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Nutraceuticals and food 21건

  1. [국내논문]   Alpha-Lipoic Acid Inhibits Glycogen Synthesis and Modifies Glucose Metabolism and Signaling Pathways in Soleus Muscles from Healthy Rats  

    Madar, Zecharia (The Hebrew University of Jerusalem, Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, Food Science and Nutrition ) , Stark, Aliza H. (The Hebrew University of Jerusalem, Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, Food Science and Nutrition ) , Ilan, Erez (The Hebrew University of Jerusalem, Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, Food Science and Nutrition ) , Timar, Bracha (The Hebrew University of Jerusalem, Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, Food Science and Nutrition ) , Borenshtein, Diana (The Hebrew University of Jerusalem, Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, Food Science and Nutrition)
    Nutraceuticals and food v.7 no.2 ,pp. 113 - 118 , 2002 , 1598-6195 ,

    초록

    Alpha-lipoic acid is a known hypoglycemic agent that may be useful in the treatment of diabetes. The objective of this study was to investigate the fate of glucose in isolated muscles incubated with lipoic acid by determining its direct effects on specific metabolic and signaling pathways. Soleus muscles from healthy rats were incubated with lipoic acid in the absence or presence of insulin. Glucose transport, glycogen synthesis, glucose oxidation and lipid synthesis were determined and affects on major pathways associated with insulin signaling were evaluated. Glucose transport was not significantly altered by the addition of lipoic acid to the incubation medium. However, lipoic acid decreased glycogen synthesis in comparison to controls. Glucose oxidation was moderately increased while de-novo lipid synthesis from glucose was inhibited. Wortmannin repressed insulin stimulation of glucose incorporation into glycogen, an effect that was augmented by the combined treatment of wortmannin and lipoic acid. Basal and insulin-stimulated serine phosphorylation of Akt was not changed by the addition of lipoic acid to the incubation medium. These data show that in this in vitro model, lipoic acid did not significantly affect glucose uptake but dramatically modified pathways of glucose metabolism within muscle tissue.

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  2. [국내논문]   A Quinolone Alkaloid, from the Aleurone Layer of Oryza sativa cv. Mihyangbyo, Inhibits Growth of Cultured Human Leukemia Cell   피인용횟수: 2

    Chung, Ha-Sook (Department of Food and Nutrition, Duksung Women′s University)
    Nutraceuticals and food v.7 no.2 ,pp. 119 - 122 , 2002 , 1598-6195 ,

    초록

    Oryza sativa cv. Mihyangbyo is one of several recently developed varieties of rice; characterized by high levels of aromatic components, which may increase its sensory and nutritional properties. In conjunction with our continuing investigation of bioactive components of improved grain varieties, a quinolone alkaloid was isolated from the n-butanol soluble fraction of the aleurone layer of Oryza sativa cv. Mihyangbyo (Gramineae) through activity-guided fractionation and isolation. The compound exhibited moderate antineoplastic activity in a human leukemia cell line (U937) with an $IC_{50}$ / value of 118.1 ug/mL, based on the MTT(3-[4, 5]dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) cell proliferation assay. The chemical structure of the functional compound was determined, based on physical and spectroscopic characteristics.

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  3. [국내논문]   Inhibitory Effects of Ninety Nine Korean Plants on Human Immunodeficiency Virus Type 1 Pretense Activity   피인용횟수: 4

    Park, Jong-Cheol (Department of Oriental Medicine Resources ) , Hur, Jong-Moon (Department of Oriental Medicine Resources ) , Park, Ju-Gwon (Department of Oriental Medicine Resources ) , Hyun, Kyu-Hawn (Department of Resources Plants, Sunchon National University ) , Lee, Kab-Yeon (Sobu Forest Experiment Station, Korea Forest Genetics Research Institute ) , Hirotsugu Miyashiro (Institute of Natural Medicine, Toyama Medical and Pharmaceutical University ) , Masao Hattori (Institute of Natural Medicine, Toyama Medical and Pharmaceutical University)
    Nutraceuticals and food v.7 no.2 ,pp. 123 - 127 , 2002 , 1598-6195 ,

