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Scientific reports 21055건

  1. [해외논문]   Erratum: Erratum: g-force induced giant efficiency of nanoparticles internalization into living cells   SCI SCIE SCOPUS

    Ocampo, Sandra M. , Rodriguez, Vanessa , de la Cueva, Leonor , Salas, Gorka , Carrascosa, Jose L. , Rodrí , guez, Marí , a Josefa , Garcí , a-Romero, Noemí , , Cuñ , ado, Jose Luis F. , Camarero, Julio , Miranda, Rodolfo , Belda-Iniesta, Cristobal , Ayuso-Sacido, Angel
    Scientific reports v.6 , 2016 ,

    초록

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease   SCI SCIE

    Cappello, Valentina (Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia Piazza San Silvestro, 12, 56127, Pisa, Italy. valentina.cappello@iit.it ) , Marchetti, Laura (Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia Piazza San Silvestro, 12, 56127, Pisa, Italy ) , Parlanti, Paola (Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia Piazza San Silvestro, 12, 56127, Pisa, Italy ) , Landi, Silvia (NEST, Scuola Normale Superiore, Piazza San Silvestro 12, 56127, Pisa, Italy ) , Tonazzini, Ilaria (NEST, Istituto Nanoscienze-CNR, Piazza San Silvestro 12, 56127, Pisa, Italy ) , Cecchini, Marco (NEST, Istituto Nanoscienze-CNR, Piazza San Silvestro 12, 56127, Pisa, Italy ) , Piazza, Vincenzo (Fondazione Umberto Veronesi, Piazza Velasca 5, 20122, Milano, Italy ) , Gemmi, Mauro (NEST, Scuola Normale Superiore, Piazza San Silvestro 12, 56127, Pisa, Italy )
    Scientific reports v.6 ,pp. 1 - 1 , 2016 ,

    초록

    Krabbe disease (KD) is a neurodegenerative disorder caused by the lack of β- galactosylceramidase enzymatic activity and by widespread accumulation of the cytotoxic galactosyl-sphingosine in neuronal, myelinating and endothelial cells. Despite the wide use of Twitcher mice as experimental model for KD, the ultrastructure of this model is partial and mainly addressing peripheral nerves. More details are requested to elucidate the basis of the motor defects, which are the first to appear during KD onset. Here we use transmission electron microscopy (TEM) to focus on the alterations produced by KD in the lower motor system at postnatal day 15 (P15), a nearly asymptomatic stage, and in the juvenile P30 mouse. We find mild effects on motorneuron soma, severe ones on sciatic nerves and very severe effects on nerve terminals and neuromuscular junctions at P30, with peripheral damage being already detectable at P15. Finally, we find that the gastrocnemius muscle undergoes atrophy and structural changes that are independent of denervation at P15. Our data further characterize the ultrastructural analysis of the KD mouse model, and support recent theories of a dying-back mechanism for neuronal degeneration, which is independent of demyelination.

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    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Generation of mutation hotspots in ageing bacterial colonies   SCI SCIE

    Sekowska, Agnieszka (Institute of Cardiometabolism and Nutrition, CHU Pitié-Salpêtrière, 47, Boulevard de l'Hôpital, 75013, Paris, France ) , Wendel, Sofie (Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK-2970, Hørsholm, Denmark ) , Fischer, Emil C. (Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK-2970, Hørsholm, Denmark ) , Nørholm, Morten H. H. (Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK-2970, Hørsholm, Denmark. morno@biosustain.dtu.dk ) , Danchin, Antoine (Institute of Cardiometabolism and Nutrition, CHU Pitié-Salpêtrière, 47, Boulevard de l'Hôpital, 75013, Paris, France. antoine.danchin@normalesup.org)
    Scientific reports v.6 ,pp. 2 - 2 , 2016 ,

    초록

    How do ageing bacterial colonies generate adaptive mutants? Over a period of two months, we isolated on ageing colonies outgrowing mutants able to use a new carbon source, and sequenced their genomes. This allowed us to uncover exquisite details on the molecular mechanism behind their adaptation: most mutations were located in just a few hotspots in the genome, and over time, mutations increasingly were consistent with the involvement of 8-oxo-guanosine, formed exclusively on the transcribed strand. This work provides strong support for retromutagenesis as a general process creating adaptive mutations during ageing.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

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  4. [해외논문]   Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer   SCI SCIE

