본문 바로가기
HOME> 저널/프로시딩 > 저널/프로시딩 검색상세

저널/프로시딩 상세정보

권호별목차 / 소장처보기

H : 소장처정보

T : 목차정보

Clinical immunology : the official journal of the ... 49건

  1. [해외논문]   Editorial Board  


    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. IFC , 2017 , 1521-6616 ,

    초록

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  2. [해외논문]   Editorial Board   SCI SCIE SCOPUS


    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. IFC - IFC , 2017 , 1521-6616 ,

    초록

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  3. [해외논문]   Alternative complement pathway hemolytic assays reveal incomplete complement blockade in patients treated with eculizumab   SCI SCIE SCOPUS

    Puissant-Lubrano, Bé (Laboratoire d'Immunologie, CHU de Toulouse, Hôpital Rangueil, Toulouse, France ) , né (Laboratoire d'Immunogénétique Moléculaire, Université) , dicte (Paul Sabatier, Toulouse 3, Toulouse, France ) , Puissochet, Sylvain (Laboratoire d'Immunologie, CHU de Toulouse, Hôpital Rangueil, Toulouse, France ) , Congy-Jolivet, Nicolas (Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France ) , Chauveau, Dominique (Department of Pediatric Nephrology, CHU Purpan, Toulouse, INSERM 1048, Institute of Cardiovascular and Metabolic Diseases, Toulouse, Université) , Decramer, Sté (de Toulouse III Paul Sabatier, Toulouse, France ) , phane (Department of Pediatric Nephrology, CHU Purpan, Toulouse, INSERM 1048, Institute of Cardiovascular and Metabolic Diseases, Toulouse, Université) , Garnier, Arnaud (de Toulouse III Paul Sabatier, Toulouse, France ) , Huart, Antoine (Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France ) , Kamar, Nassim (Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France ) , Ribes, David (Department of Nephrology and Organ Transp) , Blancher, Antoine
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 1 - 7 , 2017 , 1521-6616 ,

    초록

    Abstract Eculizumab is a monoclonal anti-C5 antibody used in the treatment of atypical hemolytic uremic syndrome (aHUS). We monitored complement inhibition in 16 eculizumab-treated patients suffering from HUS or transplant rejection (not aHUS patients). Blood samples were obtained one to four weeks after the last eculizumab injection. We observed that eculizumab efficiently blocked the terminal pathway (TP) through classical pathway (CP) activation measured by kinetic hemolytic assay (HA) ( 23%) or chicken erythrocytes HA (AP100>15%). Conversely, functional ELISA revealed a complete blockade of TP through AP activation in all patients ( Similar results were obtained after in vitro addition of increasing amounts of eculizumab to a control serum ( in vitro APH50>60% and AP100>20%). We also showed that ELISA was less sensitive than HA. Highlights Eculizumab incompletely inhibited terminal pathway through alternative pathway activation. Residual terminal pathway activity is observed in the majority of treated patients. This residual activity is observed only with hemolytic assays. ELISA in less sensitive than hemolytic assay to measure complement activity.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  4. [해외논문]   High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans   SCI SCIE SCOPUS

    Roy, Anindita (Department of Paediatrics, University of Oxford, Brno, Czech Republic ) , Bystry, Vojtech (CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic ) , Bohn, Georg (Centre for Haematology, Department of Medicine, Imperial College London, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK ) , Goudevenou, Katerina (Centre for Haematology, Department of Medicine, Imperial College London, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK ) , Reigl, Tomas (CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic ) , Papaioannou, Maria (Centre for Haematology, Department of Medicine, Imperial College London, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK ) , Krejci, Adam (Centre for Haematology, Department of Medicine, Imperial College London, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK ) , O'Byrne, Sorcha (Department of Paediatrics, University of Oxford, Brno, Czech Republic ) , Chaidos, Aristeidis (Centre for Haematology, Department of Medicine, Imperial College London, Imperia) , Grioni, Andrea , Darzentas, Nikos , Roberts, Irene A.G. , Karadimitris, Anastasios
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 8 - 16 , 2017 , 1521-6616 ,

