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H : 소장처정보

T : 목차정보

Natural product sciences 19건

  1. [국내논문]   Bioactive Metabolites from the Brittle Star Ophioplocus japonicus  

    Wang, Wei-Hong (College of Pharmacy, Pusan National University ) , Hong, Jong-Ki (Basic Science Institute ) , Lee, Chong-Ok (Korea Research Institute of Chemical Technology ) , Cho, Hee-Young (Korea Research Institute of Chemical Technology ) , Shin, Sook (Sahmyook University ) , Jung, Jee-H. (College of Pharmacy, Pusan National University)
    Natural product sciences v.10 no.6 ,pp. 253 - 261 , 2004 , 1226-3907 ,

    초록

    Ten terpenes (1-10), two sterols (11 and 12), and two unusual phenylpropanoids (13 and 14) were isolated from the brittle star Ophioplocus japonicus (Family Ophiuridae). Their structures were identified by analyses of the spectral data and by comparison with the literature data. The terpenes (1-10) and phenylpropanoids (13 and 14) are first encountered in brittle stars. These compounds were evaluated for cytotoxicity against a small panel of human solid tumor cell lines. Compounds 6-10 and 14 displayed moderate to significant cytotoxicity. The compounds were evaluated for antibacterial activity against 20 clinically isolated strains. Compound 5 exhibited antibacterial activities against three Streptococcus and three Staphylococcus strains.

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  2. [국내논문]   Validations of Analysis Methods for Decursin and Decursinol Angelate of Angelicae gigantis Radix by Reversed-Phase Liquid Chromatography  

    Lee, Jong-Pill (Department of Natural Medicines Evaluation, KFDA ) , Chang, Seung-Yeup (Department of Natural Medicines Evaluation, KFDA ) , Park, Sang-Yong (College of Pharmacy, Kyung Hee University)
    Natural product sciences v.10 no.6 ,pp. 262 - 267 , 2004 , 1226-3907 ,

    초록

    A reversed-phase liquid chromatographic method for decursin and decursinol angelate of Angelicae gigantis Radix, an important crude drug in Korean traditional medicine, was developed and validated. Decursin and decursinol angelate, the structure isomer (pyranocoumarin) each other, are the main organic constituents in Angelicae gigantis Radix. This method was developed using a RP-18 column, UV detector at 280 nm and 50% acetonitrile solution containing 0.01 M sodium dodecyl sulfate and 25 mM sodium dihydrogen phosphate (pH 5.0) as the mobile phase. Various validation parameters were included and evaluated satisfactorily. Linearity was established in range 2-75 mg/ml of decursin and decursinol angelate (correlation coefficient = 0.9997 and 0.9995, respectively). This analytical method showed good accuracy (98.1% and 99.5%, respectively). Precision (repeatability) revealed a relative standard deviation value of 1.71% (decursin) and 3.19% (decursinol angelate). For intermediate precision measure the considered variables were equipment and days. A robustness test showing the influence of deferent counter-ion concentration in mobile phase was also performed.

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  3. [국내논문]   P-Glycoprotein Inhibitory Activity of Indonesian Medicinal Plants in Human Breast Cancer Cells   피인용횟수: 1

    Kim, Hyang-Rim (College of Pharmacy, Ewha Womans University ) , Chung, Soo-Yeon (College of Pharmacy, Ewha Womans University ) , Jeong, Yeon-Hee (College of Pharmacy, Ewha Womans University ) , Go, Eun-Jung (College of Pharmacy, Ewha Womans University ) , Han, Ah-Reum (College of Pharmacy, Ewha Womans University ) , Kim, Na-Hyung (College of Pharmacy, Ewha Womans University ) , Sung, Min-Kyung (College of Pharmacy, Ewha Womans University ) , Song, Gi-Na (College of Pharmacy, Ewha Womans University ) , Jang, Jung-Ok (College of Pharmacy, Ewha Womans University ) , Nam, Joo-Won (College of Pharmacy, Ewha Womans University ) , Lee, Hwa-Jeong (College of Pharmacy, Ewha Womans University ) , Seo, Eun-Kyoung (College of Pharmacy, Ewha Womans University)
    Natural product sciences v.10 no.6 ,pp. 268 - 271 , 2004 , 1226-3907 ,

