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The journal of applied pharmacology : the official... 10건

  1. [국내논문]   Search for Constituents with Neurotrophic Factor Activity from Medicinal Plants and their Application to Drug Development  

    Ohizumi, Yasushi (Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University ) , Yamakuni, Tohru (Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University ) , Li, Yu-Shan (Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University)
    The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology v.12 no.4 ,pp. 195 - 197 , 2004 , 1225-6110 ,

    • 원문 

    초록

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [국내논문]   Neurochemical Alterations in Physical Dependence on Butorphanol  

    Ho, I. K. (Department of Pharmacology and Toxicology, University of Mississippi Medical Center ) , Fan, Lir-Wan (Department of Pharmacology and Toxicology, University of Mississippi Medical Center ) , Kim, Seong-Youl (Department of Pharmacology and Toxicology, University of Mississippi Medical Center ) , Ma, Tangeng (Department of Pharmacology and Toxicology, University of Mississippi Medical Center ) , Rockhold, Robin W. (Department of Pharmacology and Toxicology, University of Mississippi Medical Center)
    The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology v.12 no.4 ,pp. 198 - 201 , 2004 , 1225-6110 ,

    초록

    This review focuses on finding neurochemical changes in physical dependence on butorphanol, a relatively potent mixed agonist-antagonist opioid analgesic agent that is five times more potent than morphine in antinociceptive effects. The chronic administration of butorphanol induces physical dependence. Withdrawal from such dependence can be reliably precipitated by administration of a narcotic antagonist, e.g., naloxone. Evidence for critical involvement of excitatory aminoacid (glutamate), opioid receptors, and phosphorylation of proteins in these phenomena is summarized.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [국내논문]   Diabetes, Glucose Transport and Hypoglycaemic Agents   피인용횟수: 1

    Khil, Lee-Yong (Faculty of Medicine, University of Calgary)
    The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology v.12 no.4 ,pp. 202 - 208 , 2004 , 1225-6110 ,

    초록

    Diabetes mellitus is a complex metabolic derangement with hyperglycaemia being the most characteristic symptom of diabetes. Hyperglycaemia can be caused by an increase in the rate of glucose production by the liver or by a decrease in the rate of glucose use by peripheral tissues. Impaired glucose transport is one of the major factors contributing to insulin resistance in type 2 diabetic patients. The ability of insulin to mediate tissue glucose uptake is a critical step in maintaining glucose homeostasis and in clearing the post-prandial glucose load. Glucose transport is mediated by specific carriers called glucose transporters (GLUTs). In this article, the functional importance and molecular mechanisms of insulin-induced glucose transport and development of hypoglycaemic agents which increase glucose transport are reviewed.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [국내논문]   Lead increases Nitric Oxide Production in Immunostimulated Glial Cells  

    Choi, Min-Sik (Department of Pharmacology, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University ) , Shin, Chan-Young (Department of Pharmacology, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University ) , Ryu, Jae-Ryun (Department of Pharmacology, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University ) , Lee, Woo-Jong (Department of Pharmacology, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University ) , Cheong, Jae-Hoon (College of Pharmacy, Sahmyook University ) , Choi, Chang-Rak (Department of Neurosurgery, St.Marys Hospital, The Catholic University of Korea ) , Kim, Won-Ki (Department of Pharmacology, Ewha Institute of Neuroscience, Ewha Medical School ) , Ko, Kwang-Ho (Department of Pharmacology, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
    The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology v.12 no.4 ,pp. 209 - 214 , 2004 , 1225-6110 ,