    초록

    Abstract The ontogeny of the natural, public IgM repertoire remains incompletely explored. Here, high-resolution immunogenetic analysis of B cells from (unrelated) fetal, child, and adult samples, shows that although fetal liver (FL) and bone marrow (FBM) IgM repertoires are equally diversified, FL is the main source of IgM natural immunity during the 2nd trimester. Strikingly, 0.25% of all prenatal clonotypes, comprising 18.7% of the expressed repertoire, are shared with the postnatal samples, consistent with persisting fetal IgM+ B cells being a source of natural IgM repertoire in adult life. Further, the origins of specific stereotypic IgM+ B cell receptors associated with chronic lymphocytic leukemia, can be traced back to fetal B cell lymphopoiesis, suggesting that persisting fetal B cells can be subject to malignant transformation late in life. Overall, these novel data provide unique insights into the ontogeny of physiological and malignant B lymphopoiesis that spans the human lifetime. Highlights Second trimester human fetal liver and fetal bone marrow B-cells have IgM repertoires that are equally diversified Human fetal liver B-cells are the main source of innate, natural IgM responses CLL-associated, stereotypic B cell receptors are detected in fetal IgM repertoire Graphical abstract [DISPLAY OMISSION]

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  5. [해외논문]   Rare splicing defects of FAS underly severe recessive autoimmune lymphoproliferative syndrome   SCI SCIE SCOPUS

    Agrebi, N. (Laboratory of Transmission, Control and Immunobiology of Infections (LR11IPT02), Institut Pasteur de Tunis, 1002 Tunis, Belvédère, Tunisia ) , Ben-Mustapha, I. (Laboratory of Transmission, Control and Immunobiology of Infections (LR11IPT02), Institut Pasteur de Tunis, 1002 Tunis, Belvédère, Tunisia ) , Matoussi, N. (Faculty of Medicine, 1007 Tunis, Tunisia ) , Dhouib, N. (Faculty of Medicine, 1007 Tunis, Tunisia ) , Ben-Ali, M. (Laboratory of Transmission, Control and Immunobiology of Infections (LR11IPT02), Institut Pasteur de Tunis, 1002 Tunis, Belvédère, Tunisia ) , Mekki, N. (Laboratory of Transmission, Control and Immunobiology of Infections (LR11IPT02), Institut Pasteur de Tunis, 1002 Tunis, Belvédère, Tunisia ) , Ben-Ahmed, M. (Laboratory of Transmission, Control and Immunobiology of Infections (LR11IPT02), Institut Pasteur de Tunis, 1002 Tunis, Belvédère, Tunisia ) , Larguè (Laboratory of Transmission, Control and Immunobiology of Infections (LR11IPT02), Institut Pasteur de Tunis, 1002 Tunis, Belvéd&egrav) , che, B. , Ben Becher, S. , Bé , jaoui, M. , Barbouche, M.R.
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 17 - 23 , 2017 , 1521-6616 ,

    초록

    Abstract Autoimmune lymphoproliferative syndrome (ALPS) is a prototypic disorder of impaired apoptosis characterized by autoimmune features and lymphoproliferation. Heterozygous germline or somatic FAS mutations associated with preserved protein expression have been described. Very rare cases of homozygous germline FAS mutations causing severe autosomal recessive form of ALPS with a complete defect of Fas expression have been reported. We report two unrelated patients from highly inbred North African population showing a severe ALPS phenotype and an undetectable Fas surface expression. Two novel homozygous mutations have been identified underlying rare splicing defects mechanisms. The first mutation breaks a branch point sequence and the second alters a regulatory exonic splicing site. These splicing defects induce the skipping of exon 6 encoding the transmembrane domain of CD95. Our findings highlight the requirement of tight regulation of FAS exon 6 splicing for balanced alternative splicing and illustrate the importance of such studies in highly consanguineous populations. Highlights Involvement of rare splicing defects mechanisms in severe ALPS patients. Confirmation of the crucial role of tight regulation of FAS exon 6 splicing. Genetic studies in consanguineous populations bring new insights into AR diseases.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  6. [해외논문]   Identification of evidence for autoimmune pathology of bilateral sudden sensorineural hearing loss using proteomic analysis   SCI SCIE SCOPUS

    Lee, Jeon Mi (Department of Otorhinolaryngology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea ) , Kim, Jin Young (Research Center for Human Natural Defense System, Yonsei University College of Medicine, Seoul, Republic of Korea ) , Bok, Jinwoong (Department of Otorhinolaryngology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea ) , Kim, Kyu-Sung (Department of Otorhinolaryngology, Inha University College of Medicine, Incheon, Republic of Korea ) , Choi, Jae Young (Department of Otorhinolaryngology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea ) , Kim, Sung Huhn (Department of Otorhinolaryngology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea)
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 24 - 35 , 2017 , 1521-6616 ,