    초록

    In order to examine their effects on the P-glycoprotein (P-gp) activity in human breast cancer cells, MCF-7/ADR, one hundred Indonesian plant extracts were screened. Among them, the five chloroform extracts of Calotropis gigantea, Curcuma aeruginosa, Merremia mammosa, Sindora sumatrana, and Zingiber cassumunar, showed the most potent P-gp inhibitory activity. When each of these extracts was treated together with the anticancer agent, daunomycin, they increased the cytotoxic activity of daunomycin up to $IC_{50}$ values of less than $6.62\;{\mu}M$ , which is a value with a positive control, verapamil. Also, other 15 plant extracts exhibited significant P-gp inhibitory activity with $IC_{50}$ values between 6.62 and $13.20\;{\mu}M$ . These prospective samples will be subjected to further laboratory phytochemical investigation to find active principles.

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  4. [국내논문]   Antioxidant Activity of (8E,13Z,20Z)-Strobilinin/(7E,13Z,20Z)-Felixinin from a Marine Sponge Psammocinia sp.  

    Jiang, Ya-Hong (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University ) , Ryu, Seung-Hee (Department of Chemistry and Biohealth Products Research Center, Inje University ) , Ahn, Eun-Young (Department of Chemistry and Biohealth Products Research Center, Inje University ) , You, Song (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University ) , Lee, Burm-Jong (Department of Chemistry and Biohealth Products Research Center, Inje University ) , Jung, Jee-H (College of Pharmacy, Pusan National University ) , Kim, Dong-Kyoo (Department of Chemistry and Biohealth Products Research Center, Inje University)
    Natural product sciences v.10 no.6 ,pp. 272 - 276 , 2004 , 1226-3907 ,

    초록

    During the course of our screening for bioactive metabolites from marine sponges, EZZ, the inseparable 1:1 mixture of (8E,13Z,20Z)-strobilinin and (7E,13Z,20Z)-felixinin has been found to deliver significant cytotoxicity against some cancer cell lines. In this study, the antioxidant activity of EZZ was first time evaluated by a series of antioxidant assays. It was found that EZZ was weak in scavenging the stable free radical 1,1-diphenyl-2-picrylhyrazyl (DPPH), but it was comparable to ascorbic acid in scavenging ABTS and superoxide radicals. In addition, EZZ could protect DNA from hydroxyl radical-induced strand cleavage. The findings of the present study suggest that EZZ possess certain antioxidant activity, which might help to prevent occurrence of cancer by alleviating the oxidative stress in cells.

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  5. [국내논문]   Cell Cycle Regulation and Antioxidant Activity of Psammaplin A, A Natural Phenolic Compound from Marine Sponge  

    Jiang, Ya-Hong (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University ) , Ryu, Seung-Hee (Department of Chemistry and Biohealth Products Research Center, Inje University ) , Ahn, Eun-Young (Department of Chemistry and Biohealth Products Research Center, Inje University ) , You, Song (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University ) , Lee, Burm-Jong (Department of Chemistry and Biohealth Products Research Center, Inje University ) , Jung, Jee-H (College of Pharmacy, Pusan National University ) , Kim, Dong-Kyoo (Department of Chemistry and Biohealth Products Research Center, Inje University)
    Natural product sciences v.10 no.6 ,pp. 277 - 283 , 2004 , 1226-3907 ,

    초록

    Psammaplin A (PSA), a naturally occurring biophenolic compound has been demonstrated to deliver significant cytotoxicity to many cancer cell lines. In this article, we investigated the effect of PSA on cell cycle progression of lung cancer cells (A549). It was found that PSA could slightly perturb the cell cycle progression of A549 cells and lead to the cell cycle arrest at G2/M phase, indicating PSA might disturb the mitosis process of A549 cells. In addition, inspired by the two phenolic groups in the structure of PSA, the antioxidant activity of it has been evaluated. Although PSA was weak in scavenging the stable free radical 1,1-diphenyl-2-picrylhyrazyl (DPPH), it showed stronger ABTS radical scavenging activity than ascorbic acid in TEAC assay. Furthermore, it was found that PSA could effectively prevent DNA strand scission induced by oxidative stress. These results suggest that PSA have both cell cycle regulation and antioxidant activities. Herein, we suggest that PSA would be a very interesting and promising candidate to be developed as a multi-function drug.

