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Natural product sciences 13건

  1. [국내논문]   Biological Activities of Phloroglucinol Derivatives from Eucalyptus Spp.  

    Singh, Inder Pal (The United Graduate School of Agricultural Sciences, Gifu University (Shizuoka University) ) , Etoh, Hideo (Department of Applied Biological Chemistry, Shizuoka University)
    Natural product sciences v.3 no.1 ,pp. 1 - 7 , 1997 , 1226-3907 ,

    초록

    Eucalyptus is a rich source of biologically active compounds. Among these, phloroglucinol compounds such as sideroxylonals, macrocarpals, euglobals, and robustadials are unique to Eucalyptus species. Sideroxylonal A is a very potent attachment-inhibitor. Macrocarpals show very strong antibacterial activity against gram positive bacteria. Macrocarpals also show HIV-RTase inhibitory activity. Euglobals are potent inhibitors of Epstein-Barr virus activation and are developed as skin and antitumor agents. They also show granulation inhibitory activity. In this review we aim to remove the existing confusion in literature on macrocarpals and discuss the biological activities and structure-activity relationships of phloroglucinol compounds.

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  2. [국내논문]   Further Flavonol Glycosides from Myrsine africana Leaves  

    Arot, Lawrence O. Manguro (Chemistry Department, University of Nairobi ) , Midiwo, Jacob Ogweno (Chemistry Department, University of Nairobi ) , Kraus, Wolfgang (Universitat Hohenheim, Institut fur Chemie)
    Natural product sciences v.3 no.1 ,pp. 8 - 10 , 1997 , 1226-3907 ,

    초록

    A new flavonol glycoside, quercetin 3-rhamnosyl $(1{\rightarrow}3)$ galactoside [5] was isolated from the leaves of M. africana. The known compounds kaempferol 3-rutinoside [1], 3'-O-methylquercetin 3-rutinoside [2], quercetin 3-rutinoside [3], and quercetin 3-rhamnosyl $(1{\rightarrow}6)$ galactoside [4] were also isolated for the first time from this plant. Their structures were determined by chemical and spectroscopic methods.

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  3. [국내논문]   A New Furocoumarin from the Leaves of Camellia sinensis(L.) O. Kuntze  

    Banerjee, Jayashree (Bose Institute ) , Ganguly, S.N. (Bose Institute)
    Natural product sciences v.3 no.1 ,pp. 11 - 13 , 1997 , 1226-3907 ,

    초록

    From the methanolic extract of defatted tender leaf of Camellia sinensis a new 4-hydroxy angular furocoumarin $C_{12}H_8O_5$ , m.p. $212^{\circ}C$ , was isolated using high-speed counter-current chromatographic technique. The structure of the compound was established as 4-hydroxy-2'-methoxy angular furocoumarin on the basis of physical methods viz. $^1H$ NMR, $^{13}C$ NMR and MS.

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  4. [국내논문]   The Constituents of Siegesbeckia orientalis  

    Xiong, Jiang (Laboratory of Phytochemistry, Kunming Institute of Botany, The Chinese Academy of Sciences ) , Ma, Yunbao (Laboratory of Phytochemistry, Kunming Institute of Botany, The Chinese Academy of Sciences ) , Xu, Yunlong (Laboratory of Phytochemistry, Kunming Institute of Botany, The Chinese Academy of Sciences)
    Natural product sciences v.3 no.1 ,pp. 14 - 18 , 1997 , 1226-3907 ,

    초록

    Two new diterpenoids, orientalin A (1), and B (2), have been isolated together with six known compounds, kirenol (3), $ent-16{\beta},17-dihydroxykauran-19-oic$ acid (4), $ent-16{\beta},17-dihydroxykauran-19-oic$ $acid-16{\beta},l7-acetonide$ (5), $3,7-dimethylquercetin$ (6), ${\beta}-sitosterol$ (7), and daucosterol (8) from the ethanol extract of Siegesbeckia orientalis (Compositae). Their chemical structures have been elucidated as $ent-15-acetoxy-2{\alpha},16,19-trihydroxypimar-8(14)-ene$ (1), $ent-16-acetoxy-2{\alpha},15,19-trihydroxypimar-8(14)-ene$ (2), respectively, on the basis of chemical and spectral evidence.

