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Psychiatry research, Neuroimaging 13건

  1. [해외논문]   Editorial Board  


    Psychiatry research, Neuroimaging v.260 ,pp. IFC , 2017 , 0925-4927 ,

    초록

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   Editorial Board   SCI SCIE


    Psychiatry research, Neuroimaging v.260 ,pp. IFC - IFC , 2017 , 0925-4927 ,

    초록

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

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  3. [해외논문]   White matter abnormalities in long-term anabolic-androgenic steroid users: A pilot study   SCI SCIE

    Seitz, Johanna (Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ) , Lyall, Amanda E. (Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ) , Kanayama, Gen (Biological Psychiatry Laboratory, McLean Hospital, Belmont, Massachusetts, USA, and Department of Psychiatry, Harvard Medical School, Boston, MA, USA ) , Makris, Nikos (Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ) , Hudson, James I. (Biological Psychiatry Laboratory, McLean Hospital, Belmont, Massachusetts, USA, and Department of Psychiatry, Harvard Medical School, Boston, MA, USA ) , Kubicki, Marek (Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ) , Pope Jr, Harrison G. (Biological Psychiatry Laboratory, McLean Hospital, Belmont, Massachusetts, USA, and Department of Psychiatry, Harvard Medical School, Boston, MA, USA ) , Kaufman Jr, Marc J. (McLean I)
    Psychiatry research, Neuroimaging v.260 ,pp. 1 - 5 , 2017 , 0925-4927 ,

    초록

    Abstract Recent studies of long-term anabolic-androgenic steroid (AAS) users reported amygdala structural and functional connectivity abnormalities. We assessed white matter microstructure in the inferior-fronto-occipital fasciculus (IFOF), a major associative bundle of the amygdala network. Diffusion weighted images acquired from 9 male long-term AAS users and 8 matched controls aged 36–51 years old were processed using a standardized pipeline (Tract-Based Spatial Statistics). Group differences were examined using linear regression with adjustment for age and current testosterone level. Compared to nonusers, AAS users exhibited significantly higher fractional anisotropy (FA) in the IFOF. Users showed markedly greater FA than nonusers on the left IFOF but only a modest, nonsignificant difference on the right IFOF. Moreover, FA was positively associated with lifetime cumulative AAS dose. Our results suggest that long-term AAS use alters IFOF white matter organization and integrity, which in turn might affect amygdala-related processes such as reward system function. Accordingly, further studies are needed to replicate findings in larger subject groups to determine the functional significance of the FA abnormality. Highlights Anabolic-androgenic steroids (AAS) cause psychiatric and cognitive abnormalities. We performed the first Diffusion Tensor Imaging study of long-term AAS users. Fractional anisotropy (FA) was higher in AAS users in an amygdala network tract. Among AAS users, FA in this tract was positively associated with lifetime AAS dose. The FA abnormality is consistent with prior human and animal studies of AAS effects.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Brain network dysfunction in youth with obsessive-compulsive disorder induced by simple uni-manual behavior: The role of the dorsal anterior cingulate cortex   SCI SCIE

    Friedman, Amy L. (Dept. of Psychiatry & Behavioral Neurosciences, Wayne State University, Detroit, MI, USA ) , Burgess, Ashley (Dept. of Psychiatry & Behavioral Neurosciences, Wayne State University, Detroit, MI, USA ) , Ramaseshan, Karthik (Dept. of Psychiatry & Behavioral Neurosciences, Wayne State University, Detroit, MI, USA ) , Easter, Phil (Dept. of Psychiatry & Behavioral Neurosciences, Wayne State University, Detroit, MI, USA ) , Khatib, Dalal (Dept. of Psychiatry & Behavioral Neurosciences, Wayne State University, Detroit, MI, USA ) , Chowdury, Asadur (Dept. of Psychiatry & Behavioral Neurosciences, Wayne State University, Detroit, MI, USA ) , Arnold, Paul D. (Dept. of Psychiatry and Mathison Centre for Mental Health Research & Education, University of Calgary, Calgary, Alberta, Canada ) , Hanna, Gregory L. (Dept. of Psychiatry, University of Michigan, Ann Arbor, MI, USA ) , Rosenberg, David R. (Dept. of Psychiatry & Behavioral Neurosciences, Wayne State University, Detroit, MI, USA ) , Diwadkar, Vaibhav A. (Dept. of Psychiatry & Behavioral Neurosciences, Wayne State University, Detroit, MI, USA)
    Psychiatry research, Neuroimaging v.260 ,pp. 6 - 15 , 2017 , 0925-4927 ,

