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Asian Pacific journal of cancer prevention : APJCP 80건

  1. [해외논문]   Molecular Mechanisms of Casticin Action: an Update on its Antitumor Functions   SCIE

    Rasul, Azhar (The Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University ) , Zhao, Bin-Ji (Second Hospital, Jilin University ) , Liu, Jun (Second Hospital, Jilin University ) , Liu, Bao (The Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University ) , Sun, Jia-Xin (The Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University ) , Li, Jiang (Dental Hospital, Jilin University ) , Li, Xiao-Meng (The Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University)
    Asian Pacific journal of cancer prevention : APJCP v.15 no.21 ,pp. 9049 - 9058 , 2014 , 1513-7368 ,

    초록

    Casticin (3', 5-dihydroxy-3, 4', 6, 7-tetramethoxyflavone) is an active compound isolated from roots, stems, leaves, fruits and seeds of a variety of plants. It is well known for its pharmacological properties and has been utilized as an anti-hyperprolactinemia, anti-tumor, anti-inflammatory, neuroprotetective, analgesic and immunomodulatory agent. Recently, the anticancer activity of casticin has been extensively investigated. The resulkts showed that it exerts protective potential by targeting apoptosis, considered important for cancer therapies. In this article, our aim was to review the pharmacological and therapeutic applications of casticin with specific emphasis on its anticancer functions and related molecular mechanisms. Chemotherapeutic effects are dependent on multiple molecular pathways, which may provide a new perspective of casticin as a candidate anti-neoplastic drug. This review suggests that additional studies and preclinical trials are required to determine specific intracellular sites of action and derivative targets in order to fully understand the mechanisms of its antitumor activity and validate this compound as a medicinal agent for the prevention and treatment of various cancers.

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  2. [해외논문]   microRNA-29b: an Emerging Player in Human Cancer   SCIE 피인용횟수: 2

    Liu, Hao (Department of Pathology, Nanfang Hospital & School of Basic Medical Sciences, Southern Medical University ) , Wang, Bin (Department of Pathology, Nanfang Hospital & School of Basic Medical Sciences, Southern Medical University ) , Lin, Jie (Department of Pathology, Nanfang Hospital & School of Basic Medical Sciences, Southern Medical University ) , Zhao, Liang (Department of Pathology, Nanfang Hospital & School of Basic Medical Sciences, Southern Medical University)
    Asian Pacific journal of cancer prevention : APJCP v.15 no.21 ,pp. 9059 - 9064 , 2014 , 1513-7368 ,

    초록

    MicroRNAs (miRNAs) are ubiquitously expressed small, non-coding RNAs that negatively regulate gene expression at a post transcriptional/translational level. They have emerging as playing crucial roles in cancer at all stages ranging from initiation to metastasis. As a tumor suppressor miRNA, aberrant expression of microRNA-29b (miR-29b) has been detected in various types of cancer, and its disturbance is related with tumor development and progression. In this review, we summarize the latest findings with regard to the tumor suppressor signatureof miR-29b and its regulatory mechanisms. Our review highlights the diverse relationships between miR-29b and its target genes in malignant tumors.

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  3. [해외논문]   Risk Factors for Renal Cell Carcinoma in a Japanese Population   SCIE 피인용횟수: 4

    Washio, Masakazu (Department of Public Health, Sapporo Medical University School of Medicine ) , Mori, Mitsuru (Department of Public Health, Sapporo Medical University School of Medicine ) , Mikami, Kazuya (Department of Urology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine ) , Miki, Tsuneharu (Department of Urology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine ) , Watanabe, Yoshiyuki (Department of Epidemiology for Community Health and Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine ) , Nakao, Masahiro (Department of Urology, Shimanto City Hospital ) , Kubo, Tatsuhiko (Department of Public Health, University of Occupational and Environmental Health ) , Suzuki, Koji (Department of Public Health, Fujita Health University School of Health Sciences ) , Ozasa, Kotaro (Department of Epidemiology, Radiation Effects Research Foundation ) , Wakai, Kenji (Department of Preventive Medicine, Nagoya University Graduate School of Medicine ) , Tamakoshi, Akiko (Department of Public Health, Hokkaido University Graduate School of Medicine)
    Asian Pacific journal of cancer prevention : APJCP v.15 no.21 ,pp. 9065 - 9070 , 2014 , 1513-7368 ,

