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권호별목차 / 소장처보기

H : 소장처정보

T : 목차정보

Nature communications 132건

  1. [해외논문]   Finding influential nodes for integration in brain networks using optimal percolation theory  

    Del Ferraro, Gino , Moreno, Andrea , Min, Byungjoon , Morone, Flaviano , Perez-Ramirez, Ursula , Perez-Cervera, Laura , Parra, Lucas C. , Holodny, Andrei , Canals, Santiago , Makse, Hernan A.
    Nature communications v.9 ,pp. ARTN 2274 , 2018 ,

    초록

    Global integration of information in the brain results from complex interactions of segregated brain networks. Identifying the most influential neuronal populations that efficiently bind these networks is a fundamental problem of systems neuroscience. Here, we apply optimal percolation theory and pharmacogenetic interventions in vivo to predict and subsequently target nodes that are essential for global integration of a memory network in rodents. The theory predicts that integration in the memory network is mediated by a set of low-degree nodes located in the nucleus accumbens. This result is confirmed with pharmacogenetic inactivation of the nucleus accumbens, which eliminates the formation of the memory network, while inactivations of other brain areas leave the network intact. Thus, optimal percolation theory predicts essential nodes in brain networks. This could be used to identify targets of interventions to modulate brain function.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  2. [해외논문]   In-built thermo-mechanical cooperative feedback mechanism for self-propelled multimodal locomotion and electricity generation  

    Wang, Xiao-Qiao , Tan, Chuan Fu , Chan, Kwok Hoe , Lu, Xin , Zhu, Liangliang , Kim, Sang-Woo , Ho, Ghim Wei
    Nature communications v.9 ,pp. ARTN 3438 , 2018 ,

    초록

    Utilization of ubiquitous low-grade waste heat constitutes a possible avenue towards soft matter actuation and energy recovery opportunities. While most soft materials are not all that smart relying on power input of some kind for continuous response, we conceptualize a self-locked thermo-mechano feedback for autonomous motility and energy generation functions. Here, the low-grade heat usually dismissed as 'not useful' is used to fuel a soft thermo-mechano-electrical system to perform perpetual and untethered multimodal locomotions. The innately resilient locomotion synchronizes self-governed and auto-sustained temperature fluctuations and mechanical mobility without external stimulus change, enabling simultaneous harvesting of thermo- mechanical energy at the pyro/piezoelectric mechanistic intersection. The untethered soft material showcases deterministic motions (translational oscillation, directional rolling, and clockwise/anticlockwise rotation), rapid transitions and dynamic responses without needing power input, on the contrary extracting power from ambient. This work may open opportunities for thermo-mechano-electrical transduction, multigait soft energy robotics and waste heat harvesting technologies.

    원문보기

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  3. [해외논문]   Differential coding of reward and movement information in the dorsomedial striatal direct and indirect pathways  

    Shin, Jung Hwan , Kim, Dohoung , Jung, Min Whan
    Nature communications v.9 ,pp. ARTN 404 , 2018 ,

    초록

    The direct and indirect pathways of the basal ganglia have long been thought to mediate behavioral promotion and inhibition, respectively. However, this classic dichotomous model has been recently challenged. To better understand neural processes underlying reward-based learning and movement control, we recorded from direct (dSPNs) and indirect (iSPNs) pathway spiny projection neurons in the dorsomedial striatum of D1-Cre and D2-Cre mice performing a probabilistic Pavlovian conditioning task. dSPNs tend to increase activity while iSPNs decrease activity as a function of reward value, suggesting the striatum represents value in the relative activity levels of dSPNs versus iSPNs. Lick offset-related activity increase is largely dSPN selective, suggesting dSPN involvement in suppressing ongoing licking behavior. Rapid responses to negative outcome and previous reward-related responses are more frequent among iSPNs than dSPNs, suggesting stronger contributions of iSPNs to outcome-dependent behavioral adjustment. These findings provide new insights into striatal neural circuit operations.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  4. [해외논문]   Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function   SCI SCIE