    초록

    Lead has long been considered as a toxic environmental pollutant that severely damages the central nervous system. In various neurogenerative diseases, actrocytes become activated by proinflammatory cytokines. In the present study, we investigated whether lead (Pb $^{2+}$ ) affects inducible nitric oxide synthase (iNOS) expression in activated glial cells. Rat primary glial cells were stimulated with lipopolysaccharide (LPS, 1 ${\mu}$ g/ml) plus IFN $_{\gamma}$ (100 U/ml). Pre-treatment of Pb $^{2+}$ increased nitric oxide (NO) production in LPS/IFN $_{\gamma}$ -stimulated glial cells. Lead itself, however, suppressed the basal production of NO in control glial cells. Addition of the iNOS inhibitors L-NAME (1 mM) and L-NNA (800 ${\mu}$ M) prevented the Pb $^{2+}$ -induced increase in NO production. Western blot analysis showed that pre-treatment of Pb $^{2+}$ augmented LPS/IFN $_{\gamma}$ -induced increase in iNOS immunoreactivity, which was well correlated with the increased NO production. In addition, pre-treatment of Pb $^{2+}$ synergistically increased the iNOS mRNA expression induced by LPS and IFN ${\gamma}$ . The present results indicate that lead intoxication adversely affect brain function by potentiating iNOS expression and NO production in activated glial cells observed in various neurodegenerative diseases.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [국내논문]   Pharmacological Effects of KR60886, A New β3 Adrenoceptor Agonist  

    Lee, Sang-Suk (Korea Research Institute of Chemical Technology Medicinal Science Division ) , Yang, Sung-Don (Korea Research Institute of Chemical Technology Medicinal Science Division ) , Ha, Jae-Du (Korea Research Institute of Chemical Technology Medicinal Science Division ) , Choi, Joong-Kwon (Korea Research Institute of Chemical Technology Medicinal Science Division ) , Cheon, Hyae-Gyeong (Korea Research Institute of Chemical Technology Medicinal Science Division)
    The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology v.12 no.4 ,pp. 215 - 220 , 2004 , 1225-6110 ,

    초록

    In an attempt to develop new anti-diabetic agents, a series of aryloxypropanolamine derivatives was synthesized to serve as ${\beta}_3$ adrenoceptor agonists. Among these derivatives, 1-{1-methyl-3-[4-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)phenyl]propylamino}-3-phenoxy-2-propanol (KR60886) possessed a high affinity for the ${\beta}_3$ adrenoceptor (Ki = 28 nM) and moderate affinities for ${\beta}_1$ and ${\beta}_2$ adrenoceptors (Ki = 95 nM and 100 nM, respectively). In addition, KR60886 stimulated cAMP production with an EC $_{50}$ of 0.4 ${\mu}M$ , confirming its agonistic activity for the ${\beta}_3$ adrenoceptor. In vivo activities of KR60886 were examined by using a fat-fed/streptozotocin (STZ)-treated rat model and the ob/ob mouse model. Oral administration of KR60886 (10 mg/kg) for 3 days (b.i.d.) to fat-fed/STZ-treated rats significantly lowered plasma glucose levels and reduced plasma free fatty acid concentrations. Similarly, KR60886 treatment (10 mg/kg/day for 7 d) resulted in a reduction of plasma glucose concentrations in ob/ob mice. The present study suggests that KR60886 is a potent ${\beta}_3$ receptor agonist with in vivo anti-diabetic properties.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [국내논문]   Effect of ZNimesulide on the Differentiation and Survival of Endothelial Progenitor Cells  

    Oh, Ho-Kyun (Cancer Research Institute, Catholic Research of Medical Science, The Catholic University of Korea ) , Kim, Sun-Yong (Cancer Research Institute, Catholic Research of Medical Science, The Catholic University of Korea ) , Baek, Sang-Hong (Department of Internal Medicine, Division of Cardiovascular Medicine, The Catholic University of Korea ) , Lim, Sung-Cil (Department of Internal Medicine, Division of Cardiovascular Medicine, The Catholic University of Korea ) , Ahn, Hyun-Young (Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Korea Institute of Radiological and Medical Sciences ) , Shin, Jong-Chul (Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Korea Institute of Radiological and Medical Sciences ) , Hong, Sung-Hee (Laboratory of Experimental Therapeutics, Korea Institute of Radiological and Medical Sciences ) , Hong, Yong-Kil (Cancer Research Institute, Catholic Research of Medical Science, The Catholic University of Korea ) , Joe, Young-Ae (Cancer Research Institute, Catholic Research of Medical Science, The Catholic University of Korea)
    The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology v.12 no.4 ,pp. 221 - 227 , 2004 , 1225-6110 ,