    초록

    Abstract In an effort to elucidate differences in functioning brain networks between youth with obsessive-compulsive disorder and controls, we used fMRI signals to analyze brain network interactions of the dorsal anterior cingulate cortex (dACC) during visually coordinated motor responses. Subjects made a uni-manual response to briefly presented probes, at periodic (allowing participants to maintain a “motor set”) or random intervals (demanding reactive responses). Network interactions were assessed using psycho-physiological interaction (PPI), a basic model of functional connectivity evaluating modulatory effects of the dACC in the context of each task condition. Across conditions, OCD were characterized by hyper-modulation by the dACC, with loci alternatively observed as both condition-general and condition-specific. Thus, dynamically driven task demands during simple uni-manual motor control induce compensatory network interactions in cortical-thalamic regions in OCD. These findings support previous research in OCD showing compensatory network interactions during complex memory tasks, but establish that these network effects are observed during basic sensorimotor processing. Thus, these patterns of network dysfunction may in fact be independent of the complexity of tasks used to induce brain network activity. Hypothesis-driven approaches coupled with sophisticated network analyses are a highly valuable approach in using fMRI to uncover mechanisms in disorders like OCD. Highlights We studied youth with OCD compared to healthy controls using fMRI data acquired during a simple uni-manual motor response paradigm. fMRI data were modeled using functional connectivity techniques to assess network profiles of the dorsal anterior cingulate cortex (dACC) across task conditions. OCD were characterized by exaggerated network modulation by the dACC, particularly in brain regions associated with attention and executive processing. These results imply that basic visuo-motor paradigms can serve as powerful modulators of underlying brain network function, and by corollary, successfully define aberrant brain network profiles in OCD.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  5. [해외논문]   Altered patterns of association between cortical thickness and subcortical volume in patients with first episode major depressive disorder: A structural MRI study   SCI SCIE

    Zhao, Ke (Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China ) , Liu, Haiyan (Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China ) , Yan, Rui (Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China ) , Hua, Lingling (Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China ) , Chen, Yu (Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China ) , Shi, Jiabo (Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China ) , Yao, Zhijian (Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China ) , Lu, Qing (Research Center of Learning Science, Southeast University, Nanjing 210096, China)
    Psychiatry research, Neuroimaging v.260 ,pp. 16 - 22 , 2017 , 0925-4927 ,

    초록

    Abstract Depressed individuals may exhibit changes in cortical thickness and subcortical volume. However, we know little about their associated connection patterns in the brain's neural circuits. This study explored correlations between overall cortical thickness and the volume of several subcortical structures in first episode major depressive disorder (MDD) patients. Thirty-six untreated individuals experiencing their first episode of MDD were compared with healthy controls ( n = 41). Their brains were imaged by T1-weighted MRI, allowing the measurement of cortical thickness and the volume of subcortical structures. We found that in MDD patients, the cortex was thinner in four of the measured regions (frontal, temporal, parietal and insula) and the volume of the putamen and amygdala tended to be smaller compared with controls. Furthermore, the ratio of the volume of the four measured subcortical structures (left pallidum, left putamen, left amygdala and right caudate) to cortical thickness (measured in 11 regions)was significantly larger in the MDD group compared with controls. These results show that there are different relationships between subcortical volume and cortical thickness inearly-stage MDD and control subjects. Highlights Cortical thickness and subcotical volume decreased in patient group. Cortical thickness was positively correlated with subcortical volume in patient group. Altered patterns may be related to the onset of depression.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  6. [해외논문]   Lateralization of intrinsic frontoparietal network connectivity and symptoms in schizophrenia   SCI SCIE

    Son, Shuraku (Department of Psychiatry, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan ) , Miyata, Jun (Department of Psychiatry, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan ) , Mori, Yasuo (Department of Psychiatry, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan ) , Isobe, Masanori (Department of Psychiatry, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan ) , Urayama, Shin-ichi (Human Brain Research Center, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan ) , Aso, Toshihiko (Human Brain Research Center, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan ) , Fukuyama, Hidenao (Research and Educational Unit of Leaders for Integrated Medical System, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Japan ) , Murai, Toshiya (Department of Psychiatry, Graduate Schoo) , Takahashi, Hidehiko
    Psychiatry research, Neuroimaging v.260 ,pp. 23 - 28 , 2017 , 0925-4927 ,

