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Immune network : official journal of the Korean as... 9건

  1. [국내논문]   Protease-activated Receptor 2 is Associated with Activation of Human Macrophage Cell Line THP-1  

    Kang, Chon-Sik (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University ) , Tae, Jin (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University ) , Lee, Young-Mi (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University ) , Kim, Byeong-Soo (Department of Companion and Laboratory Animal Science, Kongju National University ) , Moon, Woo-Sung (Departments of Pathology, Chonguk National University Medical School ) , Kim, Dae-Ki (Departments of Immunology Chonbuk National University Medical School)
    Immune network : official journal of the Korean association of immunobiologists v.5 no.4 ,pp. 193 - 198 , 2005 , 1598-2629 ,

    초록

    Background: Protease-activated receptor 2 (PAR2) belongs to a family of G protein coupled receptors activated by proteolytic cleavage. Trypsin-like serine proteases interact with PAR2 expressed by a variety of tissues and immune cells. The aim of our study was to investigate whether PAR2 stimulation can lead to the activation of human mac rophages. Methods: PAR2-mediated proliferation of human macrophage cell line THP-1 was measured with MTT assay. We also examined the extracellular regulated kinase (ERK) phosphorylation and cytokine production induced by trypsin and PAR2-agonist using western blot and enzyme-linked immunosorbent assay (ELISA), respectively. Results: Treatment of trypsin or PAR2-activating peptide increased cell proliferation in a dose-dependent manner, and induced the activation of ERK1/2 in THP-1 cells. In addition, trypsin-induced cell proliferation was inhibited by pretreatment of an ERK inhibitor (pD98059) or trypsin inhibitor (SBTI). Moreover, PAR2 activation by trypsin increased the secretion of TNF- ${\alpha}$ in THP-1 cells. Conclusion: There results suggest that P AR2 activation by trypsin-like serine proteases can induce cell proliferation through the activation of ERK in human macrophage and that PAR2 may playa crucial role in the cell proliferation and cytokine secretion induced by trypsin-like serine proteases.

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  2. [국내논문]   Effect of Nitric Oxide on ADP-ribose Pyrophosphatase Activity  

    Kim, Jong-Hyun (Department of Obstetrics & Gynecology, Chonbuk National University Medical School)
    Immune network : official journal of the Korean association of immunobiologists v.5 no.4 ,pp. 199 - 204 , 2005 , 1598-2629 ,

    초록

    Background: ADP-ribosyl pyrophosphatases (ADPRase) has been known to catalyze the hydrolysis of ADP-ribose to ribose-5-phosphate and AMP. The role of ADPRase has been suggested to sanitize the cell by removing potentially toxic ADP-ribose. In this study, we examined the effect of nitric oxide on ADPRase activity in macrophages. Methods: ADPRase activity was measured in NO-inducing J774 cells. For in vitro experiments, recombinant human ADPRase was prepared in bacteria. Results: ADPRase activity was increased by the treatment of exogenous NO generating reagent, sodium nitroprusside (SNP), in J774 cells. The increased ADPRase activity was mediated by the post-translational modification, likely to cause cADP-ribosylation via nitrosylation of cysteine residue on the enzyme. The stimulation with endogeneous NO inducers, $TNF-{\alpha}/IFN-{\gamma}$ , also increased ADPRase activity through NO synthesis. Futhermore, ADPRase activity may be mediated by the post-translational modification of ADPRase, ADP-ribosylation. Conclusion: These results indicate that NO synthesized by macrophage activation plays a critical role in the increase in ADPRase activity following ADP-ribose metabolism.