    초록

    The incidence of renal cell carcinoma (RCC) is high in Western and Northern Europe and North America, and low in Asia. Although the incidence of RCC in Japan is lower than the rates in the other industrialized countries, there is no doubt that it is increasing. In this paper, we would like to introduce the summary of findings of JACC study, which evaluate the risk factors for RCC in a Japanese population. JACC study suggests nine risk factors (i.e., smoking, obesity, low physical activity, hypertension, diabetes mellitus, kidney diseases, beef, fondness for fatty food and black tea) and one preventive factor (i.e., starchy roots such as taro, sweet potato and potato) in a Japanese population. In Japan, however, drinking black tea may be a surrogate for westernized dietary habits while eating starchy roots may be a surrogate for traditional Japanese dietary habits. Further studies may be needed to evaluate risk factors for RCC because the number of cases is small in our studies.

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  4. [해외논문]   miR-205 in Situ Expression and Localization in Head and Neck Tumors - a Tissue Array Study   SCIE

    Ab Mutalib, Nurul-Syakima (Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia ) , Lee, Learn-Han (Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia ) , Cheah, Yoke-Kqueen (Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia)
    Asian Pacific journal of cancer prevention : APJCP v.15 no.21 ,pp. 9071 - 9075 , 2014 , 1513-7368 ,

    초록

    Background: microRNAs are small non-coding RNA that control gene expression by mRNA degradation or translational inhibition. These molecules are known to play essential roles in many biological and physiological processes. miR-205 may be differentially expressed in head and neck cancers; however, there are conflicting data and localization of expression has yet to be determined. Materials and Methods: miR-205 expression was investigated in 48 cases of inflammatory, benign and malignant tumor tissue array of the neck, oronasopharynx, larynx and salivary glands by Locked Nucleic Acid in situ hybridization (LNA-ISH) technology. Results: miR-205 expression was significantly differentially expressed across all of the inflammatory, benign and malignant tumor tissues of the neck. A significant increase in miR-205 staining intensity (p

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  5. [해외논문]   Assessing the Diagnostic Value of Serum Dickkopf-related Protein 1 Levels in Cancer Detection: a Case-control Study and Meta-analysis   SCIE

    Jiang, Xiao-Ting (Clinical Laboratory, Zhejiang Provincial People's Hospital ) , Ma, Ying-Yu (Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital ) , Guo, Kun (Wenzhou Medical University ) , Xia, Ying-Jie (Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital ) , Wang, Hui-Ju (Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital ) , Li, Li (Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital ) , He, Xu-Jun (Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital ) , Huang, Dong-Sheng (Department of Gastrointestinal Surgery, Zhejiang Provincial People's Hospital ) , Tao, Hou-Quan (Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital)
    Asian Pacific journal of cancer prevention : APJCP v.15 no.21 ,pp. 9077 - 9083 , 2014 , 1513-7368 ,

