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International journal of molecular sciences 198건

  1. [해외논문]   Dextran Sulfate Sodium Inhibits Alanine Synthesis in Caco-2 Cells   SCIE

    Ye, Zhong (Department of Nutrition, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA) , Mishchuk, Darya O. (E-Mail: zye@ucdavis.edu ) , Stephens, Natasha S. (Department of Food Science and Technology, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA) , Slupsky, Carolyn M. (E-Mails: domishchuk@ucdavis.edu (D.O.M.))
    International journal of molecular sciences v.12 no.12 ,pp. 2325 - 2335 , 2011 , 1661-6596 ,

    초록

    To understand and characterize the pathogenic mechanisms of inflammatory bowel disease, dextran sulfate sodium (DSS) has been used to induce acute and chronic colitis in animal models by causing intestinal epithelium damage. The mechanism of action of DSS in producing this outcome is not well understood. In an effort to understand how DSS might impact epithelial cell metabolism, we studied the intestinal epithelial cell line Caco-2 incubated with 1% DSS over 56 hours using 1 H NMR spectroscopy. We observed no difference in cell viability as compared to control cultures, and an approximately 1.5-fold increase in IL-6 production upon incubation with 1% DSS. The effect on Caco-2 cell metabolism as measured through changes in the concentration of metabolites in the cell supernatant included a three-fold decrease in the concentration of alanine. Given that the concentrations of other amino acids in the cell culture supernatant were not different between treated and control cultures over 56 hours suggest that DSS inhibits alanine synthesis, specifically alanine aminotransferase, without affecting other key metabolic pathways. The importance of alanine aminotransferase in inflammatory bowel disease is discussed.

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  2. [해외논문]   Molecular Biomarkers for the Diagnosis of Primary Vitreoretinal Lymphoma   SCIE

    Wang, Yujuan (Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA) , Shen, Defen (E-Mails: yujuan.wang@nih.gov (Y.W.)) , Wang, Vinson M. (shend@nei.nih.gov (D.S.)) , Sen, H. Nida (vinson.wang@nih.gov (V.M.W.) ) , Chan, Chi-Chao (Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA)
    International journal of molecular sciences v.12 no.12 ,pp. 5684 - 5697 , 2011 , 1661-6596 ,

    초록

    Primary vitreoretinal lymphoma (PVRL) or primary intraocular lymphoma, a subtype of primary central nervous system lymphoma, often masquerades as uveitis. The diagnosis of PVRL requires identification of lymphoma cells inside the eye, which is often challenging due to the frequent necrosis and admixing of PVRL cells with reactive lymphocytes. Therefore, detection of immunoglobulin heavy chain ( IgH ) and T-cell receptor ( TCR ) gene rearrangements provide molecular diagnosis of B- and T-cell lymphoma, respectively. We retrospectively evaluated 208 cases with a clinical diagnosis of masquerade syndrome from 1998 to 2010. In 200 cases with molecular analyses using microdissection and polymerase chain reaction, we found that 110 cases had IgH gene rearrangement, 5 cases had TCR gene rearrangement, and 85 cases were negative for these two gene arrangements. The molecular data corroborated the cytopathological diagnoses of PVRL and uveitis in the majority of cases. Cytokine above the detected levels in the specimens were also measured in 80 of the 208 cases. A ratio of vitreous IL-10 to IL-6 greater than 1, suggesting PVRL, was found in 56/80 cases; 53/56 had the correct diagnosis. A ratio less than 1, suggesting uveitis, was found in 24/80 cases; 17/24 correctly confirmed the diagnosis. Moreover, the molecular data corresponded well with the clinical course of the diseases. The sensitivity and specificity of these molecular biomarkers for the diagnosis of PVRL are higher than 95%.

