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Evidence-based Complementary and Alternative Medic... 760건

  1. [해외논문]   Molecular Mechanism of Yisui Shengxue Granule, a Complex Chinese Medicine, on Thalassemia Patients Suffering from Hemolysis and Anemia of Erythrocytes  

    Chu, Na-Li (Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China ) , Wu, Zhi-kui (Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China ) , Zhang, Xin-Hua (303 Hospital of Chinese People's Liberation Army (PLA), Nanning 530000, China ) , Fang, Su-Ping (Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China ) , Wang, Wen-Juan (The Capital Medical University, Beijing 100069, China ) , Cheng, Yan-Ling (Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 213782 , 2014 , 1741-427x ,

    초록

    The objective of this study was to investigate the therapeutic biological mechanism of Yisui Shengxue Granule (YSSXG), a complex Chinese medicine, on the hemolysis and anemia of erythrocytes from patient with thalassemia disease. Sixteen patients with thalassemia (8 cases of α -thalassemia and 8 cases of β -thalassemia) disease were collected and treated with YSSXG for 3 months. The improvements of blood parameter demonstrated that YSSXG had a positive clinical effect on patients with thalassemia disease. For patients with α -thalassemia disease, RT-PCR showed that YSSXG upregulated the relative mRNA expression level of α -globin to β -globin and downregulated DNMT1, DNMT3a, and DNMT3b mRNA compared with pretreatment. Western blotting showed that YSSXG downregulated the expression of DNMT1 and DNMT3a. For patients with β -thalassemia disease, the relative expression level of A γ -globin to α -globin had an increasing trend and the level of BCL11A mRNA expression obviously increased. For all patients, RT-PCR showed that YSSXG upregulated mRNA expression of SPTA1 and SPTB. Activities of SOD and GSH-Px significantly increased and MDA obviously reduced on erythrocyte and blood serum after YSSXG treatment. TEM showed that YSSXG decreased the content of inclusion bodies. Activities of Na + K + -ATPtase and T-ATPtase of erythrocyte increased significantly after YSSXG treatment. This study provides the basis for mechanisms of YSSXG on thalassemia suffering with hemolysis and anemia of erythrocytes from patient.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   Role of Complementary and Alternative Medicine in Controlling Dyslipidemia  

    Qidwai, Waris (Family Medicine Department, Aga Khan University, Karachi 74800, Pakistan ) , Jahan, Firdous (Family Medicine Department, Oman Medical College, P.O. Box 391, Sohar, Oman ) , Nanji, Kashmira (Family Medicine Department, Aga Khan University, Karachi 74800, Pakistan)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 215731 , 2014 , 1741-427x ,

    초록

    The objective of this study was to investigate the therapeutic biological mechanism of Yisui Shengxue Granule (YSSXG), a complex Chinese medicine, on the hemolysis and anemia of erythrocytes from patient with thalassemia disease. Sixteen patients with thalassemia (8 cases of α -thalassemia and 8 cases of β -thalassemia) disease were collected and treated with YSSXG for 3 months. The improvements of blood parameter demonstrated that YSSXG had a positive clinical effect on patients with thalassemia disease. For patients with α -thalassemia disease, RT-PCR showed that YSSXG upregulated the relative mRNA expression level of α -globin to β -globin and downregulated DNMT1, DNMT3a, and DNMT3b mRNA compared with pretreatment. Western blotting showed that YSSXG downregulated the expression of DNMT1 and DNMT3a. For patients with β -thalassemia disease, the relative expression level of A γ -globin to α -globin had an increasing trend and the level of BCL11A mRNA expression obviously increased. For all patients, RT-PCR showed that YSSXG upregulated mRNA expression of SPTA1 and SPTB. Activities of SOD and GSH-Px significantly increased and MDA obviously reduced on erythrocyte and blood serum after YSSXG treatment. TEM showed that YSSXG decreased the content of inclusion bodies. Activities of Na + K + -ATPtase and T-ATPtase of erythrocyte increased significantly after YSSXG treatment. This study provides the basis for mechanisms of YSSXG on thalassemia suffering with hemolysis and anemia of erythrocytes from patient.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Acupuncture Stimulation Attenuates Impaired Emotional-Like Behaviors and Activation of the Noradrenergic System during Protracted Abstinence following Chronic Morphine Exposure in Rats  

    Lee, Bombi (Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea ) , Sur, Bong-Jun (The Graduate School of Basic Science of Oriental Medicine, College of Oriental Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea ) , Shim, Insop (Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea ) , Hahm, Dae-Hyun (Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea ) , Lee, Hyejung (Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 216503 , 2014 , 1741-427x ,