    초록

    Background: This study aimed to summarize the potential diagnostic value of serum DKK1 levels in cancer detection. Materials and Methods: Serum DKK1 was measured using enzyme-linked immunosorbent assay in a case-control study. Then we performed a meta-analysis and the pooled sensitivity, specificity, diagnostic odds ratio, and summary receiver operating characteristic (sROC) curves were used to evaluate the overall test performance. Results: Serum DKK1 levels were found to be significantly upregulated in gastric cancer as compared to controls. ROC curve analysis revealed an AUC of 0.636, indicating the test has the potential to diagnose cancer with poor accuracy. The summary estimates of the pooled sensitivity, specificity and diagnostic odds ratio in meta-analysis were 0.55 with a 95% confidence interval (CI) (0.53-0.57), 0.86 (95%CI, 0.84-0.88) and 12.25 (95%CI, 5.31-28.28), respectively. The area under the sROC was 0.85. Subgroup analysis revealed that the diagnostic accuracy of serum DKK1 in lung cancer (sensitivity: 0.69 with 95%CI, 0.66-0.74; specificity: 0.95 with 95%CI, 0.92-0.97; diagnostic odds ratio: 44.93 with 95%CI, 26.19-77.08) was significantly higher than for any other cancer. Conclusions: Serum DKK1 might be useful as a noninvasive method for confirmation of cancer diagnosis, particularly in the case of lung cancer.

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  6. [해외논문]   Phytoestrogen Intake and Risk of Ovarian Cancer: a Meta-Analysis of 10 Observational Studies   SCIE 피인용횟수: 1

    Qu, Xin-Lan (The Reproductive Medicine Center, Zhongnan Hospital of Wuhan University ) , Fang, Yuan (Department of Oncology, Zhongnan Hospital of Wuhan University ) , Zhang, Ming (The Reproductive Medicine Center, Zhongnan Hospital of Wuhan University ) , Zhang, Yuan-Zhen (The Reproductive Medicine Center, Zhongnan Hospital of Wuhan University)
    Asian Pacific journal of cancer prevention : APJCP v.15 no.21 ,pp. 9085 - 9091 , 2014 , 1513-7368 ,

    초록

    Background: Epidemiology studies have shown an inconclusive relationship between phytoestrogen intake and ovarian cancer risk and there have been no relevant meta-analyses directly regarding this topic. The purpose of the present meta-analysis was therefore to investigate any association between phytoestrogen intake and ovarian cancer in detail. Materials and Methods: We conducted a search of PubMed, EMBASE, EBSCO, the Cochrane Library, CNKI and Chinese Biomedical Database (up to April 2014) using common keywords for studies that focused on phytoestrogen and ovarian cancer risk. Study-specific risk estimates (RRs) were pooled using fixed effect or random-effect models. Results: Ten epidemiologic studies were finally included in the meta-analysis. The total results indicated higher phytoestrogen intake was associated with a reduced ovarian cancer risk (RR, 0.70; 95%CI: 0.56-0.87). The association was similar in sensitivity analysis. Meta regression analysis demonstrated sources and possibly types and regions as heterogeneous factors. Subgroup analysis of types, sources and regions showed that isoflavones (RR: 0.63; 95%CI: 0.46, 0.86), soy foods (RR: 0.51; 95%CI: 0.39, 0.68) and an Asian diet (RR: 0.48; 95%CI: 0.37, 0.63) intake could reduce the incidence of ovarian cancer. Conclusions: Our findings show possible protection by phytoestrogens against ovarian cancer. We emphasize specific phytoestrogens from soy foods, but not all could reduce the risk. The habit of plentiful phytoestrogen intake by Asians is worthy to recommendation. However, we still need additional larger well designed observational studies to fully characterize underlying associations.

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  7. [해외논문]   Lack of Effects of Peroxisome Proliferator-Activated Receptor Gamma Genetic Polymorphisms on Breast Cancer Risk: a Case-Control Study and Pooled Analysis   SCIE

    Park, Boyoung (National Cancer Control Institute, National Cancer Center ) , Shin, Aesun (Department of Preventive Medicine, College of Medicine, Seoul National University ) , Kim, Kyee-Zu (Department of Preventive Medicine, College of Medicine, Seoul National University ) , Lee, Yeon-Su (Cancer Genomics Branch, National Cancer Center ) , Hwang, Jung-Ah (Cancer Genomics Branch, National Cancer Center ) , Kim, Yeonju (Cancer Epidemiology Program, University of Hawai'i Cancer Center ) , Sung, Joohon (Department of Epidemiology and Institute of Health and Environment, School of Public Health, Seoul National University ) , Yoo, Keun-Young (Department of Preventive Medicine, College of Medicine, Seoul National University ) , Lee, Eun-Sook (Center for Breast Cancer, National Cancer Center)
    Asian Pacific journal of cancer prevention : APJCP v.15 no.21 ,pp. 9093 - 9099 , 2014 , 1513-7368 ,

