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Brain stimulation 47건

  1. [해외논문]   Table of Contents  


    Brain stimulation v.11 no.4 ,pp. A3 - A6 , 2018 , 1935-861x ,

    초록

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   Information for Authors  


    Brain stimulation v.11 no.4 ,pp. A7 - A10 , 2018 , 1935-861x ,

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Editorial Board  


    Brain stimulation v.11 no.4 ,pp. A2 - A2 , 2018 , 1935-861x ,

    초록

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Masthead  


    Brain stimulation v.11 no.4 ,pp. A1 - A1 , 2018 , 1935-861x ,

    초록

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Comparison of cortical responses to the activation of retina by visual stimulation and transcorneal electrical stimulation  

    Sun, Pengcheng (School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China ) , Li, Heng (School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China ) , Lu, Zhuofan (School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China ) , Su, Xiaofan (School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China ) , Ma, Zengguang (School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, China ) , Chen, Jianpin (School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China ) , Li, Liming (School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China ) , Zhou, Chuanqing (School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China ) , Chen, Yao (School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China ) , Chai, Xinyu (School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China)
    Brain stimulation v.11 no.4 ,pp. 667 - 675 , 2018 , 1935-861x ,

    초록

    Abstract Background Electrical stimulation has been widely used in many ophthalmic diseases to modulate neuronal activities or restore partial visual function. Due to the different processing pathways and mechanisms, responses to visual and electrical stimulation in the primary visual cortex and higher visual areas might be different. This differences would shed some light on the properties of cortical responses evoked by electrical stimulation. Objective This study's goal was to directly compare the cortical responses evoked by visual and electrical stimulation and investigate the cortical processing of visual information and extrinsic electrical signal. Methods Optical imaging of intrinsic signals (OIS) was used to probe the cortical hemodynamic responses in 11 cats. Transcorneal electrical stimulation (TES) through an ERG-jet contact lens electrode was used to activate visual cortices. Full-field and peripheral drifting gratings were used as the visual stimuli. Results The response latency evoked by TES was shorter than that responding to visual stimulation (VS). Cortical responses evoked by VS were retinotopically organized, which was consistent with previous studies. On the other hand, the cortical region activated by TES was preferentially located in the secondary visual cortex (Area 18), while the primary visual cortex (Area 17) was activated by a higher current intensity. Compared with the full-field VS, the cortical response in Area 18 to TES with a current intensity above 1.2 mA was significantly stronger. Conclusion According to our results, we provided some evidence that the cortical processing of TES was influenced by the distribution of the electrical field in the retina and the activating threshold of different retinal ganglion cells. Highlights Transcorneal electrical stimulation (TES) elicited shorter cortical response latency than visual stimulation (VS) did. Compared with full-field VS, TES elicited a stronger response in Area 18 with a current intensity greater than 1.2 mA. In superficial cortex, the threshold to activate Area 17 by TES was significantly higher than that to activate Area 18.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Long-lasting effects of transcranial static magnetic field stimulation on motor cortex excitability  

    Dileone, Michele (CINAC, Hospital Universitario HM Puerta del Sur, Universidad CEU-San Pablo, Móstoles, Madrid, Spain ) , Mordillo-Mateos, Laura (Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain ) , Oliviero, Antonio (Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain ) , Foffani, Guglielmo (CINAC, Hospital Universitario HM Puerta del Sur, Universidad CEU-San Pablo, Móstoles, Madrid, Spain)
    Brain stimulation v.11 no.4 ,pp. 676 - 688 , 2018 , 1935-861x ,

    초록

    Abstract Background Transcranial static magnetic field stimulation (tSMS) was recently added to the family of inhibitory non-invasive brain stimulation techniques. However, the application of tSMS for 10–20 min over the motor cortex (M1) induces only short-lasting effects that revert within few minutes. Objective We examined whether increasing the duration of tSMS to 30 min leads to long-lasting changes in cortical excitability, which is critical for translating tSMS toward clinical applications. Methods The study comprised 5 experiments in 45 healthy subjects. We assessed the impact of 30-min-tSMS over M1 on corticospinal excitability, as measured by the amplitude of motor evoked potentials (MEPs) and resting motor thresholds (RMTs) to single-pulse transcranial magnetic stimulation (TMS) (experiments 1–2). We then assessed the impact of 30-min-tSMS on intracortical excitability, as measured by short-interval intracortical facilitation (SICF) and short-interval intracortical inhibition (SICI) using paired-pulse TMS protocols (experiments 2–4). We finally assessed the impact of 10-min-tSMS on SICF and SICI (experiment 5). Results 30-min-tSMS decreased MEP amplitude compared to sham for at least 30 min after the end of the stimulation. This long-lasting effect was associated with increased SICF and reduced SICI. 10-min-tSMS –previously reported to induce a short-lasting decrease in MEP amplitude– produced the opposite changes in intracortical excitability, decreasing SICF while increasing SICI. Conclusions These results suggest a dissociation of intracortical changes in the consolidation from short-lasting to long-lasting decrease of corticospinal excitability induced by tSMS. The long-lasting effects of 30-min-tSMS open the way to the translation of this simple, portable and low-cost technique toward clinical trials. Highlights Transcranial static magnetic field stimulation (tSMS) is a recent, portable and inexpensive brain stimulation technique. 10-min-tSMS induces a short-lasting decrease of corticospinal and intracortical excitability. 30-min-tSMS leads to a long-lasting decrease of corticospinal excitability with an increase of intracortical excitability The short-term effects of 10-min tSMS are attractive for pathophysiological studies. The long-term effects of 30-min tSMS open the way toward clinical applications.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Non-invasive vagus nerve stimulation reduces blood-brain barrier disruption in a rat model of ischemic stroke  

