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Cardiovascular revascularization medicine : includ... 17건

  1. [해외논문]   The ORBITA Trial: What Does It Mean for Practice?  

    King III, Spencer B.
    Cardiovascular revascularization medicine : including molecular interventions v.19 no.4 ,pp. 397 - 398 , 2018 , 1553-8389 ,

    초록

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   The Forgotten Art of Balloon Angioplasty  

    Di Mario, Carlo (Division of Cardiology, Careggi University Hospital, Florence, Italy ) , Mattesini, Alessio (Division of Cardiology, Careggi University Hospital, Florence, Italy ) , Secco, Gioel (Interventional Cardiology, “Santi Antonio e Biagio e Cesare Arrigo” Hospital, Alessandria, Italy)
    Cardiovascular revascularization medicine : including molecular interventions v.19 no.4 ,pp. 399 - 400 , 2018 , 1553-8389 ,

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Size Matters: Moving Toward a Slender Transradial Artery Approach  

    Villablanca, Pedro (Corresponding author at: 423 East 23rd Street, 12023-W, New York, NY 10010.) , Shah, Binita
    Cardiovascular revascularization medicine : including molecular interventions v.19 no.4 ,pp. 401 - 402 , 2018 , 1553-8389 ,

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Full stent expansion of chronic total occlusion lesions requires prolonged inflation  

    Vallurupalli, Srikanth (Central Arkansas Veterans Health System, Little Rock, AR, USA ) , Garg, Aatish (Central Arkansas Veterans Health System, Little Rock, AR, USA ) , Carlino, Mauro (San Raffaele Hospital, Milan, Italy ) , Hakeem, Abdul (Central Arkansas Veterans Health System, Little Rock, AR, USA ) , Uretsky, Barry F. (Central Arkansas Veterans Health System, Little Rock, AR, USA)
    Cardiovascular revascularization medicine : including molecular interventions v.19 no.4 ,pp. 403 - 406 , 2018 , 1553-8389 ,

    초록

    Abstract Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has been associated in some studies with higher target vessel revascularization (TVR) rates than non-CTO PCI. Optimal stent inflation time and its effect on TVR in CTO PCI is unknown. We investigated the time required for stent deployment using the previously described pressure optimized protocol (POP), which uses stent balloon pressure stability rather than an arbitrary inflation time as an end point for balloon deflation. We also compared TVR with CTO PCI vs non-CTO using the POP protocol in both groups. Methods Patients with successful CTO PCI using POP between 2012 and 2015 were included. Patients having non-CTO PCI using POP and matched for stent diameter and length and temporal proximity constituted the control group to compare inflation time ( n = 83 each). TVR at 1year was compared between PCI during the time period using POP (CTO=83, non-CTO=263). Results Stent inflation time to achieve optimal stent inflation using POP was longer in CTO vs non-CTO lesions (136±60 vs 108±51s, p = 0.001). TVR at 365days was similar in CTO and non-CTO cohorts (2.4% vs 2.6%, p = 0.9). Conclusion Stent expansion using POP in CTO lesions requires longer inflation duration but leads to similar TVR rates at 1year in CTO PCI compared with non-CTO PCI. Highlights The inflation time for optimal stent expansion in chronic total occlusions(CTO) is unknown In this study, stent expansion in CTO lesions required significantly longer than non-CTO lesions(136±60 vs 108±51s, p = 0.001) when stent balloon pressure stability(dubbed the “POP protocol”) is used as an endpoint Target vessel revascularization rates at 1year were similar between CTO and non-CTO PCI performed using the POP protocol(2.4% vs 2.6%, p = 0.9) A prospective, multi-center study is needed to confirm these results

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Novel proctorship effectively teaches interventionists coronary artery chronic total occlusion lesions  