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  3. [해외논문]   Antioxidant Properties of the Edible Basidiomycete Armillaria mellea in Submerged Cultures   SCIE

    Lung, Ming-Yeou (Department of Chemical and Materials Engineering, Minghsin University of Science and Technology, Hsin Fong, Hsin Chu 304, Taiwan) , Chang, Yu-Cheng (E-Mail: moonriversnow@hotmail.com )
    International journal of molecular sciences v.12 no.12 ,pp. 6367 - 6384 , 2011 , 1661-6596 ,

    초록

    Antioxidant components, ascorbic acid, total flavonoids and total phenols are produced effectively by Armillaria mellea submerged cultures. Dried mycelia and mycelia-free broths obtained by A. mellea submerged cultures are extracted with methanol and hot water and investigated for antioxidant properties. Methanolic extracts from dried mycelia (MEM) and mycelia-free broth (MEB) and hot water extracts from dried mycelia (HWEM) by A. mellea submerged cultures show good antioxidant properties as evidenced by low EC 50 values ( A. mellea are potential good substitutes for synthetic antioxidants and can be applied to antioxidant-related functional food and pharmaceutical industries.

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  4. [해외논문]   Assessment of Tamarindus indica Extracts for Antibacterial Activity   SCIE

    Nwodo, Uchechukwu U. (Applied and Environmental Microbiology Research Group (AEMREG), Department of Biochemistry and Microbiology, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa) , Obiiyeke, Grace E. (E-Mails: vchigor@ufh.ac.za (V.N.C.)) , Chigor, Vincent N. (aokoh@ufh.ac.za (A.I.O.) ) , Okoh, Anthony I. (Department of Botany, Delta State University, Abraka, 330106, Delta State, Nigeria)
    International journal of molecular sciences v.12 no.12 ,pp. 6385 - 6396 , 2011 , 1661-6596 ,

    초록

    Ethanolic and aqueous (hot and cold) extracts of the fruit pulp, stem bark and leaves of Tamarindus indica were evaluated for antibacterial activity, in vitro , against 13 Gram negative and 5 Gram positive bacterial strains using agar well diffusion and macro broth dilution techniques, simultaneously. The fruit pulp extracts exhibited a wide spectrum of activity; the cold water extract against 95.5% of the test bacterial strains; and the hot water and ethanolic extracts against 90.9% and 86.4%, respectively. In contrast the cold water extract of the leaves and stem bark, each was active against 16.7%; while the ethanolic extract of each was active against 75% of the test strains. The minimum inhibitory concentrations (MIC) ranged from 7.81 mg/mL against Bacillus subtilis ATCC 6051 to 31.25 mg/mL against Escherichia coli ATCC 11775; and the minimum bactericidal concentration (MBC) ranged from 125 mg/mL against Pseudomonas aeruginosa ATCC 10145 to 250 mg/mL against Bacillus subtilis ATCC 6051.

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  5. [해외논문]   MOssbauer Spectroscopy and X-ray Diffraction Study of 57 Fe-Labeled Tetrachloroferrate(III)-Based Magnetic Ionic Liquids   SCIE

    Herber, Rolfe H. (The Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel) , Nowik, Israel (E-Mail: nowik@vms.huji.ac.il ) , Kostner, Mirco E. (The Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel) , Kahlenberg, Volker (E-Mail: nowik@vms.huji.ac.il ) , Kreutz, Christoph (Faculty of Chemistry and Pharmacy, University of Innsbruck, Innsbruck 6020, Austria) , Laus, Gerhard (E-Mails: mirco.kostner@student.uibk.ac.at (M.E.K.)) , Schottenberger, Herwig (christoph.kreutz@uibk.ac.at (C.K.))
    International journal of molecular sciences v.12 no.12 ,pp. 6397 - 6406 , 2011 , 1661-6596 ,

    초록

    Four 57 Fe-labeled tetrachloroferrates(III) of organic cations (1-butyl-3-methylimidazolium, 1-allyl-3-methylimidazolium, 1-methyl-1-propylpyrrolidinium, tetraphenylphosphonium) were examined by temperature-dependent MOssbauer spectroscopy. The hyperfine and dynamic parameters of the iron(III) site were determined. Single crystal X-ray diffraction data of [Ph 4 P][FeCl 4 ] were collected at four temperatures (295, 223, 173, and 123 K), and the dynamics of the iron atom inferred from the MOssbauer data and the single crystal U i,j parameters have been compared.

