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H : 소장처정보

T : 목차정보

Rapid communications in mass spectrometry : RCM 20건

  1. [해외논문]   Determination of tebuconazole and penconazole fungicides in rat and human hair by liquid chromatography/tandem mass spectrometry  

    Polledri, Elisa (EPIGET –) , Mercadante, Rosa (Epidemiology, Epigenetics, and Toxicology Lab, Department of Clinical Sciences and Community Health, Università) , Fustinoni, Silvia (degli Studi di Milano and Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy)
    Rapid communications in mass spectrometry : RCM v.32 no.15 ,pp. 1243 - 1249 , 2018 , 0951-4198 ,

    초록

    Rationale Tebuconazole (TEB) and penconazole (PEN) are widely applied fungicides and environmental contaminants; their toxicological properties include possible effects to the unborn child, therefore, the evaluation of human exposure is relevant to risk assessment. Hair is a non‐invasive specimen that incorporates pollutants allowing an extended exposure window to be surveyed. The aim of this work was to develop and validate an assay for the determination of TEB and PEN in human hair. Methods Under optimised conditions, analytes were extracted by soaking hair in acetonitrile, in the presence of deuterated analogues, under heating and agitation. Chemical separation was achieved using a C18 reversed‐phase chromatographic column and detection and quantification were performed, after positive electrospray ionization, by triple quadrupole mass spectrometry operating in selected reaction monitoring mode. Results The assay validation showed a linear dynamic range up to 5 μg/L or 200 pg/mg hair, inter‐ and intra‐run precisions Conclusions The results of this study indicate that the developed assay is useful to evaluate the exposure to TEB and PEN in humans.

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  2. [해외논문]   Assimilation of nitrogen and carbon isotopes from fish diets to otoliths as measured by nanoscale secondary ion mass spectrometry  

    Shiao, Jen‐ (Institute of Oceanography, College of Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan) , Chieh (Atmosphere and Ocean Research Institute, University of Tokyo, 5‐1‐5, Kashiwanoha, Kashiwa‐shi, Chiba, 277‐8564, Japan) , Shirai, Kotaro (Atmosphere and Ocean Research Institute, University of Tokyo, 5‐1‐5, Kashiwanoha, Kashiwa‐shi, Chiba, 277‐8564, Japan) , Tanaka, Kentaro (Atmosphere and Ocean Research Institute, University of Tokyo, 5‐1‐5, Kashiwanoha, Kashiwa‐shi, Chiba, 277‐8564, Japan) , Takahata, Naoto (Atmosphere and Ocean Research Institute, University of Tokyo, 5‐1‐5, Kashiwanoha, Kashiwa‐shi, Chiba, 277‐8564, Japan) , Sano, Yuji (Institute of Earth Science, Academia Sinica, No. 128, Sec. 2, Academic Road, Nankang, Taip) , Sung‐ , Yun Hsiao, Silver , Lee, Der‐ , Chuen , Tseng, Yung‐ , Che
    Rapid communications in mass spectrometry : RCM v.32 no.15 ,pp. 1250 - 1256 , 2018 , 0951-4198 ,

    초록

    RATIONALE Nitrogen and carbon stable isotope ratios (δ 15 N and δ 13 C values) of carbonate‐bound organic materials in otoliths can provide information to address the biological and ecological functions of fish. Correct interpretation of otolith δ 15 N and δ 13 C profiles requires knowledge of the metabolic routes of nitrogen and carbon isotopes. However, the isotopic assimilation of δ 15 N and δ 13 C compositions from diets to otoliths has rarely been investigated. METHODS This study traced the daily nitrogen and carbon isotopic assimilation between diets and otoliths using nanoscale secondary ion mass spectrometry (NanoSIMS). Isotopically labeled algae ( Tetraselmis chui ) were fed to tilapia ( Oreochromis niloticus ) for 14–17 days. NanoSIMS and conventional isotope ratio mass spectrometry were used to measure δ 15 N and δ 13 C variations in the otoliths and fish muscle, respectively. RESULTS Otolith δ 15 N values abruptly surged from natural abundance levels by 1000–2300‰ after the fish ate 15 N‐spiked algae with δ 15 N values of approximately 2200‰. However, the δ 15 N values of fish muscle increased to only approximately 500‰ at the end of the feeding experiment. Much higher δ 15 N values (3700–14 000‰) and moderate δ 13 C values (60–200‰) were detected in the otoliths after the tilapia ate 15 N‐ and 13 C‐spiked algae with a δ 15 N value of 36667‰ and a δ 13 C value of 272‰. Mapping analysis showed sub‐micrometer‐scale distribution of 15 N embedded in the otolith growth increments with a low‐to‐high δ 15 N signal after the tilapia shifted diets from non‐spiked to 15 N‐labeled algae. CONCLUSIONS These results suggest that otolith nitrogen and carbon isotopes from food were directly assimilated on the same day. Food is the major and in some cases only source of otolith nitrogen isotopes but makes only a partial contribution to otolith carbon isotopes. Therefore, the δ 15 N values recorded in the sclerochronological layers of the otoliths can be used to determine the trophic levels, food sources and diet changes of fish.