    Wyss, Annah B. (Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, 27709 USA ) , Sofer, Tamar (Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115 USA ) , Lee, Mi Kyeong (Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, 27709 USA ) , Terzikhan, Natalie (Department of Respiratory Medicine, Ghent University Hospital, Ghent, 9000 Belgium ) , Nguyen, Jennifer N. (Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908 USA ) , Lahousse, Lies (Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3000 CA The Netherlands ) , Latourelle, Jeanne C. (Department of Neurology, Boston University School of Medicine, Boston, MA 02118 USA ) , Smith, Albert Vernon (Icelandic Heart Association, Kopavogur, 201 Iceland ) , Bartz, Traci M. (Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101 USA ;) , Feitosa, Mary F. , Gao, Wei , Ahluwalia, Tarunveer S. , Tang, Wenbo , Oldmeadow, Christopher , Duan, Qing , de Jong, Kim , Wojczynski, Mary K. , Wang, Xin-Qun , Noordam, Raymond , Hartwig, Fernando Pires , Jackson, Victoria E. , Wang, Tianyuan , Obeidat, Ma'en , Hobbs, Brian D. , Huan, Tianxiao , Gui, Hongsheng , Parker, Margaret M. , Hu, Donglei , Mogil, Lauren S. , Kichaev, Gleb , Jin, Jianping , Graff, Mariaelisa , Harris, Tamara B. , Kalhan, Ravi , Heckbert, Susan R. , Paternoster, Lavinia , Burkart, Kristin M. , Liu, Yongmei , Holliday, Elizabeth G. , Wilson, James G. , Vonk, Judith M. , Sanders, Jason L. , Barr, R. Graham , de Mutsert, René , e , Menezes, Ana Maria Baptista , Adams, Hieab H. H. , van den Berge, Maarten , Joehanes, Roby , Levin, Albert M. , Liberto, Jennifer , Launer, Lenore J. , Morriso
    Nature communications v.9 ,pp. 2976 , 2018 ,

    초록

    Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European ( N = 60,552), African ( N = 8429), Asian ( N = 9959), and Hispanic/Latino ( N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12 . Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci. Pulmonary function is influenced by environmental factors, lifestyle, and genetics. Here, in a multiethnic GWAS meta-analysis for pulmonary function traits, the authors identify over 50 additional genetic loci, a subset of which are specific for European, African, Asian, or Hispanic/Latino ancestry.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  5. [해외논문]   Energy-efficient CO2 hydrogenation with fast response using photoexcitation of CO2 adsorbed on metal catalysts   SCI SCIE

    Kim, Chanyeon , Hyeon, Seokwon , Lee, Jonghyeok , Kim, Whi Dong , Lee, Doh C. , Kim, Jihan , Lee, Hyunjoo
    Nature communications v.9 ,pp. 3027 , 2018 ,

    초록

    Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European ( N = 60,552), African ( N = 8429), Asian ( N = 9959), and Hispanic/Latino ( N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12 . Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci. Pulmonary function is influenced by environmental factors, lifestyle, and genetics. Here, in a multiethnic GWAS meta-analysis for pulmonary function traits, the authors identify over 50 additional genetic loci, a subset of which are specific for European, African, Asian, or Hispanic/Latino ancestry.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  6. [해외논문]   Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids   SCI SCIE

    Jung, Kwang Bo , Lee, Hana , Son, Ye Seul , Lee, Mi-Ok , Kim, Young-Dae , Oh, Soo Jin , Kwon, Ohman , Cho, Sunwha , Cho, Hyun-Soo , Kim, Dae-Soo , Oh, Jung-Hwa , Zilbauer, Matthias , Min, Jeong-Ki , Jung, Cho-Rok , Kim, Janghwan , Son, Mi-Young
    Nature communications v.9 ,pp. 3039 , 2018 ,