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  6. [해외논문]   Effect of Celluclast 1.5L on the Physicochemical Characterization of Gold Kiwifruit Pectin   SCIE

    Yuliarti, Oni (Institute of Food Nutrition and Human Health, Massey University, Palmerston North 4474, New Zealand) , Matia-Merino, Lara (E-Mails: oniyuliarti@yahoo.co.nz (O.Y.)) , Goh, Kelvin K. T. (l.matia-merino@massey.ac.nz (L.M.-M.)) , Mawson, John A. (k.t.goh@massey.ac.nz (K.K.T.G.) ) , Brennan, Charles S. (Institute of Food Nutrition and Human Health, Massey University, Palmerston North 4474, New Zealand)
    International journal of molecular sciences v.12 no.12 ,pp. 6407 - 6417 , 2011 , 1661-6596 ,

    초록

    The effects of Celluclast 1.5L concentration on the physicochemical characterization of gold kiwifruit pectin was evaluated. Varying the enzyme concentration affected the pectin yield and pectin physicochemical properties. The viscosity of extracted pectin was largely dependent on the enzyme concentration. Celluclast 1.5L with medium concentration exhibited the highest viscosity. Varying the enzyme concentration also influenced the molecular weight distribution. High molecular weight ( M w ) pectin (1.65 × 10 6 g/mol) was obtained when the medium concentration was used. Overall, the study clearly reflects the importance of taking into consideration the amount of cellulytic enzyme added in order to determine the final quality of pectin.

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  7. [해외논문]   Genetic Variation of the Nile Soft-Shelled Turtle ( Trionyx triunguis )   SCIE

    Gü (Department of Güzelyurt Vocational School Fermantation, Aksaray University, Güzelyurt/Aksaray 68200, Turkey) , ç (E-Mail: ozgguclu@yahoo.com ) , lü (Department of Biology, Faculty of Science and Arts, Adnan Menderes University, Aydin 09010, Turkey) , , Ö (E-Mail: turkozan@adu.edu.tr ) , zgü (Department of Biology, Faculty of Science and Arts, Adnan Menderes University, Aydin 09010, Turkey) , r (E-Mail: turkozan@adu.edu.tr) , Ulger, Celal , Tü , rkozan, Oğ , uz
    International journal of molecular sciences v.12 no.12 ,pp. 6418 - 6431 , 2011 , 1661-6596 ,

    초록

    We studied the genetic structure of Trionyx triunguis populations from the Mediterranean and African continent based on mtDNA D-loop (776 bp) and nine microsatellite loci. A total of 102 polymorphic sites and 13 mtDNA haplotypes were described. Nucleotide diversity and haplotypes diversity were 0.047 and 0.974 respectively. Both mtDNA and nDNA supported the existence of two main management units as the Mediterranean and Africa. Based on the mtDNA results, the Mediterranean can be divided into two subunits; western Turkey and the eastern Mediterranean.

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  8. [해외논문]   Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents   SCIE

    Limban, Carmen (Pharmaceutical Chemistry Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, Bucharest 020956, Romania) , Chifiriuc, Mariana Carmen (E-Mail: carmen_limban@yahoo.com )
    International journal of molecular sciences v.12 no.12 ,pp. 6432 - 6444 , 2011 , 1661-6596 ,

    초록

    In this paper we present the antimicrobial activity of some newly synthesized dibenz[ b , e ]oxepin derivatives bearing the oximino moiety, and fluorine (F) and trifluoromethyl (CF 3 ) group substituents. The chemical structure and purity of the new compounds were assessed by using elemental analysis, NMR and FTIR spectroscopy. The new compounds were screened for their antibacterial activity towards Gram-positive and Gram-negative strains, by qualitative and quantitative assays. Our results demonstrated that the CF 3 and F disubstituted compounds could be considered for the further development of novel antimicrobial drugs.