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  3. [해외논문]   Are stable isotope ratios and oscillations consistent in all baleen plates along the filtering apparatus? Validation of an increasingly used methodology  

    Garcí (Institute of Biodiversity Research (IRBio) and Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, 08028, Barcelona, Spain) , a‐ (Institute of Biodiversity Research (IRBio) and Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, 08028, Barcelona, Spain) , Vernet, Raquel (Marine and Freshwater Research Institute, PO Box 1390, Skúlagata 4, 121, Reykjavík, Iceland) , Sant, Pol (Institute of Biodiversity Research (IRBio) and Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, 08028, Barcelona, Spain) , Ví (Institute of Biodiversity Research (IRBio) and Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, 08028,) , kingsson, Gí , sli , Borrell, Asunció , n , Aguilar, Alex
    Rapid communications in mass spectrometry : RCM v.32 no.15 ,pp. 1257 - 1262 , 2018 , 0951-4198 ,

    초록

    Rationale Baleen plates are anatomical structures composed of inert tissue that hang from the upper jaw in mysticetes. Baleen plates may differ in size and in coloration between different segments of the filtering row or between sides of the mouth. Concern has been raised that variation in baleen plate characteristics may reflect dissimilar structural composition and growth rates liable to affect stable isotope ratios and their oscillation patterns. Methods We measured stable carbon (δ 13 C values) and nitrogen (δ 15 N values) isotope ratios at intervals of 1 cm along the longitudinal axis of six baleen plates collected from different positions along the mouth of a fin whale. All samples were analysed using a continuous flow isotope ratio mass spectrometer. Generalized additive models were fitted to the data from each baleen plate and the results of the models were compared visually. Results A total of 206 samples were analysed. Visually, all baleen plates presented nearly identical oscillations, independent of the position or the coloration of the baleen plate. However, the variation in δ 13 C and δ 15 N values occurring between the different baleen plates was higher in the segments of oscillations exhibiting steeper slopes. Conclusions Differences in size between plates in an individual are due to differential erosion rates according to their position in the mouth. Therefore, the position of sampling along the baleen plate row should not be a reason for concern when conducting stable isotope studies.

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  4. [해외논문]   A new method for quantitative determination of renalase based on mass spectrometric determination of a proteotypic peptide labelled with stable isotopes  

    Kopylov, A. T. (Institute of Biomedical Chemistry, 10 Pogodinskaya Street, Moscow, 119121, Russia) , Fedchenko, V. I. (Institute of Biomedical Chemistry, 10 Pogodinskaya Street, Moscow, 119121, Russia) , Buneeva, O. A. (Institute of Biomedical Chemistry, 10 Pogodinskaya Street, Moscow, 119121, Russia) , Pyatakova, N. V. (Institute of Biomedical Chemistry, 10 Pogodinskaya Street, Moscow, 119121, Russia) , Zgoda, V. G. (Institute of Biomedical Chemistry, 10 Pogodinskaya Street, Moscow, 119121, Russia) , Medvedev, A. E. (Institute of Biomedical Chemistry, 10 Pogodinskaya Street, Moscow, 119121, Russia)
    Rapid communications in mass spectrometry : RCM v.32 no.15 ,pp. 1263 - 1270 , 2018 , 0951-4198 ,

    초록

    Rationale Renalase is a recently discovered kidney secretory protein, which is considered as an important component involved in blood pressure regulation. Although altered levels of renalase have been detected in plasma and urine of patients with various kidney diseases, there is certain inconsistency of changes in the renalase levels reported by different laboratories. The latter is obviously associated with the use of the ELISA as the only available approach for quantitative analysis of renalase. Thus there is a clear need for the development of antibody‐independent approaches for renalase quantification. Methods We have developed a new method for quantitative determination of human renalase, which is based on mass spectrometric detection of a proteotypic peptide containing С‐terminal 13 C 15 N‐labelled lysine. It corresponds to a tryptic peptide of human renalase, which has been previously detected in most mass spectrometric determinations of this protein. Results Using the labelled peptide H ‐EGDCNFVAPQGISSIIK‐ OH , corresponding to positions 100–116 of the human renalase sequence, as an internal standard and recombinant human renalase we have generated a calibration curve, which covered the concentration range 0.005–50 ng/mL with a limit of quantitation of 5 pg/mL. Using this calibration curve we were able to detect urinary renalase only after enrichment of initial urinary samples by ammonium sulfate precipitation (but not in untreated urine). Conclusions Results of our study indicate that quantitative determination of renalase based on mass spectrometric detection of a proteotypic peptide labelled with stable isotopes gives significantly lower values of this protein in human urine than those reported in the literature and based on the ELISA.

