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Marine drugs 18건

  1. [해외논문]   Diversity of Peptides Produced by Nodularia spumigena from Various Geographical Regions   SCIE

    Mazur-Marzec, Hanna (Department of Marine Biology and Ecology, University of Gdansk, Al. Marszałka Piłsudskiego 46, Gdynia 81-378, Poland) , Kaczkowska, Monika J. (E-Mails: monika.j.kaczkowska@gmail.com (M.J.K.)) , Blaszczyk, Agata (oceabl@ug.edu.pl (A.B.) ) , Akcaalan, Reyhan (Department of Marine Biology and Ecology, University of Gdansk, Al. Marszałka Piłsudskiego 46, Gdynia 81-378, Poland) , Spoof, Lisa (E-Mails: monika.j.kaczkowska@gmail.com (M.J.K.)) , Meriluoto, Jussi (oceabl@ug.edu.pl (A.B.) )
    Marine drugs v.11 no.1 ,pp. 1 - 19 , 2013 ,

    초록

    Cyanobacteria produce a great variety of non-ribosomal peptides. Among these compounds, both acute toxins and potential drug candidates have been reported. The profile of the peptides, as a stable and specific feature of an individual strain, can be used to discriminate cyanobacteria at sub-population levels. In our work, liquid chromatography-tandem mass spectrometry was used to elucidate the structures of non-ribosomal peptides produced by Nodularia spumigena from the Baltic Sea, the coastal waters of southern Australia and Lake Iznik in Turkey. In addition to known structures, 9 new congeners of spumigins, 4 aeruginosins and 12 anabaenopeptins (nodulapeptins) were identified. The production of aeruginosins by N. spumigena was revealed in this work for the first time. The isolates from the Baltic Sea appeared to be the richest source of the peptides; they also showed a higher diversity in peptide profiles. The Australian strains were characterized by similar peptide patterns, but distinct from those represented by the Baltic and Lake Iznik isolates. The results obtained with the application of the peptidomic approach were consistent with the published data on the genetic diversity of the Baltic and Australian populations.

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  2. [해외논문]   Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1 H -indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov   SCIE

    Yang, Xian-Wen (Luxembourg Public Research Center for Health (CRP-SANTE), 84 Val Fleuri, Luxembourg L-1526, Luxembourg) , Zhang, Gai-Yun (E-Mails: xianwen.yang@crp-sante.lu (X.-W.Y.)) , Ying, Jian-Xi (andre.steinmetz@crp-sante.lu (A.S.) ) , Yang, Bing (Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China) , Zhou, Xue-Feng (E-Mails: zhgyun2008@yahoo.com.cn (G.-Y.Z.)) , Steinmetz, Andre (yingjianxiah@126.com (J.-X.Y.) ) , Liu, Yong-Hong (Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China) , Wang, Ning (E-Mails: zhgyun2008@yahoo.com.cn (G.-Y.Z.))
    Marine drugs v.11 no.1 ,pp. 33 - 39 , 2013 ,

    초록

    One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1 H -indole ( 1 ) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds ( 2 – 6 ). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 μg/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702).

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  3. [해외논문]   Assessing the Effectiveness of Functional Genetic Screens for the Identification of Bioactive Metabolites   SCIE

    Penesyan, Anahit (School of Biotechnology and Biomolecular Sciences and Centre for Marine Bio-Innovation, University of New South Wales, Sydney 2052, New South Wales, Australia) , Ballestriero, Francesco (E-Mails: anahit.penesyan@mq.edu.au (A.P.)) , Daim, Malak (f.ballestriero@unsw.edu.au (F.B.)) , Kjelleberg, Staffan (malak.daim@gmail.com (M.D.)) , Thomas, Torsten (s.kjelleberg@unsw.edu.au (S.K.)) , Egan, Suhelen (t.thomas@unsw.edu.au (T.T.) )
    Marine drugs v.11 no.1 ,pp. 40 - 49 , 2013 ,

    초록

    A common limitation for the identification of novel activities from functional (meta) genomic screens is the low number of active clones detected relative to the number of clones screened. Here we demonstrate that constructing libraries with strains known to produce bioactives can greatly enhance the screening efficiency, by increasing the “hit-rate” and unmasking multiple activities from the same bacterial source.