    초록

    The purpose of this study was to evaluate whether acupuncture stimulation attenuates withdrawal-induced behaviors in the rats during protracted abstinence following chronic morphine exposure. To do this, male rats were first exposed to morphine gradually from 20 to 100 mg/kg for 5 days, and subsequently naloxone was injected once to extend despair-related withdrawal behaviors for 4 weeks. Acupuncture stimulation was performed once at the SP6 (Sanyinjiao) acupoint on rat's; hind leg for 5 min during protracted abstinence from morphine. The acupuncture stimulation significantly decreased despair-like behavior deficits in the forced swimming test and low sociability in the open-field test as well as increased open-arm exploration in the elevated plus maze test in the last week of 4-week withdrawal period. Also the acupuncture stimulation significantly suppressed the increase in the hypothalamic corticotropin-releasing factor (CRF) expression, the decrease in the tyrosine hydroxylase expression in the locus coeruleus, and the decrease in the hippocampal brain-derived neurotrophic factor mRNA expression, induced by repeated injection of morphine. Taken together, these findings demonstrate that the acupuncture stimulation of SP6 significantly reduces withdrawal-induced behaviors, induced by repeated administration of morphine in rats, possibly through the modulation of hypothalamic CRF and the central noradrenergic system.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Effects of Acupuncture on Leucopenia, Neutropenia, NK, and B Cells in Cancer Patients: A Randomized Pilot Study  

    Pais, Irene (Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal ) , Correia, Nuno (Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal ) , Pimentel, Isabel (Service of Oncology, Hospital Center of S. João, Oporto, Portugal ) , Teles, Maria José (Service of Clinical Pathology, Hospital Center of S. João, Oporto, Portugal ) , (Service of Clinical Pathology, Porto Hospital Center, Oporto, Portugal ) , Neves, Esmeralda (Service of Clinical Pathology, Porto Hospital Center, Oporto, Portugal ) , Vasconcelos, Jú (Service of Clinical Pathology, Porto Hospital Center, Oporto, Portugal ) , lia (Service of Clinical Pathology, Porto Hospital Center, Oporto, Portugal ) , Guimarã (Department of Oncology, Hospital Center of Vila Nova de Gaia/Espinho, Portugal ) , es, Judite (Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal ) , Azevedo, Nancy (Department of Pharmaceutical) , Moreira Pinto, Antó , nio , Machado, Jorge , Efferth, Thomas , Greten, Henry J.
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 217397 , 2014 , 1741-427x ,

    초록

    Chemotherapy is one of most significant therapeutic approaches to cancer. Immune system functional state is considered a major prognostic and predictive impact on the success of chemotherapy and it has an important role on patients' psychoemotional state and quality of life. In Chinese medicine, chemotherapy is understood as “toxic cold” that may induce a progressive hypofunctional state of immune system, thus compromising the fast recovery of immunity during chemotherapy. In this study, we performed a standardized acupuncture and moxibustion protocol to enhance immunity in cancer patients undergoing chemotherapy and to assess if the improvement of immunity status correlates with a better psychoemotional state and quality of life.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Effect of Nourishing “Yin”-Removing “Fire” Chinese Herbal Mixture on Hypothalamic NKB/NK3R Expression in Female Precocious Rats  

    Wang, Shiran (Department of Neurobiology and Integrative Medicine, Shanghai Medical College, Fudan University, P.O. Box 291, 138 Yi-Xue-Yuan Road, Shanghai 200032, China ) , Zhu, Liting (Department of Neurobiology and Integrative Medicine, Shanghai Medical College, Fudan University, P.O. Box 291, 138 Yi-Xue-Yuan Road, Shanghai 200032, China ) , Yu, Jian (Department of Integrative Medicine, Children's Hospital, Fudan University, 399 WanYuan Road, Shanghai 200032, China ) , Tian, Zhanzhuang (Department of Neurobiology and Integrative Medicine, Shanghai Medical College, Fudan University, P.O. Box 291, 138 Yi-Xue-Yuan Road, Shanghai 200032, China)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 217424 , 2014 , 1741-427x ,

    초록

    Aim . The present study aims to investigate the effects of nourishing “Yin”-removing “Fire” Chinese herb mixture on the hypothalamic NKB/NK3R expression in female precocious model rats. Materials and Methods . Female Sprague-Dawley rats were randomly divided into four groups: normal (N), central precocious puberty (CPP) model (M), CPP fed with Chinese herbal mixture (CHM), and CPP fed with normal saline (MS). Rats on postnatal day 5 were given a single subcutaneous injection of 300 μ g to establish CPP model rats. Rats of CHM and MS groups were continuously administered with nourishing “Yin”-removing “Fire” Chinese herb mixture or saline since postnatal day 15. The expressions of hypothalamic NKB/NK3R were detected by means of real-time PCR, western blot, and immunofluorescence histochemistry. Results . The day of vaginal opening and establishment of two regular estrous cycles were delayed in the CHM group compared with M and MS groups. The expression of hypothalamic NKB/NK3R mRNA and protein in the arcuate nucleus (ARC) and medial preoptic (MPO) area were decreased significantly in the CHM group compared with the M and MS groups on the day of onset-puberty. Conclusions . These results indicate that the NKB/NK3R signaling pathway might be involved in the effect of herbal mixture treatment on CPP.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Evaluation of the Effects of Vaccinium arctostaphylos L. Fruit Extract on Serum Lipids and hs-CRP Levels and Oxidative Stress in Adult Patients with Hyperlipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial  

