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Case reports in hepatology 24건

  1. [해외논문]   Fulminant Liver Failure Associated with Abdominal Crush Injury in an Eleven-Year Old: A Case Report  

    Gordon, Erin (Department of Pediatrics, Division of Critical Care, University of Iowa Children's Hospital, Iowa City, IA 52242, USA ) , Kamath, Sameer (Department of Pediatrics, Division of Critical Care, University of Iowa Children's Hospital, Iowa City, IA 52242, USA)
    Case reports in hepatology v.2013 ,pp. 1 - 5 , 2013 , 2090-6587 ,

    초록

    An 11-year-old obese male was involved in an all-terrain vehicle rollover accident. He had elevated transaminase levels along with a lactic acidosis. The imaging studies did not reveal any major intra-abdominal or thoracic injuries. The physical exam was unremarkable. The patient had an unremarkable PICU course and was transferred to the floor the next day. Within 24 hours of his transfer, he was noted to have interval worsening in liver function tests. He developed fulminant liver failure (FLF), renal failure, and encephalopathy. An ultrasound of the liver revealed increased echogenicity in the right lobe with focal sparing. Patient was listed for transplant. Investigations into any underlying medical cause of FLF were negative. Liver failure was presumed to be related to ischemia/reperfusion injury of the liver. The renal failure was due to rhabdomyolysis and was supported with renal replacement therapy. Patient received supportive care for FLF and was noted to have significant recovery of liver and renal function with time. He was discharged home after a 3-week hospitalization. Patients with crush abdominal injuries and elevated transaminase levels without evidence of parenchymal liver disruption may need to be closely monitored for liver failure related to ischemia reperfusion.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  2. [해외논문]   Death from Liver Failure despite Lamivudine Prophylaxis during R-CHOP Chemotherapy due to Rapid Emergence M204 Mutations  

    Win, Lay Lay (Hepatology, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, 6b-176, Toronto, ON, Canada M5T 2S8 ) , Powis, Jeff (Infectious Diseases, Toronto East General Hospital, 825 Coxwell Avenue, East York, ON, Canada M4C 3E7 ) , Shah, Hemant (Hepatology, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, 6b-176, Toronto, ON, Canada M5T 2S8 ) , Feld, Jordan J. (Hepatology, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, 6b-176, Toronto, ON, Canada M5T 2S8 ) , Wong, David K. (Hepatology, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, 6b-176, Toronto, ON, Canada M5T 2S8)
    Case reports in hepatology v.2013 ,pp. 1 - 5 , 2013 , 2090-6587 ,

    초록

    Background . Rapid and early emergence of clinically significant LAM resistance is thought to be unlikely during the first year of treatment, and as a result LAM is thought to be a reasonable choice as a first line agent for prophylaxis during chemotherapy. Aim . To report fatal HBV reactivation despite appropriate LAM prophylaxis in two previously treatment-naive individuals undergoing R-CHOP chemotherapy. Case Presentation . Case 1 is a 65-year-old man with chronic HBV infection: HBeAg-negative, HBV DNA 6.65E5 IU/mL, ALT 43 IU/L, and Fibroscan 4.4 kPa, consistent with F0, who was diagnosed with lymphoma that was treated with R-CHOP and LAM prophylaxis. HBV DNA fell to 2.18E1 IU/mL within 2 months of starting LAM. Four months after chemotherapy, despite ongoing LAM of 7-month duration with confirmed adherence, severe asymptomatic hepatitis was noted during routine monitoring with ALT 1019 IU/L, HBeAg negative, HBV DNA 1.43E7 IU/mL, and genotyping confirmed L80I and M204I mutations. He died 14 days after flare diagnosis despite a switch to tenofovir (HBV DNA had fallen to 1.94E5 IU/mL 2 weeks after starting tenofovir). Case 2 is a 50-year-old man who was found to have HBeAg-negative hepatitis B, ALT 37 IU/L, and no clinical features of cirrhosis (platelets 283, APRI 0.19) after lymphoma diagnosis. Lymphoma was treated with R-CHOP and LAM prophylaxis. Pretreatment HBV DNA was not done but was 8.90E4 IU/mL 3 weeks after starting LAM and 3.96E3 IU/mL 3 months after starting LAM. Two months after chemotherapy, despite ongoing LAM of 7-month duration with confirmed adherence, severe symptomatic hepatitis presenting with jaundice, abdominal pain, and confusion was noted. ALT 902 IU/L, HBeAg negative, HBV DNA 1.02E8 IU/mL, and genotyping confirmed L80I, M80V, and M204V/S mutations. He died 3 days after flare diagnosis despite the addition of tenofovir. Conclusion . Lamivudine should not be used for prophylaxis of patients with chronic hepatitis B with detectable HBV DNA undergoing chemotherapy with rituximab containing cytotoxic chemotherapy even if they have never had exposure to lamivudine in the past. In this setting, lamivudine failure due to resistance can develop quickly leading to liver failure that cannot be salvaged with tenofovir. Whether LAM is safe for prophylaxis with rituximab-based cytotoxic chemotherapy for patients with undetectable HBV DNA is unknown, but agents with a high barrier to resistance may be preferable.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  3. [해외논문]   Pleuro-Pulmonary Nocardiosis as Opportunistic Infection in a Patient with Chronic Hepatitis C under Combination Treatment with Pegylated Interferon, Ribavirin, and Boceprevir  