    Fu, Leilei (State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China ) , Wang, Shuya (State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China ) , Wang, Xuan (Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois, 60611, USA ) , Wang, Peiqi (State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China ) , Zheng, Yaxin (State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China ) , Yao, Dahong (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China ) , Guo, Mingrui (State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan Un) , Zhang, Lan , Ouyang, Liang
    Scientific reports v.6 ,pp. 3 - 3 , 2016 ,

    초록

    Poly (ADP-ribose) polymerase-1 (PARP1) is a highly conserved enzyme focused on the self-repair of cellular DNA damage. Until now, numbers of PARP inhibitors have been reported and used for breast cancer therapy in recent years, especially in TNBC. However, developing a new type PARP inhibitor with distinctive skeleton is alternatively promising strategy for TNBC therapy. In this study, based on co-crystallization studies and pharmacophore-docking-based virtual screening, we discovered a series of dihydrodibenzo[b,e]-oxepin compounds as PARP1 inhibitors. Lead optimization result in the identification of compound OL-1 (2-(11-(3-(dimethylamino)propylidene)-6,11- dihydrodibenzo[b,e]oxepin )-2-yl)acetohydrazide), which has a novel chemical scaffold and unique binding interaction with PARP1 protein. OL-1 demonstrated excellent potency (inhibiting PARP1 enzyme activity with IC 50  = 0.079 μM), as well as inhibiting PARP-modulated PARylation and cell proliferation in MDA-MB-436 cells (BRAC1 mutation). In addition, OL-1 also inhibited cell migration that closely related to cancer metastasis and displayed remarkable anti-tumor efficacy in MDA-MB-436 xenograft model without apparent toxicities. These findings highlight a new small-molecule PAPR1 inhibitor (OL-1) that has the potential to impact future TNBC therapy.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  5. [해외논문]   Mitigating Herding in Hierarchical Crowdsourcing Networks   SCI SCIE

    Yu, Han (Joint NTU-UBC Research Centre of Excellence in Active Living for the Elderly (LILY), Nanyang Technological University,, Singapore, Singapore. han.yu@ntu.edu.sg ) , Miao, Chunyan (Joint NTU-UBC Research Centre of Excellence in Active Living for the Elderly (LILY), Nanyang Technological University,, Singapore, Singapore. ascymiao@ntu.edu.sg ) , Leung, Cyril (School of Computer Science and Engineering, Nanyang Technological University, Singapore, Singapore. ascymiao@ntu.edu.sg ) , Chen, Yiqiang (Joint NTU-UBC Research Centre of Excellence in Active Living for the Elderly (LILY), Nanyang Technological University,, Singapore, Singapore ) , Fauvel, Simon (Department of Electrical and Computer Engineering, The University of British Columbia, Vancouver, BC, Canada ) , Lesser, Victor R. (Joint NTU-UBC Research Centre of Excellence in Active Living for the Elderly (LILY), Nanyang Technological University,, Singapore, Singapore. yqchen@ict.ac.cn ) , Yang, Qiang (Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China. yqchen@ict.ac.cn )
    Scientific reports v.6 ,pp. 4 - 4 , 2016 ,

    초록

    Hierarchical crowdsourcing networks (HCNs) provide a useful mechanism for social mobilization. However, spontaneous evolution of the complex resource allocation dynamics can lead to undesirable herding behaviours in which a small group of reputable workers are overloaded while leaving other workers idle. Existing herding control mechanisms designed for typical crowdsourcing systems are not effective in HCNs. In order to bridge this gap, we investigate the herding dynamics in HCNs and propose a Lyapunov optimization based decision support approach - the Reputation-aware Task Sub-delegation approach with dynamic worker effort Pricing (RTS-P) - with objective functions aiming to achieve superlinear time-averaged collective productivity in an HCN. By considering the workers’ current reputation, workload, eagerness to work, and trust relationships, RTS-P provides a systematic approach to mitigate herding by helping workers make joint decisions on task sub-delegation, task acceptance, and effort pricing in a distributed manner. It is an individual-level decision support approach which results in the emergence of productive and robust collective patterns in HCNs. High resolution simulations demonstrate that RTS-P mitigates herding more effectively than state-of-the-art approaches.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  6. [해외논문]   Mixing of quantum states: A new route to creating optical activity   SCI SCIE