    초록

    Ninety nine extracts from Korean plants were screened for their inhibitory activities on human immunodeficiency virus (HIV) type 1 pretense by an HPLC method. The pretense inhibitory activities were determined by incubating the extracts in reaction mixtures containing pretense and substrate (His-Lys-Ala-Arg-Val-Leu-(p-NO $_2$ - Phe)-Glu-Ala-Nle-Ser-NH $_2$ ) to perform proteolytic cleavage reactions. Of the extracts tested, the water extracts of Viburnum awabuki (stem and leaves) and Distylium racemosum (leaves) had the highest pretense inhibitory activities at a concentration of 100ug/mL. Activity-guided fractionation, revealed that the n-butanol fraction of the V. awabuki extract and the ethyl acetate fraction from the D. racemosum extract had the greatest inhibitory activity on HIV-1 pretense.

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  4. [국내논문]   Apoptosis of MCF7 Cells Treated with PKC Inhibitors and Daunorubicin  

    Park, Won-Chul (Dept. of Biology, College of Natural Sciences, Pusan National University ) , Son, Joo-Young (Dept. of Biology, College of Natural Sciences, Pusan National University ) , Chung, Sook-Hyun (Dept. of Food Engineering, Dongseo University ) , An, Woon-Gun (Dept. of Biology, College of Natural Sciences, Kyungpook National University)
    Nutraceuticals and food v.7 no.2 ,pp. 128 - 132 , 2002 , 1598-6195 ,

    초록

    The present study was performed to observe the role of protein kinase C (PKC) inhibitors (H-7, staurosporine) and daunorubicin in the cell death process of MCF7 cells; and examined whether or not the type of induced cell death was apoptosis. The usefulness of the combined therapy of PKC inhibitors and daunorubicin to improve the adverse effect of daunorubicin was also investigated. Cell death was induced by treatment with PKC inhibitors or daunorubicin. Characteristic morphologic features of cell shrinkage, chromatic condensation, and cytoplasmic vacuolization were observed. These treatments also stimulated the cleavage of poly-(ADP-ribose) polymerase (PARP), an early event in apoptosis. With slight differences in the percentage of apoptosis-induced cells, staurosporine, H-7 and daunorubicin effectively induced apoptosis in MCF7 cells. Furthermore, combined treatment of PKC inhibitors and daunorubicin significantly drove the cells into an apoptotic state. Hence, our results revealed the possible therapeutic value of combined therapy for the prevention of drug resistance and adverse side effects.

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  5. [국내논문]   Effect of Extruded Products Made with Cassava Starch Blended with Oat Fiber and Resistant Starch on the Hypocholesterolemic Properties as Evaluated in Hamsters  

    Chang, Y.K. (Departamento de Tecnologia de Alimentos, FEA/UNICAMP, Cidade Universitaria “Zeferino Vaz”. Distrito Barao Geraldo, CEP ) , He, Martinez-Flores (Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada del IPN. Jose Siurob ) , Martinez-Bustos, F. (Centro de investigacion y de Estudios Avanzados del I.P.N. Libramiento Norponients 2000. Frac. Real de Juriquilla ) , Sgarbieri, V.C. (Centro de Quimica de Alimentos e Nutricao Aplicada. Instituto de Tecnologia de Alimentos)
    Nutraceuticals and food v.7 no.2 ,pp. 133 - 138 , 2002 , 1598-6195 ,

    초록

    To examine the cholesterol-towering effects of extruded products made with cassava starch (CS) and blends of cassava starch with either resistant starch (CS-RS) or oat fiber (CS-OF) hamsters were fed with diets containing a high-cholesterol (2%) and high-fat (17%) diet for 20 days. Hamsters fed with a diet containing no cholesterol were used as a control. Total cholesterol (TC) levels in the CS-RS and CS-OF groups were significantly (p>0.05) lower compared to the CS group by 11.5% and 8.5%, respectively. Also, the diets containing fibers decreased the value of low-density lipoproteins plus very low-density lipoproteins fraction by 32.4% (CS-RS diet) and 51.7% (CS-OF), respectively, as compared to the CS diet. Total lipid values were significantly (p