    Putz-Bankuti, Csilla , Kessler, Harald H. , Valentin, Thomas , Leitner, Eva , Talakic, Emina , Schoellnast, Helmut , Fickert, Peter , Krejs, Guenter J. , Stauber, Rudolf E.
    Case reports in hepatology v.2013 ,pp. 1 - 4 , 2013 , 2090-6587 ,

    초록

    Nocardiosis is an infrequent but serious pulmonary infection caused by Gram-positive aerobic actinomycetes. In this paper, we report on a 48-year-old patient with pleuropulmonary nocardiosis and cirrhosis due to chronic hepatitis C virus infection treated with triple antiviral treatment complicated by prolonged neutropenia.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Hypofractionated Stereotactic Radiotherapy after Transarterial Chemoembolisation Failure in an Unresectable Hepatocellular Carcinoma: A Case Presentation  

    Fiorica, Francesco (Department of Radiation Oncology, University Hospital “S. Anna,” Corso Giovecca 203, 44100 Ferrara, Italy ) , Greco, Carlo (Department of Radiation Oncology, University Hospital “S. Chiara,” Via Roma 67, 56126 Pisa, Italy ) , Boccia, Sergio (Department of Gastroenterology, University Hospital “S. Anna,” Via Aldo Moro 8, 44124 Ferrara, Italy ) , Sartori, Sergio (Department of Internal Medicine, Section of Interventional Ultrasound, University Hospital “S. Anna,” Via Aldo Moro 8, 44124 Ferrara, Italy ) , Stefanelli, Antonio (Department of Radiation Oncology, University Hospital “S. Anna,” Corso Giovecca 203, 44100 Ferrara, Italy ) , Cartei, Francesco (Department of Radiation Oncology, University Hospital “S. Anna,” Corso Giovecca 203, 44100 Ferrara, Italy ) , Ursino, Stefano (Department of Radiation Oncology, University Hospital “S. Anna,” Corso Giovecca 203, 44100 Ferrara, Italy)
    Case reports in hepatology v.2013 ,pp. 1 - 4 , 2013 , 2090-6587 ,

    초록

    Introduction . Transarterial chemoembolization is the first-line treatment in unresectable hepatocellular carcinoma. There is no standard treatment after transarterial chemoembolization failure. We report the case of a patient with advanced hepatocellular carcinoma who showed a complete response and a long cancer control with hypofractionated stereotactic radiotherapy after transarterial chemoembolization failure. Case Presentation . A 70-year-old Caucasian woman was treated with transarterial chemoembolization for advanced hepatocellular, but no cancer control was obtained. A hypofractionated stereotactic radiotherapy was planned delivering 40 Gy in 5 fractions. A dramatic reduction in alpha-fetoprotein was observed. Contrast-enhanced ultrasonography at 1 and 2 months showed large necrotic areas. Computerised tomography scan showed a 90% objective tumour response, then a complete remission at 3 and 6 months after treatment, respectively. Status of patient remained unchanged for 2 years. Conclusions . Hypofractionated stereotactic radiotherapy can improve survival and prognosis of unresectable hepatocellular carcinoma patient.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Hepatitis B Virus Reactivation Induced by Infliximab Administration in a Patient with Crohn's Disease  

    Miyake, Yuka (Gastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, Japan ) , Hasebe, Aki (Internal Medicine, Saiseikai Imabari Hospital, Imabari 799-1502, Japan ) , Tanihira, Tetsuya (Gastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, Japan ) , Shiraishi, Akiko (Gastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, Japan ) , Imai, Yusuke (Gastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, Japan ) , Tatsukawa, Haruka (Gastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, Japan ) , Yamago, Hiroka (Gastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, Japan ) , Nakahara, Hiromasa (Gastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, Japan ) , Shimizu, Yuko (Gastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, Japan ) , Ninomiya, Keiko (Gastroenterology Center, Ehime) , Hiraoka, Atsushi , Miyata, Hideki , Ninomiya, Tomoyuki , Michitaka, Kojiro
    Case reports in hepatology v.2013 ,pp. 1 - 4 , 2013 , 2090-6587 ,

