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Nutritional sciences 11건

  1. [국내논문]   Effects of Low Calorie Diet and Platycodon Grandiflorum Extract on Fatty Acid Binding Protein Expression in Rats with Diet-induced Obesity  

    Park, Yoon-Shin (Department of Biomedical Sciences, Division of Cardiovascular Disease, National Institute of Health ) , Cha, Min-Ho (Department of Medical research, Korea Institute of Oriental Medicine ) , Yoon, Yoo-Sik (Department of Medical research, Korea Institute of Oriental Medicineand ) , Ahn, Hong-Seok (Department of Food and Nutrition, College of Human Ecology, Sungshin Women's University)
    Nutritional sciences v.8 no.1 ,pp. 3 - 9 , 2005 , 1229-232x ,

    초록

    Obesity can be defined as a metabolic disease due to an increased fat accumulation in the body caused by an imbalance of calorie intake and output The prevalence of obesity has increased substantially over the past 2-3 decades in developed and developing countries. The health impact of weight gain is so marked that obesity has now been classified as a major global public health problem In order to investigate the effect of diet conversion and oral administration of Platycodon grandiflorum extracts on the treatment of obesity, male Spraque-Dawley rats were divided into four groups: a group converted to normal diet (Control group), a group maintained high fat (30%) diet (H), and two groups with Platycodon grandiflorum extract added to the previously mentioned two groups. All animals were fed high fat diet for 7 weeks to induce the obesity. Then they were divided as mentioned above. Animals were fed experimental diet and Platycodon grandiflorum extract (150 mg/ml/rat/day) for 7 weeks. Body weight, adipose tissue weight (subcutaneous, epididymal, peritoneal fat pads) and serum lipids (total cholesterol and triglyceride) showed some differences among groups. The Platycodon grandiflorum feeding markedly decreased both body weight and adipose tissue weight in control group compared to H, high fat diet maintaining, group. Platycodon grandiflorum extracts significantly decreased the concentrations of serum lipids compared to H group. Fat cell numbers and sizes were significantly reduced in the oriental medicinal herb extract administrated group. Increased fatty acid binding protein (FABP) expression in high fat diet group was decreased by the dietary conversion to normal diet and the oral administration of Platycodon glandiflorum extracts. In contrast, there was no significant effect on FABP expression in the high fat maintenance group. In this study, the conversion from high fat diet to low fat or normal diet had a beneficial effect on body weight loss and serum lipid profiles. Dietary Platycodon glandiflorum extracts had an additive beneficial effect on the prevention and treatment of obesity.

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  2. [국내논문]   Polyunsaturated/saturated Fatty Acid Ratios and Antioxidant Supplementation under the Control of Dietary Peroxidizability Index Value: Impact on Serum Lipid Profiles in Young and Adult Rats   피인용횟수: 1

    Kang, Min Jeong (Department of Food & Nutrition, Hanyang University ) , Lee, Eun Kyung (Department of Hotel Cuisine, Korea Tourism College ) , Lee, Sang Sun (Department of Food & Nutrition, Hanyang University)
    Nutritional sciences v.8 no.1 ,pp. 10 - 15 , 2005 , 1229-232x ,

    초록

    An increase in serum cholesterol is directly associated with high incidences of cardiovascular diseases (CVD) and atherosclerosis. Serum lipid profiles are highly dependent on dietary fatty acids and age. The purpose of this study was to examine the age-related effects of polyunsaturated/saturated fatty acid ratios and antioxidant supplementation under the control of the dietary peroxidizability index (PI) value on serum lipid profiles in rats. While the PI level of dietary fatty acids was controlled at 81.22, the P/S ratios of fatty acids were 0.38 and 4.81 (LP and HP). The diets were supplemented with a vitamin E 1000 mg/kg diet and a selenium 2.5 mg/kg diet (LPS and HPS). Female Sprague-Dawley rats ages 3 weeks (young) and 16 weeks (adult) were fed four different experimental diets for 4 weeks. The serum triglyceride concentration of LPS was significantly higher in young rats than in adult rats. The total-cholesterol concentration of LP and HPS were higher in young rats than in adult rats. The high-density lipoprotein-cholesterol (HDL-C) concentration of LP, LPS and HP was higher in adult rats than in young rats. The low-density lipoprotein-cholesterol (LDL-C) concentration was higher in young rats than in adult rats. T-C/HDL-C and LDL-C/HDL-C ratios were much higher in young rats than in adult rats. In conclusion, P/S ratios and antioxidant supplementation did not affect T-C/HDL-C and LDL-C/HDL-C ratios as risk factors of CVD in adult rats when we controlled the PI value in the diet Probably, the invisible and confounding effects of dietary PI value implicate the beneficial roles of dietary P/S ratios and antioxidants in CVD. Accordingly, controlling the dietary PI value may be advantageous to lower the risk of CVD in adult rats.