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  6. [국내논문]   A Further Study on the Inhibition of Tumor Growth and Metastasis by Red Ginseng Acidic Polysaccharide (RGAP)   피인용횟수: 2

    Shin, Han-Jae (KT&G Central Research Institute ) , Kim, Young-Sook (KT&G Central Research Institute ) , Kwak, Yi-Seong (KT&G Central Research Institute ) , Song, Yong-Bum (KT&G Central Research Institute ) , Kyung, Jong-Soo (KT&G Central Research Institute ) , Wee, Jae-Joon (KT&G Central Research Institute ) , Park, Jong-Dae (KT&G Central Research Institute)
    Natural product sciences v.10 no.6 ,pp. 284 - 288 , 2004 , 1226-3907 ,

    초록

    We have recently reported that red ginseng acidic polysaccharide (RGAP), isolated from Korean red ginseng (Panax ginseng C. A. Meyer), showed immunomodulatory antitumor activities, mainly mediated by nitric oxide (NO) production by macrophage. In this study, we examined the effect of RGAP on anticancer activity using lung carcinoma 3LL, sarcoma 180 and adenocarcinoma JC tumor cells transplanted into mice as well as antimetastatic activity using B16-F10 melanoma. When RGAP (300 mg/kg) were treated to mice implanted with one of the three kinds of tumor cells, the tumor weight significantly decreased compared with control mice. Tumor inhibition ratios of RGAP (300 mg/kg) in mice transplanted with lung carcinoma 3LL, sarcoma 180 and adenocarcinoma JC cells were 26.8%, 29.3% and 31.6%, respectively. Hundred mg/kg of RGAP did not cause a significant decrease in tumor weight compared with control group. When RGAP was administered i.p. with the dose of 100 and 300 mg/kg in B16-F10 melanoma-bearing mice, lung metastasis were reduced significantly in mice. Corrected phagocytic index was also remarkably increased by RGAP. These results suggest that stimulation of phagocytic activity of macrophages may be a mechanism for in vivo anticancer and antimetastasis activities of RGAP.

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  7. [국내논문]   Protection of NMDA-Induced Neuronal Cell Damage by Methanol Extract of Myristica Fragrans Seeds in Cultured Rat Cerebellar Granule Cells  

    Ban, Ju-Yeon (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University ) , Cho, Soon-Ock (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University ) , Kim, Ji-Ye (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University ) , Bang, Kyong-Hwan (National Institute of Crop Science, RDA ) , Seong, Nak-Sul (National Institute of Crop Science, RDA ) , Song, Kyung-Sik (College of Agriculture and Life-Sciences, Kyungpook National University ) , Bae, Ki-Whan (College of Pharmacy, Chungnam National University ) , Seong, Yeon-Hee (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
    Natural product sciences v.10 no.6 ,pp. 289 - 295 , 2004 , 1226-3907 ,

    초록

    Myristica fragrans seed from Myristica fragrans Houtt (Myristicaceae) has various pharmacological activities peripherally and centrally. The present study aims to investigate the effect of the methanol extract of Myristica fragrans seed (MF) on N-methyl-D-aspartate (NMDA)-induced neurotoxicity in primary cultured rat cerebellar granule neuron. MF, over a concentration range of 0.05 to $5\;{\mu}g/ml$ , inhibited NMDA (1 mM)- induced neuronal cell death, which was measured by trypan blue exclusion test and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay. MF $(0.5\;{\mu}g/ml)$ inhibited glutamate release into medium induced by NMDA (1 mM), which was measured by HPLC. Pretreatrnent of MF $(0.5\;{\mu}g/ml)$ inhibited NMDA (1 mM)-induced elevation of cytosolic calcium concentration $([Ca^{2+}]_c)$ , which was measured by a fluorescent dye, Fura 2-AM, and generation of reactive oxygen species (ROS). These results suggest that MF prevents NMDA-induced neuronal cell damage in vitro.