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  3. [국내논문]   Ulcerative Colitis is Associated with Novel Polymorphisms in the Promoter Region of MIP-3${\alpha}$/CCL20 Gene  

    Choi, Suck-Chei (Digestive Disease Research Institute ) , Lee, Eun-Kyung (Department of Physiology, Kyungpook National University School of Medicine ) , Lee, Sung-Ga (Department of Physiology, Kyungpook National University School of Medicine ) , Chae, Soo-Cheon (Genome Research Center for Immune Disorders, Wonkwang University School of Medicine ) , Lee, Myeung-Su (Digestive Disease Research Institute ) , Seo, Geom-Seog (Digestive Disease Research Institute ) , Kim, Sang-Wook (Department of Internal Medicine, Chonbuk National University College of Medicine ) , Yeom, Joo-Jin (Department of Internal Medicine, Chonbuk National University College of Medicine ) , Jun, Chang-Duk (Department of Physiology, Kyungpook National University School of Medicine)
    Immune network : official journal of the Korean association of immunobiologists v.5 no.4 ,pp. 205 - 214 , 2005 , 1598-2629 ,

    초록

    Background: We examined global gene expression profiles of peripheral blood mononuclear cells (PBMCs) in patients with ulcerative colitis (DC), and tested whether the identified genes with the altered expression might be associated with susceptibility to UC. Methods: PBMCs from 8 UC and 8 normal healthy (NH) volunteers were collected, and total RNAs were subjected to the human 8.0K cDNA chip for the micro array analysis. Real time-PCR (RT-PCR) was performed to verify the results of micro array. One hundred forty UC patients and 300 NH controls were recruited for single nucleotide polymorphism (SNP) analysis. Results: Twenty-five immune function-related genes with over 2-fold expression were identified. Of these genes, two chemokines, namely, CXCL1 and CCL20, were selected because of their potential importance in the evocation of host innate and adaptive immunity. Four SNPs were identified in the promoter and coding regions of CXCL1, while there was no significant difference between all patients with UC and controls in their polymorphisms, except minor association at g.57A>G (rs2071425, p=0.02). On the other hand, among three novel and one known SNPs identified in the promoter region of CCL20, g. -1,706 G>A (p=0.000000055), g. -1,458 G>A (p=0.0048), and g. -962C>A (p=0.0006) were found to be significantly associated with the susceptibility of Uc. Conclusion: Altered gene expression in mononuclear cells may contribute to IBD pathogenesis. Although the findings need to be confirmed in other populations with larger numbers of patients, the current results demonstrated that polymorphisms in the promoter region of CCL20 are positively associated with the development of Uc.

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  4. [국내논문]   마우스 내장 림프조직에서 우세하게 발현되는 IgA Isotype Switching 관련 전사체의 분석  

    채병철 (강원대학교 자연대학 미생물학과 ) , 전성기 (강원대학교 자연대학 미생물학과 ) , 서구영 (강원대학교 자연대학 미생물학과 ) , 김현아 (강원대학교 자연대학 미생물학과 ) , 김평현 (강원대학교 자연대학 미생물학과)
    Immune network : official journal of the Korean association of immunobiologists v.5 no.4 ,pp. 215 - 220 , 2005 , 1598-2629 ,

    초록

    Background: Transforming growth factor- ${\beta}$ (TGF- ${\beta}1$ ) directs class switch recombination (CSR) to IgA isotype, which is a predominant antibody in mucosal surfaces. Although IgA is preferentially committed in mucosal lymphoid tissues, it is not definitely established whether hallmarks of IgA CSR such as IgA germ-line transcripts (GLT ${\alpha}$ ), post-switch transcripts (PST ${\alpha}$ ) and circle transcripts (CT ${\alpha}$ ) are readily expressed in such tissues. Therefore, we compared the expression of these transcripts among mouse Peyer's patches (PP), mesenteric lymph nodes (MLN), and spleen. Methods: Levels of GLTs, PSTs and CTs were measured by RT-PCR in isolated PPs, MLNs and spleen cells. Results: GLT ${\alpha}$ and PST ${\alpha}$ were well expressed in PP and MLN cells but in spleen cells. Similar patterns were observed in the expression of GL ${\gamma}$ 2b and PST ${\gamma}$ 2b. On the other hand, these transcripts were only inducible in spleen cells upon stimulated with LPS and TGF- ${\beta}1$ . In addition, CT ${\alpha}$ and CT ${\gamma}$ 2b were detected in PP cells. Conclusion: PP B cells readily express IgA GLT, PST, and CT. Overall expression patterns of these transcripts were similar in MLN cells. Thus, these results suggest that microenvironment of PP and MLN influences spontaneous IgA CSR, which lacks in systemic lymphoid tissues such as spleen.

