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Natural product sciences 10건

  1. [국내논문]   Chemical Constituents and Pharmacological Activities of Hedyotis diffusa   피인용횟수: 1

    Xu, Bao-Jun (The Pharmaceutical Institute, Dalian University ) , Sung, Chang-Keun (Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University)
    Natural product sciences v.11 no.1 ,pp. 1 - 9 , 2005 , 1226-3907 ,

    초록

    The chemical constituents from Hedyotis diffusa Willd and their pharmacological activities were summarized. It has been known data that this herb contains anthraquinones, terpenoids, steroids, flavonoids, organic acid, and polysaccharides. The studies of pharmacology have shown that Hedyotis diffusa Willd possess various levels of activities such as anticancer, anti-inflammatory, immunostimulatory, antioxidative, neuroprotective, and hepatoprotective activities.

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  2. [국내논문]   Flavonol Galactosides from Artemisia apiacea   피인용횟수: 4

    Kim, Kyoung-Soon (College of Pharmacy, Seoul National University ) , Lee, Sang-Hyun (College of Pharmacy, Seoul National University ) , Kang, Kyoung-Hwan (Lotte Pharm. Co. Ltd. ) , Kim, Bak-Kwang (College of Pharmacy, Seoul National University)
    Natural product sciences v.11 no.1 ,pp. 10 - 12 , 2005 , 1226-3907 ,

    초록

    Flavonol galactosides were isolated from the EtOAc fraction of Artemisia apiacea by repeated column chromatography. Their structures were elucidated as $isorhamnetin-3-O-{\beta}-D-galactoside$ (1) and $quercetin-3-O-{\beta}-D-galactoside$ (2) by chemical and spectroscopic analysis. This is the first report on the isolation of compound 2 from this plant.

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  3. [국내논문]   Phytochemical Investigation of the Leaves of Flaveria trinervia  

    Umadevi, S. (Department of Pharmacy, Annamalai University ) , Mohanta, G.P. (Department of Pharmacy, Annamalai University ) , Balakrishna, K. (Central Research Institute for Siddha ) , Manavalan, R. (Department of Pharmacy, Annamalai University)
    Natural product sciences v.11 no.1 ,pp. 13 - 15 , 2005 , 1226-3907 ,

    초록

    Phytochemical study of the methanolic extract of Flaveria trinervia (Asteraceae) leaves has led to the isolation of three constituents characterised as 3,5,7,4' tetrahydroxy-6-methoxy flavone (6-methoxy kaempferol), oleanolic acid and ${\beta}-sitosterol-{\beta}-D-glucoside$ . The identities of the compounds were confirmed by the physical and spectroscopic data and by comparison with authentic samples.

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  4. [국내논문]   Inhibitory Activity of Medicinal Herbs on Nitric Oxide Synthesis in Activated Macrophages   피인용횟수: 1

    Lee, Hwa-Jin (College of Pharmacy, Sookmyung Women's University ) , Kim, Ji-Sun (College of Pharmacy, Sookmyung Women's University ) , Jin, Chang-Bae (Division of Life Sciences, Korea Institute of Science & Technology ) , Ryu, Jae-Ha (College of Pharmacy, Sookmyung Women's University)
    Natural product sciences v.11 no.1 ,pp. 16 - 21 , 2005 , 1226-3907 ,

    초록

    Nitric Oxide (NO), derived from L-arginine, is produced by two types (constitutive and inducible) of nitric oxide synthase (NOS: cNOS and iNOS). The NO produced in large amounts by the iNOS is known to be responsible for the vasodilation and hypotension observed in septic shock, cancer metastasis and inflammation. The inhibitors of iNOS, thus, may be useful candidates for the treatment of inflammatory diseases accompanied by the overproduction of NO. We prepared alcoholic extracts of herbal drugs which have been used for the treatment of inflammation in oriental medicine. We have screened the inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages after the treatment of these extracts. Among 82 kinds of extracts of herbal drugs, 35 extracts showed the potent inhibitory activity of NO production above 50% at the concentration of $50\;{\mu}g/mL$ . The inhibitory activities of NO production were also evaluated for several solvent fractions at two different concentrations. Especially, hexane and EtOAc fractions of Alpinia officinarum, Angelica gigas, Ostericum koreanum, Saussurea lappa, Torilis japonica, and hexane fractions of Agrimonia pilosa, Machilus thunbergii, Hydrangea serrata, Magnolia obovata, Prunella vulgaris, Tussilago farfara, and EtOAC fractions of Perilla frutescence showed a significant activity at 10 and/or $25\;{\mu}g/mL$ . In Western blot analysis, the hexane fractions ( $5\;{\mu}g/mL$ ) of Magnolia obovata and Saussurea lappa, and EtOAc fractions ( $20\;{\mu}g/mL$ ) of Hydrangea Serrata, Perilla frutescence and Torilis japonica inhibited the expression of iNOS protein in LPS-activated macrophages. These plants may be promising candidates for the study of the activity-guided purification of active compounds and might be useful for the treatment of inflammatory diseases and endotoxemia accompanying overproduction of NO.