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  3. [국내논문]   Effects of a Selective COX-2 Inhibitor Celecoxib and Soy-Isoflavones on Molecular Markers Related to Apoptosis, and COX-2 and Mapkinase Expression in Estrogen-Fed Rats  

    Kim, Tae-Kyung (Department of Food and Nutrition, Hannam University ) , Park, Ock Jin (Department of Food and Nutrition, Hannam University)
    Nutritional sciences v.8 no.1 ,pp. 16 - 22 , 2005 , 1229-232x ,

    초록

    The present study examined the effects of cyclooxygenase-2 (COX-2) inhibitor celecoxib or soy-isoflavones in the presence of estrogen on apoptosis related gene expression, COX-2 and mapkinase in 48-week old female rats. Expressions of bel-2 and bax proteins, which are known to be involved in the regulation of apoptosis, were investigated in mammary glands and heart tissues. The elevated expression of bel-2 expression was observed in mammary glands of celecoxib supplemented rats as well as soy-isoflavones. The mammary glands bel-2/bax ratio was found to be higher in celecoxib or soy-isoflavones supplemented rats. However, in heart tissues, expression of bel-2 and bax was in the order of control, celecoxib and soy-isoflavones. The up-regulation of COX-2 was observed in celecoxib or soy-isoflavones in mammary glands. 'The similar trend was not displayed with the mapkinase expression. In heart tissues, the down-regulation of COX-2 as well as mapkinase was observed in celecoxib or soy-isoflavones supplemented rats. Soy-isoflavones and celecoxib both had a similar regulatory pattern of bel-2, bax and COX-2 in mammary glands, and in heart tissues, only COX-2 exhibited a similar down-regulatory properly. These findings revealed that in estrogen sufficient state, celecoxib and soy-isoflavones might not exhibit proapoptotic potential or COX-2 inhibition in normal mammary glands.

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  4. [국내논문]   Effects of Allicin on the Gene Expression Profile of Mouse Hepatocytes in vivo with DNA Microarray Analysis  

    Park, Ran-Sook (Department of Food & Nutrition, Soong Eui Women's College)
    Nutritional sciences v.8 no.1 ,pp. 23 - 27 , 2005 , 1229-232x ,

    초록

    The major garlic component, Allicin [diallylthiosulfinate, or (R, S)-diallyldissulfid-S-oxide] is known for its medicinal effects, such as antihypertensive activity, microbicidal activity, and antitumor activity. Allicin and diallyldisulfide, which is a converted form of allicin, inhibited the cholesterol level in hepatocytes, in vivo and in vitro. The metabolism of allicin reportedly occurs in the microsomes of hepatocytes, predominantly with the contribution of cytochrome P-450. However, little is known about how allicin affects the genes involved in the activity of hepatocytes in vivo. In the present study, we used the short-term intravenous injection of allicin to examine the in vivo genetic profile of hepatocytes. Allicin up-regulate ten genes in the hepatocytes. For example, the interferon regulator 1 (IRF-I), the wingless-related MMTV (mouse mammary tumor virus) integration site 4 (wnt-4), and the fatty acid binding protein 1. However, allicin down-regulated three genes: namely, glutathione S-transferase mu6, a-2-HS glycoprotein, and the corticosteroid binding globulin of hepatocytes. The up-regulated wnt-4, IRF-1, and mannose binding lectin genes can enhance the growth factors, cytokines, transcription activators and repressors that are involved in the immune defense mechanism. These primary data, which were generated with the aid of the Atlas Plastic Mouse 5 K Microarray, help to explain the mechanism which enables allicin to act as a therapeutic agent, to enhance immunity, and to prevent cancer. The data suggest that these benefits of allicin are partly caused by the up-regulated or down-regulated gene profiles of hepatocytes. To evaluate the genetic profile in more detail, we need to use a more extensive mouse genome array.