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  5. [국내논문]   제2형 콜라겐 경구관용 유도 동물모델에서 수지상 세포의 Indoleamine 2,3-dioxygenase의 의존성 관절염 항원 특이 T세포 증식반응 제어 연구  

    박민정 (가톨릭대학교 의과학연구원 류마티스연구센터 ) , 민소연 (가톨릭대학교 의과학연구원 류마티스연구센터 ) , 박경수 (가톨릭대학교 의과학연구원 류마티스연구센터 ) , 조미라 (가톨릭대학교 의과학연구원 류마티스연구센터 ) , 조영규 (가톨릭대학교 의과학연구원 류마티스연구센터 ) , 민준기 (가톨릭대학교 의과학연구원 류마티스연구센터 ) , 윤종현 (가톨릭대학교 의과학연구원 류마티스연구센터 ) , 박성환 (가톨릭대학교 의과학연구원 류마티스연구센터 ) , 김호연 (가톨릭대학교 의과학연구원 류마티스연구센터)
    Immune network : official journal of the Korean association of immunobiologists v.5 no.4 ,pp. 221 - 231 , 2005 , 1598-2629 ,

    초록

    Background: Immune regulatory dendritic cells (DCs) play an important role in maintaining self-tolerance. Recent evidences demonstrate that DCs expressing indoleamine 2,3-dioxygenase (IDO), which is involved in tryptophan catabolism, play an important role in immunoregulation and tolerance and induce T cell apoptosis. This study was devised to examine the role of IDO in the oral tolerance induction in collagen-induced arthritis (CIA) mouse model. Methods: Beginning 2 weeks before immunization, CII was fed six times to DBA/1 mice and the effect on arthritis was assessed. In tolerized mice, $CD11c^+$ DCs were isolated and stimulated with CII, IFN- ${\gamma}$ , and LPS with or without IDO inhibitor, 1-methyl-DL-tryptophan (1-MT) and IDO expression by $CD11c^+$ DCs was analyzed using FACS and RT-PCR. The expression of IDO, MHC II, CD80, and CD86 by $CD11c^+$ DCs were examined using confocal microscopy. Regulatory effect of $CD11c^+$ DCs on Ag-specific T cell proliferative response to CII was examined by mixed lymphocyte reaction (MLR) with or without 1-MT. Results: The proportion of IDO-expressing $CD11c^+$ DCs was slightly higher in tolerized mice than in CIA mice and significantly increased after stimulation with CII, IFN- ${\gamma}$ , and LPS in an IDO-dependent manner. On confocal microscopic examination, the expression of IDO was higher and those of MHC II and CD86 were lower in CD11c + DCs from tolerized mice compared to those from CIA mice. On MLR, $CD11c^+$ DCs from tolerized mice inhibited T cell proliferative response to CII in an IDO-dependent manner. Conclusion: Enhanced IDO expression by $CD11c^+$ DCs from tolerized mice may contribute to the regulation of proliferative response of CII-reactive T cells and could be involved in the induction of oral tolerance to CII.

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  6. [국내논문]   훈련방법의 차이가 SOD, Neutrophils 및 T세포에 미치는 영향  

    곽이섭 (동의대학교 레저스포츠학과 ) , 엄상용 (서울여자간호대학 ) , 김동은 (동의대학교 생명공학과 ) , 황혜진 (동의대학교 식품영양학과)
    Immune network : official journal of the Korean association of immunobiologists v.5 no.4 ,pp. 232 - 236 , 2005 , 1598-2629 ,