    Yamamoto, Masanori (Department of Cardiovascular Medicine, Toyohashi Heart Center, Toyohashi, Aichi, Japan ) , Tsuchikane, Etsuo (Department of Cardiovascular Medicine, Toyohashi Heart Center, Toyohashi, Aichi, Japan ) , Kagase, Ai (Department of Cardiovascular Medicine, Toyohashi Heart Center, Toyohashi, Aichi, Japan ) , Shimura, Tetsuro (Department of Cardiovascular Medicine, Toyohashi Heart Center, Toyohashi, Aichi, Japan ) , Teramoto, Tomohiko (Department of Cardiovascular Medicine, Toyohashi Heart Center, Toyohashi, Aichi, Japan ) , Kimura, Masashi (Department of Cardiovascular Medicine, Toyohashi Heart Center, Toyohashi, Aichi, Japan ) , Matsuo, Hitoshi (Department of Cardiovascular Medicine, Gifu Heart Center, Gifu, Japan ) , Kawase, Yoshiaki (Department of Cardiovascular Medicine, Gifu Heart Center, Gifu, Japan ) , Suzuki, Yoriyasu (Department of Cardiovascular Medicine, Nagoya Heart Center, Nagoya, Aichi, Japan ) , Kano, Seiji (Department of Cardiovascular Medicine, Nagoya Heart Center, Nagoya, Aichi, Japan ) , Habara, Maoto (Department of Cardiovascular Medicine, Toyohashi Heart Center, Toyohashi, Aichi, Japan ) , Nasu, Kenya (Department of Cardiovascular Medicine, Toyohashi Heart Center, Toyo) , Kinoshita, Yoshihisa , Terashima, Mitsuyasu , Matsubara, Tetsuo , Suzuki, Takahiko
    Cardiovascular revascularization medicine : including molecular interventions v.19 no.4 ,pp. 407 - 412 , 2018 , 1553-8389 ,

    초록

    Abstract Background Interventionists' experience and skills are essential factors for successful chronic total occlusion-percutaneous coronary intervention (CTO-PCI). However, the construction of theoretical strategy independent from interventionists' procedure may also improve it. We sought to assess the feasibility of CTO-PCI using an educational system supported by a single expert proctor. Methods A total of 160 patients underwent CTO-PCI between 2009 and 2016 at 92 Japanese centers in the Hands-on proctorship project. The CTO-PCI strategy was discussed with all participants and their specialists, before and during the procedure. We divided patients into 2 groups based on the CTO-PCI experience of their interventionist: (1) the less experienced group (CTO-PCI ≤50 cases, n=65) and (2) the more experienced group (CTO-PCI >50 cases, n=95). Baseline characteristics, procedural complications, and clinical outcomes were compared between groups. Results No significant differences in patient age, sex, prevalence for coronary risk factors, and lesion complexity was observed between groups. The retrograde approach was used equivalently between groups (55.4% vs. 60.0%, p=0.56), and procedural success rates were similar (96.9% vs. 90.5%, p=0.12). The rate of proctor's bailout for recanalization were not frequent between groups (4.6% vs. 5.3%, p=0.85). No procedure-related mortality was noted in either group. In addition, no significant differences in procedural cardiac complications, including coronary dissection, perforation, or tamponade, were observed between groups (10.8% vs. 14.7%, p=0.47). Conclusions The expert-supported CTO-PCI maintained high success rates regardless of interventionists' experience. This highlights the importance of theoretical strategy for the management patients undergoing CTO-PCI.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Identifying a better strategy for ad hoc percutaneous coronary intervention in patients with anticipated unfavorable radial access: the Little Women study  

    Sgueglia, Gregory A. (Sant'Eugenio Hospital, Rome, Italy ) , Todaro, Daniel (S.M. Goretti Hospital, Latina, Italy ) , De Santis, Antonella (Sant'Eugenio Hospital, Rome, Italy ) , Conte, Micaela (S.M. Goretti Hospital, Latina, Italy ) , Gioffrè (Sant'Eugenio Hospital, Rome, Italy ) , , Gaetano (Fondazione Policlinico Universitatio Agostino Gemelli, Rome, Italy ) , Di Giorgio, Angela (Sant'Eugenio Hospital, Rome, Italy ) , D'Errico, Fabrizio (Sant'Eugenio Hospital, Rome, Italy ) , Piccioni, Fabiana (Sant'Eugenio Hospital, Rome, Italy ) , Summaria, Francesco (Sant'Eugenio Hospital, Rome, Italy) , Gaspardone, Achille
    Cardiovascular revascularization medicine : including molecular interventions v.19 no.4 ,pp. 413 - 417 , 2018 , 1553-8389 ,

