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Macromolecular bioscience 21건

  1. [해외논문]   Development of a Polymer‐Based Biodegradable Neurovascular Stent Prototype: A Preliminary In Vitro and In Vivo Study  

    Nikoubashman, Omid (Department of Diagnostic and Interventional Neuroradiology, University Hospital, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany) , Heringer, Sarah (Department of Diagnostic and Interventional Neuroradiology, University Hospital, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany) , Feher, Katalin (Institute of Tissue Engineering and Textile Implants, RWTH Aachen University, Otto‐Blumenthal‐Str. 1, 52074, Aachen, Germany) , Brockmann, Marc‐ (Department of Diagnostic and Interventional Neuroradiology, University Hospital Mainz, 55131, Mainz, Germany) , Alexander (Institute of Neuropathology, University Hospital, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany) , Sellhaus, Bernd (Institute of Neuropathology, University Hospital, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany) , Dreser, Alice , Kurtenbach, Kathrin , Pjontek, Rastislav , Jockenhö , vel, Stefan , Weis, Joachim , Kießling, Fabian , Gries, Thomas , Wiesmann, Martin
    Macromolecular bioscience v.18 no.7 ,pp. 1700292 , 2018 , 1616-5187 ,

    초록

    Abstract Biodegradable stents are not established in neurovascular interventions. In this study, mechanical, radiological, and histological characteristics of a stent prototype developed for neurovascular use are presented. The elasticity and brittleness of PLA 96/4, PLDL 70/30, PCL, and PLGA 85/15 and 10/90 polymers in in vitro experiments are first analyzed. After excluding the inapt polymers, degradability and mechanical characteristics of 78 PLGA 85/15 and PLGA 10/90 stent prototypes are analyzed. After excluding PLGA 10/90 stents because of rapid loss of mass PLGA 85/15 stents in porcine in vivo experiments are analyzed. Angiographic occlusion rates 7 d, 1 month, 3 months, and 6 months after stent implantation are assessed. Histological outcome measures are the presence of signs of inflammation, endothelialization, and the homogeneity of degradation after six months. One case of stent occlusion occurs within the first 7 d. There is a prominent foreign‐body reaction with considerable mononuclear and minor granulocytic inflammation combined with incomplete fragmental degradation of the struts. It is possible to produce a stent prototype with dimensions that fit the typical size of carotid arteries. Major improvements concerning thrombogenicity, degradation, and inflammatory response are required to produce biodegradable stents that are suitable for neurovascular interventions.

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  2. [해외논문]   TGF‐β1‐Modified Hyaluronic Acid/Poly(glycidol) Hydrogels for Chondrogenic Differentiation of Human Mesenchymal Stromal Cells  

    Bö (Department of Trauma, Hand, Plastic and Reconstructive Surgery, University of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany) , ck, Thomas (Department of Functional Materials for Medicine and Dentistry and Bavarian Polymer Institute, University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany) , Schill, Verena (Department of Trauma, Hand, Plastic and Reconstructive Surgery, University of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany) , Krä (Orthopedic Center for Musculoskeletal Research, University of Würzburg, Brettreichstr. 11, 97074, Würzburg, Germany) , hnke, Martin (Department of Functional Materials for Medicine and Dentistry and Bavarian Polymer Institute, University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany) , Steinert, Andre F. (Department of Trauma, Hand, Plasti) , Tessmar, Jö , rg , Blunk, Torsten , Groll, Jü , rgen
    Macromolecular bioscience v.18 no.7 ,pp. 1700390 , 2018 , 1616-5187 ,

    초록

    Abstract In cartilage regeneration, the biomimetic functionalization of hydrogels with growth factors is a promising approach to improve the in vivo performance and furthermore the clinical potential of these materials. In order to achieve this without compromising network properties, multifunctional linear poly(glycidol) acrylate (PG‐Acr) is synthesized and utilized as crosslinker for hydrogel formation with thiol‐functionalized hyaluronic acid via Michael‐type addition. As proof‐of‐principle for a bioactivation, transforming growth factor‐beta 1 (TGF‐β1) is covalently bound to PG‐Acr via Traut's reagent which does not compromise the hydrogel gelation and swelling behavior. Human mesenchymal stromal cells (MSCs) embedded within these bioactive hydrogels show a distinct dose‐dependent chondrogenesis. Covalent incorporation of TGF‐β1 significantly enhances the chondrogenic differentiation of MSCs compared to hydrogels with supplemented noncovalently bound TGF‐β1. The observed chondrogenic response is similar to standard cell culture with TGF‐β1 addition with each medium change. In general, multifunctional PG‐Acr offers the opportunity to introduce a range of biomimetic modifications (peptides, growth factors) into hydrogels and, thus, appears as an attractive potential material for various applications in regenerative medicine.