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  5. [국내논문]   Effects of a High Protein Diet and Aerobic Exercise on Body Weight Changes and Blood Lipids in Slightly Overweight Women   피인용횟수: 1

    Suh, Kyoung Yeo (College of Physical Education, Kookmin University ) , Lee, Dae Taek (College of Physical Education, Kookmin University)
    Nutritional sciences v.8 no.1 ,pp. 28 - 34 , 2005 , 1229-232x ,

    초록

    To examine the combined effects of a high-protein diet and aerobic exercise on body weight and composition and blood lipid profiles in overweight women, 30 young women were recruited and placed into three groups: The high-protein diet and exercise group (HPE), the exercise-only group (EXO) and the control group (CON) (30 $\pm$ 3%, 27 $\pm$ 2%, and 29 $\pm$ 3% body fat, respectively) for an 8-week experimental period. Daily diet included 25% isolated soybean protein (>90% protein, approximately 400 kcal) combined with each subject s usual diet for the HPE group. The exercise program consisted of aerobic-type exercises undertaken >3 times/wk and for>30 min/session at 50-60% of maximal capacity. Physical fitness, body composition, serum total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG) and glucose were measured before and after the experiment. Maximal aerobic capacity increased by the end of experiment in both the HPE (from 27.2 $\pm$ 3.5 to 35.l $\pm$ 5.9 ml/kg/min, p $\pm$ 5.4 to 33.8 $\pm$ 3.8 mㅣ/kg/min, p $\pm$ 20 to 155 $\pm$ 18 mg/dL and HDL-C increased from 57 $\pm$ l0 to 61 $\pm$ 9 mg/dL in HPE (p

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  6. [국내논문]   Dietary and Health-Related Lifestyle Habits and Blood Parameters of Non-Insulin Dependent Diabetes Patients   피인용횟수: 1

    Song, In-Ja (Department of Food and Nutrition, Chonnam National University ) , Lee, Jeong-A (Department of Food and Nutrition, Chonnam National University ) , Lim, Hyeon-Sook (Department of Food and Nutrition, Chonnam National University)
    Nutritional sciences v.8 no.1 ,pp. 35 - 41 , 2005 , 1229-232x ,

    초록

    Controlling dietary behaviors and health-related lifestyle habits is important to manage non-insulin dependent diabetes mellitus (NIDDM). If NIDDM is not treated properly, the prevalence of macro-vascular complications (MC) may increase. The goal of NIDDM therapy is to maintain normal concentrations of blood glucose and lipid profiles by having regular meals, controlling alcohol drinking, quitting smoking, and performing physical exercise regularly. This study was performed to investigate the dietary and health-related lifestyle habits and blood parameters of NIDDM patients of both genders and compared these characteristics between the patients with and without MC. Our results show that the subjects with MC compared to without MC and the female patients than the males controlled their diets more regularly, tended to regulate the number of meals better, and smoke less than those without MC. Although plasma lipid profiles were not significantly different between the genders and between the subjects with and without MC, the men had higher blood glucose and plasma tHcy concentrations than the women and plasma tHcy concentration was higher in the female subjects without MC. These results imply that the male patients of NIDDM without MC might have more problems in maintaining their blood glucose. In addition, smoking may be the most important life-style factor influencing some blood parameters like blood glucose, HbAlc, and total cholesterol in the NIDDM patients.

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  7. [국내논문]   Public Health Nutrition Policies and the Role of the Government: International Examples and the Need for Action in the Republic of Korea  

    Engellhardt, Katrin (School of Public Health Seoul National University ) , Joung, Hyojee (School of Public Health Seoul National University)
    Nutritional sciences v.8 no.1 ,pp. 42 - 49 , 2005 , 1229-232x ,

    초록

    Many of the non-communicable diseases, which are now the major causes of death and disability worldwide, can be linked to our lifestyles, and thus to what eat The life-style related risk factors are - to a great extent - preventable. Public health nutrition (PHN) policies are means through which govemments can have an enornous impact on the reduction of nutrition-related non-communicable diseases, such as diabetes, hypertension, obesity, cancer and cardiovascular disease, by creating and supporting environments which enable healthier food choices and which are conducive to healthy nutrition behavior. More and more countries are developing nutrition policies. Nutrition policies are tools through which governments can intervene and control nutrition-related concerns throughout all levels of society. The need for more concerted action in the Republic of Korea is demonstrated, by showing the lack of priority for nutrition issues. Four recommendations for action are made; the first recommendation places emphasis on the need to implement a structure at the political level, through which nutrition concerns can be addressed, such as a nutrition unit within the Ministry of Health and Welfare. The second recommendation stresses the need for a strong nutrition advocacy strategy, to raise the awareness of the gains that can be achieved by promoting healthy nutrition. The third recommendation calls for more vigorous regulations and stricter enforcement of food and nutrition advertisement, and the fourth recommendation emphasizes the need for a settings-bsed approach to nutrition interventions. Acknowledging the developments that have already occurred in Korea, public health nutrition has yet to become a priority on the agenda of policy makers in Korea.