    초록

    Abstract It has been frequently reported that schizophrenia patients have reduced functional lateralization in the areas related to language processing. Furthermore, there is evidence supporting that schizophrenia patients have disrupted functional connectivity in the bilateral frontoparietal networks (FPNs), of which the left is strongly associated with a cognition-language paradigm, using resting-state functional magnetic resonance imaging (rsfMRI). To examine the laterality of resting-state functional connectivity in schizophrenia, we investigated the bilateral FPNs. We investigated 41 schizophrenia and 35 healthy participants using independent component analysis for rsfMRI. We extracted mean connectivity values of both left and right FPNs and calculated their laterality index by (left - right)/(left + right). Subsequently, we investigated group differences of these values and the correlation between these values and symptoms. In schizophrenia, mean connectivity values of both left and right FPNs were significantly lower than in healthy controls, whereas their laterality indices were not significantly different. However, correlation analyses revealed that the laterality index was negatively correlated with positive symptoms, and that mean connectivity of left FPN was negatively correlated with depressive symptoms in schizophrenia. Our results suggest that language-related networks and their laterality might be one of the neural correlates of schizophrenia symptoms. Highlights Laterality of bilateral FPN connectivity was not different in schizophrenia. It was negatively correlated with positive symptoms in schizophrenia. Left one was negatively correlated with depressive symptoms in schizophrenia.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  7. [해외논문]   White matter microstructure and volitional motor activity in schizophrenia: A diffusion kurtosis imaging study   SCI SCIE

    Docx, Lise (Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium ) , Emsell, Louise (University Psychiatry Centre (UPC)-KU Leuven, Leuven, Belgium ) , Van Hecke, Wim (Department of Radiology, Antwerp University Hospital & University of Antwerp, Antwerp, Belgium ) , De Bondt, Timo (Department of Radiology, Antwerp University Hospital & University of Antwerp, Antwerp, Belgium ) , Parizel, Paul M. (Department of Radiology, Antwerp University Hospital & University of Antwerp, Antwerp, Belgium ) , Sabbe, Bernard (Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium ) , Morrens, Manuel (Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium)
    Psychiatry research, Neuroimaging v.260 ,pp. 29 - 36 , 2017 , 0925-4927 ,

    초록

    Abstract Avolition is a core feature of schizophrenia and may arise from altered brain connectivity. Here we used diffusion kurtosis imaging (DKI) to investigate the association between white matter (WM) microstructure and volitional motor activity. Multi-shell diffusion MRI and 24-h actigraphy data were obtained from 20 right-handed patients with schizophrenia and 16 right-handed age and gender matched healthy controls. We examined correlations between fractional anisotropy (FA), mean diffusivity (MD), mean kurtosis (MK), and motor activity level, as well as group differences in these measures. In the patient group, increasing motor activity level was positively correlated with MK in the inferior, medial and superior longitudinal fasciculus, the corpus callosum, the posterior fronto-occipital fasciculus and the posterior cingulum. This association was not found in control subjects or in DTI measures. These results show that a lack of volitional motor activity in schizophrenia is associated with potentially altered WM microstructure in posterior brain regions associated with cognitive function and motivation. This could reflect both illness related dysconnectivity which through altered cognition, manifests as reduced volitional motor activity, and/or the effects of reduced physical activity on brain WM. Highlights Patients with schizophrenia are less physically active than healthy controls. These motor activity levels are correlated with white matter microstructural changes in patients with schizophrenia but not in healthy controls. DKI and DTI are complementary indices for investigating microstructural changes in schizophrenia.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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    Fig. 1 이미지
  8. [해외논문]   Lost emotion: Disrupted brain-based tracking of dynamic affective episodes in anxiety and depression   SCI SCIE

    Carlson, Joshua M. (Department of Psychology, 1401 Presque Isle Avenue Northern Michigan University, Marquette, MI, USA ) , Rubin, Denis (Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA ) , Mujica-Parodi, Lilianne R. (Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA)
    Psychiatry research, Neuroimaging v.260 ,pp. 37 - 48 , 2017 , 0925-4927 ,

    초록

    Abstract In our day-to-day lives we are confronted with dynamic sensory inputs that elicit a continuously evolving emotional response. Insight into the brain basis of the dynamic nature of emotional reactivity may be critical for understanding chronic symptoms of anxiety and depression. Here, individuals with generalized anxiety disorder, major depressive disorder, and healthy controls watched a video with dynamic affective content while fMRI activity was recorded. Across all participants there was a large-scale tracking of affective content in emotion processing regions and the default mode network. Anxious and depressed individuals displayed less brain-based coupling within these regions and the extent of this uncoupling correlated with variability in emotional numbing. Thus, abnormal neural tracking of affective information during dynamic emotional episodes appears to represent a disconnection between affective cues in the environment and an individual’s response to these cues—providing a putative neural basis for context insensitive affective reactivity and emotional numbing. Highlights Dynamics in affective valence and arousal were tracked by the brain. Default mode network and emotion regions track these dynamics in affective content. Brain-based tracking of emotion is disrupted in patients with anxiety and depression. Weakened brain-based tracking of emotion is linked to symptoms of emotional numbing.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Evidence for the changes of pituitary volumes in patients with post-traumatic stress disorder   SCI SCIE

