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Marine drugs 193건

  1. [해외논문]   Sarcophine-Diol, a Skin Cancer Chemopreventive Agent, Inhibits Proliferation and Stimulates Apoptosis in Mouse Melanoma B 16 F 10 Cell Line   SCIE

    Szymanski, Pawel T. (Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA) , Kuppast, Bhimanna (Email: pawel.szymanski@sdstate.edu (P.T.S.)) , Ahmed, Safwat A. (bhimanna.kuppast@sdstate.edu (B.K.) ) , Khalifa, Sherief (Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA) , Fahmy, Hesham (Email: pawel.szymanski@sdstate.edu (P.T.S.))
    Marine drugs v.10 no.12 ,pp. 1 - 19 , 2012 ,

    초록

    Sarcodiol (SD) is a semi-synthetic derivative of sarcophine, a marine natural product. In our previous work, we reported the significant chemopreventive effects of SD against non-melanoma skin cancer both in vitro and in vivo mouse models. In this investigation, we extended this work to study the effect of sarcodiol on melanoma development, the more deadly form of skin cancer, using the mouse melanoma B 16 F 10 cell line. In this study we report that SD inhibits the de novo DNA synthesis and enhances fragmentation of DNA. We also evaluated the antitumor effect of SD on melanoma cell viability using several biomarkers for cell proliferation and apoptosis. SD inhibits the expression levels of signal transducers and activators of transcription protein (STAT-3) and cyclin D1, an activator of cyclin-dependent kinase 4 (Cdk4). SD treatment also enhances cellular level of tumor suppressor protein 53 (p53) and stimulates cleavage of the nuclear poly (ADP-ribose) polymerase (cleaved-PARP). SD also enhances cellular levels of cleaved Caspase-3, -8, -9 and stimulates enzymatic activities of Caspase-3, -8 and -9. These results, in addition to inhibition of cell viability, suggest that SD inhibits melanoma cell proliferation by arresting the cell-division cycle in a Go quiescent phase and activates programmed cell death (apoptosis) via extrinsic and intrinsic pathways. Finally, these studies demonstrate that SD shows a very promising chemopreventive effect in melanoma B 16 F 10 tumor cells.

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  2. [해외논문]   A Chronic Oral Toxicity Study of Marine Collagen Peptides Preparation from Chum Salmon ( Oncorhynchus keta ) Skin Using Sprague-Dawley Rat   SCIE

    Liang, Jiang (Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China) , Pei, Xin-Rong (Email: liangjiangty@163.com (J.L.)) , Zhang, Zhao-Feng (rongpx@163.com (X.-R.P.)) , Wang, Nan (zhangzhaofeng@126.com (Z.-F.Z.)) , Wang, Jun-Bo (wn1983117@163.com (N.W.)) , Li, Yong (bmuwjbxy@bjmu.edu.cn (J.-B.W.) )
    Marine drugs v.10 no.12 ,pp. 20 - 34 , 2012 ,

    초록

    Due to the increased consumption of marine collagen peptides preparation (MCP) as ingredients in functional foods and pharmaceuticals, it was necessary to carry out safety requirements in the form of an oral chronic toxicity assessment. In order to define the oral chronic toxicity of MCP, a 24-month feeding study of MCP was carried out. Sprague-Dawley (S-D) rats at the age of four-week of both sexes were treated with MCP at the diet concentrations of 0%, 2.25%, 4.5%, 9% and 18% (wt/wt). The actual food intake and bodyweight of the individual animals were recorded periodically until sacrifice. Blood and urine samples were collected for serum chemistry evaluations and urinalysis. Throughout the experimental period, there was no toxicologically significant difference between the vehicle and MCP-treated animals with respect to the survival rate, body weight, food consumption, urinalysis, clinical biochemistry parameter and relative organ weight in either sex. Moreover, incidences of non-neoplastic lesions in MCP-treated groups did not significantly increase compared with the control group. Under the present experimental conditions, no higher risk of chronic toxic effects was observed in MCP-treated rats at the diet concentrations of 2.25%, 4.5%, 9% and 18% (wt/wt) than in the rats fed with basal rodent diet.