    초록

    Background: A physically active lifestyle and regular exercise training incurs many health benefits. One recently recognized benefit of regular moderate exercise is stress reduction and immune enhancement. Thus, a physical stress such as exercise may act at any number of points in the complex sequence of events collectively termed the immune response. Although exercise causes many propound changes in parameters of immune function, the nature and magnitude of such changes rely on several factors including the immune parameters of interest; type, intensity, and duration of exercise; fitness level or exercise history of the subject; environmental factors such as ambient temperature and humidity. Methods: This study was undertaken to investigate the effect of different type of exercise on superoxide dismutase (SOD), neutrophils, and T lymphocytes of Sprague-Dawley rats. Sprague-Dawley rats were randomly divided into three groups; a non-Trained group (NTG, n=6), a swim-Trained group (STG), and a treadmill-Trained group (TTG). The exercise regimen was designed in a treadmill (5 times/5 days/week) during 8-weeks for TTG, and swim training (5 times/5 days/week) during 8-weeks for STG, and the volume of exercise training was the same in both groups. Results: 8 weeks of regular swim and treadmill training significantly increased liver SOD concentration however, muscle SOD concentration was not statistically significant. In the level of neutrophils, TTG and STG showed significant difference, compared to NTG. TTG was the highest level of neutrophils. In the level of immune cell counts, there was significant difference among TTG, STG, and NTG both in the spleen and thymus. Conculsion: In conclusion, it can be stated that eight weeks swim and treadmill exercise training has beneficial effect in improving immune response and antioxidant defence capacity by augmenting immune cells and SOD activities of SD rats.

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  7. [국내논문]   사람 단핵구에서 결핵균에 의해 유도되는 CCL3 및 CCL4 발현에 대한 Phospholipase-Protein Kinase C-MEK-ERK 경로의 역할 분석  

    양철수 (충남대학교 의과대학 미생물학교실 ) , 송창화 (충남대학교 의과대학 미생물학교실 ) , 정샛별 (충남대학교 의과대학 미생물학교실 ) , 이길수 (충남대학교 의과대학 미생물학교실 ) , 김수영 (충남대학교 의과대학 미생물학교실 ) , 이지숙 (건양대학교 의과대학 미생물학교실 ) , 신아름 (충남대학교 의과대학 미생물학교실 ) , 오재희 (충남대학교 의과대학 미생물학교실 ) , 권유미 (충남대학교 의과대학 미생물학교실 ) , 김화중 (충남대학교 의과대학 미생물학교실 ) , 박정규 (충남대학교 의과대학 미생물학교실 ) , 백태현 (건양대학교 의과대학 미생물학교실 ) , 조은경 (충남대학교 의과대학 미생물학교실)
    Immune network : official journal of the Korean association of immunobiologists v.5 no.4 ,pp. 237 - 246 , 2005 , 1598-2629 ,

    초록

    Background: Little information is available on the identification and characterization of the upstream regulators of the signal transduction cascades for Mycobacterium tuberculosis (M. tbc)-induced ERK 1/2 activation and chemokine expression. We investigated the signaling mechanisms involved in expression of CCL3 /MIP-1 and CCL4/MIP-1 in human primary monocytes infected with M. tbc. Methods: MAP kinase phosphorylation was determined using western blot analysis with specific primary antibodies (ERK 1/2, and phospho-ERK1/2), and the upstream signaling pathways were further investigated using specific inhibitors. Results: An avirulent strain, M. tbc H37Ra, induced greater and more sustained ERK 1/2 phosphorylation, and higher CCL3 and CCL4 production, than did M. tbc H37Rv. Specific inhibitors for mitogen-activated protein kinase (MAPK) kinase (MEK; U0126 and PD98059) significantly inhibited the expression of CCL3 and CCL4 in human monocytes. Mycobactetia-mediated expression of CCL3 and CCL4 was not inhibited by the Ras inhibitor manumycin A or the Raf-1 inhibitor GW 5074. On the other hand, phospholipase C (PLC) inhibitor (U73122) and protein kinase C (PKC)specific inhibitors ( $G\ddot{o}6976$ and Ro31-8220) significantly reduced M. tbc-induced activation of ERK 1/2 and chemokine synthesis. Conclusion: These results are the first to demonstrate that the PLC-PKC-MEK-ERK, not the Ras-Raf-MEK-ERK, pathway is the major signaling pathway inducing M. tbc-mediated CCL3 and CCL4 expression in human primary monocytes.