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  4. [해외논문]   Fucoxanthin Enhances Cisplatin-Induced Cytotoxicity via NFκB-Mediated Pathway and Downregulates DNA Repair Gene Expression in Human Hepatoma HepG2 Cells   SCIE

    Liu, Cheng-Ling (Department of Food Science and Biotechnology, National Chung Hsing University, Taichung 402, Taiwan) , Lim, Yun-Ping (E-Mail: liouoiu@msn.com ) , Hu, Miao-Lin (Department of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan)
    Marine drugs v.11 no.1 ,pp. 50 - 66 , 2013 ,

    초록

    Cisplain, a platinum-containing anticancer drug, has been shown to enhance DNA repair and to inhibit cell apoptosis, leading to drug resistance. Thus, the combination of anticancer drugs with nutritional factors is a potential strategy for improving the efficacy of cisplatin chemotherapy. In this study, we investigated the anti-proliferative effects of a combination of fucoxanthin, the major non-provitamin A carotenoid found in Undaria Pinnatifida , and cisplatin in human hepatoma HepG2 cells. We found that fucoxanthin (1–10 μΜ) pretreatment for 24 h followed by cisplatin (10 μΜ) for 24 h significantly decreased cell proliferation, as compared with cisplatin treatment alone. Mechanistically, we showed that fucoxanthin attenuated cisplatin-induced NFκB expression and enhanced the NFκB-regulated Bax/Bcl-2 mRNA ratio. Cisplatin alone induced mRNA expression of excision repair cross complementation 1 (ERCC1) and thymidine phosphorylase (TP) through phosphorylation of ERK, p38 and PI3K/AKT pathways. However, fucoxanthin pretreatment significantly attenuated cisplatin-induced ERCC1 and TP mRNA expression, leading to improvement of chemotherapeutic efficacy of cisplatin. The results suggest that a combined treatment with fucoxanthin and cisplatin could lead to a potentially important new therapeutic strategy against human hepatoma cells.

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  5. [해외논문]   Lipid Peroxidation Is another Potential Mechanism besides Pore-Formation Underlying Hemolysis of Tentacle Extract from the Jellyfish Cyanea capillata   SCIE

    Wang, Tao (Department of Chemical Defense Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China) , Wen, Xiao-Juan (E-Mails: wangtao2086@163.com (T.W.)) , Mei, Xiao-Bin (shengnan19871016@163.com (X.-J.W.)) , Wang, Qian-Qian (abc_w@163.com (Q.-Q.W.)) , He, Qian (trados1@126.com (J.-M.Z.)) , Zheng, Jie-Min (zs1010@hotmail.com (J.Z.) ) , Zhao, Jie (Department of Chemical Defense Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China) , Xiao, Liang (E-Mails: wangtao2086@163.com (T.W.)) , Zhang, Li-Ming (shengnan19871016@163.com (X.-J.W.))
    Marine drugs v.11 no.1 ,pp. 67 - 80 , 2013 ,

    초록

    This study was performed to explore other potential mechanisms underlying hemolysis in addition to pore-formation of tentacle extract (TE) from the jellyfish Cyanea capillata . A dose-dependent increase of hemolysis was observed in rat erythrocyte suspensions and the hemolytic activity of TE was enhanced in the presence of Ca 2+ , which was attenuated by Ca 2+ channel blockers (Diltiazem, Verapamil and Nifedipine). Direct intracellular Ca 2+ increase was observed after TE treatment by confocal laser scanning microscopy, and the Ca 2+ increase could be depressed by Diltiazem. The osmotic protectant polyethylenglycol (PEG) significantly blocked hemolysis with a molecular mass exceeding 4000 Da. These results support a pore-forming mechanism of TE in the erythrocyte membrane, which is consistent with previous studies by us and other groups. The concentration of malondialdehyde (MDA), an important marker of lipid peroxidation, increased dose-dependently in rat erythrocytes after TE treatment, while in vitro hemolysis of TE was inhibited by the antioxidants ascorbic acid—Vitamin C (Vc)—and reduced glutathione (GSH). Furthermore, in vivo hemolysis and electrolyte change after TE administration could be partly recovered by Vc. These results indicate that lipid peroxidation is another potential mechanism besides pore-formation underlying the hemolysis of TE, and both Ca 2+ channel blockers and antioxidants could be useful candidates against the hemolytic activity of jellyfish venoms.