    Soltani, Rasool (Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran ) , Hakimi, Mustafa (Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran ) , Asgary, Sedigheh (Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran ) , Ghanadian, Syed Mustafa (Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran ) , Keshvari, Mahtab (Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran ) , Sarrafzadegan, Nizal (Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 217451 , 2014 , 1741-427x ,

    초록

    Background. Dyslipidemia produces atherosclerosis, which in turn results in coronary artery disease (CAD). Atherosclerosis is being considered as an inflammatory disease. Vaccinium arctostaphylos L. is a plant with fruits rich in anthocyanins. The aim of this study was to evaluate the effects of fruit extract of this plant on serum levels of lipids, hs-CRP, and malondialdehyde (MDA) as a marker of oxidative stress, in hyperlipidemic adult patients. Methods. In this randomized, double-blind, placebo-controlled clinical trial, 50 hyperlipidemic adult patients were randomly and equally assigned to receive either medicinal ( V. arctostaphylos fruit extract) or placebo capsules twice daily for 4 weeks. Each medicinal capsule contained 45 ± 2 mg of anthocyanins. Fasting serum levels of total cholesterol, TG, LDL-C, HDL-C, hs-CRP, and MDA were obtained before and after the intervention and compared. Results. V. arctostaphylos fruit extract significantly reduced total cholesterol ( P P = 0.004), TG ( P P = 0.013) compared to placebo but did not have any significant effect on HDL-C ( P = 0.631) and hs-CRP ( P = 0.190). Conclusion. Fruit extract of Vaccinium arctostaphylos has beneficial effects on serum lipid profile and oxidative stress in hyperlipidemic adult patients. Therefore, it could be considered as a supplement for treatment of dyslipidemia and prevention of atherosclerosis development.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Effects of Nigella sativa ( Habbatus sauda ) Oil and Nicotine Chronic Treatments on Sperm Parameters and Testis Histological Features of Rats  

    Cho Ping, Ng (Institute of Graduate Studies, University of Malaya, 50603 Kuala Lumpur, Malaysia ) , Hashim, Noor Hashida (Center for Foundation Studies in Science, University of Malaya, 50603 Kuala Lumpur, Malaysia ) , Hasan Adli, Durriyyah Sharifah (Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 218293 , 2014 , 1741-427x ,

    초록

    Twenty-four Sprague-Dawley male rats (7–9 weeks old, 200–250 g) were divided into Nicotine (N) (0.5 mg/100 g body weight (BW), Nicotine Control (NC) (saline, 0.1 mL/100 g BW), Habbatus sauda oil (HS) (6.0 μ L/100 g BW), and Habbatus sauda Control (HSC) (corn oil, 0.1 mL/100 g BW) groups and treated for 100 days. Sperm parameters and seminiferous tubules measurements were evaluated. The N showed a significantly lower sperm motility (1.03 ± 0.05 × 10 6 sperm/mL) and percentage of normal (82.61 ± 0.03%) and live (93.88 ± 0.01%) sperm, higher value for the seminiferous tubule (253.36 ± 1.83 μ m) and lumen (100.15 ± 2.38 μ m) diameters and spermatogonia (19.85 ± 0.39 μ m) and spermatocytes (33.37 ± 0.59 μ m) layers, and thinner spermatid-sperm layer (22.14 ± 0.71 μ m) than the NC ( P 6 sperm/mL) and percentage of normal (90.61 ± 0.01%) and live (96.98 ± 0.01%) sperm, smaller lumen diameter (67.53 ± 2.34 μ m) and thinner spermatogonia (17.67 ± 0.32 μ m) and wider spermatid-sperm (36.95 ± 0.79 μ m) layers than the HSC ( P Habbatus sauda oil increased sperm quality and gave better testis histological features.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   Protective Effect of Huoxiang Zhengqi Oral Liquid on Intestinal Mucosal Mechanical Barrier of Rats with Postinfectious Irritable Bowel Syndrome Induced by Acetic Acid  

    Liu, Yao (School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China ) , Liu, Wei (School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China ) , Peng, Qiu-Xian (School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China ) , Peng, Jiang-Li (College of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410028, China ) , Yu, Lin-Zhong (School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China ) , Hu, Jian-Lan (School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 218383 , 2014 , 1741-427x ,