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  6. [국내논문]   Food Safety of Functional Neoglycoproteins Prepared by Covalent Attachment of Galactomannan to Food Proteins  

    Nakamura, Soichiro (Department of Life and Environment Sciences, Shimane University ) , Dokai, Kazumi (Department of Life and Environment Sciences, Shimane University ) , Matsuura, Megumi (Department of Life and Environment Sciences, Shimane University ) , Hata, Junya (Department of Life and Environment Sciences, Shimane University ) , Saeki, Hiroki (Graduate School of Fisheries Sciences, Hokkaido University)
    Nutraceuticals and food v.7 no.2 ,pp. 139 - 145 , 2002 , 1598-6195 ,

    초록

    Hen egg-white lysozyme, ovalbumin, egg-yolk phosvitin, acid-precipitated soy protein and $\alpha$ $_{sl}$ milk casein were covalently linked with galactomannan through a controlled dry-heating at 6 $0^{\circ}C$ under 79% relative humidity without any chemical reagent. Neoglycosylation by the covalent binding of polysaccharide chains brought a significant improvement into the surface functionalities of food proteins. Excellent emulsifying properties and foaming properties were observed in all protein-galactomannan conjugates. Bacterial mutagenesis tests and animal dose test were done to evaluate the food safety of the protein-galactomannan conjugates. The neo-glycoproteins were negative for Ames test using Salmonella typhimurium TA100 (hisG46) and TA98 (hisD3052) strains, and rec-assay using Bacillus subtilis Hl7 (rec) and M45 (re $c^{+}$ ) strains. All substances were also nontoxic for oral administration to rats. L $D_{50}$ 's of these substances were all more than 7.5 g/kg body-weight of rat. No effect was also observed in the weight increases and the concentrations of total cholesterol, triglyceride and phospholipids in blood serum of the administrated rats with 7.5 g/kg conjugates. Thus, Maillard-type protein-polysaccharide conjugates prepared by covalent attachment of galactomannan to food proteins were proposed to be useful as a safe functional biopolymer in this study.y.

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  7. [국내논문]   Antioxidative Activity of the Korean Wild Leafy Vegetables: Aster scarer mild Ligularia fischeri   피인용횟수: 4

    Cho, Youn-Ok (Department of Food and Nutrition, Duksung Women′s University)
    Nutraceuticals and food v.7 no.2 ,pp. 146 - 150 , 2002 , 1598-6195 ,

    초록

    The purpose of this study was to evaluate the antioxidative potential of Korean wild leafy vegetables in vivo as well as in vitro. Antioxidative activities of Aster scaber and Ligularia fischeri were evaluated against a reference of Spinacia oleracea Forty rats were fed either control diet or respective vegetable diets for four weeks. The level of thiobarbituric acid reactive substances (TBARS) and the activities of catalase and superoxide dismutase (SOD) in liver were compared. The plasma concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) were also compared. Korean wild leafy vegetables were assayed for $\beta$ -carotene, vitamin C and vitamin E and total phenolic compound including flavonoid and thiobarbituric acid (TBA) value using the linoleic acid model system. SOD activity in rats fed Aster scaber was significantly higher(as much as 289%) than those fed Spinacia oleracea. Compared to control animals, the Aster scaber fed animals had significantly lower TC and lower atherogenic index. Compared to Spinacia oleracea, Aster scaber and Ligularia fischeri had vitamin C concentration of 150% and 400%, flavonoid concentrations of 470% and 310%, and phenolic compound concentrations of 326% and 203%, respectively, but tended to have lower $\beta$ -carotene and significantly lower vitamin E concentrations. TBA values were only 18% of the control value in Aster scarier and Ligularia fischeri and 41% of the control value in Spinacia oleracea. These results suggest that Aster scaber could have potent antioxidative activity in vivo as well as in vitro and potential vague as a functional food to improve the plasma lipid profiles. Furthermore, phenolic and flavonoid compounds may be a major contributing factor to the antioxidative potential of Korean wild leafy vegetables.