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  3. [해외논문]   Dual Electrospun Supramolecular Polymer Systems for Selective Cell Migration  

    Thakkar, Shraddha H. (Department of Biomedical Engineering, Soft Tissue Biomechanics & Tissue Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands) , Di Luca, Andrea (Department of Biomedical Engineering, Soft Tissue Biomechanics & Tissue Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands) , Zaccaria, Sabrina (Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands) , Baaijens, Frank P. T. (Department of Biomedical Engineering, Soft Tissue Biomechanics & Tissue Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands) , Bouten, Carlijn V. C. (Dep) , Dankers, Patricia Y. W.
    Macromolecular bioscience v.18 no.7 ,pp. 1800004 , 2018 , 1616-5187 ,

    초록

    Abstract Dual electrospinning can be used to make multifunctional scaffolds for regenerative medicine applications. Here, two supramolecular polymers with different material properties are electrospun simultaneously to create a multifibrous mesh. Bisurea (BU)‐based polycaprolactone, an elastomer providing strength to the mesh, and ureido‐pyrimidinone (UPy) modified poly(ethylene glycol) (PEG), a hydrogelator, introducing the capacity to deliver compounds upon swelling. The dual spun scaffolds are modularly tuned by mixing UPyPEG hydrogelators with different polymer lengths, to control swelling of the hydrogel fiber, while maintaining the mechanical properties of the scaffold. Stromal cell derived factor 1 alpha (SDF1α) peptides are embedded in the UPyPEG fibers. The swelling and erosion of UPyPEG increase void spaces and released the SDF1α peptide. The functionalized scaffolds demonstrate preferential lymphocyte recruitment proposed to be created by a gradient formed by the released SDF1α peptide. This delivery approach offers the potential to develop multifibrous scaffolds with various functions.

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  4. [해외논문]   Nonionic Dendritic and Carbohydrate Based Amphiphiles: Self‐Assembly and Transport Behavior  

    Prasad, Suchita (Department of Chemistry, University of Delhi, Delhi, 110 007, India) , Achazi, Katharina (Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany) , Schade, Boris (Forschungszentrum für Elektronenmikroskopie, Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstraße 36a, 14195, Berlin, Germany) , Haag, Rainer (Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany) , Sharma, Sunil K. (Department of Chemistry, University of Delhi, Delhi, 110 007, India)
    Macromolecular bioscience v.18 no.7 ,pp. 1800019 , 2018 , 1616-5187 ,

    초록

    Abstract Herein, a new series of non‐ionic dendritic and carbohydrate based amphiphiles is synthesized employing biocompatible starting materials and studied for supramolecular aggregate formation in aqueous solution. The dendritic amphiphiles 12 and 13 possessing poly(glycerol) [G2.0] as hydrophilic unit and C‐10 and C‐18 hydrophobic alkyl chains, respectively, exhibit low critical aggregation concentration (CAC) in the order of 10 −5 m and hydrodynamic diameters in the 8–10 nm range and supplemented by cryogenic transmission electron microscopy. Ultraviolet‐visible (UV‐Vis) and fluorescence spectroscopy suggests the effective solubilization of hydrophobic guests by the self‐assembled architectures, with the nanotransporters 12 and 13 possessing the highest encapsulation efficiency of 80.74 and 98.03% for curcumin. Efficient uptake of encapsulated curcumin in adenocarcinomic human alveolar basal epithelial (A549) cells is observed by confocal laser scanning microscopy. Amphiphiles 12 and 13 are non‐cytotoxic at the concentrations studied, however, curcumin encapsulated samples efficiently reduce the viability of A549 cells in vitro. Experimental studies indicate the ability of amphiphile 13 to encapsulate 1‐anilinonaphthalene‐8‐sulfonic acid (ANS) and curcumin with binding constant of 1.16 × 105 5 m −1 and 1.43 × 10 6 m −1 , respectively. Overall, our findings demonstrate the potential of these dendritic amphiphiles for the development of prospective nanocarriers for the solubilization of hydrophobic drugs.