    초록

    A growing body of evidence suggests that the peroxisome proliferator-activated receptor-gamma ( $PPAR{\gamma}$ ) gene may harbor targets for the chemoprevention of breast cancer. However, it is unclear whether polymorphisms in the $PPAR{\gamma}$ gene are associated with the susceptibility of breast cancer. We performed a candidate gene association study between $PPAR{\gamma}$ polymorphisms and breast cancer and a meta-analysis on the association of breast cancer with selected $PPAR{\gamma}$ variants. Six single nucleotide polymorphisms (SNPs) in the $PPAR{\gamma}$ gene were analyzed among 456 breast cancer patients and 461 controls from the National Cancer Center in Korea. Association between the polymorphisms and breast cancer risk were assessed using the Cochrane-Armitage test for trend and a multivariate logistic regression model. Two SNPs, rs3856806 and rs1801282, had been previously analyzed, thus enabling us to perform pooled analyses on their associations with breast cancer susceptibility. Our findings from the candidate gene association study showed no association between the $PPAR{\gamma}$ gene polymorphisms and breast cancer risk. A meta-analysis combining existing studies and our current study also refuted an association of the $PPAR{\gamma}$ gene with breast cancer. Our findings suggest that the $PPAR{\gamma}$ gene may not harbor variants that alter breast cancer susceptibility, although a moderate sample size might have precluded a decisive conclusion.

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  8. [해외논문]   Comparison of Automated Breast Volume Scanning and Hand-Held Ultrasound in the Detection of Breast Cancer: an Analysis of 5,566 Patient Evaluations   SCIE

    Choi, Woo Jung (Department of Radiology, Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan ) , Cha, Joo Hee (Department of Radiology, Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan ) , Kim, Hak Hee (Department of Radiology, Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan ) , Shin, Hee Jung (Department of Radiology, Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan ) , Kim, Hyunji (Department of Radiology, Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan ) , Chae, Eun Young (Department of Radiology, Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan ) , Hong, Min Ji (Department of Radiology, Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan)
    Asian Pacific journal of cancer prevention : APJCP v.15 no.21 ,pp. 9101 - 9105 , 2014 , 1513-7368 ,

    초록

    Background: The purpose of this study was to compare the accuracy and effectiveness of automated breast volume scanning (ABVS) and hand-held ultrasound (HHUS) in the detection of breast cancer in a large population group with a long-term follow-up, and to investigate whether different ultrasound systems may influence the estimation of cancer detection. Materials and Methods: Institutional review board approval was obtained for this retrospective study, and informed consent was waived. From September 2010 to August 2011, a total of 1,866 ABVS and 3,700 HHUS participants, who underwent these procedures at our institute, were included in this study. Cancers occurring during the study and subsequent follow-up were evaluated. The reference standard was a combination of histology and follow-up imaging ( ${\geq}12months$ ). The recall rate, cancer detection yield, diagnostic accuracy, sensitivity, specificity, and positive (PPV) and negative (NPV) predictive values were calculated with exact 95% confidence intervals. Results: The recall rate was 2.57 per 1,000 (48/1,866) for ABVS and 3.57 per 1,000 (132/3,700) for HHUS, with a significant difference (p=0.048). The cancer detection yield was 3.8 per 1,000 for ABVS and 2.7 per 1,000 for HHUS. The diagnostic accuracy was 97.7% for ABVS and 96.5% for HHUS with statistical significance (p=0.018). The specificity of ABVS and HHUS were 97.8%, 96.7%, respectively (p=0.022). Conclusions: ABVS shows a comparable diagnostic performance to HHUS. ABVS is an effective supplemental tool for mammography in breast cancer detection in a large population.