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  3. [해외논문]   Purification, Characterization and Antitumor Activities of a New Protein from Syngnathus acus , an Officinal Marine Fish   SCIE

    Wang, Mengyue (School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China) , Nie, Yuxiao (Email: mywang@sjtu.edu.cn (M.W.)) , Peng, Ying (nieyuxiaolw@hotmail.com (Y.N.)) , He, Fen (ypeng@sjtu.edu.cn (Y.P.)) , Yang, Jingyu (fen_he@hotmail.com (F.H.) ) , Wu, Chunfu (School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China) , Li, Xiaobo (Email: mywang@sjtu.edu.cn (M.W.))
    Marine drugs v.10 no.12 ,pp. 35 - 50 , 2012 ,

    초록

    Discovery and development of new antitumor agents from abundant marine fish are attracting an increasing interest. In the present study, we extracted and purified a novel antitumor protein Syngnathusin from the whole body of Syngnathus acus L., a precious marine fish traditionally used for tumors. Syngnathusin was comprised of 16 kinds of amino acids, mainly acidic amino acids. Its molecular weight was 67.3 kDa and its isoelectric point was 4.57. The N -terminal amino acid sequence of Syngnathusin was determined to be Lys-Arg-Asp-Leu-Gly-Phe-Val-Asp-Glu-Ile-Ser-Ala-His-Tyr and showed no significant homology with the known proteins. Syngnathusin could significantly inhibit the growth of A549 and CCRF-CEM cells. However, the obvious proliferation inhibition against human non-tumor cell lines was not observed. Flow cytometry, morphologic assessment and comet assay revealed that Syngnathusin could induce apoptosis in A549 and CCRF-CEM cells and strongly cooperated with MTX. Syngnathusin could inhibit the growth of S180 tumor transplanted in mice. Syngnathusin may be developed as a novel, selective and effective antineoplastic agent.

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  4. [해외논문]   Aplisulfamines, New Sulfoxide-Containing Metabolites from an Aplidium Tunicate: Absolute Stereochemistry at Chiral Sulfur and Carbon Atoms Assigned Through an Original Combination of Spectroscopic and Computational Methods   SCIE

    Aiello, Anna (The NeaNat Group, Dipartimento di Chimica delle Sostanze Naturali, Università) , Fattorusso, Ernesto (degli Studi di Napoli "Federico II", Via D. Montesano 49, 80131 Napoli, Italy) , Imperatore, Concetta (Email: aiello@unina.it (A.A.)) , Luciano, Paolo (fattoru@unina.it (E.F.)) , Menna, Marialuisa (cimperat@unina.it (C.I.)) , Vitalone, Rocco (rocco.vitalone@unina.it (R.V.) )
    Marine drugs v.10 no.12 ,pp. 51 - 63 , 2012 ,

    초록

    Two new sulfoxide-containing metabolites, aplisulfamines A ( 1 ) and B ( 2 ), have been isolated from an Aplidium sp. collected in the Bay of Naples. Their planar structure and geometry of a double bond were readily determined by using standard methods, mainly NMR spectroscopy. An original approach was used to assign the absolute configuration at the three contiguous chiral centers present in the structures of both aplisulfamines, two at carbon and one at sulfur. This involved Electronic Circular Dichroism (ECD) studies, J -based configuration analysis and Density Functional Theory (DFT) calculations and represents an interesting integration of modern techniques in stereoanalysis, which could contribute to the enhancement of theoretical protocols recently applied to solve stereochemical aspects in structure elucidation.

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  5. [해외논문]   Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells   SCIE

    Edwards, Vicki (Department of Medical Biotechnology, School of Medicine, Flinders University, GPO Box 2100, Adelaide, S.A. 5001, Australia) , Benkendorff, Kirsten (Email: edwa0223@flinders.edu.au (V.E.)) , Young, Fiona (Fiona.young@flinders.edu.au (F.Y.) )
    Marine drugs v.10 no.12 ,pp. 64 - 83 , 2012 ,

    초록

    Anticancer properties of tyrindoleninone and 6-bromoisatin from Dicathais orbita were tested against physiologically normal primary human granulosa cells (HGC) and reproductive cancer cell lines. Tyrindoleninone reduced cancer cell viability with IC 50 values of 39 μM (KGN; a tumour-derived granulosa cell line), 39 μM (JAr), and 156 μM (OVCAR-3), compared to 3516 μM in HGC. Apoptosis in HGC's occurred after 4 h at 391 μM tyrindoleninone compared to 20 μM in KGN cells. Differences in apoptosis between HGC and KGN cells were confirmed by TUNEL, with 66 and 31% apoptotic nuclei at 4 h in KGN and HGC, respectively. These marine compounds therefore have potential for development as treatments for female reproductive cancers.