    초록

    Nonsteroidal anti-inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 inhibitors have been shown to decrease the growth of tumor, in part, by inhibition of neovascularization. Recently, besides mature endothelial cells, endothelial progenitor cells (EPCs) have been shown to contribute neovascularization in angiogenic tissues. In this study, we addressed a question whether nimesulide, a selective COX-2 inhibitor, could affect differentiation of EPCs into adhesive endothelial cells in vitro. Total mononuclear cells were isolated from cord blood by Ficoll density gradient centrifugation, and then the cells were incubated with nimesulide or vehicle control for 7 days. The number of adherent and spindle-shaped cells decreased by nimesulide treatment in a concentration-dependent fashion at a concentration range of 5 - 200 ${\mu}M$ . Moreover, the adherent cells double positive for DiI-ac-LDL uptake and lectin binding significantly decreased upon nimesulide treatment. There was no change of expression of CD31 between treatment and control groups, whereas slight reduction was detected upon treatment in expression of VE-cadherin, ICAM-1, vWF, ${\alpha}v$ , and ${\alpha}5$ . Nimesulide also reduced cell viability during first 3 days' culture and induced apoptosis in adherent EPCs, resulting in increased annexin-V-positive and propidium iodide-negative cells. Taken together, these results suggest that nimesulide could be applied for the inhibition of new vessel formation, in part, by inhibiting differentiation and survival of EPCs.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [국내논문]   Hydrogen Peroxide Mediates Brazilin-induced Glucose Transport in Adipocytes  

    Khil, Lee-Yong (College of Pharmacy, Seoul National University ) , Moon, Chang-Kiu (College of Pharmacy, Seoul National University)
    The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology v.12 no.4 ,pp. 228 - 234 , 2004 , 1225-6110 ,

    초록

    Brazilin shows hypoglycemic effect in diabetic animals through enhancement of glucose metabolisms in insulin responsive tissues. One of the major mechanisms of brazilin to enhance glucose metabolism is stimulation of glucose transport in adipocytes. In this study, the essential molecular moiety of brazilin for the stimulation of glucose transport was investigated. We found that brazilin undergoes a structural change in physiological buffer and produces hydrogen peroxide. Methylation of hydroxyl group of brazilin or addition of catalase along with brazilin resulted in the complete inhibition of brazilin-induced glucose transport in adipocytes. Because hydrogen peroxide increases glucose transport by inhibition of phosphatases, we examined the effect of brazilin on phosphatase activity. Brazilin inhibited phosphatases in a wide range of activity, and protein phosphatase 1 and 2A were also inhibited. These results suggest that the production of hydrogen peroxide by oxidation of catechol hydroxyl group of brazilin mediates glucose transport through inhibition of phosphatases which otherwise decrease glucose transport in adipocytes.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [국내논문]   Regulatory Effect of Atopic Allergic Reaction by Modified Gagam-danguieumja  

    Na, Ho-Jeong (College of Oriental Pharmacy, Wonkwang University, College of Oriental Medicine, Kyung Hee University ) , Kwon, Dong-Yeul (College of Oriental Pharmacy, Wonkwang University ) , Kim, Hyung-Min (College of Oriental Medicine, Kyung Hee University ) , Park, Eun-Jeong (College of Oriental Medicine, Wonkwang University ) , Lee, Eun-Hee (Division of Beauty Arts, Jeonbuk Science College ) , Hong, Seung-Heon (College of Oriental Pharmacy, Wonkwang University)
    The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology v.12 no.4 ,pp. 235 - 241 , 2004 , 1225-6110 ,

    초록

    Gagam-danguiemja (GDGJ), a traditional Korean prescription, has been used as therapeutics for atopic allergic diseases such as atopic dermatitis. To evaluate the atopic allergic effect of modified GDGJ, we investigated a possible effect of GDGJ on mast cell-mediated allergic reaction, cytokinases secretion and mRNA expression in vivo and in vitro. Mast cells are a potent source of mediators that regulate the inflammatory response in allergic reaction. In mice orally administered by GDGJ (0.01, 0.1 and 1.0 g/kg) for 1 h, compound 48/80-induced ear oedema was significantly reduced. TNF- ${\alpha}$ , IL-8, and IL-6 secretion were inhibited by GDGJ in the human mast cell line (HNC-1). But TNF- ${\alpha}$ , IL-8, and IL-6 mRNA expression were not inhibited by GDGJ at the dose of 0.01 mg/ml. These findings may help in understanding the mechanism of action of this herbal medication, leading to the control of mast cells in atopic allergic reaction like AD.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [국내논문]   Stress related activities of Sun-ginseng in SD Rats and ICR Mice   피인용횟수: 1