    Baimuratov, Anvar S. (ITMO University, 197101, Saint Petersburg, Russia ) , Tepliakov, Nikita V. (ITMO University, 197101, Saint Petersburg, Russia ) , Gun'ko, Yurii K. (ITMO University, 197101, Saint Petersburg, Russia ) , Baranov, Alexander V. (School of Chemistry and CRANN Institute, Trinity College, Dublin, Dublin 2, Ireland ) , Fedorov, Anatoly V. (ITMO University, 197101, Saint Petersburg, Russia ) , Rukhlenko, Ivan D. (ITMO University, 197101, Saint Petersburg, Russia )
    Scientific reports v.6 ,pp. 5 - 5 , 2016 ,

    초록

    The ability to induce optical activity in nanoparticles and dynamically control its strength is of great practical importance due to potential applications in various areas, including biochemistry, toxicology, and pharmaceutical science. Here we propose a new method of creating optical activity in originally achiral quantum nanostructures based on the mixing of their energy states of different parities. The mixing can be achieved by selective excitation of specific states or via perturbing all the states in a controllable fashion. We analyze the general features of the so produced optical activity and elucidate the conditions required to realize the total dissymmetry of optical response. The proposed approach is applicable to a broad variety of real systems that can be used to advance chiroptical devices and methods.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  7. [해외논문]   Polarization conversion when focusing cylindrically polarized vortex beams   SCI SCIE

    Porfirev, Alexey P. (Samara National Research University, Technical Cybernetics Department, Samara, 443086, Russia. lporfirev@rambler.ru ) , Ustinov, Andrey V. (Image Processing Systems Institute - Branch of the Federal Scientific Research Centre “Crystallography and Photonics” of Russian Academy of Sciences, Samara, 443001, Russia. lporfirev@rambler.ru ) , Khonina, Svetlana N. (Samara National Research University, Technical Cybernetics Department, Samara, 443086, Russia )
    Scientific reports v.6 ,pp. 6 - 6 , 2016 ,

    초록

    Currently, cylindrical beams with radial or azimuthal polarization are being used successfully for the optical manipulation of micro- and nano-particles as well as in microscopy, lithography, nonlinear optics, materials processing, and telecommunication applications. The creation of these laser beams is carried out using segmented polarizing plates, subwavelength gratings, interference, or light modulators. Here, we demonstrate the conversion of cylindrically polarized laser beams from a radial to an azimuthal polarization, or vice versa, by introducing a higher-order vortex phase singularity. To simultaneously generate several vortex phase singularities of different orders, we utilized a multi-order diffractive optical element. Both the theoretical and the experimental results regarding the radiation transmitted through the diffractive optical element show that increasing the order of the phase singularity leads to more efficient conversation of the polarization from radial to azimuthal. This demonstrates a close connection between the polarization and phase states of electromagnetic beams, which has important implications in many optical experiments.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  8. [해외논문]   Cardioprotective effects of Cu(II)ATSM in human vascular smooth muscle cells and cardiomyocytes mediated by Nrf2 and DJ-1   SCI SCIE

    Srivastava, Salil (Cardiovascular Division, British Heart Foundation Centre of Research Excellence, Faculty of Life Sciences & Medicine, King's College London, 150 Stamford Street, London, SE1 9NH, UK ) , Blower, Philip J. (Imaging Sciences & Biomedical Engineering Division, British Heart Foundation Centre of Research Excellence, Faculty of Life Sciences & Medicine, King's College London, The Rayne Institute, St. Thomas' Hospital, London, SE1 7EH, UK ) , Aubdool, Aisah A. (Cardiovascular Division, British Heart Foundation Centre of Research Excellence, Faculty of Life Sciences & Medicine, King's College London, 150 Stamford Street, London, SE1 9NH, UK ) , Hider, Robert C. (Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, 150 Stamford Street, London, SE1 9NH, UK ) , Mann, Giovanni E. (Cardiovascular Division, British Heart Foundation Centre of Research Excellence, Faculty of Life Sciences & Medicine, King's College London, 150 Stamford Street, London, SE1 9NH, UK. richard.siow@kcl.ac.uk) , Siow, Richard C.
    Scientific reports v.6 ,pp. 7 - 7 , 2016 ,