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  5. [국내논문]   Detection of Antiinflammatory Agents from Natural Products as Inhibitors of Cyclooxygenase I and II  

    Lee, Dong-Hee (Natural Products Research Institute, Seoul National University ) , Kang, Sam-Sik (Natural Products Research Institute, Seoul National University ) , Chang, Il-Moo (Natural Products Research Institute, Seoul National University ) , Mar, Woong-Chon (Natural Products Research Institute, Seoul National University)
    Natural product sciences v.3 no.1 ,pp. 19 - 28 , 1997 , 1226-3907 ,

    초록

    Constitutive cyclooxygenase (COX-I) is present in cells under physiological conditions, whereas inducible cyclooxygenase (COX-II) is induced by some cytokines, mitogens, and endotoxin presumably in pathological conditions such as inflammation. We have evaluated the inhibitory effects of solvent fractionated extracts of natural products on the activities of COX-I and COX-II. Oxygen uptake COX assay was performed, as a primary screening from the tissue extracts of bovine seminal vesicles (BSV), by monitoring the initial rate of oxygen uptake using an oxygen electrode. Additionally, we evaluated plant extracts for the inhibitory effects of COX-I (in HEL cells) and COX-II (in lipopolysaccharide activated J774A.1 macrophages) using thin layer chromatography of prostanoids produced from $^{14}C-labelled$ arachidonic acid (AA). The use of such models of COX-I and COX-II assay will lead to the identification of specific inhibitors of cyclooxygenases with presumably less side effects than present therapies. Inhibitory effects of 50 kinds of plant extracts on the COX-I and COX-II activities were determined and the active fractions were found in the ethyl acetate fractions of Dryopteris crassirhizoma (roots), Amomum cardamomum (roots), Triticum aestivum (seeds), Perilla sikokiana (leaves), Anemarrhena asphodeloides (roots). Especially, the ethyl acetate fraction of Dryopteris crassirhizoma (roots), which exhibited the strong inhibition against BSV COX $(IC_{50},\;65.4\;{\mu}g/ml)$ , COX-I $(IC_{50},\;8.5\;{\mu}g/ml)$ , and COX-II $(IC_{50},\;17.2\;{\mu}g/ml)$ , is under investigation to isolate active principles using activity-guided fractionation method.

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  6. [국내논문]   Protein Kinase C Receptor Binding Assay for the Detection of Chemopreventive Agents from Natural Products  

    An, Geon-Ho (Natural Products Research Institute, Seoul National University ) , Suh, Young-Bae (Natural Products Research Institute, Seoul National University ) , Son, Kun-Ho (Department of Food and Nutrition, Andong National University ) , Chang, Il-Moo (Natural Products Research Institute, Seoul National University ) , Mar, Woong-Chon (Natural Products Research Institute, Seoul National University)
    Natural product sciences v.3 no.1 ,pp. 29 - 37 , 1997 , 1226-3907 ,

    초록

    Protein Kinase C (PKC) is generally believed to play a central role in signal transduction, cellular growth control, gene expression, and tumor promotion. And it has been suggested that inhibitors of PKC might play important roles for the prevention and treatment of cancer. In order to investigate the possible inhibitors of PKC from natural products, PKC receptor binding assay was performed using bovine brain particulate as a source of PKC and the amount of $[^3H]Phorbol$ 12,13-dibutyrate (PDBu) bound to PKC was measured in the presence of test materials. Total methanol extracts from 100 kinds of natural products were partitioned into 3 fractions (n-hexane, ethyl acetate and aqueous layer) and their binding ability to the regulatory domain of PKC was evaluated. The ethyl acetate fractions of Morus alba $(roots,\;IC_{50}:\;156.6\;{\mu}g/ml)$ , Rehmannia glutinosa $(roots,\;IC_{50}:\;134.3\;{\mu}g/ml)$ , Lysimachia foenum-graecum $(roots,\;IC_{50}:\;167.8\;{\mu}g/ml)$ , Polygonum cuspidata $(roots,\;IC_{50}:\;157.3\;{\mu}g/ml)$ , Cnidium officinale $(aerial\;parts,\;IC_{50}:\;145.2\;{\mu}g/ml)$ , and the hexane $(IC_{50}:\;179.3\;{\mu}g/ml)$ and the EtOAc fraction of Symplocarpus nipponicus $(roots,\;IC_{50}:\;155.9\;{\mu}g/ml)$ showed inhibitory activity of $[^3H]PDBu$ binding to PKC.