    초록

    A 47-year-old man diagnosed with Crohn's disease was treated with infliximab. He tested negative for hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (anti-HBs) but positive for anti-HB core antibody (anti-HBc). He tested positive for hepatitis B virus (HBV-) DNA 3 months after treatment and was administered entecavir. HBV-DNA test showed negative results 1 month later. ALT was persistently within the normal range, and HBV-DNA was persistently negative thereafter despite the continuation of infliximab every 8 weeks. In our hospital, 14 patients with inflammatory bowel disease, who tested negative for HBsAg, were treated with infliximab; 2 of them tested positive for anti-HBs and/or anti-HBc, and HBV reactivation was observed in 1 patient (the present patient). The present case and these findings highlight that careful follow-up is needed in patients with inflammatory bowel disease treated with infliximab who test positive for anti-HBc and/or anti-HBs.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  6. [해외논문]   Spontaneous Intraperitoneal Rupture of a Hepatic Hydatid Cyst with Subsequent Anaphylaxis: A Case Report  

    Tinsley, Benjamin (Department of Upper Gastrointestinal Surgery, Ealing Hospital NHS Trust, London UB1 3HW, UK ) , Abbara, Aula (Department of Infectious Disease, Ealing Hospital NHS Trust, London UB1 3HW, UK ) , Kadaba, Raghunandan (Department of Upper Gastrointestinal Surgery, Ealing Hospital NHS Trust, London UB1 3HW, UK ) , Sheth, Hemant (Department of Upper Gastrointestinal Surgery, Ealing Hospital NHS Trust, London UB1 3HW, UK ) , Sandhu, Gurjinder (Department of Infectious Disease, Ealing Hospital NHS Trust, London UB1 3HW, UK)
    Case reports in hepatology v.2013 ,pp. 1 - 4 , 2013 , 2090-6587 ,

    초록

    Hydatid cyst rupture into the abdomen is a serious complication of cystic hydatid disease of the liver (Cystic Echinococcosis) with an incidence of up to 16% in some series and can result in anaphylaxis or anaphylactoid reactions in up to 12.5% of cases. At presentation, 36–40% of hydatid cysts have ruptured or become secondarily infected. Rupture can be microscopic or macroscopic and can be fatal without surgery. Hydatid disease of the liver is primarily caused by the tapeworm Echinococcus granulosus and occurs worldwide, with incidence of up to 200 per 100,000 in endemic areas. Our case describes a 24-year-old Bulgarian woman presenting with epigastric pain and evidence of anaphylaxis. Abdominal CT demonstrated a ruptured hydatid cyst in the left lobe of the liver. A partial left lobe hepatectomy, cholecystectomy, and peritoneal washout was performed with good effect. She was treated for anaphylaxis and received antihelminthic treatment with Albendazole and Praziquantel. She made a good recovery following surgery and medical treatment and was well on follow-up. Intraperitoneal rupture with anaphylaxis is a rare occurrence, and there do not seem to be any reported cases from UK centres prior to this.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Conservative Treatment for Cystic Duct Stenosis in a Child  

    Gasparetto, Marco (Unit for Gastroenterology, Digestive Endoscopy, Hepatology, and Care of Children with Liver Transplants, Department of Women's and Children's Health, Padova University Hospital, Via Giustiniani 3, 35128 Padova, Italy ) , Giordano, Laura (Unit for Gastroenterology, Digestive Endoscopy, Hepatology, and Care of Children with Liver Transplants, Department of Women's and Children's Health, Padova University Hospital, Via Giustiniani 3, 35128 Padova, Italy ) , Cananzi, Mara (Unit for Gastroenterology, Digestive Endoscopy, Hepatology, and Care of Children with Liver Transplants, Department of Women's and Children's Health, Padova University Hospital, Via Giustiniani 3, 35128 Padova, Italy ) , Beltrame, Valeria (Department of Medical Diagnostic Sciences and Special Therapies, Radiology Institute, Padova University Hospital, Via Giustiniani 1, 35128 Padova, Italy ) , Bisogno, Gianni (Hematology and Oncology Unit, SPeLeS Project Coordinator, Department of Women's and Children's Health, Padova University Hospital, Via Giustiniani 3, 35128 Padova, Italy ;) , Guariso, Graziella
    Case reports in hepatology v.2013 ,pp. 1 - 3 , 2013 , 2090-6587 ,