    초록

    Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European ( N = 60,552), African ( N = 8429), Asian ( N = 9959), and Hispanic/Latino ( N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12 . Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci. Pulmonary function is influenced by environmental factors, lifestyle, and genetics. Here, in a multiethnic GWAS meta-analysis for pulmonary function traits, the authors identify over 50 additional genetic loci, a subset of which are specific for European, African, Asian, or Hispanic/Latino ancestry.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  7. [해외논문]   Directed evolution of CRISPR-Cas9 to increase its specificity   SCI SCIE

    Lee, Jungjoon K. , Jeong, Euihwan , Lee, Joonsun , Jung, Minhee , Shin, Eunji , Kim, Young-hoon , Lee, Kangin , Jung, Inyoung , Kim, Daesik , Kim, Seokjoong , Kim, Jin-Soo
    Nature communications v.9 ,pp. 3048 , 2018 ,

    초록

    Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European ( N = 60,552), African ( N = 8429), Asian ( N = 9959), and Hispanic/Latino ( N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12 . Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci. Pulmonary function is influenced by environmental factors, lifestyle, and genetics. Here, in a multiethnic GWAS meta-analysis for pulmonary function traits, the authors identify over 50 additional genetic loci, a subset of which are specific for European, African, Asian, or Hispanic/Latino ancestry.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  8. [해외논문]   Development of MPFC function mediates shifts in self-protective behavior provoked by social feedback   SCI SCIE

    Yoon, Leehyun , Somerville, Leah H. , Kim, Hackjin
    Nature communications v.9 ,pp. 3086 , 2018 ,

    초록

    Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European ( N = 60,552), African ( N = 8429), Asian ( N = 9959), and Hispanic/Latino ( N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12 . Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci. Pulmonary function is influenced by environmental factors, lifestyle, and genetics. Here, in a multiethnic GWAS meta-analysis for pulmonary function traits, the authors identify over 50 additional genetic loci, a subset of which are specific for European, African, Asian, or Hispanic/Latino ancestry.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  9. [해외논문]   A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy   SCI SCIE

    Yang, Letao , Chueng, Sy-Tsong Dean , Li, Ying , Patel, Misaal , Rathnam, Christopher , Dey, Gangotri , Wang, Lu , Cai, Li , Lee, Ki-Bum
    Nature communications v.9 ,pp. 3147 , 2018 ,

    초록

    Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European ( N = 60,552), African ( N = 8429), Asian ( N = 9959), and Hispanic/Latino ( N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12 . Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci. Pulmonary function is influenced by environmental factors, lifestyle, and genetics. Here, in a multiethnic GWAS meta-analysis for pulmonary function traits, the authors identify over 50 additional genetic loci, a subset of which are specific for European, African, Asian, or Hispanic/Latino ancestry.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  10. [해외논문]   Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine   SCI SCIE

    Ribeiro, Efrain A. , Salery, Marine , Scarpa, Joseph R. , Calipari, Erin S. , Hamilton, Peter J. , Ku, Stacy M. , Kronman, Hope , Purushothaman, Immanuel , Juarez, Barbara , Heshmati, Mitra , Doyle, Marie , Lardner, Casey , Burek, Dominicka , Strat, Ana , Pirpinias, Stephen , Mouzon, Ezekiell , Han, Ming-Hu , Neve, Rachael L. , Bagot, Rosemary C. , Kasarskis, Andrew , Koo, Ja Wook , Nestler, Eric J.
    Nature communications v.9 ,pp. 3149 , 2018 ,

    초록

    Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European ( N = 60,552), African ( N = 8429), Asian ( N = 9959), and Hispanic/Latino ( N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12 . Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci. Pulmonary function is influenced by environmental factors, lifestyle, and genetics. Here, in a multiethnic GWAS meta-analysis for pulmonary function traits, the authors identify over 50 additional genetic loci, a subset of which are specific for European, African, Asian, or Hispanic/Latino ancestry.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지

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