    Lee, Geum-Seon (Department of Pharmacy, Sahmyook University ) , Tan-Lee, Blendyl Saguan (Department of Pharmacy, Sahmyook University ) , Kim, Mi-Kang (Department of Pharmacy, Sahmyook University ) , Dong, Kyung-Uoo (Department of Pharmacy, Sahmyook University ) , Kim, Joo-Yun (Department of Pharmacy, Sahmyook University ) , Yu, Gu-Young (Department of Chemistry, Sahmyook University ) , Han, Jeong-Sup (Department of Pharmacy, Sahmyook University ) , Ko, Hong-Sook (Department of Pharmacy, Sahmyook University ) , Park, Il-Ho (Department of Pharmacy, Sahmyook University ) , Cheong, Jae-Hoon (Department of Pharmacy, Sahmyook University)
    The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology v.12 no.4 ,pp. 242 - 249 , 2004 , 1225-6110 ,

    초록

    The main aim of this study was to investigate stress related activities of Sun-ginseng extract as a candidate for anti-stress-related functional supplement by comparing its effect to those of red ginseng, which is also known to alleviate stress. Normal group was not exposed to stress while the control group was exposed to stress. Rats were orally administered once a day with 200 mg red ginseng (RG) extract, 100 or 200 mg Sun-ginseng (SG) extract/kg body weight. Mice were given water containing 400 mg red ginseng extract, 200 or 400 mg SG/100 mL potable water. Rats were given supplements for 5 days without stress, and 5 days with restraint and electroshock stress. After final stress, stress-related behavioral changes of experimental animals were recorded and levels of blood corticosterone were measured. Mice were given supplements for 5 days through drinking water, and then fatigue related motor activity were recorded. SG-supplementation partially blocked stress effect on locomotion and elevated plus maze test in rats, and also partially blocked stress-induced behavioral changes such as freezing, burrowing, smelling, facewashing, grooming and rearing behavior in rats. SG-supplementation decreased blood corticosterone level which is increased by stress in rats. Effects of SG may not be modulated by GABAnergic nervous system. SG-supplementation prolonged swimming time and staying time on the wire and rotarod wheel in mice. These results suggest that SG partially protects living organisms from stress attack in some cases and thus has the potential to be used as a functional food to alleviate stress response.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  10. [국내논문]   Characterization of Acetoxyscirpendiol of Paecilomyces tenuipes as Inhibitor of Sodium Glucose Co-transporters Expressed in Xenopus laevis Oocytes  

    Park, Il-Woon (Department of Life Sciences, University of Seoul ) , Hwang, Gwi-Seo (College of Oriental Medicine Kyungwon University ) , Kim, Ha-Won (Department of Life Sciences, University of Seoul ) , Lee, Dong-Hee (Department of Life Sciences, University of Seoul)
    The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology v.12 no.4 ,pp. 250 - 256 , 2004 , 1225-6110 ,

    초록

    Cordyceps possesses numerous health-promoting ingredients including hypoglycemic agents. The mechanism for the reduction of circulatory sugar content, however, is still not fully understand. In this study, 4-beta acetoxyscirpendiol (ASD) was purified from the methanolic extracts from fruiting bodies of Paecilomyces tenuipes. Na+/Glucose transporter-1 (SGLT-1) was expressed in the Xenopus oocytes. The effect of ASD on the oocyte expressed SGLT-1 was analyzed utilizing the voltage clamp and 2-deoxy-D-glucose (2-DOG) uptake studies. ASD was shown to significantly inhibit SGLT-1 activity compared to the non-treated control in a dose- dependent manner. In the presense of its two derivatives (diacetoxyscirpenol or 15-acetoxyscirpendiol), SGLT-1 activity was greatly inhibited similarly as ASD. Between ASD derivatives, 15-acetoxyscirepenol showed inhibition equivalent to that of ASD while diacetoxyscirpenol did less degree of inhibition. Insummary , these results strongly indicate that ASD in P. tenuipes may serve as a functional substance in lowering blood sugar in the circulatory system. ASD and its derivatives can be utilized as inhibitors of SGLT-1.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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