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  5. [해외논문]   Determination of carbon isotope ratios for honey samples by means of a liquid chromatography/isotope ratio mass spectrometry system coupled with a post‐column pump  

    Kawashima, Hiroto (Akita Prefectural University, Department of Management Science and Engineering, Faculty of Systems Science and Technology, 84‐4, Ebinokuchi, Tuchiya, Yuri‐Honjyo, Akita, 015‐0055, Japan) , Suto, Momoka (Akita Prefectural University, Department of Management Science and Engineering, Faculty of Systems Science and Technology, 84‐4, Ebinokuchi, Tuchiya, Yuri‐Honjyo, Akita, 015‐0055, Japan) , Suto, Nana (Akita Prefectural University, Department of Management Science and Engineering, Faculty of Systems Science and Technology, 84‐4, Ebinokuchi, Tuchiya, Yuri‐Honjyo, Akita, 015‐0055, Japan)
    Rapid communications in mass spectrometry : RCM v.32 no.15 ,pp. 1271 - 1279 , 2018 , 0951-4198 ,

    초록

    Rationale Liquid chromatography/isotope ratio mass spectrometry (LC/IRMS) has been used to authenticate and trace products such as honey, wine, and lemon juice, and compounds such as caffeine and pesticides. However, LC/IRMS has several disadvantages, including the high cost of the CO 2 membrane and blocking by solidified sodium persulfate. Here, we developed an improved system for determining carbon isotope ratios using LC/IRMS. Methods The main improvement was the use of a post‐column pump. Using the improved system, we determined δ 13 C values for glucose with high accuracy and precision (0.1‰ and 0.1‰, respectively; n = 3). The glucose, fructose, disaccharide, trisaccharide, and organic acid constituents of honey samples were analyzed using LC/IRMS. Results The δ 13 C values for glucose, fructose, disaccharides, trisaccharides, and organic acids ranged from −27.0 to −24.2‰, −26.8 to −24.0‰, −28.8 to −24.0‰, −27.8 to −22.8‰, and − 30.6 to −27.4‰, respectively. The analysis time was a third to a half of that required for analysis by previously reported methods. Conclusions The column flow rate could be arbitrarily adjusted with the post‐column pump. We applied the improved method to 26 commercial honey samples. Our results can be expected to be useful for other researchers who use LC/IRMS.

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  6. [해외논문]   Rapid analysis of fentanyls and other novel psychoactive substances in substance use disorder patient urine using paper spray mass spectrometry  

    Kennedy, Joseph H. (Prosolia Inc., Indianapolis, IN, 46202, USA) , Palaty, Jan (LifeLabs Medical Laboratory Services, Burnaby, BC, V5G 4V8, Canada) , Gill, Chris G. (Vancouver Island University, Applied Environmental Research Laboratories (AERL), Chemistry Department, Nanaimo, BC, V9R 5S5, Canada) , Wiseman, Justin M. (Prosolia Inc., Indianapolis, IN, 46202, USA)
    Rapid communications in mass spectrometry : RCM v.32 no.15 ,pp. 1280 - 1286 , 2018 , 0951-4198 ,

    초록

    Rationale Drug overdose deaths due to fentanyls and other novel psychoactive substances (NPS) are on the rise. The higher potencies of fentanyl analogs compared with morphine require new technologies to identify and quantitate NPS. Methods Paper spray tandem mass spectrometry (MS/MS) and high‐resolution mass spectrometry were used to identify and measure fentanyl analogs as well as common drugs of abuse in urine samples from substance use disorder clinics. Ten‐microliter urine samples were deposited directly on paper spray cartridges previously loaded with internal standards, dried, and analyzed with no other sample treatment. Quantitative results were obtained using MS/MS. Individual drugs were identified using high‐resolution accurate mass spectrometry, and confirmed by data‐dependent MS/MS. Results Calibration curves in urine were linear over a range of 0.5–50 ng/mL with R 2 of 0.99 or better for eight representative fentanyl analogs. Cartridges preloaded with internal standards demonstrated satisfactory quantitative results compared with LC/MS. Direct identification and confirmation of fentanyl analogs and other common drugs of abuse in urine using high‐resolution accurate mass and MS/MS fragmentation were demonstrated at low picogram levels. Conclusions Paper spray mass spectrometry can reliably identify and quantitate fentanyl analogs and other drugs of abuse in urine. Using paper spray cartridges as collection devices reduces exposure and transportation risks associated with biological fluids. Cartridges preloaded with labeled internal standards can be effective for targeted screening of fentanyl analogs and other drugs of abuse.