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  7. [국내논문]   Hypoglycemic Activity of Ficus racemosa L. (Moraceae) Leaves in Streptozotocin-induced Diabetic Rats  

    Mandal, Subhash C. (Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University ) , Mukherjee, Pulok K. (Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University ) , Saha, Kakali (Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University ) , Das, J. (Department of Pharmacology, Dr. B.C. Roy P.G. Institute of Basic Medical Science, University College of Medicine ) , Pal, M. (Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University ) , Saha, B.P. (Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University)
    Natural product sciences v.3 no.1 ,pp. 38 - 41 , 1997 , 1226-3907 ,

    초록

    The hypoglycemic effect of the extract of Ficus racemosa leaves was studied on streptozotocin-induced diabetic rats. Petroleum ether $(60-80^{\circ}C)$ extract of the plant obtained by soxhlet extraction from coarsely pulverised leaves was used. In the $LD_{50}$ determination of the extract no abnormalities were observed at the dose range of 3 g/kg (p.o.) of the extract. The extract (200 mg/kg and 400 mg/kg orally) caused a reduction of blood glucose levels in streptozotocin-induced diabetic rats by 28.9% (P $(60-80^{\circ}C)$ extract of the leaves possesses significant hypoglycemic activity in hyperglycemic animals compared with glybenclamide as standard drug.

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  8. [국내논문]   Alkaloids from The Roots of Tabernaemontana Macrocarpa Jack  

    Husain, Khairana (Department of Chemistry, University Kebangsaan Malaysia ) , Said, Ikram M. (Department of Chemistry, University Kebangsaan Malaysia ) , Din, Laily B. (Department of Chemistry, University Kebangsaan Malaysia ) , Takayama, Hiromitsu (Faculty of Pharmaceutical Sciences, Chiba University ) , Kitajima, Mariko (Faculty of Pharmaceutical Sciences, Chiba University ) , Aimi, Norio (Faculty of Pharmaceutical Sciences, Chiba University)
    Natural product sciences v.3 no.1 ,pp. 42 - 48 , 1997 , 1226-3907 ,

    초록

    The roots of Tabernaemontana macrocarpa Jack (Apocynaceae) yielded nine indole alkaloids which were identified as coronaridine (2), voacangine hydroxy-indolenine (3), 3-oxo-coronaridine (4), 19-R-heyneanine (7), coronaridine pseudoindoxyl (8) and voacangine pseudoindoxyl (9) while 3-(2-oxopropyl)-coronaridine (1), 3-(2-oxopropyl)-coronaridine-pseudoindoxyl (5) and 3-(2-oxopropyl)-voacangine-pseudoindoxyl (6) were isolated as artefacts formed during the isolation process. All of the alkaloids were identified by spectroscopic methods $(UV,\;MS,\;^1H-NMR\;&\;^{13}C-NMR)$ and in comparison with the literature data.

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  9. [국내논문]   Flavonoids and Stilbenes as Repellents against the Blue Mussel, Mytilus edulis galloprovincialis  

    Singh, Inder Pal (The United Graduate School of Agricultural Sciences, Gifu University (Shizuoka University), Shizuoka University ) , Etoh, Hideo (Department of Applied Biological Chemistry, Shizuoka University ) , Asai, Eiko (Department of Applied Biological Chemistry, Shizuoka University ) , Kikuchi, Kojiro (Department of Applied Biological Chemistry, Shizuoka University ) , Ina, Kazuo (Department of Applied Biological Chemistry, Shizuoka University ) , Koyasu, Katsuya (Faculty of Pharmacy, Meijo University ) , Terada, Yukimasa (Faculty of Pharmacy, Meijo University)
    Natural product sciences v.3 no.1 ,pp. 49 - 54 , 1997 , 1226-3907 ,

    초록

    We studied the attachment-repelling activity of flavonoids, stilbenes, and their glycosides against the blue mussel Mytilus edulis galloprouincialis. Molecular mechanics calculations have shown that the most stable conformations of potent repellents 29 and 32 were the same. On the basis of these results, structure-activity relationships of these compounds are discussed.

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  10. [국내논문]   Phytochemistry and Bioassay Studies of Fijian Palaquium stehlinii Christoph (Sapotaceae)  

    Sotheeswaran, Subramanium (Department of Chemistry, University of the South Pacific ) , Sharif, Mirja (Department of Chemistry, University of the South Pacific ) , Ali, Sadaquat (Department of Chemistry, University of the South Pacific ) , Davies, Noel W. (Central Science Laboratory, University of Tasmania, Australia)
    Natural product sciences v.3 no.1 ,pp. 55 - 58 , 1997 , 1226-3907 ,

    초록

    Water extract of the bark of Palaquium stehlinii has been bioassayed for antimicrobial activity and was found to inhibit the growth of Escherichia coli and Penicillium chrysogens. Phytochemical study revealed the presence of amyrin esters and 3,4',5,7-tetrahydroxyflavanone in the extract.

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