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  5. [해외논문]   Fabrication of Reduction‐Sensitive Amphiphilic Cyclic Brush Copolymer for Controlled Drug Release  

    Tu, Xiao‐ (State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, Gansu, China) , Yan (State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, Gansu, China) , Meng, Chao (State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, Gansu, China) , Zhang, Xiao‐ (State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and) , Long , Jin, Miao‐ , Ge , Zhang, Xian‐ , Shuo , Zhao, Xue‐ , Zhi , Wang, Yun‐ , Fei , Ma, Li‐ , Wei , Wang, Bao‐ , Yan , Liu, Ming‐ , Zhu , Wei, Hua
    Macromolecular bioscience v.18 no.7 ,pp. 1800022 , 2018 , 1616-5187 ,

    초록

    Abstract The cyclic brush polymers, due to the unique topological structure, have shown in the previous studies higher delivery efficacy than the bottlebrush analogues as carriers for drug and gene transfer. However, to the best of knowledge, the preparation of reduction‐sensitive cyclic brush polymers for drug delivery applications remains unexplored. For this purpose, a reduction‐sensitive amphiphilic cyclic brush copolymer, poly(2‐hydroxyethyl methacrylate‐g‐poly(ε‐caprolactone)‐disulfide link‐poly(oligoethyleneglycol methacrylate)) (P(HEMA‐ g ‐PCL‐SS‐POEGMA)) with reducible block junctions bridging the hydrophobic PCL middle layer and the hydrophilic POEGMA outer corona is designed and synthesized successfully in this study via a “grafting from” approach using sequential ring‐opening polymerization (ROP) and atom transfer free radical polymerization (ATRP) from a cyclic multimacroinitiator PHEMA. The resulting self‐assembled unimolecular core–shell–corona (CSC) micelles show sufficient salt stability and efficient destabilization in the intracellular reducing environment for a promoted drug release toward a greater therapeutic efficacy relative to the reduction‐insensitive analogues. The overall results demonstrate the reducible cyclic brush copolymers developed herein provides an elegant solution to the tradeoff between extracellular stability and intracellular high therapeutic efficacy toward efficient anticancer drug delivery.

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  6. [해외논문]   Dual Ag/ZnO‐Decorated Micro‐/Nanoporous Sulfonated Polyetheretherketone with Superior Antibacterial Capability and Biocompatibility via Layer‐by‐Layer Self‐Assembly Strategy  

    Deng, Yi (School of Chemical Engineering, Sichuan University, Chengdu, 610065, China) , Yang, Lei (School of Materials and Engineering, Sichuan University, Chengdu, 610065, China) , Huang, Xiaobing (School of Chemical Engineering, Sichuan University, Chengdu, 610065, China) , Chen, Junhong (School of Materials and Engineering, Sichuan University, Chengdu, 610065, China) , Shi, Xiuyuan (School of Materials and Engineering, Sichuan University, Chengdu, 610065, China) , Yang, Weizhong (School of Materials and Engineering, Sichuan University, Chengdu, 610065, China) , Hong, Min (Centre for Future Materials, University of Southern Queensland, Springfield, Queensland, 4300, Australia) , Wang, Yuan (Centre for Future Materials, University of Southern Queensland, Springfield, Queensland, 4300, Australia) , Dargusch, Matthew S. , Chen, Zhi‐ , Gang
    Macromolecular bioscience v.18 no.7 ,pp. 1800028 , 2018 , 1616-5187 ,