    초록

    Introduction . Few cases of common bile duct stenosis have been reported in the literature, and observations of strictures in the cystic duct are even more rare. Surgical cholecystectomy is the treatment needed in most cases of gallbladder hydrops. This paper describes the diagnosis and successful medical treatment of a rare pediatric case of cystic duct stenosis and gallbladder hydrops. Case Report . A formerly healthy one-year-old girl was admitted with colicky abdominal pain. Blood tests were normal, except for an increase in transaminases. Abdominal ultrasound excluded intestinal intussusception and identified a distended gallbladder with biliary sludge. MR cholangiography revealed a dilated gallbladder containing bile sediment and no detectable cystic duct, while the rest of the intra- and extrahepatic biliary tree and hepatic parenchyma were normal. This evidence was consistent with gallbladder hydrops associated with cystic duct stenosis. The baby was treated with i.v. hydration, corticosteroids, antibiotics, and ursodeoxycholic acid. Her general condition rapidly improved, with no further episodes of abdominal pain and normalization of liver enzymes. This allowed to avoid cholecystectomy, and the child is well 1.5 years after diagnosis. Conclusions . Although cholecystectomy is usually necessary in case of gallbladder hydrops, our experience suggests that surgical procedures can be avoided when the distension is caused by a cystic duct stenosis.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   Primary Pleomorphic Liposarcoma of Liver: A Case Report and Review of the Literature  

    Naik, P. R. Thippeswamy (Department of General Surgery, Victoria Hospital, Bangalore Medical College & Research Institute, Bangalore, Karnataka 560002, India ) , Kumar, Prem (Department of General Surgery, Victoria Hospital, Bangalore Medical College & Research Institute, Bangalore, Karnataka 560002, India ) , Kumar, P. Vinod (Department of General Surgery, Victoria Hospital, Bangalore Medical College & Research Institute, Bangalore, Karnataka 560002, India)
    Case reports in hepatology v.2013 ,pp. 1 - 5 , 2013 , 2090-6587 ,

    초록

    Primary liver liposarcoma is a rare disease. The knowledge of the clinical course, management, and prognosis of primary liver liposarcoma are all limited because of its rarity. Twelve cases of primary liposarcoma of the liver have been previously reported. We present the thirteenth case, which occurred in an adult male patient. A 42-year-old male patient came to our outpatient department with complaints of pain abdomen, mass per abdomen, and weight loss. Ultrasonography showed a mass arising from the the left lobe of liver. CT abdomen showed a heterogenous enhancing mass from left lobe of liver with multiple cystic and necrotic areas compressing the stomach and spleen with no evidence of metastasis. Differential diagnosis included adenoma and primary malignancy. Exploratory laparotomy and resection were done. HPE was found to be pleomorphic liposarcoma of liver.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Epithelioid Angiomyolipoma of Liver with an Inflammatory Component: A Case Report  

    C. R., Jyothi (Department of Pathology, Government Medical College, Thrissur 680596, India ) , Menon, Dhanya P. (Department of Pathology, Government Medical College, Thrissur 680596, India ) , Augustine, Joy (Department of Pathology, Government Medical College, Thrissur 680596, India ) , Abdul Siyad, A. K. (Department of General Surgery, Government Medical College, Thrissur 680596, India)
    Case reports in hepatology v.2013 ,pp. 1 - 3 , 2013 , 2090-6587 ,

    초록

    Angiomyolipomas (AMLs) are benign mesenchymal tumors seen in kidneys in association with tuberous sclerosis. They are uncommon in liver. Angiomyolipomas of liver show great histological diversity and various types and patterns are described. Among them, epithelioid and inflammatory angiomyolipomas are rare. We report a case of epithelioid angiomyolipoma of Liver with an inflammatory component.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  10. [해외논문]   An Unusual CongenitalIn SituMalrotation of the Liver  

    Zhong, Hua (Department of Pathology and Laboratory Medicine, Rutgers Robert Wood Johnson Medical School, Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, Room 2045, New Brunswick, NJ 08903, USA)
    Case reports in hepatology v.2013 ,pp. 1 - 2 , 2013 , 2090-6587 ,

    초록

    Angiomyolipomas (AMLs) are benign mesenchymal tumors seen in kidneys in association with tuberous sclerosis. They are uncommon in liver. Angiomyolipomas of liver show great histological diversity and various types and patterns are described. Among them, epithelioid and inflammatory angiomyolipomas are rare. We report a case of epithelioid angiomyolipoma of Liver with an inflammatory component.

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