    초록

    Abstract Background Transradial percutaneous coronary intervention (PCI) offers important advantages over transfemoral PCI, including better outcomes. However, when there is indication to ad hoc PCI, a 6 French workflow is a common default strategy, hence potentially influencing vascular access selection in patients with anticipated small size radial artery. Methods A multidimensional evaluation was performed to compare two ad hoc interventional strategies in women Results Overall 120 women (68±11years) were enrolled in the study. Coronary angiography has been performed using 5 French or 6 French diagnostic catheters in 57 (47.5%) and 63 (52.5%) cases, respectively. Radial spasm and switch to another access occurred more frequently among women who underwent coronary angiography with 6 French rather than 5 French diagnostic catheters (43% vs. 25%, p=0.03 and 2% vs. 11%, p=0.04, respectively). Total time to guidewire lesion crossing was also significantly higher when PCI has been preceded by 6 French rather than 5 French coronary angiography (23±11min vs 16±7min, p=0.013). Conclusions In patients with anticipated unfavorable radial access, a workflow consisting in 6 French introducer sheath placement, 5 French coronary angiography, and 6 French coronary intervention is on multiple parameters the most straightforward and effective strategy. Highlights For ad hoc revascularization, a 6 French workflow is a common default strategy, hence potentially influencing vascular access selection. A multidimensional evaluation was performed to compare two transradial ad hoc interventional strategies in women. The best workflow consisted in 6 French introducer sheath placement, 5 French coronary angiography, and 6 French coronary intervention.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   MynxGrip® vascular closure device versus manual compression for hemostasis of percutaneous transfemoral venous access closure: Results from a prospective multicenter randomized study  

    Ben-Dor, Itsik (Division of Cardiology, MedStar Washington Hospital Center, Washington, DC, United States ) , Craig, Paige (Division of Cardiology, MedStar Washington Hospital Center, Washington, DC, United States ) , Torguson, Rebecca (Division of Cardiology, MedStar Washington Hospital Center, Washington, DC, United States ) , Rogers, Toby (Division of Cardiology, MedStar Washington Hospital Center, Washington, DC, United States ) , Buchanan, Kyle D. (Division of Cardiology, MedStar Washington Hospital Center, Washington, DC, United States ) , Pokharel, Shreejana (Division of Cardiology, MedStar Washington Hospital Center, Washington, DC, United States ) , Gai, Jiaxiang (Division of Cardiology, MedStar Washington Hospital Center, Washington, DC, United States ) , Okubagzi, Petros G. (Division of Cardiology, MedStar Washington Hospital Center, Washington, DC, United States ) , Satler, Lowell F. (Division of Cardiology, MedStar Washington Hospital Center, Washington, DC, United States ) , Pichard, Augusto D. (Division of Cardiology, MedStar Washington Hospital Center, Washington, DC, United States ) , Baker, Nevin C. (Interventional Cardiology, Excela Health Heart and Vascular Center, Greensburg,) , Waksman, Ron
    Cardiovascular revascularization medicine : including molecular interventions v.19 no.4 ,pp. 418 - 422 , 2018 , 1553-8389 ,

    초록

    Abstract Purpose Evaluate the safety of MynxGrip? for common femoral vein closure. Methods and materials This is a multicenter, randomized, prospective study of 208 patients who were slated to undergo diagnostic/interventional procedures via femoral venous access. Patients were randomized 1:1 to receive venous hemostasis via MynxGrip? (n = 104) or manual compression (n = 104) utilizing 5, 6, and 7 Fr sheaths. Bilateral calf and thigh circumferences were measured serially. Patients were followed up through hospital discharge. There were no differences in the baseline characteristics between the two groups. Results There was no difference between the groups for venous thrombosis, (0%, p = 1). Overall, there was no significant change in access site calf (−0.18 ± 1.38 cm, p = 0.18) or thigh diameter (0.33 ± 2.86, p = 0.81). In both groups, none of the patients had major or minor vascular complications, access site infection, nerve injury, or access site bleeding requiring transfusion. The pre- to post-procedure hemoglobin drop was −0.51 ± 1.1 vs. −0.64 ± 1.3 g/dL, p = 0.59 in the manual compression group and MynxGrip? group, respectively. Time to hemostasis, was significantly lower in the MynxGrip? group compared to the manual compression group with 0.12 ± 0.89 vs. 7.6 ± 5.7 min, respectively (p Conclusions The MynxGrip? extravascular sealant is safe and effective for femoral venous access site closure. Highlights First randomized trial testing safety of MynxGrip? for venous access hemostasis No difference between MynxGrip? and manual compression for venous thrombosis MynxGrip? is safe and effective for femoral venous access site closure.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   Percutaneous angioplasty versus atherectomy for treatment of symptomatic infra-popliteal arterial disease  

