expression was comparatively studied, given the view that these enzymes are involved in terminal detoxification events for high energy intermediates of xenobiotics. Treatment of rats with a single dose of DSF (20-200 mg/kg, po) resulted in 2- to 15-fold increases in the mEH mRNA level at 24 hr with the ED $_{50}$ value being noted as 60 mg/kg. The mEH mRNA level was elevated ~15-fold at 24 hr after treatment at the dose of 100 mg/kg, whereas the hepatic mRNA level was rather decreased from the maximum at the dose of 200 mg/kg, indicating that DSF might cause cytotoxicity at the dose. In contrast to the effect of DSF, DDC only minimally elevated the mEH mRNA level at the doses employed. DSF moderately increased the major GST mRNA levels in the liver as a function of dose, resulting in rGSTA2, rGSTA3/5 or rGSTM1 mRNA levels being elevated 3- to 4-fold at 24 hr post-treatment, whereas the rGSTM2 mRNA level was not altered. DDC, however, failed to stimulate the mRNA levels for major GST subunits, indicating that the reduced form of DSF was ineffective in stimulating the GST the expression. The effect of other organosulfides including aldrithiol, 2, 2'-dithiobis(benzothiazole) (DTB), tetramethylthiouram disulfide (TMTD) and allyl disulfide (ADS) on the hepatic mEH and GST mRNA expression was assessed in rats in order to further confirm the increase in the gene expression by other disulfides. Treatment of rats with aldrithiol (100 mg/kg, po) resulted in a 16-fold increase in the mEH mRNA level at 24 hr post-treatment. DTB, TMTD and ADS also caused 5-, 9- and 12-fold increases in the rnRNA level, respectively, as compared to control. Thus, all of the disulfides examined were active in stimulating the mEH gene in the liver. The organosulfides significantly increased the rGSTA2, rGSTA3, rGSTA5 and rGSTM1 mRNA levels at 24 hr after administration. In particular, aldrithiol was very efficient in stimulating the rGSTA and rGSTM genes among the disulfides examined. These results provide evidence that DSF and other sulfides effectively stimulate the mEH and major GST gene expression at early times in the liver and that DDC, a reduced form of DSF, was ineffective in stimulating the expression of the genes, supporting the conclusion that reduced form(s) of organosulfur compound(s) might be less effective in inducing the mEH and GST genes through the antioxidant responsive element(s).

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  7. [국내논문]   낭탕근의 급성독성 연구  

    마진열 (한국 한의학연구원 ) , 신현규 (한국 한의학연구원 ) , 성현제 (한국 한의학연구원 ) , 전원경 (한국 한의학연구원 ) , 김인락 (한국 한의학연구원 ) , 고병섭 (한국 한의학연구원 ) , 정규용 (한국 한의학연구원)
    한국독성학회지 = The Korean journal of toxicology v.13 no.4 ,pp. 349 - 352 , 1997 , 0258-2368 ,

    초록

    Scopoliae rhizoma is a perennial herb which has a similar effect with atropine on the cardiovascular system. It is also known to have a seditive and anticonvulsant activity on the central nerve system. In order to evaluate an acute toxicity of Scopoliae rhizoma, the present study was performed after administration the Scopoliae rhizoma prepared by both decoctional and frozen dried extract through three different routes (oral; 5,000 mg/kg, intraperitoneal; 2,000 mg/kg, subcutaneous; 5,000 mg/kg) to the female ICR mice. In the group treated intraperitoneally with a frozen dried extract, abnormal clinical signs such as decreased activity, crouch, potosis and abnormal walking were observed for 40 rain after administration. With regard to WBC, decreased number of lymphocyte and increased number of monocyte and granulocyte were also observed in the animals received intraperitoneally with Scopoliae rhizoma extract. Taken together, what toxicity of Scopoliae rhizoma was shown differently depending on its type for administration may be resulted in the differency of administered dose. The results provided here support a pharmacological and toxicological consideration for its clinical use in the regard of oriental medicine.