    초록

    Abstract Sudden sensorineural hearing loss (S-SNHL) is an inner ear disorder with an abrupt hearing loss occurring S-SNHL: sudden sensorineural hearing loss; LC-MS: liquid chromatography-mass spectrometry; MS: mass spectrometry; autoAb: autoantibody; 1-DE: one-dimensional electrophoresis. Highlights Evidences for autoimmunity were revealed by proteomic techniques in bilateral S-SNHL. Multiple autoantibodies and their target antigens were involved in the autoimmunity. The results can provide a basis for understanding autoimmune inner ear disorder. Biomarkers in autoimmune inner ear disorder can be developed based on the results.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  7. [해외논문]   Idiopathic T cell lymphopenia identified in New York State Newborn Screening   SCI SCIE SCOPUS

    Albin-Leeds, Stephanie (Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, United States ) , Ochoa, Juliana (Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, United States ) , Mehta, Harshna (Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, United States ) , Vogel, Beth H. (Wadsworth Center, New York State Department of Health, Albany, NY, United States ) , Caggana, Michele (Wadsworth Center, New York State Department of Health, Albany, NY, United States ) , Bonagura, Vincent (Division of Allergy, Asthma and Immunology, Northwell Health System, Great Neck, NY, United States ) , Lehman, Heather (Division of Allergy, Immunology, and Pediatric Rheumatology, Women and Children's Hospital of Buffalo, Buffalo, NY, United States ) , Ballow, Mark (Division of Allergy, Immunology, and Pediatric Rheumatology, Women and Children's Hospital of Buffalo, Buffalo, NY, United States ) , Rubinstein, Arye (Division of Allergy and Immunology, Montefiore Hospital Medical Center, Bronx, NY, United States ) , Siegel, Subhadra (Department of Pediatrics, New York Medical College, Valhal) , Weiner, Leonard , Weinberg, Geoffrey A. , Cunningham-Rundles, Charlotte
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 36 - 40 , 2017 , 1521-6616 ,

    초록

    Abstract Quantification of T-cell receptor excision circles (TRECs) for newborn screening for SCID has advanced the diagnosis of severe combined immune deficiency (SCID). However, it has led to the identification of infants with T cell lymphopenia without known cause. The clinical characteristics, appropriate laboratory monitoring, and outcomes of patients remain unclear. We performed a retrospective review of clinical and laboratory studies for 26 infants collected from 7 New York State referral centers from 2010 to 2016 with low TRECs (mean, 70copies/μl) and subnormal CD3 counts (mean, 1150/cubicmm). Over time absolute CD3 counts increased in 17 and decreased in 9; 22 (85%) have done well clinically regardless of absolute T cell values. Additional infants with TCL will continue to be identified in newborn screening panels. While most patients seem to do well clinically, parameters for diagnosis and monitoring have yet to be formalized, and additional information needs to be collected, causes and outcomes reported. Highlights The TREC assay identifies newborns with SCID and other severe T cell defects. Occasional infants with idiopathic lymphopenia are also identified. Idiopathic lymphopenia is poorly understood and does not resolve in all infants While most infants with idiopathic lymphopenia do well clinically, persistent medical problems occur in some.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  8. [해외논문]   Terminal 14q32.33 deletion as a novel cause of agammaglobulinemia   SCI SCIE SCOPUS

    Geier, Christoph B. (Immunology Outpatient Clinic, Vienna, Austria ) , Piller, Alexander (Immunology Outpatient Clinic, Vienna, Austria ) , Eibl, Martha M. (Immunology Outpatient Clinic, Vienna, Austria ) , Ciznar, Peter (Department of Pediatrics, Faculty of Medicine Comenius University and Children's University Hospital, Bratislava, Slovakia ) , Ilencikova, Denisa (Department of Pediatrics, Faculty of Medicine Comenius University and Children's University Hospital, Bratislava, Slovakia ) , Wolf, Hermann M. (Immunology Outpatient Clinic, Vienna, Austria)
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 41 - 45 , 2017 , 1521-6616 ,