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  5. [국내논문]   Free Radical Scavenging and Lipid Peroxidation Inhibition Potential of Hygrophila auriculata   피인용횟수: 1

    Vijayakumar, Madhavan (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute ) , Govindarajan, Raghavan (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute ) , Shirwaikar, Arun (College of Pharmaceutical sciences, MAHE ) , Kumar, Vivek (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute ) , Rawat, Ajay Kumar Singh (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute ) , Mehrotra, Shanta (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute ) , Pushpangadan, Palpu (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute)
    Natural product sciences v.11 no.1 ,pp. 22 - 26 , 2005 , 1226-3907 ,

    초록

    Hygrophila auriculata (K. Schum.) Heine is a wild herb commonly found in moist places on the banks of tanks, ditches and paddy fields throughout India and is one of the main sources of Ayurvedic 'Rasayana' drug. The free radical scavenging potential of 50% aqueous alcoholic extract of H. auriculata (HAEt) was studied for DPPH scavenging activity, nitric oxide, hydroxyl radical and ferryl bipyridyl complex scavenging activity along with lipid peroxidation and total antioxidant capacity inhibition using Thiobarbituric acid reactive substances (TBARS) in rat liver homogenate. Integral antioxidative capacity was determined by photochemiluminescence assay. HAEt showed good radical scavenging activity at various concentrations $(200-1000\;{\mu}g/ml)$ against 1,1 diphenyl, 2-picrylhydrazyl (DPPH) (32.32-77.02%) with moderate scavenging activity against Nitric oxide (12.46-52.84%), hydroxyl radical (11.69-55.26%), ferryl bipyridyl complex (17.66-58.67%) and lipid peroxidation (0.829-0.416nmoles/mg protein). The above results indicate HAEt to be very effective antioxidant. It was suggested that the varied therapeutic activities claimed for the plant in the Indian indigenous systems of medicine may be in the part due to the free radical scavenging and/ or potent antioxidant activity.

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  6. [국내논문]   Inhibitory Effects of Resina Pini on the Growth and Glucosyltransferase activity of Streptococcus mutans   피인용횟수: 1

    Seo, Young-A (College of Pharmacy, Catholic University of Daegu ) , Choi, Nam-Ju (College of Pharmacy, Catholic University of Daegu ) , Suk, Kui-Duk (College of Pharmacy, Catholic University of Daegu)
    Natural product sciences v.11 no.1 ,pp. 27 - 32 , 2005 , 1226-3907 ,

    초록

    The purpose of this study is to evaluate the inhibitory effects of Resina Pini against Streptococcus mutans (S. mutans) that is one of the major causes of dental caries and oral diseases. Topically applied Resina Pini (RP) would be incorporated in saliva and thus the factor associated with water solubility should be considered. In this paper, therefore, effects of various treatment for RP and activities of water extracts from unprocessed and processed RP were compared. The crude RP (RP1) and the recrystallized RP (RP2) in ethanol solution showed strong antimicrobial activities (d.>15mm) against S. mutans. All RP samples exhibited considerable inhibitory effect against glucosyltransferase produced by S. mutans $(IC_{50}=91.2\;to\;276.2\;{\mu}g/ml)$ . The very considerable increase in cellular permeability of S. mutans was observed with RP1, RP2 and their water extracts. These results suggest that RP1 and RP2 may be a potential source for pharmaceutical products used for prevention and/or treatment of dental caries and periodontal disease.

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  7. [국내논문]   Influence of ${\beta}-Eudesmol$ on Blood Pressure  

    Lim, Dong-Yoon (Department of Pharmacology, College of Medicine, Chosun University ) , Kee, Young-Woo (Department of Pharmacology, College of Medicine, Chosun University)
    Natural product sciences v.11 no.1 ,pp. 33 - 40 , 2005 , 1226-3907 ,

    초록

    The present study was undertaken to investigate the effects of ${\beta}-eudesmol$ , one of various ingredients isolated and identified from the bark of Magnolia obovata Thunberg, on arterial blood pressure and vascular contractile responses in the normotensve rats and to establish its mechanism of action. ${\beta}-Eudesmol\;(30{\sim}300\;{\mu}g/kg)$ given into a femoral vein of the normotensive rat produced a dose-dependent depressor response. These ${\beta}-eudesmol-induced$ hypotensive responses were markedly inhibited in the presence of chlorisondamine (1.0 mg/kg, i.v.) or phentolamine (2.0 mg/kg, i.v.). Interestingly, the infusion of ${\beta}-eudesmol$ (1.0 mg/kg/30min) into a femoral vein made a significant reduction in pressor responses induced by intravenous norepinephrine. Furthermore, the phenylephrine $(10^{-5}\;M)-induced$ contractile responses were depressed in the presence of high concentrations of ${\beta}-eudesmol\;(10{\sim}40\;{\mu}g/ml)$ , but not affected in low concentration of ${\beta}-eudesmol\;(2.5{\sim}5\;{\mu}g/ml)$ . Also, high potassium $(5.6{\times}10^{-2}\;M)-induced$ contractile responses were greatly inhibited in the presence of ${\beta}-eudesmol\;(10{\sim}40\;{\mu}g/ml)$ in a dose-dependent fashion. Taken together, these results obtained from the present study demonstrate that intravenous ${\beta}-eudesmol$ causes a dose-dependent depressor action in the anesthetized rat at least partly through the blockade of vascular adrenergic ${\alpha}_1-receptors$ , in addition to the some unknown mechanism of direct vasorelaxation.