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  8. [국내논문]   Selective Stimulating Effect of Flavonoids on the Antioxidant Defense System in Normal and Transformed Hepatic Cell Lines  

    Kim, Beom-Tae (Research Center of Bioactive Materials, Chonbuk National University ) , Lee, Jeong-Chae (Research Center of Bioactive Materials,Lab. of Cell Biology in Department of Orthodontics and Institute of Oral Bioscience, Chonbuk National University)
    Natural product sciences v.10 no.6 ,pp. 296 - 301 , 2004 , 1226-3907 ,

    초록

    Previously, a flavonoid fraction, which consisted mainly of protocatechuic acid, fustin, fisetin, sulfuretin, and butein, here named RCMF $({\underline{R}}VS\;{\underline{c}}hloroform-{\underline{m}}ethanol\;{\underline{f}}raction)$ , was prepared from a crude acetone extract of Rhus verniciflua Stokes (RVS) which is traditionally used as a food additive and as an herbal medicine. In this study, we evaluated the effects of RCMF on the antioxidant defense system using embryonic normal hepatic cell line (BNL CL.2) and its SV40-mediated transformed cell line (BNL SV A.8). This study demonstrates that RCMF selectively stimulated the antioxidant defense system of normal cells, as BNL CL.2 cells proved to be more sensitive to RCMF-mediated increases of superoxide dismutase, catalase, glutathione, and glutathione reductase than BNL SV A.8 cells. In particular, RCMF caused a significant increase in the malonaldehyde content of BNL SV A.8 cells, which is believed to be closely associated with cytotoxicity of RCMF and RCMF-mediated growth inhibition. Collectively, our findings suggest that the flavonoid fraction, RCMF, selectively stimulates the antioxidant defense system in normal rather than hepatic tumor cells.

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  9. [국내논문]   Studies on The Lypolitic Enzymes of Carum Roxburgllianum Seed Meal  

    Mahmud, Shahid (Applied Chemistry Research Centre, PCSIR Laboratories Complex ) , Waheed, Amran (Applied Chemistry Research Centre, PCSIR Laboratories Complex ) , Khanum, Razia (Applied Chemistry Research Centre, PCSIR Laboratories Complex)
    Natural product sciences v.10 no.6 ,pp. 302 - 305 , 2004 , 1226-3907 ,

    초록

    The lipase and phospholipase activities of meals of resting seeds of C. roxburghianum were studied at different temperatures, solvents and pH. Both the enzymes showed the maximum activities at $40^{\circ}C$ and in n-heptane used as solvent. However, lipase showed maximum activities at two different pH, one at pH 5 (acidic) and other at pH 8 (alkaline) whereas phospholipase showed only one pH optimum at pH 8. During the course of germination, the lipase showed an increase whereas reverse was the case with phospholipase.

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  10. [국내논문]   Triterpenoids from Orostachys japonicus   피인용횟수: 2

    Lee, Sang-Hyun (College of Pharmacy, Seoul National University ) , Paek, Sun-Ha (Department of Neurosurgery, Seoul National University College of Medicine ) , Kim, Seung-Ki (Department of Neurosurgery, Seoul National University College of Medicine ) , Kim, Bak-Kwang (College of Pharmacy, Seoul National University ) , Shin, Kuk-Hyun (College of Pharmacy, Seoul National University)
    Natural product sciences v.10 no.6 ,pp. 306 - 309 , 2004 , 1226-3907 ,

    초록

    Triterpenoids were isolated from the whole plant of Orostachys japonicus (Crassulaceae) by repeated column chromatography. Their structures were identified as friedelin (1), glutinol (2), ${\beta}-sitosterol$ (3), friedelinol (4), $5{\alpha},8{\alpha}-peroxyergosterol$ (5), ${\beta}-sitostenone$ (6) and glutinone (7) by spectral analysis. Among them, compounds 5 and 6 were isolated for the first time from this plant.

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