    Atmaca, Murad (Firat University School of Medicine Department of Psychiatry, Elazig, Turkey ) , Ozer, Omer (Firat University School of Medicine Department of Psychiatry, Elazig, Turkey ) , Korkmaz, Sevda (Firat University School of Medicine Department of Psychiatry, Elazig, Turkey ) , Taskent, Ismail (Firat University School of Medicine Department of Radiology, Elazig, Turkey ) , Yildirim, Hanefi (Firat University School of Medicine Department of Radiology, Elazig, Turkey)
    Psychiatry research, Neuroimaging v.260 ,pp. 49 - 52 , 2017 , 0925-4927 ,

    초록

    Abstract In pubertal and postpubertal patients with post-traumatic stress disorder (PTSD), significantly greater pituitary gland volumes have been reported. Moving from this point, in the present study, we aimed to investigate pituitary gland volumes in patients with PTSD and hypothesized that volumes of the gland would be structurally changed. Volumetric magnetic resonance imaging of the pituitary gland was performed among sixteen patients with PTSD and fifteen healthy control subjects. We found that the mean volume of the pituitary gland was statistically significant and smaller than that of healthy subjects (0.69±0.08cm 3 for patient group and 0.83±0.21 for control subjects). Consequently, in the present study, we found that patients with PTSD had smaller pituitary gland volumes than those of healthy controls like other anxiety disorders. It is important to provide support for this finding in future longitudinal investigations. Highlights In the present study, we aimed to investigate pituitary gland volumes in patients with PTSD and hypothesized that volumes of the gland would be structurally changed. We found that the mean volume of the pituitary gland was statistically significant and smaller than that of healthy subjects. PTSD had smaller pituitary gland volumes than those of healthy controls like other anxiety disorders.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  10. [해외논문]   Cerebral blood flow and its connectivity features of auditory verbal hallucinations in schizophrenia: A perfusion study   SCI SCIE

    Cui, Long-Biao (Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China ) , Chen, Gang (Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China ) , Xu, Zi-Liang (School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China ) , Liu, Lin (School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China ) , Wang, Hua-Ning (Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China ) , Guo, Li (Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China ) , Liu, Wen-Ming (Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China ) , Liu, Ting-Ting (Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China ) , Qi, Shun (Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China ) , Liu, Kang (Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, Chi) , Qin, Wei , Sun, Jin-Bo , Xi, Yi-Bin , Yin, Hong
    Psychiatry research, Neuroimaging v.260 ,pp. 53 - 61 , 2017 , 0925-4927 ,

    초록

    Abstract The goal of the study was to investigate cerebral blood flow (CBF) and its connectivity (an across-subject covariance measure) patterns of schizophrenia (SZ) patients with auditory verbal hallucinations (AVHs). A total of demographically matched 25 SZ patients with AVHs, 25 without AVHs, and 25 healthy controls (HCs) underwent resting state perfusion imaging using a pulsed arterial spin labeling sequence. CBF and its connectivity were analyzed and then CBF topological properties were calculated. AVHs patients exhibited decreased CBF in the bilateral superior and middle frontal gyri and postcentral gyri, and right supplementary motor area compared with SZ patients without AVHs. SZ patients without AVHs showed reduced CBF in the left middle frontal gyrus relative to HCs. Moreover, AVHs groups showed distinct connectivity pattern, an intermediate level between HCs and patients without AVHs in the global efficiency. Our study demonstrates aberrant CBF in the brain regions associated with inner speech monitoring and language processing in SZ patients with AVHs. The complex network measures showed by CBF-derived functional connectivity indicate dysconnectivity between different functional units within the network of AVHs in SZ. Our findings might shed light on the neural underpinnings behind AVHs in this devastating disease at the level of CBF and its connectivity. Highlights AVHs in SZ show dysfunction of the regions involving speech imagery, production, and monitoring. SZ patients with AVHs showed deficit communication within the brain network. CBF values help to discriminate SZ patients with AVHs from those without AVHs. CBF measure might be an effective indicator of AVHs vulnerability in SZ patients.

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