    Abdullah, Obai (Cardiovascular Medicine Department, University of Missouri-Columbia School of Medicine, Columbia, MO, United States ) , Omran, Jad (Division of Cardiovascular Medicine, University of California-San Diego, La Jolla, CA, United States ) , Enezate, Tariq (Cardiovascular Medicine Department, University of Missouri-Columbia School of Medicine, Columbia, MO, United States ) , Mahmud, Ehtisham (Division of Cardiovascular Medicine, University of California-San Diego, La Jolla, CA, United States ) , Shammas, Nicolas (Midwest Cardiovascular Research Foundation, Davenport, IA, United States ) , Mustapha, Jihad (Metro Health Hospital, Wyoming, MI, United States ) , Saab, Fadi (Metro Health Hospital, Wyoming, MI, United States ) , Abu-fadel, Mazen (Internal Medicine Department, Section of Cardiovascular Disease, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States ) , Ghadban, Rugheed (Cardiovascular Medicine Department, University of Missouri-Columbia School of Medicine, Columbia, MO, United States ) , Alpert, Martin (Cardiovascular Medicine Department, University of Missouri-Columbia School of Medicine, Columbia, MO, United State) , Al-Dadah, Ashraf
    Cardiovascular revascularization medicine : including molecular interventions v.19 no.4 ,pp. 423 - 428 , 2018 , 1553-8389 ,

    초록

    Abstract Background Outcomes for debulking by atherectomy (ATH) for adjunctive treatment of below the knee (BTK) symptomatic arterial disease compared to percutaneous transluminal angioplasty alone (PTA) are unclear. Methods MEDLINE, EMBASE, PubMed and the Cochrane Central Register of Controlled Trials were queried from between 2000 and 2017 including studies comparing PTA alone to PTA-ATH. Random effect meta-analysis model was used to pool the data across the studies. Study endpoints included: vessel dissection, residual stenosis ( Results A total of 2587 patients (72.9years; 63% male) were included from 4 studies (2 prospective, one of which was randomized, and 2 retrospective) comparing PTA alone to ATH-PTA in patients with symptomatic infra-popliteal disease. There was no significant difference between the two approaches in terms of vessel dissection [OR 3.73 with 95% CI 0.83 to 16.64, p=0.08] or residual stenosis [OR 0.41 with 95% CI 0.11 to 1.60, p=0.18]. Clinical outcomes did not differ in terms of 12month mortality [OR 3.47 with 95% CI 0.15 to 81.37, p=0.44], or limb amputation at 1month [OR 1.23 with 95% CI 0.91 to 1.67, p=0.18] or 12months [OR: 1.02 with 95% CI 0.83 to 1.26, p=0.83]. Conclusion In patients undergoing (BTK) intervention, PTA alone and ATH-PTA was associated with similar outcomes in terms of vessel dissection and residual stenosis, mortality at 12months, and limb amputation at 1 or 12months. Highlights Comparison between Percutaneous Angioplasty and Atherectomy in infrapopliteal PAD Safety and effectiveness of atherectomy in infrapopliteal interventions Angioplasty vs ATH-Angioplasty yielded similar results in infrapopliteal PAD.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Long-term results of a sirolimus-eluting stent with biodegradable polymer (RAPSTROM™) in de novo coronary stenoses  