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  6. [해외논문]   Tasco ® : A Product of Ascophyllum nodosum Enhances Immune Response of Caenorhabditis elegans Against Pseudomonas aeruginosa Infection   SCIE

    Kandasamy, Saveetha (Department of Environmental Sciences, Nova Scotia Agricultural College, P.O. Box 550, Truro, NS, B2B 5E3, Canada) , Khan, Wajahatullah (Email: skandasamy@nsac.ca ) , Evans, Franklin (Genome Research Chair Unit, Department of Biochemistry, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia) , Critchley, Alan T. (Email: wkhan@ksu.edu.sa ) , Prithiviraj, Balakrishnan (Acadian Seaplants Limited, 30 Brown Avenue, Dartmouth, NS, B3B 1X8, Canada)
    Marine drugs v.10 no.12 ,pp. 84 - 105 , 2012 ,

    초록

    The effects of Tasco ? , a product made from the brown seaweed ( Ascophyllum nodosum ) were tested for the ability to protect Caenorhabditis elegans against Pseudomonas aeruginosa infection. A water extract of Tasco ? (TWE) reduced P. aeruginosa inflicted mortality in the nematode. The TWE, at a concentration of 300 μg/mL, offered the maximum protection and induced the expression of innate immune response genes viz. ; zk6.7 ( Lypases ), lys-1 ( Lysozyme ), spp-1 ( Saponin like protein ), f28d1.3 ( Thaumatin like protein ), t20g5.7 ( Matridin SK domain protein ), abf-1 ( Antibacterial protein ) and f38a1.5 ( Lectin family protein ). Further, TWE treatment also affected a number of virulence components of the P. aeuroginosa and reduced its secreted virulence factors such as lipase, proteases and toxic metabolites; hydrogen cyanide and pyocyanin. Decreased virulence factors were associated with a significant reduction in expression of regulatory genes involved in quorum sensing, lasI , lasR , rhlI and rhlR . In conclusion, the TWE-treatment protected the C. elegans against P. aeruginosa infection by a combination of effects on the innate immunity of the worms and direct effects on the bacterial quorum sensing and virulence factors.

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  7. [해외논문]   A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp. F00120 Isolated from a Deep Sea Sediment Sample   SCIE

    Lin, Xiuping (Key Laboratory of Marine Bio-Resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China) , Zhou, Xuefeng (Email: xiupinglin@hotmail.com (X.L.)) , Wang, Fazuo (xfzhou@scsio.ac.cn (X.Z.)) , Liu, Kaisheng (wangfazuo@scsio.ac.cn (F.W.)) , Yang, Bin (bingo525@163.com (B.Y.)) , Yang, Xianwen (xwyang@scsio.ac.cn (X.Y.)) , Peng, Yan (py00_2006@126.com (Y.P.)) , Liu, Juan (ljuan2010@qq.com (J.L.) ) , Ren, Zhe (Key Laboratory of Marine Bio-Resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China) , Liu, Yonghong (Email: xiupinglin@hotmail.com (X.L.))
    Marine drugs v.10 no.12 ,pp. 106 - 115 , 2012 ,

    초록

    A new fungal strain, displaying strong toxic activity against brine shrimp larvae, was isolated from a deep sea sediment sample collected at a depth of 1300 m. The strain, designated as F00120, was identified as a member of the genus Penicillium on the basis of morphology and ITS sequence analysis. One new sesquiterpene quinone, named penicilliumin A ( 1 ), along with two known compounds ergosterol ( 2 ) and ergosterol peroxide ( 3 ), were isolated and purified from the cultures of F00120 by silica gel column, Sephadex LH-20 column, and preparative thin layer chromatography. Their structures were elucidated by detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analysis as well as comparison with literature data. The new compound penicilliumin A inhibited in vitro proliferation of mouse melanoma (B16), human melanoma (A375), and human cervical carcinoma (Hela) cell lines moderately.