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  9. [해외논문]   A Determination of Potential α-Glucosidase Inhibitors from Azuki Beans ( Vigna angularis )   SCIE

    Yao, Yang (Institute of Crop Science, Chinese Academy of Agricultural Sciences, South Xueyuan Road, Haidian District No.80, Beijing 100081, China) , Cheng, Xuzhen (E-Mails: yaoyang@caas.net.cn (Y.Y.)) , Wang, Lixia (chengxz@caas.net.cn (X.C.)) , Wang, Suhua (wanglx@caas.net.cn (L.W.)) , Ren, Guixing (wangsh@caas.net.cn (S.W.))
    International journal of molecular sciences v.12 no.12 ,pp. 6445 - 6451 , 2011 , 1661-6596 ,

    초록

    A 70% ethanol extract from azuki beans ( Vigna angularis ) was extracted further with CH 2 Cl 2 , EtOAc and n-BuOH to afford four fractions: CH 2 Cl 2 -soluble, EtOAc-soluble, n -BuOH-soluble and residual extract fractions. The EtOAc-soluble fractions showed the highest α-glucosidase inhibitory activity. Two pure flavonoid compounds, vitexin and isovitexin, were isolated (using the enzyme assay-guide fractionation method) from the EtOAc-soluble fractions. We further evaluated the interaction between the flavonoid compounds and α-glucosidase by fluorescence spectroscopy. Vitexin and isovitexin showed high inhibitory activities, with IC 50 values of 0.4 mg·mL −1 and 4.8 mg·mL −1 , respectively. This is the first study of the active compositions of azuki beans against α-glucosidase.

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  10. [해외논문]   Betalain, Acid Ascorbic, Phenolic Contents and Antioxidant Properties of Purple, Red, Yellow and White Cactus Pears   SCIE

    Sumaya-Martí (Secretary of Research and Graduate Studies, Autonomous University of Nayarit, Ciudad de la Cultura “Amado Nervo”, Boulevard Tepic-Xalisco S/N. Tepic, Nayarit, Mexico) , nez, Marí (E-Mails: digapa1@hotmail.com (J.D.G.-P.)) , a Teresa (leonarm2@yahoo.com.mx (L.M.-C.) ) , Cruz-Jaime, Sandra (Institute of Health Sciences, Autonomous University of Hidalgo State, Ex-Hacienda de la Concepción, Tilcuautla, 42080 Pachuca de Soto, Hgo, Mexico) , Madrigal-Santillá (E-Mails: crzjms@msn.com (S.C.-J.)) , n, Eduardo (eomsmx@yahoo.com.mx (E.M.-S.)) , Garcí (raque_nat@hotmail.com (R.C.-C.)) , a-Paredes, Juan Diego (cruz_cansino@hotmail.com (N.C.-C.)) , Cariñ (m.valadezvega@lycos.com (C.V.-V.)) , o-Corté (ernesto_alanisgarcia@hotmail.com (E.A.-G.) ) , s, Raquel (Institute of Health Sciences, Autonomous University of Hidalgo State, Ex-Hacienda de la Concepción, Tilcuautla, 42080 Pachuca de Soto, Hgo, Mexico) , Cruz-Cansino, Nelly (E-Mails: crzjms@msn.com (S.C.-J.)) , Valadez-Vega, Carmen (eomsmx@yahoo.com.mx (E.M.-S.)) , Martinez-Cardenas, Leonardo (raque_nat@hotmail.com (R.C.-C.)) , Alaní (cruz_cansino@hotmail.com (N.C.-C.)) , s-Garcí (m.valadezvega@lycos.com (C.V.-V.)) , a, Ernesto (ernesto_alanisgarcia@hotmail.com (E.A.-G.) )
    International journal of molecular sciences v.12 no.12 ,pp. 6452 - 6468 , 2011 , 1661-6596 ,

    초록

    Commercialization of cactus pears based on their antioxidant properties can generate competitive advantages, and these can turn into business opportunities and the development of new products and a high-value ingredient for the food industry. This work evaluated the antioxidant activities (1,1-diphenyl-2-picrylhydrazyl radical-scavenging, protection against oxidation of a β-carotene-linoleic acid emulsion, and iron (II) chelation), the content of total phenolic compounds, ascorbic acid, betacyanin, betaxanthin and the stability of betacyanin pigments in presence of Cu (II)-dependent hydroxyl radicals (OH•), in 18 cultivars of purple, red, yellow and white cactus pear from six Mexican states. Our results indicated that the antiradical activities from yellow and white cactus pear cultivars were not significantly different ( p p R 2 = 0.90) and ascorbic acid ( R 2 = 0.86). All 18 cultivars of cactus pears studied showed significant chelating activity of ferrous ions. The red and purple cactus pears showed a great stability when exposed to OH•.

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    Fig. 1 이미지

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