    Yang, Yirong (College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA ) , Yang, Lisa Y. (Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA ) , Orban, Lilla (Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA ) , Cuylear, Darnell (Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA ) , Thompson, Jeffrey (Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA ) , Simon, Bruce (ElectroCore LLC, Basking Ridge, NJ 07920, USA ) , Yang, Yi (Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA)
    Brain stimulation v.11 no.4 ,pp. 689 - 698 , 2018 , 1935-861x ,

    초록

    Abstract Background Vagus nerve stimulation (VNS) significantly reduces infarct volume in rat models of cerebral ischemia, but the mechanism of this protective effect remains open. Hypothesis This study tested the hypothesis that non-invasive VNS (nVNS), during transient middle cerebral artery occlusion (MCAO), protects the blood-brain barrier (BBB), leading to reduced infarct size in ischemic brain. Methods Spontaneous hypertensive rats (SHRs) were subjected to a 90 min MCAO. nVNS treated rats received 5 stimulations (duration: 2 min; every 10 min) on the skin overlying the cervical vagus nerve in the neck beginning 30 min after MCAO onset. Control rats received the same stimulations on the quadriceps femoris muscle. Twenty-four hours after MCAO onset, MRI and immunohistochemistry (IHC) were performed for analyses of infarct size and BBB leakage. Results Compared with the control group, anatomic MRI T2-weighted images showed significantly smaller infarct sizes in the nVNS group. Dynamic contrast-enhanced (DCE)-MRI showed a significantly decreased BBB transfer rate (Ki map) in the lesion area in the nVNS group, which was spatially correlated with the attenuation of the infarct size. Furthermore, significantly lower serum IgG leakage, visualized by IHC, was seen in the ischemic hemisphere in nVNS treated rats. nVNS also protected vascular tight junction proteins from disruption in microvessels, and reduced expression of matrix metalloproteinases-2/9 in reactive astrocytes surrounding the compromised vessels in the ischemic hemispheres. Conclusion Our data suggest that the neuroprotective role of a series of nVNS administrations during MCA occlusion, spatially correlates with protection of BBB integrity from damage and reduction of infarct extent induced by ischemic stroke. Highlights nVNS applied during occlusion of MCA significantly reduced BBB leakage after stroke. Protection of nVNS on BBB integrity was spatially correlated with the attenuation of the infarct size. nVNS protection of BBB from breakdown was associated with reduction of MMP-mediated TJP disruption.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   Short trains of transcutaneous auricular vagus nerve stimulation (taVNS) have parameter-specific effects on heart rate  

    Badran, Bashar W. (Department of Neuroscience, Medical University of South Carolina, Charleston SC 29425, United States ) , Mithoefer, Oliver J. (Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston SC 29425, United States ) , Summer, Caroline E. (Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston SC 29425, United States ) , LaBate, Nicholas T. (College of Charleston, Charleston SC 29403, United States ) , Glusman, Chloe E. (Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston SC 29425, United States ) , Badran, Alan W. (Department of Aviation and Technology, San Jose State University, San Jose CA 95192, United States ) , DeVries, William H. (Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston SC 29425, United States ) , Summers, Philipp M. (Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston SC 29425, United States ) , Austelle, Christopher W. (Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston SC 29425, United States) , McTeague, Lisa M. , Borckardt, Jeffrey J. , George, Mark S.
    Brain stimulation v.11 no.4 ,pp. 699 - 708 , 2018 , 1935-861x ,

    초록

    Abstract Background Optimal parameters of transcutaneous auricular vagus nerve stimulation (taVNS) are still undetermined. Given the vagus nerve's role in regulating heart rate (HR), it is important to determine safety and HR effects of various taVNS parameters. Objective We conducted two sequential trials to systematically test the effects of various taVNS parameters on HR. Methods 15 healthy individuals participated in the initial two-visit, crossover exploratory trial, receiving either tragus (active) or earlobe (control) stimulation each visit. Nine stimulation blocks of varying parameters (pulse width: 100 μs, 200 μs, 500 μs; frequency: 1 Hz, 10 Hz, 25 Hz) were administered each visit. HR was recorded and analyzed for stimulation-induced changes. Using similar methods and the two best parameters from trial 1 (500μs 10 Hz and 500μs 25 Hz), 20 healthy individuals then participated in a follow-up confirmatory study. Results Trial 1- There was no overall effect of the nine conditions on HR during stimulation. However multivariate analysis revealed two parameters that significantly decreased HR during active stimulation compared to control (500μs 10 Hz and 500μs 25 Hz; p Trial 2- For these two conditions, active taVNS significantly decreased HR compared to control (p = 0.02), with the strongest effects at 500μs 10 Hz (p = 0.032). Conclusion These studies suggest that 60s blocks of tragus stimulation are safe, and some specific parameters modulate HR. Of the nine parameters studied, 500μs 10 Hz induced the greatest HR effects. Highlights 2 sequential trials were conducted to explore HR effects of taVNS. The effect on HR of 9 taVNS parameters was explored in trial 1. Both 500μs 10 Hz and 25 Hz determined to optimally decrease HR. Trial 2 reveals greatest HR reduction by active 500 μs, 10 Hz. Future taVNS clinical trials should use either 500μs 10 Hz or 25 Hz