    초록

    Abstract Polyetheretherketone is attractive for dental and orthopedic applications due to its mechanical attributes close to that of human bone; however, the lack of antibacterial capability and bioactivity of polyetheretherketone has substantially impeded its clinical applications. Here, a dual therapy implant coating is developed on the 3D micro‐/nanoporous sulfonated polyetheretherketone via layer‐by‐layer self‐assembly of Ag ions and Zn ions. Material characterization studies have indicated that nanoparticles consisting of elemental Ag and ZnO are uniformly incorporated on the porous sulfonated polyetheretherketone surface. The antibacterial assays demonstrate that Ag‐decorated sulfonated polyetheretherketone and Ag/ZnO‐codecorated sulfonated polyetheretherketone effectively inhibit the reproduction of Gram‐negative and Gram‐positive bacteria. Owing to the coordination of micro‐/nanoscale topological cues and Zn induction, the Ag/ZnO‐codecorated sulfonated polyetheretherketone substrates are found to enhance biocompatibility (cell viability, spreading, and proliferation), and hasten osteodifferentiation and ‐maturation (alkaline phosphate activity (ALP) production, and osteogenesis‐related genetic expression), compared with the Ag‐decorated sulfonated polyetheretherketone and the ZnO‐decorated sulfonated polyetheretherketone counterparts. The dual therapy Ag/ZnO‐codecorated sulfonated polyetheretherketone has an appealing bacteriostatic performance and osteogenic differentiation potential, showing great potential for dental and orthopedic implants.

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  7. [해외논문]   Electrospun Heparin‐Loaded Core–Shell Nanofiber Sutures for Achilles Tendon Regeneration In Vivo  

    Ye, Ya‐ (Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, China) , Jing (Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, China) , Zhou, Ya‐ (Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, China) , Qing (Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, China) , Jing, Zhuo‐ (Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, China) , Yuan , Liu, Yang‐ , Yang , Yin, Da‐ , Chuan
    Macromolecular bioscience v.18 no.7 ,pp. 1800041 , 2018 , 1616-5187 ,

    초록

    Abstract Achilles tendon reconstruction surgery is the primary clinical method for repairing acute Achilles tendon ruptures. However, the efficacy of the postoperative healing process and the recovery of physiological function are inadequate. This study examines the healing mechanism of ruptured rat Achilles tendons seamed with heparin‐loaded core–shell fiber sutures fabricated via near‐field electrospinning. High‐heparin‐concentration sutures (PPH3.0) perform better than the low‐heparin‐concentration sutures and commercial sutures (CSs). The PPH3.0 suture recruits fewer inflammatory cells and shows good histocompatibility in peritoneal implantation experiments. Staining of the Achilles tendon rupture repair zone demonstrates that a high heparin concentration in sutures reduces immune‐inflammatory responses. Immunohistochemical analysis reveals that the transforming growth factor‐β staining scores of the PPH3.0 sutures are not significantly different from those of the corresponding control group but are significantly different from those of the CSs and non‐heparin‐loaded‐suture groups. According to vascular endothelial growth factor (VEGF) analysis, the concentration of VEGF in the group treated with the PPH3.0 suture increases by 37.5% compared with that in its control group. No significant difference in tension strength is observed between the PPH3.0 group and healthy Achilles tendons. These findings illustrate that this novel method effectively treats Achilles tendon rupture and promotes healing and regeneration.

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  8. [해외논문]   Preparation of Biocomposite Microfibers Ready for Processing into Biologically Active Textile Fabrics for Bioremediation  

    Kaiser, Patrick (Process Biotechnology, University of Bayreuth, D‐95447, Bayreuth, Germany) , Reich, Steffen (Macromolecular Chemistry and Bavarian Polymer Institute, University of Bayreuth, D‐95447, Bayreuth, Germany) , Greiner, Andreas (Macromolecular Chemistry and Bavarian Polymer Institute, University of Bayreuth, D‐95447, Bayreuth, Germany) , Freitag, Ruth (Process Biotechnology, University of Bayreuth, D‐95447, Bayreuth, Germany)
    Macromolecular bioscience v.18 no.7 ,pp. 1800046 , 2018 , 1616-5187 ,

    초록

    Abstract Biocomposites, i.e., materials consisting of metabolically active microorganisms embedded in a synthetic extracellular matrix, may find applications as highly specific catalysts in bioproduction and bioremediation. 3D constructs based on fibrous biocomposites, so‐called “artificial biofilms,” are of particular interest in this context. The inability to produce biocomposite fibers of sufficient mechanical strength for processing into bioactive fabrics has so far hindered progress in the area. Herein a method is proposed for the direct wet spinning of microfibers suitable for weaving and knitting. Metabolically active bacteria (either Shewanella oneidensis or Nitrobacter winogradskyi ( N. winogradskyi )) are embedded in these fibers, using poly(vinyl alcohol) as matrix. The produced microfibers have a partially crystalline structure and are stable in water without further treatment, such as coating. In a first application, their potential for nitrite removal ( N. winogradskyi ) is demonstrated, a typical challenge in potable water treatment.