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  9. [해외논문]   PLCE1 rs2274223 Polymorphism and Susceptibility to Esophageal Cancer: a Meta-analysis   SCIE 피인용횟수: 1

    Guo, Li-Yan (Department of Public Health, Jining Medical University ) , Yang, Ning (Department of Physical Examination Center, the Affiliated Hospital of Jining Medical University ) , Hu, Die (Department of Public Health, Jining Medical University ) , Zhao, Xia (Department of Cardio-Thoracic Surgery, The First People's Hospital of Jining City ) , Feng, Bing (International Cooperation Department, Jining Medical University ) , Zhang, Yan (Department of Public Health, Jining Medical University ) , Zhai, Min (Department of Public Health, Jining Medical University)
    Asian Pacific journal of cancer prevention : APJCP v.15 no.21 ,pp. 9107 - 9112 , 2014 , 1513-7368 ,

    초록

    Purpose: To investigate and study the relationship between the PLCE1 rs2274223 gene polymorphism and susceptibility to esophageal cancer by meta-analysis. Materials and Methods: The literature was searched in Wanfang, CNKI, PubMed, CBM, Web of Science, MEDLINE, EMBASE, Springer, Elsevier and Cochrane databases from the date of January $1^{st}$ 2004 to April $1^{st}$ 2014 to collect case-control studies on the PLCE1 polymorphism and susceptibility to esophageal cancer. For the population genotype distributions of both esophagus cancer and control groups, their odds ratios (ORs) and 95% confidence intervals (CIs) were taken as effect indexes. Disqualified studies were excluded. Odds ratios of PLCE1 rs2274223 genotype distributions in the group of patients with esophageal cancer and the group of healthy control were calculated. The metaanalysis software, RevMan5.0, was applied for heterogeneity test, pooled OR and 95% confidence intervals. Sensitivity analysis and publication bias were also explored. Results: A total of twelve case-control studies were included, covering a total of 9, 912 esophageal cancer cases and 13, 023 controls were included. The pooled odds ratio of PLCE1 rs2274223 genotype GA vs AA was 1.29 (95%CI=1.17~1.43), p

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  10. [해외논문]   Application of Laparospic Ultrasonography in Surgery of Small Renal Cell Carcinoma   SCIE 피인용횟수: 1

    Wang, Xiang-Zhu (Department of Ultrasound, DongZhiMeng Hospital of Beijing University of Chinese Medicine ) , Yu, Ze-Xing (Department of Ultrasound, ChaoYang Hospital, Capital Medical University ) , Guo, Rui-Jun (Department of Ultrasound, ChaoYang Hospital, Capital Medical University ) , Xing, Nian-Zeng (Department of Urology, Chaoyang Hospital, Capital Medical University)
    Asian Pacific journal of cancer prevention : APJCP v.15 no.21 ,pp. 9113 - 9116 , 2014 , 1513-7368 ,

    초록

    Purpose: : To assess the clinic value of application of laparospic ultrasonography (LU) in partial nephrectomy of small renal cell carcinoma. Materials and Methods: From 2007 to 2011, 28 small renal cell carcinoma patients in ou clinic underwent laparoscopic partial nephrectomy with LU. For comparison with preoperative conventional ultrasound and CT, we collected ultrasonic performance of the affected side kidney, renal tumor location, size, echo change, blood supply situation and the relationship with the surrounding tissue. Results: LU could more clearly show the tumor interior structure and blood supply, as well as the relationship with the surrounding tissue. It also can provided doctor assistance with real-time tumor resection, reducing operative complications. Conclusions: LU can clearly show tumor internal structure and blood supply, which is helpful for explicit diagnosis. Moreover, it supplies accurate information for surgeons and assists surgery. Therefore LU has an important guiding value in partial nephrectomy for small renal cell carcinoma.

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