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  6. [해외논문]   Fucoidan Extract Enhances the Anti-Cancer Activity of Chemotherapeutic Agents in MDA-MB-231 and MCF-7 Breast Cancer Cells   SCIE

    Zhang, Zhongyuan (Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan) , Teruya, Kiichiro (E-Mails: zzyszy2012@yahoo.co.jp (Z.Z.)) , Yoshida, Toshihiro (sirahata@grt.kyushu-u.ac.jp (S.S.) ) , Eto, Hiroshi (Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan) , Shirahata, Sanetaka (E-Mails: zzyszy2012@yahoo.co.jp (Z.Z.))
    Marine drugs v.11 no.1 ,pp. 81 - 98 , 2013 ,

    초록

    Fucoidan, a fucose-rich polysaccharide isolated from brown alga, is currently under investigation as a new anti-cancer compound. In the present study, fucoidan extract (FE) from Cladosiphon navae-caledoniae Kylin was prepared by enzymatic digestion. We investigated whether a combination of FE with cisplatin, tamoxifen or paclitaxel had the potential to improve the therapeutic efficacy of cancer treatment. These co-treatments significantly induced cell growth inhibition, apoptosis, as well as cell cycle modifications in MDA-MB-231 and MCF-7 cells. FE enhanced apoptosis in cancer cells that responded to treatment with three chemotherapeutic drugs with downregulation of the anti-apoptotic proteins Bcl-xL and Mcl-1. The combination treatments led to an obvious decrease in the phosphorylation of ERK and Akt in MDA-MB-231 cells, but increased the phosphorylation of ERK in MCF-7 cells. In addition, we observed that combination treatments enhanced intracellular ROS levels and reduced glutathione (GSH) levels in breast cancer cells, suggesting that induction of oxidative stress was an important event in the cell death induced by the combination treatments.

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  7. [해외논문]   Soft Coral-Derived Lemnalol Alleviates Monosodium Urate-Induced Gouty Arthritis in Rats by Inhibiting Leukocyte Infiltration and iNOS, COX-2 and c-Fos Protein Expression   SCIE

    Lee, Hsin-Pai (Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan) , Huang, Shi-Ying (E-Mails: hplee0929@gmail.com (H.-P.L.)) , Lin, Yen-You (johnjohnkings@gmail.com (S.-Y.H.)) , Wang, Hui-Min (chas6119@gmail.com (Y.-Y.L.)) , Jean, Yen-Hsuan (yihduh@mail.nsysu.edu.tw (C.-Y.D.) ) , Wu, Shu-Fen (Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan) , Duh, Chang-Yih (E-Mails: hplee0929@gmail.com (H.-P.L.)) , Wen, Zhi-Hong (johnjohnkings@gmail.com (S.-Y.H.))
    Marine drugs v.11 no.1 ,pp. 99 - 113 , 2013 ,

    초록

    An acute gout attack manifests in the joint as dramatic inflammation. To date, the clinical use of medicinal agents has typically led to undesirable side effects. Numerous efforts have failed to create an effective and safe agent for the treatment of gout. Lemnalol—an extract from Formosan soft coral—has documented anti-inflammatory and anti-nociceptive properties. In the present study, we attempt to examine the therapeutic effects of lemnalol on intra-articular monosodium urate (MSU)-induced gouty arthritis in rats. In the present study, we found that treatment with lemnalol (intramuscular [im]), but not colchicine (oral [po]), significantly attenuated MUS-induced mechanical allodynia, paw edema and knee swelling. Histomorphometric and immunohistochemistry analysis revealed that MSU-induced inflammatory cell infiltration, as well as the elevated expression of c-Fos and pro-inflammatory proteins (inducible nitric oxide synthase and cyclooxygenase-2) observed in synovial tissue, were significantly inhibited by treatment with lemnalol. We conclude that lemnalol may be a promising candidate for the development of a new treatment for gout and other acute neutrophil-driven inflammatory diseases.