    초록

    Cu (II) ATSM was developed as a hypoxia sensitive positron emission tomography agent. Recent reports have highlighted the neuroprotective properties of Cu (II) ATSM, yet there are no reports that it confers cardioprotection. We demonstrate that Cu (II) ATSM activates the redox-sensitive transcription factor Nrf2 in human coronary artery smooth muscle cells (HCASMC) and cardiac myocytes (HCM), leading to upregulation of antioxidant defense enzymes. Oral delivery of Cu (II) ATSM in mice induced expression of the Nrf2-regulated enzymes in the heart and aorta. In HCASMC, Cu (II) ATSM increased expression of the Nrf2 stabilizer DJ-1, and knockdown of Nrf2 or DJ-1 attenuated Cu (II) ATSM-mediated heme oxygenase-1 and NADPH quinone oxidoreductase-1 induction. Pre-treatment of HCASMC with Cu (II) ATSM protected against the pro-oxidant effects of angiotensin II (Ang II) by attenuating superoxide generation, apoptosis, proliferation and increases in intracellular calcium. Notably, Cu (II) ATSM-mediated protection against Ang II-induced HCASMC apoptosis was diminished by Nrf2 knockdown. Acute treatment with Cu (II) ATSM enhanced the association of DJ-1 with superoxide dismutase-1 (SOD1), paralleled by significant increases in intracellular Cu (II) levels and SOD1 activity. We describe a novel mechanism by which Cu (II) ATSM induces Nrf2-regulated antioxidant enzymes and protects against Ang II-mediated HCASMC dysfunction via activation of the Nrf2/DJ-1 axis. Cu (II) ATSM may provide a therapeutic strategy for cardioprotection via upregulation of antioxidant defenses.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Controllable and fast quantum-information transfer between distant nodes in two-dimensional networks   SCI SCIE

    Zhong, Zhi-Rong (Department of Physics, Fuzhou University, Fuzhou, 350002, P. R. China. zhirz@fzu.edu.cn)
    Scientific reports v.6 ,pp. 8 - 8 , 2016 ,

    초록

    We construct shortcuts to adiabatic passage to achieve controllable and fast quantum-information transfer (QIT) between arbitrary two distant nodes in a two-dimensional (2D) quantum network. Through suitable designing of time-dependent Rabi frequencies, we show that perfect QIT between arbitrary two distant nodes can be rapidly achieved. Numerical simulations demonstrate that the proposal is robust to the decoherence caused by atomic spontaneous emission and cavity photon leakage. Additionally, the proposed scheme is also insensitive to the variations of the experimental parameters. Thus, the proposed scheme provides a new perspective on robust quantum information processing in 2D quantum networks.

    원문보기

    원문보기
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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

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  10. [해외논문]   Nitric Oxide (NO) Mediates the Inhibition of Form-Deprivation Myopia by Atropine in Chicks   SCI SCIE

    Carr, Brittany J. (Neuroscience Graduate Program, Snyder Institute for Chronic Diseases, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Calgary, Alberta, Canada ) , Stell, William K. (Department of Cell Biology and Anatomy and Department of Surgery)
    Scientific reports v.6 ,pp. 9 - 9 , 2016 ,

    초록

    Myopia is the most common childhood refractive disorder. Atropine inhibits myopia progression, but its mechanism is unknown. Here, we show that myopia-prevention by atropine requires production of nitric oxide (NO). Form-deprivation myopia (FDM) was induced in week-old chicks by diffusers over the right eye (OD); the left eye (OS) remained ungoggled. On post-goggling days 1, 3, and 5, OD received intravitreally 20 μL of phosphate-buffered saline (vehicle), or vehicle plus: NO source: L-arginine (L-Arg, 60–6,000 nmol) or sodium nitroprusside (SNP, 10–1,000 nmol); atropine (240 nmol); NO inhibitors: L-NIO or L-NMMA (6 nmol); negative controls: D-Arg (10 μmol) or D-NMMA (6 nmol); or atropine plus L-NIO, L-NMMA, or D-NMMA; OS received vehicle. On day 6 post-goggling, refractive error, axial length, equatorial diameter, and wet weight were measured. Vehicle-injected goggled eyes developed significant FDM. This was inhibited by L-Arg (ED50 = 400 nmol) or SNP (ED50 = 20 nmol), but not D-Arg. Higher-dose SNP, but not L-Arg, was toxic to retina/RPE. Atropine inhibited FDM as expected; adding NOS-inhibitors (L-NIO, L-NMMA) to atropine inhibited this effect dose-dependently, but adding D-NMMA did not. Equatorial diameter, wet weight, and metrics of control eyes were not affected by any treatment. In summary, intraocular NO inhibits myopia dose-dependently and is obligatory for inhibition of myopia by atropine.

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