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  8. [국내논문]   Body Mass Index and Body Fat Percent of Koreans in Seoul and Pusan Compared to those of Caucasians  

    Moon, Hyun-Kyung (Dankook University ) , Deurenberg, Paul (Dankook University)
    Nutritional sciences v.8 no.1 ,pp. 50 - 55 , 2005 , 1229-232x ,

    초록

    This study was conducted to determine the relationship between the body fat percent (BF%) and body mass index (BMI) of Koreans and the differences with Caucasians. Complete data were collected from 3297 subjects (2441females and 856 males) between the ages of 18 and 79. Data were collected between September 2001 and November 2001 in Seoul and Pusan. For the statistical analysis, only the data on subjects between the ages of 18 and 65(3200) were used Body weight and height were measured BMI (kg/ $m^2$ ) was computed From BMI, BF (%) was calculated using age- and sex-specific prediction formulas. BF% was assessed using an INBODY 2.0 body fat analyser. Data analysis showed that the females were significantly younger than the males, were smaller, lighter and had a lower body mass index. Body fat percent of the females was higher than that of the males. 1he differences between actual measured BF% and BF% as predicted from prediction equations from the literature, based on BMI, age and sex, were correlated with level of body fat and age. There is a significant age-related decrease in body fat in Koreans for any given BMI and sex, which is remarkably different compared to age-related increases in body fat in the European reference group. For the same age and BF%, Korean females have a slightly lower BMI than their European counterparts. Korean males have, for the same age and BF%, a higher BMI than their European counterparts. The differences between females and males were not significant. It was concluded that, assuming that the data on body fat percent was correct, that the relationship between BF% and BMI is quite different in Koreans than in European Caucasians. Thus, for younger Koreans cut-off values for obesity should be slightly lower than those for Caucasians whereas for older Koreans the cut-off points for obesity should be higher than those for Caucasians.

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  9. [국내논문]   Studies on Body Fat Ratio and Nutrient Intakes of College Students  

    Lee, Ji-Hyang (Department of Food & Nutrition, Myung-Ji University ) , Song, Kyung-Hee (Department of Food & Nutrition, Myung-Ji University)
    Nutritional sciences v.8 no.1 ,pp. 56 - 60 , 2005 , 1229-232x ,

    초록

    The aim of this study researchs status of the nutrient intake between male and female students and the nutrient intake by BMI. This study was done to investigate the body composition and nutrient intakes of 340 college students (170 males, 170 females) in Gyeonggi area. Weight, height, BMI, and blood pressure of these college students were measured Nutrient intake was assessed using the 24-hour recall method, and then calculated using the nutritional evaluation program [CAN Pro 2.0 professional (Korean Nutrition Society, 2002)]. Average height and weight were 176 $\pm$ 5.1 cm, 70.60 $\pm$ l.l kg in male students and 162.2/ $\pm$ 4.5 cm, 54.4 $\pm$ 7.7 kg in female students respectively. Subjects were divided into three groups by BMI: underweight (less than 18.5), normal weight (18.5 to less than 23), and overweight (more than 23). The ratios of male and female subjects among these groups were 5.3% and 17.6% in underweight, 50% and 65.3% in normal weight, and 44.7% and 17.2% in overweight. Systolic and diastolic blood pressures were 124.0 $\pm$ 1.5 mmHg and 76.1 $\pm$ 14.8 mmHg in males and 1l0.l $\pm$ 12.9 mmHg and 70.l $\pm$ 10.8 mmHg in females, all in the normal range. Using nutrient values of the 7th Recommended Dietary Allowanes, the nutrient intake was calculated to Korean RDA (%). Nutrients below 75% Korean RDA were Calcium, Vitamin $B_2$ , and Folate and nutrients above 100% RDA were Protein, Fe, Phosphorous, and Vitamin $B_6$ . BMI showed positive correlations with body fat (%)(p

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  10. [국내논문]   A Study on Dietary Behaviors and Food Preference of Elementary School Children in Gyeonggi Area  

    Nam, Mi-Sung (Department of Food and Nutrition, Myongji University ) , Song, Kyung-Hee (Department of Food and Nutrition, Myongji University)
    Nutritional sciences v.8 no.1 ,pp. 61 - 70 , 2005 , 1229-232x ,

    초록

    To investigate the dietary behavior and food preference by the obesity index, 524 children (male 265, female 259) from 4 elementary schools in Gyeonggi area participated in this study. The overweight group included more boys (52.5%) than girls (47.5%). The overweight group had significantly higher values in height, weight, Obesity index (OI), Body mass index (BMI), and Rohrer index (RI) than the underweight or normal weight groups. The majority (43.4%) of children showed 11-20 minutes of eating time, and boys ate significantly rapidly than girls (p

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