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  8. [국내논문]   Chemical Constituents of the Aerial Parts of Chloranthus japonicus Sieb.  

    Heo, Jung-Eun (Natural Products Research Institute, Seoul National University ) , Jin, Jing Ling (Natural Products Research Institute, Seoul National University ) , Lee, Yong-Yook (Natural Products Research Institute, Seoul National University ) , YunChoi, Hye-Sook (Natural Products Research Institute, Seoul National University)
    Natural product sciences v.11 no.1 ,pp. 41 - 44 , 2005 , 1226-3907 ,

    초록

    Chemical investigation of the aerial parts of Chloranthus japonicus Sieb. led to the isolation a new compound, 9-hydroxy heterogorgiolide (1) and $isofraxidin-7-O-{\beta}-D-glucopyranoside$ (2), the isolation of which is reported for the first time from this plant, along with the known components, ${\beta}-sitosterol,\;{\beta}-sitosterol-3-O-{\beta}-D-glucopyranoside$ , palmitic acid and octacosanoic acid. The structures of compound 1 and 2 were determined on the basis of spectroscopic data including two dimensional NMR and high resolution MS.

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  9. [국내논문]   Accelerating Effect of $TNF-{\alpha}$ on the Rhus verniciflua-induced Growth Inhibition and Apoptosis in Human Osteosarcoma Cells  

    Kim, Hyun-Duck (Laboratory of Cell Biology in Department of Orthodontics and Institute of Oral Bioscience ) , Kook, Sung-Ho (Laboratory of Cell Biology in Department of Orthodontics and Institute of Oral Bioscience ) , Kim, Beom-Tae (Research Center of Bioactive Materials, Chonbuk National University ) , Kim, Jong-Ghee (Laboratory of Cell Biology in Department of Orthodontics and Institute of Oral Bioscience ) , Jeon, Young-Mi (Laboratory of Cell Biology in Department of Orthodontics and Institute of Oral Bioscience ) , Lee, Jeong-Chae (Laboratory of Cell Biology in Department of Orthodontics and Institute of Oral Bioscience,Research Center of Bioactive Materials, Chonbuk National University)
    Natural product sciences v.11 no.1 ,pp. 45 - 49 , 2005 , 1226-3907 ,

    초록

    Previously, a flavonoid fraction, which consisted mainly of protocatechuic acid, fustin, fisetin, sulfuretin, and butein, here named RCMF [ ${\underline{R}}hus$ verniciflua Stokes (RVS) ${\underline{c}}hloroform-{\underline{m}}ethanol\;{\underline{f}}raction$ ], was prepared from a crude acetone extract of RVS which is traditionally used as a food additive and as an herbal medicine. In the present study, we investigated the effects of $TNF-{\alpha}$ on RCMF-induced growth inhibition and apoptosis induction using human osteosarcoma (HOS) cells. The results from tritium uptake and MTT assays showed that $TNF-{\alpha}$ treatment itself (10 ng/ml) did not induce any cytotoxicity, but it actively accelerated RCMF-mediated cytotoxicity of HOS cells. RCMF-induced cytotoxicity and its facilitation by $TNF-{\alpha}$ was verified to be apoptotic, based on the increased DNA fragmentation and low fluorescence intensity in nuclei after propidium iodide (PI) staining of HOS cells. This speculation was further demonstrated by monitoring the Annexin V/PI double staining which could discriminate the difference between apoptotic and necrotic deaths. Collectively, our findings indicate that $TNF-{\alpha}$ accelerates RCMF-induced cytotoxicity in HOS cells.

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  10. [국내논문]   Trisoxazole Macrolide from a Marine Sponge Sarcotragus Species  

    Liu, Yong-Hong (College of Pharmacy, Pusan National University ) , Shinde, Pramod B. (College of Pharmacy, Pusan National University ) , Hong, Jong-Ki (Hazardous Substance Research Team, Korea Basic Science Institute ) , Lee, Chong-O. (Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology ) , Im, Kwang-Sik (College of Pharmacy, Pusan National University ) , Jung, Jee-H. (College of Pharmacy, Pusan National University)
    Natural product sciences v.11 no.1 ,pp. 50 - 53 , 2005 , 1226-3907 ,

    초록

    Bioassay-directed fractionation of the lipophilic extract of a marine sponge Sarcotragus sp. led to the isolation of a known trisoxazole containing macrolide, mycalolide B (1). Its structure was identified by NMR and MS analyses. This is the first report on the isolation of macrolide from a sponge of the genus Sarcotragus (Order: Dictyoceratida).

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