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  8. [국내논문]   Experimental Allergic Encephalomyelitis Study of Combined Vaccine (KGCC-95VI) Against Japanese Encephalitis and Hantaan Virus Infection  

    An, Chang-Nam ; Shin, Kwang-Soon ; Yun, Hyo-In ; Park, Jong-Il ; Cha, Shin-Woo ; Shin, Hyeong-Soon ; Kim, Chul-Joong
    한국독성학회지 = The Korean journal of toxicology v.13 no.4 ,pp. 353 - 357 , 1997 , 0258-2368 ,

    초록

    The possibility of the allergic encephalomyelitis caused by the combined vaccine (KGCC95VI) for the prophylaxis against Japanese encephalitis and Hantaan virus infection, recently developed by Korea Green Cross Corporation, was investigated in the Hartley guinea pigs. The KGCC-95VI was administered to the guinea pigs subcutaneously to sensitize the animals three times at one month intervals. There were no clinical signs or gross pathological findings. There were no abnormal histopathological findings at cerebrums, cerebellums, brain stems and the spinal cords. The concentration of myelin basic protein was 1.10 ng/dose quantified by ELISA, which met the guide4ine of below 2 ng/ml/dose recommended by American Society of Health -System Pharmacists(AHPS) Drug Information. Accordingly, the KGCC-95VI is considered not to induce any allergic immune responses which may lead to the experimental allergic encephalomyelitis.

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  9. [국내논문]   흰쥐 해마 절편에서 저산소증에 의한 [$^3H$-5-Hydroxytrytamine의 유리 변동에 미치는 superoxide dismutase/catalase의 영향  

    이경은 (이화여자대학교 의과대학 약리학교실 ) , 박월미 (이화여자대학교 의과대학 약리학교실 ) , 배영숙 (이화여자대학교 의과대학 약리학교실)
    한국독성학회지 = The Korean journal of toxicology v.13 no.4 ,pp. 359 - 365 , 1997 , 0258-2368 ,

    초록

    Many factors are known to be responsible for cerebral ischemic injury, such as excitatory neurotransmitters, increased intraneuronal calcium, or disturbance of cellular energy metabolism. Recently, oxygen free radicals, formed during ischemia/reperfusion, have been proposed as one of the main causes of ischemia/reperfusion injury. Therefore, to investigate the role of oxygen free radical during ischemia/reperfusion, in the present study the effect of endogenous oxygen free radical scavenger, superoxide dismutase / catalase(SOD / catalase) on the release of [ $^3$ H]-5-hydroxytryptamine([ $^3$ H]-5-HT) during hypoxia/reoxygenation in rat hippocampal slices was measured. The hippocampus was obtained from the rat brain and sliced 400 gm thickness with manual chopper. After 30 min's preincubation in the normal buffer, the slices were incubated for 20 min in a buffer containing [ $^3$ H]-5-HT(0.1 $\mu$ M, 74 $\mu$ Ci) for uptake, and washed. To measure the release of [ $^3$ H]-5-HT into the buffer, the incubation medium was drained off and refilled every ten minutes through a sequence of 14 tubes. Induction of hypoxia for 20 min (gassing it with 95% N $_2$ /5% CO $_2$ ) was done in the 6th and 7th tube, and oxygen free radical scavenger, SOD / catalase was added 10 minutes prior to induction of hypoxia. The radioactivity in each buffer and the tissue were counted using liquid scintillation counter and the results were expressed as a percentage of the total activity. When slices were exposed to hypoxia for 20 min, [ $^3$ H]-5-HT release was markedly decreased and a rebound release of [ $^3$ H]-5-HT was observed on the post-hypoxic reoxygenation period. SOD / catalase did not changed the release of [ $^3$ H]-5-HT in control group, but inhibited the decrease of [ $^3$ H]-5-HT release in hypoxic period and rebound increase of [ $^3$ H]-5-HT in reoxygenation period. This result suggest that superoxide anion may play a role in the hypoxic-, and reoxygenation-induced change of [ $^3$ H]-5-HT release in rat hippocampal slices.

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  10. [국내논문]   A Limited Survey of Fumonisin $B_{1}$ Content of Domestic and Imported Corns in Korea  

    Lim, Chae Woong
    한국독성학회지 = The Korean journal of toxicology v.13 no.4 ,pp. 367 - 370 , 1997 , 0258-2368 ,

    초록

    Fumonisin $B_{1}$ ( $FB_{1}$ ) is hepatotoxic in all species, and initiator and promotor for hepatocarcinogenesis produced mainly by Fusarium moniliforme. This fungus is commonly natural contaminant of corn and other grains worldwide, and has been associated with animal and human diseases. In these study, natural occurrence of $FB_{1}$ was surveyed in 30 healthy domestic corn kernels in Chonbuk and Kangwon province, harvested in 1994 and intended for human consumption, and 15 imported American and Chinese samples of each, collected from different ship-loading at Inchon harbor for animal foodstuffs. $FB_{1}$ contents were measured by high-performance liquid chromatography (HPLC) with a fiourescence detector. The data revealed that 2 out of 12 corn kernels from Kangwon province with 1.1 and 0.7 ppm, and 2 out of 18 corns from Chonbuk province with 0.5 and 1.3 ppm, respectively. However, there was no detection of $FB_{1}$ in imported corn samples, even though those were visibly moldy.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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