    초록

    Abstract Over the past decades, a pleiotropic spectrum of B-cell intrinsic defects leading to early onset agammaglobulinemia and absent B cells has been described. Herein we report terminal 14q32.33 deletion as a novel cause of agammaglobulinemia. We describe a 20-year old man with a 1MB terminal 14q32.33 deletion resulting in a loss of the entire Immunoglobulin heavy chain gene region of chromosome 14. The patient presented with absent serum immunoglobulin levels and absent circulating B cells since age 2. The clinical picture was dominated by severe episodes of recurrent upper respiratory tract infections. In the literature, the most prevalent features of terminal 14q32.33 deletions include mental disability, facial malformation, hypotonia, seizures, and visual problems with retinal abnormalities. Neither increased susceptibility to infections nor agammaglobulinemia have been described as a manifestation of terminal 14q32.33 deletion. Thus, our findings expand the known clinical spectrum of terminal 14q32.33 deletion to include susceptibility to infections. Highlights Terminal 14q32.33 deletion causes agammaglobulinemia with absent circulating B-cells. Severe bacterial infections of the upper respiratory tract are the leading cause of mortality. CNS disease and skeletal dysmorphia with muscular atrophy developed in later years.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  9. [해외논문]   The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus   SCI SCIE SCOPUS

    Xu, Bihua (Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ) , Wang, Shuang (Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ) , Zhou, Mianjing (Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ) , Huang, Yuefang (Department of Pediatrics, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ) , Fu, Rong (Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ) , Guo, Chaohuan (Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ) , Chen, Jingxian (Department of Pediatrics, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ) , Zhao, Jijun (Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ) , Gaskin, Felicia (Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908-0133, USA ) , Fu, Shu Man (Division of Rheumatolog) , Yang, Niansheng
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 46 - 53 , 2017 , 1521-6616 ,

    초록

    Abstract Follicular T regulatory (Tfr) cells inhibit follicular T helper (Tfh) cells mediated B cell responses. Tfh cells are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the role of Tfr cells in SLE remains unclear. The frequency of circulating Tfr and Tfh cells were examined in SLE patients and healthy controls. The frequency of circulating Tfr cell decreased and Tfh/Tfr ratio increased in SLE patients. Serum anti-dsDNA antibody level positively correlated with frequency of Tfh cells and Tfh/Tfr ratios but negatively correlated with the frequency of Tfr cells. Moreover, the frequency of Tfr and Tfh/Tfr ratio but not that of Tfh was correlated with diseases activity. In addition, increase in Tfr cell numbers and decrease in the Tfh/Tfr ratios were observed with successful treatments. Thus, Tfr cells should be considered as a biomarker for SLE and their role in the pathogenesis of SLE warrants further investigation. Highlights The frequency of circulating Tfr cells decreased and Tfh/Tfr ratio increased in SLE patients. Increased active subpopulation was found in Tfh and Tfr cells of SLE. The frequency of Tfr and Tfh/Tfr ratio but not that of Tfh was correlated with diseases activity. Increase in Tfr cell numbers and decrease in the Tfh/Tfr ratios were observed with successful treatments.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  10. [해외논문]   X-Linked Agammaglobulinaemia: Outcomes in the modern era   SCI SCIE SCOPUS

    Shillitoe, Ben (Corresponding author.) , Gennery, Andrew
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 54 - 62 , 2017 , 1521-6616 ,

    초록

    Abstract Colonel Ogden Bruton reported X-Linked Agammaglobulinaemia in 1952 and treated the child with replacement immunoglobulin therapy. Over 60years later, the treatment for XLA has largely remained unchanged. Replacement immunoglobulin lacks the isotypes IgA and IgM, leading to concerns that patients continue to experience recurrent sinopulmonary tract infections and be at increased risk of bronchiectasis. There is potential hope of earlier diagnosis with newborn screening, and a potential cure for these patients, in the form of gene therapy. However, it is first necessary to evaluate current management and outcomes to aid decisions regarding further research and clinical trials. This article reviews current management and outcomes of XLA, whilst identifying gaps in our knowledge base that may need answering before we proceed with novel diagnostic methods and treatment for XLA. Highlights Current therapy is likely to be limited in its ability to prevent complications. Of particular concerns is the development of bronchiectasis. Rates of bronchiectasis are significant in XLA despite current optimal therapy. Novel management options are possible, notably newborn screening and gene therapy. More data are needed to fully evaluate current outcomes in XLA.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지

논문관련 이미지