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  8. [국내논문]   Corticotropin-Releasing Hormone (CRH)에 의한 인간 자연 살해 세포(NK-92MI)의 Migration 억제  

    천소영 (숙명여자대학교 이과대학 생명과학과 면역학실험실 ) , 방사익 (성균관대학교 의과대학 성형외과학교실 ) , 조대호 (숙명여자대학교 이과대학 생명과학과 면역학실험실)
    Immune network : official journal of the Korean association of immunobiologists v.5 no.4 ,pp. 247 - 251 , 2005 , 1598-2629 ,

    초록

    Background: Natural killer (NK) cells are CD3 (-) CD14 (-) CD56 (+) lymphocytes. They play an important role in the body's innate immune response. They can induce spontaneous killing of cancer cells or virus-infected cells via the Fas/Fas ligand or the granzyme/perforin systems. The corticotropin-releasing hormone (CRH) is an important regulator for the body's stress response. It promotes proliferation and migration of various cancer cells through the CRH type 1 receptor under stress, and also inhibits NK or T cell activity. However, the relationship of CRH and NK cell migration to the target has not been confirmed. Herein, we study the effect of CRH on NK cell migration. Methods: We used the human NK cell line, NK-92MI, and tested the expression of CRH receptor type 1 on NK-92MI by RT-PCR. This was to examine the effect of CRH on tumor and NK cell migration, thus NK cells (NK-92MI) were incubated with or without CRH and then each CRH treated cell's migration ability compared to that of the CRH untreated group. Results: We confirmed that CRH receptor type 1 is expressed in NK-92MI. CRH can decrease NK cell migration in a time-/dose-dependent manner. Conclusion: These data suggest CRH can inhibit NK cell migration to target cells.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  9. [국내논문]   운동이 SAMP8 마우스의 노화와 기억장애에 미치는 영향  

    구우영 (동의대학교 체육학과 ) , 이종수 (부경대학교 식품영양학과 ) , 곽이섭 (동의대학교 레저스포츠학과)
    Immune network : official journal of the Korean association of immunobiologists v.5 no.4 ,pp. 252 - 257 , 2005 , 1598-2629 ,

    초록

    Background: This study was designed to investigate the effect of exercise training on defense mechanism of chronic degenerative disease, aging, and memory impairments of senescence-accelerated mouse (SAM)P8 under the hypothesis that "Senile dementia may be prevented by regular exercises". Methods: To evaluate the effects of exercise training on the defense mechanism of aging and memory impairment, SAMP8 were divided into two groups, the control group and exercise training groups. the exercise training group were performed with low $(\dot{V}O_2max\;25{\sim}33%)$ , middle ( $\dot{V}O_2max$ 50%) and high $(\dot{V}O_2max\;66{\sim}75%)$ intensity exercise. All SAMP8 mice were fed experimental diet ad libitum until 4, 8 months, and dead period. Results: Median lifespan in middle exercise group resulted in a significantly increased (23.5% and 18.7%, respectively), whereas these lifespan in high exercise group resulted in an unexpectedly decreased (13.5% and 12.1%, respectively) compared with control group. Body fat levels in 4 and 8 months of age were significantly decreased 43% to 51% in middle exercise group, whereas were remarkably deceased to 57% in high exercise group compared with control group. It is believed that extended median and maximum lifespan may be effected by calory restriction through the exercise training. Acetylcholine (ACh) levels were significantly increased 6.7% and 8.5% in middle and high exercise groups, and also choline acetyltransfease (ChAT) activities were significantly increased 10.3% and 11.9% in middle and high exercise groups. Conclusion: These results suggest that proper and regular exercises such as middle group ( $\dot{V}O_2max$ 50%) may play an effective role in attenuating an oxygen radicals and may play an important role in improving a learning and memory impairments of senile dementia.

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    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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