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  8. [해외논문]   A New Spatane Diterpenoid from the Cultured Soft Coral Sinularia leptoclados   SCIE

    Tsai, Tsung-Chang (Department of Superintendent, Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan) , Wu, Yu-Jen (E-Mail: a088186@mail.tsmh.org.tw ) , Su, Jui-Hsin (Department of Beauty Science, Meiho University, Pingtung 91202, Taiwan) , Lin, Wei-Tung (E-Mail: wyr924@ms24.hinet.net or x00002180@meiho.edu.tw ) , Lin, Yun-Sheng (National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan)
    Marine drugs v.11 no.1 ,pp. 114 - 123 , 2013 ,

    초록

    A new spatane diterpenoid, leptoclalin A ( 1 ), along with two previously reported known norcembranoid diterpenes ( 2 and 3 ), were isolated from a cultured soft coral Sinularia leptoclados . The structures were determined by extensive spectroscopic analyses and by comparison with the spectral data of related known compounds. Metabolite 1 is rarely found in spatane skeletons reported from soft corals. In addition, compound 1 exhibited weak cytotoxicity towards human tumor cell lines T-47 D and K-562.

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  9. [해외논문]   Antibacterial Polyketides from the Marine Alga-Derived Endophitic Streptomyces sundarbansensis : A Study on Hydroxypyrone Tautomerism   SCIE

    Djinni, Ibtissem (Laboratory of Applied Microbiology, Faculty of Nature Science and Life, University of Bejaia, Targa Ouzemmour 06000, Algeria) , Defant, Andrea (E-Mails: ibtissem.djinni@yahoo.fr (I.D.)) , Kecha, Mouloud (kmkmsetif@yahoo.fr (M.K.) ) , Mancini, Ines (Bioorganic Chemistry Laboratory, Department of Physics, University of Trento, via Sommarive 14, I-38123 Povo-Trento, Italy)
    Marine drugs v.11 no.1 ,pp. 124 - 135 , 2013 ,

    초록

    Polyketide 13 [=2-hydroxy-5-((6-hydroxy-4-oxo-4 H -pyran-2-yl)methyl)-2-propylchroman-4-one] and three related known compounds 7 , 9 and 11 were obtained and structurally characterized from Streptomyces sundarbansensis strain, an endophytic actinomycete isolated from the Algerian marine brown algae Fucus sp. Compound 13 was obtained as the major metabolite from optimized culture conditions, by using Agar state fermentation. Due to tautomeric equilibrium, 13 in CD 3 OD solution was able to incorporate five deuterium atoms, as deduced by NMR and ESI-MS/MS analysis. The 2-hydroxy-γ-pyrone form was established for these metabolites based on the comparison of their experimental IR spectra with the DFT calculated ones, for both the corresponding 4-hydroxy-α-pyrone and 2-hydroxy-γ-pyrone forms. During antibacterial evaluation, compound 13 stood out as the most active of the series, showing a selective activity against the gram positive pathogenic methicillin-resistant S. aureus (MRSA, MIC = 6 μΜ), with a bacteriostatic effect.

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  10. [해외논문]   Steroidal Carboxylic Acids from Soft Coral Paraminabea acronocephala   SCIE

    Chao, Chih-Hua (Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan) , Wu, Yang-Chang (E-Mails: chaochihhua@hotmail.com (C.-H.C.)) , Wen, Zhi-Hong (wzh@mail.nsysu.edu.tw (Z.-H.W.) ) , Sheu, Jyh-Horng (Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan)
    Marine drugs v.11 no.1 ,pp. 136 - 145 , 2013 ,

    초록

    Three new steroidal carboxylic acids, paraminabic acids A–C ( 1 – 3 ) were isolated from a Formosan soft coral Paraminabea acronocephala . The structures of these compounds were established by extensive spectroscopic analysis and chemical methods. Application of the PGME method allowed the establishment of the absolute configurations at C-25 and C-24 for 1 and 2 , respectively. Compound 3 showed potent cytotoxicity toward Hep3B, MDA-MB-231, MCF-7, and A-549 cancer cell lines, with IC 50 values ranging from 2.05 to 2.83 μg/mL. Compounds 2 and 3 were found to inhibit the accumulation of the pro-inflammatory iNOS protein.

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