    Figini, Filippo (Pederzoli Hospital, Peschiera del Garda, Italy ) , Manjunath, Cholenahaly N. (Jayadeva Hospital, Bangalore, Karnataka, India ) , Srinivas, Budanur C. (Jayadeva Hospital, Bangalore, Karnataka, India ) , Sadananda, Kanvar Sarat (Jayadeva Hospital, Bangalore, Karnataka, India ) , Sreedharan, Madhu (NIMS Hospital, Trivandrum, Kerala, India ) , Fischer, Louie (MOSC Medical College, Kerala, India ) , Pillai, Ramakrishna (KIMS Hospital, Kerala, India ) , Varghese, Kiron (St John's Medical College, Bangalore, India ) , Gopal, Ajay K. (Moulana Hospital, Kerala, India ) , Nagesh, Chamarajnagar Mahadevappa (Jayadeva Hospital, Bangalore, Karnataka, India ) , Sheiban, Imad (Pederzoli Hospital, Peschiera del Garda, Italy)
    Cardiovascular revascularization medicine : including molecular interventions v.19 no.4 ,pp. 429 - 432 , 2018 , 1553-8389 ,

    초록

    Abstract Objectives To report long-term results of a novel sirolimus-eluting stent with biodegradable polymer Background Newer generation drug-eluting stents are characterized by thin struts, improved platform design and highly biocompatible polymer carrying the antiproliferative drug. The RapstromTM stent, sharing these features, showed promising outcomes in preclinical models and in a first-in-man trial. Methods The present study is a multicenter, non-randomized post-market registry, including patients with de novo coronary artery disease treated with implantation of one or more Rapstrom stents. Primary endpoint of the study was the rate of major adverse cardiac events (MACE) at three-year follow-up. Results 1073 patients were enrolled, with a high prevalence of diabetes (35%) and acute coronary syndrome at presentation (82%); at three-year follow up, MACE rate was 14.8%, with a low incidence of definite or probable stent thrombosis (0.75%). Conclusions These data confirm the good clinical performance of the Rapstrom stent, supporting the concept that the combination of thin struts and biodegradable polymer is associated with positive clinical outcomes. Highlights Rapstrom™ is a newer generation, thin-struts, sirolimus-eluting stent with a biodegradable polymer In our registry, the incidence of major adverse cardiovascular events at 3years was 14.8%, with a low rate of stent thrombosis These results support data in favour of the combination of thin struts and biodegradable polymer

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  10. [해외논문]   Preclinical evaluation of a paclitaxel-incorporated nanoparticle-coated balloon in rabbit and porcine models  

    Yamamoto, Erika (Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan ) , Watanabe, Shin (Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan ) , Bao, Bingyuan (Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan ) , Watanabe, Hiroki (Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan ) , Nakatsuma, Kenji (Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan ) , Izuhara, Masayasu (Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan ) , Ono, Koh (Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan ) , Nakazawa, Gaku (Department of Cardiology, Tokai University School of Medicine, Kanagawa, Japan ) , Kimura, Takeshi (Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan ) , Saito, Naritatsu (Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan)
    Cardiovascular revascularization medicine : including molecular interventions v.19 no.4 ,pp. 433 - 437 , 2018 , 1553-8389 ,

    초록

    Abstract Background The main drawback of current available drug coated balloons (DCB) is that a certain percentage of the coated drug is lost in the bloodstream during its delivery to the target lesion. We integrated the nanoparticle-mediated drug delivery technology and polydimethylsiloxane (PDMS) as a new excipient to facilitate an efficient drug delivery and uptake by endothelial cells. The present study aimed to evaluate the efficacy of the new DCB. Method and results The novel DCB were coated with 5.6mg of paclitaxel–incorporated nanoparticles using PDMS. The efficacy of the new DCB was examined in rabbit iliac stent model (n=12) and in the swine in-stent restenosis model (n=8) by quantitative coronary angiography (QCA) and optical coherence tomography (OCT). At 28days follow-up in the swine in-stent restenosis model, the area stenosis was significantly lower in DCB group as compared with that of the control group in OCT analysis (0.31±0.05 vs 0.49±0.06, p=0.04) though there was no significant differences observed in the rabbit iliac stent model in QCA and OCT analysis. Conclusion The study results indicated that the paclitaxel-incorporated nanoparticle-coated balloon using PDMS has an inhibitory effect for the proliferation of smooth muscle cell in a swine coronary in-stent restenosis model. Highlights We developed a novel paclitaxel-incorporated nanoparticle-coated balloon. The novel drug-coated balloon showed that tissue concentrations of paclitaxel were within a therapeutic range. The novel drug-coated balloon inhibited smooth muscle cell proliferation in a swine coronary stent-restenosis model.

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