    초록

    In this study, a rat model with acetic acid-induced PI-IBS was used to study the role of HXZQ oral liquid in repairing the colonic epithelial barrier and reducing intestinal permeability. Pathomorphism of colonic tissue, epithelial ultrastructure, DAO activity in serum, and the protein expression of ZO-1 and occludin were examined to investigate protective effect mechanisms of HXZQ on intestinal mucosa barrier and then present experimental support for its use for prevention and cure of PI-IBS.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Traditional Japanese Medicine Daikenchuto Improves Functional Constipation in Poststroke Patients  

    Numata, Takehiro (Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-Machi, Aoba Ward, Sendai City, Miyagi 980-8575, Japan ) , Takayama, Shin (Department of Kampo Medicine, Tohoku University Hospital, 1-1 Seiryo-Machi, Aoba Ward, Sendai City, Miyagi 980-8574, Japan ) , Tobita, Muneshige (National Yonezawa Hospital, 26100-1 Oh-Aza Misawa, Yonezawa City, Yamagata 992-1202, Japan ) , Ishida, Shuichi (Ishinomaki Rehabilitation Hospital, 1-2-21 Kadonowaki-cho, Ishinomaki City, Miyagi 986-0834, Japan ) , Katayose, Dai (Miyagi Rifu Ekisaikai Hospital, 51 Morigo Aza Shintaishido, Rifu Town, Miyagi 981-0103, Japan ) , Shinkawa, Mitsutoshi (Hikarigaoka Spellman Hospital, 6-7-1 Higashi-Sendai, Miyagino Ward, Sendai City, Miyagi 983-0833, Japan ) , Oikawa, Takashi (National Hachinohe Hospital, 3-13-1 Fukiage, Hachinohe City, Aomori 031-0003, Japan ) , Aonuma, Takanori (Wakuya Medical and Welfare Center, 278 Wakuya Aza Nakakonan, Wakuya Town, Miyagi 987-0121, Japan ) , Kaneko, Soichiro (Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-Machi, Aoba Ward, Sendai City, Miyagi 98) , Tanaka, Junichi , Kanemura, Seiki , Iwasaki, Koh , Ishii, Tadashi , Yaegashi, Nobuo
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 231258 , 2014 , 1741-427x ,

    초록

    Poststroke patients with functional constipation, assessed by the Rome III criteria, from 6 hospitals were recruited in a study on the effects of the traditional Japanese medicine Daikenchuto (DKT) on constipation. Thirty-four patients (17 men and 17 women; mean age: 78.1 ± 11.6 years) were randomly assigned to 2 groups; all patients received conventional therapy for constipation, and patients in the DKT group received 15 g/day of DKT for 4 weeks. Constipation scoring system (CSS) points and the gas volume score (GVS) (the measure of the intestinal gas volume calculated from plain abdominal radiographs) were recorded before and after a 4-week observation period. The total score on the CSS improved significantly in the DKT group compared to the control ( P P P = 0.049, and P = 0.03, resp.). The GVS was also significantly reduced in the DKT group compared to the control ( P = 0.03). DKT in addition to conventional therapy is effective in treating functional constipation in poststroke patients. This study was a randomized controlled trial and was registered in the UMIN Clinical Trial Registry (no. UMIN000007393).

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  10. [해외논문]   Targeting FASN in Breast Cancer and the Discovery of Promising Inhibitors from Natural Products Derived from Traditional Chinese Medicine  

    Cheng, Chien-shan (School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong ) , Wang, Zhiyu (School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong ) , Chen, Jianping (School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 232946 , 2014 , 1741-427x ,

    초록

    Molecular targeted therapy has been developed for cancer chemoprevention and treatment. Cancer cells process a fundamental change in its bioenergetic metabolism from normal cells on an altered lipid metabolism, also known as the de novo fatty acid synthesis, for sustaining their high proliferation rates. Fatty acid synthesis is now associated with clinically aggressive tumor behavior and tumor cell growth and has become a novel target pathway for chemotherapy development. Although the underlying mechanisms of the altered de novo fatty acid synthesis still remains unclear, recent progress has shown that by targeting Fatty acid synthase (FASN), a key enzyme that catalyzes the synthesis of endogenous long chain fatty acid could be a critical target for drug discovery. However, relatively few FASN inhibitors have been discovered. With the long history of clinical practices and numerous histological case study reports, traditional Chinese medicine enjoys an important role in seeking bioactive anticancer natural compounds. Herein, we will give an overall picture of the current progress of molecular targeted therapy in cancer fatty acid synthesis, describe the advances in the research on natural products-derived FASN inhibitors and their potential for enhancing our understanding of fatty acids in tumor biology, and may provide new therapeutic moieties for breast cancer patient care.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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