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  8. [해외논문]   Marine Carotenoids and Oxidative Stress   SCIE

    Riccioni, Graziano (Cardiology Unit, San Camillo de Lellis Hospital, via Isonzo, Manfredonia, Foggia 71043, Italy)
    Marine drugs v.10 no.12 ,pp. 116 - 118 , 2012 ,

    초록

    Oxidative stress induced by reactive oxygen species plays an important role in the etiology of many diseases. Dietary phytochemical products, such as bioactive food components and marine carotenoids (asthaxantin, lutein, β-carotene, fucoxanthin), have shown an antioxidant effect in reducing oxidative markers stress. Scientific evidence supports the beneficial role of phytochemicals in the prevention of some chronic diseases. Many carotenoids with high antioxidant properties have shown a reduction in disease risk both in epidemiological studies and supplementation human trials. However, controlled clinical trials and dietary intervention studies using well-defined subjects population have not provided clear evidence of these substances in the prevention of diseases. The most important aspects of this special issue will cover the synthesis, biological activities, and clinical applications of marine carotenoids, with particular attention to recent evidence regarding anti-oxidant and anti-inflammatory properties in the prevention of cardiovascular disease.

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  9. [해외논문]   Antioxidant Properties of Polysaccharide from the Brown Seaweed Sargassum graminifolium (Turn.), and Its Effects on Calcium Oxalate Crystallization   SCIE

    Zhang, Chao-Yan (Shanghai Key Laboratory of Functional Materials Chemistry, Research Center of Analysis and Testing, East China University of Science and Technology, Shanghai 200237, China ) , Wu, Wen-Hui (College of Food Science and Technology, Institutes of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China) , Wang, Jue (Email: chyzhang@shou.edu.cn (C.-Y.Z.)) , Lan, Min-Bo (whwu@shou.edu.cn (W.-H.W.))
    Marine drugs v.10 no.12 ,pp. 119 - 130 , 2012 ,

    초록

    We investigated the effects of polysaccharides from the brown seaweed Sargassum graminifolium (Turn.) (SGP) on calcium oxalate crystallization, and determined its antioxidant activities. To examine the effects of SGP on calcium oxalate crystallization, we monitored nucleation and aggregation of calcium oxalate monohydrate crystals, using trisodium citrate as a positive control. We assessed antioxidant activities of SGP by determining its reducing power, its ability to scavenge superoxide radicals, and its activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The nucleation inhibition ratio of trisodium citrate and SGP was 58.5 and 69.2%, respectively, and crystal aggregation was inhibited by 71.4 and 76.8%, respectively. Increasing concentrations of SGP resulted in increased scavenging of superoxide anions and DPPH radicals (IC 50 = 1.9 and 0.6 mg/mL, respectively). These results suggest that SGP could be a candidate for treating urinary stones because of its ability to inhibit calcium oxalate crystallization and its antioxidant properties.

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  10. [해외논문]   Secondary Metabolites from an Algicolous Aspergillus versicolor Strain   SCIE

    Miao, Feng-Ping (Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China) , Li, Xiao-Dong (Email: fpmiao@yic.ac.cn (F.-P.M.)) , Liu, Xiang-Hong (imnli@163.com (X.-D.L.)) , Cichewicz, Robert H. (xianghong1127@163.com (X.-H.L.) ) , Ji, Nai-Yun (Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China)
    Marine drugs v.10 no.12 ,pp. 131 - 139 , 2012 ,

    초록

    Two new compounds, asperversin A ( 1 ) and 9ξ- O -2(2,3-dimethylbut-3-enyl)brevianamide Q ( 2 ), and nine known compounds, brevianamide K ( 3 ), brevianamide M ( 4 ), aversin ( 5 ), 6,8-di- O -methylnidurufin ( 6 ), 6,8-di- O -methylaverufin ( 7 ), 6- O -methylaverufin ( 8 ), 5 α ,8 α -epidioxyergosta-6,22-dien-3 β -ol ( 9 ), ergosta-7,22-diene-3 β ,5 α ,6 β -triol ( 10 ), and 6 β -methoxyergosta-7,22-diene-3 β ,5 α -diol ( 11 ), were obtained from the culture of Aspergillus versicolor , an endophytic fungus isolated from the marine brown alga Sargassum thunbergii . The structures of these compounds were established by spectroscopic techniques. Compounds 4 , 7 and 8 exhibited antibacterial activities against Escherichia coli and Staphyloccocus aureus , and 7 also showed lethality against brine shrimp ( Artemia salina ) with an LC 50 value of 0.5 μg/mL.

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