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  9. [해외논문]   An Extracellular Matrix‐Mimicking Hydrogel for Full Thickness Wound Healing in Diabetic Mice  

    Qin, Xianyan (Key Laboratory of Drug Targeting and Delivery, West China School of Pharmacy, Sichuan University, No. 17, Section 3, Southern Renmin Rd, Chengdu, 610041, China) , Qiao, Weizhen (Key Laboratory of Drug Targeting and Delivery, West China School of Pharmacy, Sichuan University, No. 17, Section 3, Southern Renmin Rd, Chengdu, 610041, China) , Wang, Yuejing (Key Laboratory of Drug Targeting and Delivery, West China School of Pharmacy, Sichuan University, No. 17, Section 3, Southern Renmin Rd, Chengdu, 610041, China) , Li, Tingyu (Key Laboratory of Drug Targeting and Delivery, West China School of Pharmacy, Sichuan University, No. 17, Section 3, Southern Renmin Rd, Chengdu, 610041, China) , Li, Xiang (Key Laboratory of Drug Targeting and Delivery, West China School of Pharmacy, Sichuan University, No. 17, Section 3, Southern Renmin Rd, Chengdu, 610041, China) , Gong, Tao , Zhang, Zhi‐ , Rong , Fu, Yao
    Macromolecular bioscience v.18 no.7 ,pp. 1800047 , 2018 , 1616-5187 ,

    초록

    Abstract An extracellular matrix‐mimicking hydrogel is developed consisting of a hyaluronan‐derived component with anti‐inflammatory activity, and a gelatin‐derived component offering adhesion sites for cell anchorage. The in situ‐forming hyaluronan‐gelatin (HA‐GEL) hydrogel displays a sponge‐like microporous morphology. Also, HA‐GEL shows a rapid swelling pattern reaching maximum weight swelling ratio within 10 min, while at the equilibrium state, fully swollen hydrogels display an exceedingly high water content with ≈2000% of the dry gel weight. Under typical 2D cell culture conditions, murine 3T3 fibroblasts adhere to, and proliferate on top of the HA‐GEL substrates, which demonstrate that HA‐GEL provides a favorable microenvironment for cell survival, adhesion, and proliferation. In vivo healing study further demonstrates HA‐GEL as a viable and effective treatment option to improve the healing outcome of full thickness wounds in diabetic mice by effectively depleting the inflammatory chemokine monocyte chemoattractant protein‐1 in the wound bed.

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  10. [해외논문]   Liposomes‐Camouflaged Redox‐Responsive Nanogels to Resolve the Dilemma between Extracellular Stability and Intracellular Drug Release  

    Ma, Jinfeng (Department of Polymer Science and Engineering, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China) , Deng, Hongzhang (Department of Polymer Science and Engineering, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China) , Zhao, Fuli (Department of Polymer Science and Engineering, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China) , Deng, Liandong (Department of Polymer Science and Engineering, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China) , Wang, Weiwei (Institute of Biomedical Engi) , Dong, Anjie , Zhang, Jianhua
    Macromolecular bioscience v.18 no.7 ,pp. 1800049 , 2018 , 1616-5187 ,

    초록

    Abstract Liposomes have shown great promises for pharmaceutical applications, but still suffer from the poor storage stability, undesirable drug leakage, and uncontrolled drug release. Herein, liposomes‐camouflaged redox‐responsive nanogels platform (denoted as “R‐lipogels”) is prepared to integrate the desirable features of sensitive nanogels into liposomes to circumvent their intrinsic issues. The results indicate that drug‐loaded R‐lipogels with controlled size and high stability not only can achieve a very high doxorubicin (DOX)‐loading capacity (12.9%) and encapsulation efficiency (97.3%) by ammonium sulfate gradient method and very low premature leakage at physiological condition, but also can quickly release DOX in the reducing microenvironment of tumor cells, resulting in effective growth inhibition of tumor cells. In summary, the strategy given here provides a facile approach to develop liposomes–nanogels hybrid system with combined beneficial features of stealthy liposomes and responsive nanogels, which potentially resolves the dilemma between systemic stability and intracellular rapid drug release.

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