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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    Fig. 1 이미지
  9. [해외논문]   Noisy vestibular stimulation increases gait speed in normals and in bilateral vestibulopathy  

    Iwasaki, Shinichi (Department of Otolaryngology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan ) , Fujimoto, Chisato (Department of Otolaryngology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan ) , Egami, Naoya (Department of Otolaryngology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan ) , Kinoshita, Makoto (Department of Otolaryngology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan ) , Togo, Fumiharu (Educational Physiological Laboratory, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan ) , Yamamoto, Yoshiharu (Educational Physiological Laboratory, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan ) , Yamasoba, Tatsuya (Department of Otolaryngology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan)
    Brain stimulation v.11 no.4 ,pp. 709 - 715 , 2018 , 1935-861x ,

    초록

    Abstract Background Galvanic vestibular stimulation delivered as zero-mean current noise (noisy GVS) has been shown to improve static and dynamic postural stability probably by enhancing vestibular information. Objective /Hypothesis: To examine the effect of an imperceptible level of noisy GVS on dynamic locomotion in normal subjects as well as in patients with bilateral vestibulopathy. Methods Walking performance of 19 healthy subjects and 12 patients with bilateral vestibulopathy at their preferred speed was examined during application of noisy GVS with an amplitude ranging from 0 to 1000 μA. The gait velocity, stride length and stride time were analyzed. Results Noisy GVS had significant effects on gait velocity, stride length and stride time in healthy subjects as well as in patients with bilateral vestibulopathy (p 0.4). Conclusion Noisy GVS is effective in improving gait performance in healthy subjects as well as in patients with bilateral vestibulopathy. Highlights Noisy GVS improved gait velocity, stride length and stride time in healthy subjects. Noisy GVS also improved dynamic walking performance in bilateral vestibulopathy. Improved walking performance was similar to those in healthy subjects without GVS. Noisy GVS is effective in improving dynamic locomotion in bilateral vestibulopathy.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  10. [해외논문]   Exhibition of stochastic resonance in vestibular tilt motion perception  

    Galvan-Garza, R.C. (Man Vehicle Laboratory, Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA, 02139, USA ) , Clark, T.K. (Man Vehicle Laboratory, Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA, 02139, USA ) , Mulavara, A.P. (KBRwyle, 2400 E NASA Pkwy, Houston, TX, 77058, USA ) , Oman, C.M. (Man Vehicle Laboratory, Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA, 02139, USA)
    Brain stimulation v.11 no.4 ,pp. 716 - 722 , 2018 , 1935-861x ,

    초록

    Abstract Background Stochastic Resonance (SR) is a phenomenon broadly described as “noise benefit”. The application of subsensory electrical Stochastic Vestibular Stimulation (SVS) via electrodes behind each ear has been used to improve human balance and gait, but its effect on motion perception thresholds has not been examined. Objective This study investigated the capability of subsensory SVS to reduce vestibular motion perception thresholds in a manner consistent with a characteristic bell-shaped SR curve. Methods We measured upright, head-centered, roll tilt Direction Recognition (DR) thresholds in the dark in 12 human subjects with the application of wideband 0–30 Hz SVS ranging from ±0–700 μA. To conservatively assess if SR was exhibited, we compared the proportions of both subjective and statistical SR exhibition in our experimental data to proportions of SR exhibition in multiple simulation cases with varying underlying SR behavior. Analysis included individual and group statistics. Results As there is not an established mathematical definition, three humans subjectively judged that SR was exhibited in 78% of subjects. “Statistically significant SR exhibition”, which additionally required that a subject's DR threshold with SVS be significantly lower than baseline (no SVS), was present in 50% of subjects. Both percentages were higher than simulations suggested could occur simply by chance. For SR exhibitors, defined by subjective or statistically significant criteria, the mean DR threshold improved by −30% and −39%, respectively. The largest individual improvement was −47%. Conclusion At least half of the subjects were better able to perceive passive body motion with the application of subsensory SVS. This study presents the first conclusive demonstration of SR in vestibular motion perception. Highlights Electrical stochastic vestibular stimulation improves human motion perception. The improvement is consistent with the exhibition of stochastic resonance. Simulations quantified false positive rates of stochastic resonance identification.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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