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  8. [국내논문]   Antioxidant Activity of Green Tea Extract in Soybean and Rice Bran Oils   피인용횟수: 4

    Kim, Chang-Soon (Department of Food and Nutrition, Changwon National University ) , Park, Jae-Hee (Department of Food and Nutrition, Changwon National University)
    Nutraceuticals and food v.7 no.2 ,pp. 151 - 156 , 2002 , 1598-6195 ,

    초록

    Antioxidant activity or green tea extracts (GTE) was evaluated in soybean oil (SBO), rice bran oil (RBO) and winterized rice bran oil (WRBO) stored at 63 $^{\circ}C$ for 36 days. Lipid oxidation of the oils was determined using the active oxygen method (AOM), peroxide value (POV), change in unsaturated free fatty acid concentrations and by sensory evaluation. SBO had a higher concentration of the polyunsaturated fatty acids, linoleic and linolenic acid than RBO and WRBO. WRBO and RBO were more stable against lipid oxidation than SBO. Addition of GTE (200 ppm) to the stored oils, increased the induction period (IP) in AOM, reduced the increase in POV, and lessened the change in unsaturated fatty acids. Furthermore, GTE prevented the development of rancid flavors resulting from storage, all of which demonstrate the protective antioxidative activity of GTE. However, oil color became darker in the GTE treated oils. The antioxidant protection of GTE was most effective in RBO.

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  9. [국내논문]   Isolation of Angiotensin Converting Enzyme Inhibitors from Compositae Plants   피인용횟수: 1

    Song, Kyung-Bin (Department of Food Science and Technology, College of Agriculture, Chungnam National University ) , Kim, Ji-youn (Department of Food Science and Technology, College of Agriculture, Chungnam National University ) , Jung, Hye-young (Department of Food Science and Technology, College of Agriculture, Chungnam National University)
    Nutraceuticals and food v.7 no.2 ,pp. 157 - 161 , 2002 , 1598-6195 ,

    초록

    Thirty plants of the Compositae family were screened for inhibitory activity of angiotensin converting enzyme (ACE). Among them, Chrysanthemum boreale Makino and Ixeris dentate Nakai were selected for further investigation since they had the highest inhibitory activity. Crude water extracts of the flowers of Chrysanthemum boreale Makino and the roots of Ixeris dentate Nakai were prepared by heating at 95 $^{\circ}C$ and 6 $0^{\circ}C$ for 2 hr, respectively, followed by centrifugation at 8000 $\times$ g far 30 min. Crude extracts were then filtered using YM-3 and YM-1 membranes. The ACE inhibitors were isolated using consecutive chromatographic methods including: Sephadex G-15, ion exchange, FPLC, and reverse phase HPLC. The inhibitors were identified to have molecular masses of 204 and 283 daltons, respectively, by mass spectrometry. These results demonstrate that crude extracts of Compositae plants may be useful as functional food ingredients with anti-hypertensive properties.

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  10. [국내논문]   Red Pepper Powder and Kimchi Reduce Body Weight and Blood and Tissue Lipids in Rats Fed a High Fat Diet   피인용횟수: 16

    Park, Kun-Young (Department of Food Science and Nutrition, and Kimchi Research Institute, Pusan National National University ) , Park, Sun-Mi (Department of Food Science and Nutrition, and Kimchi Research Institute, Pusan National National University ) , Jeon, Young-Soo (Department of Food Science and Nutrition, and Kimchi Research Institute, Pusan National National University ) , Rhee, Sook-Hee (Department of Food Science and Nutrition, and Kimchi Research Institute, Pusan National National University)
    Nutraceuticals and food v.7 no.2 ,pp. 162 - 167 , 2002 , 1598-6195 ,

    초록

    The effect of red pepper powder (RPP) or kimchi on body weight and blood and tissue lipids was evaluated in male Sprague-Dawley rats fed a high fat diet (HFD). RPP (0.006% capsaicin) diet contained 5% RPP in HFD; the kimchi diet was 10% kimchi (50% RPP by dry weight) in HFD. Food consumption of the RPP and kimchi diet groups was not different than the normal or HFD groups, but final body weights were significantly lower than the HFD group (p

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