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  7. [해외논문]   Coupling trapped ion mobility spectrometry to mass spectrometry: trapped ion mobility spectrometry–time‐of‐flight mass spectrometry versus trapped ion mobility spectrometry–Fourier transform ion cyclotron resonance mass spectrometry  

    Tose, Lilian V. (Federal University of Espírito Santo, Petroleomic and Forensic Chemistry Laboratory, Department of Chemistry, 29075‐910, Vitória, ES, Brazil) , Benigni, Paolo (Florida International University, Department of Chemistry and Biochemistry, Miami, FL, 33199, USA) , Leyva, Dennys (Florida International University, Department of Chemistry and Biochemistry, Miami, FL, 33199, USA) , Sundberg, Abigail (Florida International University, Department of Chemistry and Biochemistry, Miami, FL, 33199, USA) , Ramí (Florida International University, Department of Chemistry and Biochemistry, Miami, FL, 33199, USA) , rez, Cé (Bruker Daltonics Inc., Billerica, MA, 01821, USA) , sar E. (Bruker Daltonics Inc., Billerica, MA, 01821, USA) , Ridgeway, Mark E. (Federal University of Espírito Santo, Petroleomic and F) , Park, Melvin A. , Romã , o, Wanderson , Jaffé , , Rudolf , Fernandez‐ , Lima, Francisco
    Rapid communications in mass spectrometry : RCM v.32 no.15 ,pp. 1287 - 1295 , 2018 , 0951-4198 ,

    초록

    Rationale There is a need for fast, post‐ionization separation during the analysis of complex mixtures. In this study, we evaluate the use of a high‐resolution mobility analyzer with high‐resolution and ultrahigh‐resolution mass spectrometry for unsupervised molecular feature detection. Goals include the study of the reproducibility of trapped ion mobility spectrometry (TIMS) across platforms, applicability range, and potential challenges during routine analysis. Methods A TIMS analyzer was coupled to time‐of‐flight mass spectrometry (TOF MS) and Fourier transform ion cyclotron resonance mass spectrometry (FT‐ICR MS) instruments for the analysis of singly charged species in the m / z 150–800 range of a complex mixture (Suwannee River Fulvic Acid Standard). Molecular features were detected using an unsupervised algorithm based on chemical formula and IMS profiles. Results TIMS‐TOF MS and TIMS‐FT‐ICR MS analysis provided 4950 and 7760 m / z signals, 1430 and 3050 formulas using the general C x H y N 0–3 O 0–19 S 0–1 composition, and 7600 and 22 350 [ m / z ; chemical formula; K; CCS] features, respectively. Conclusions TIMS coupled to TOF MS and FT‐ICR MS showed similar performance and high reproducibility. For the analysis of complex mixtures, both platforms were able to capture the major trends and characteristics; however, as the chemical complexity at the level of nominal mass increases with m / z ( m / z >300–350), only TIMS‐FT‐ICR MS was able to report the lower abundance compositional trends.

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  8. [해외논문]   Plant growth chamber design for subambient pCO2 and δ13C studies  

    Hagopian, William M. (Centre for Earth Evolution and Dynamics, University of Oslo, N‐0315, Oslo, Norway) , Schubert, Brian A. (School of Geosciences, University of Louisiana at Lafayette, Lafayette, LA, 70504, USA) , Graper, Robert A. (School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, HI, 96822, USA) , Hope Jahren, A. (Centre for Earth Evolution and Dynamics, University of Oslo, N‐0315, Oslo, Norway)
    Rapid communications in mass spectrometry : RCM v.32 no.15 ,pp. 1296 - 1302 , 2018 , 0951-4198 ,

    초록

    Rationale Subambient p CO 2 has persisted across the major Phanerozoic ice ages, including the entire late Cenozoic ( ca 30 Ma to present). Stable isotope analysis of plant‐derived organic matter is used to infer changes in p CO 2 and climate in the geologic past, but a growth chamber that can precisely control environmental conditions, including p CO 2 and δ 13 C value of CO 2 ( δ 13 C CO2 ) at subambient p CO 2 , is lacking. Methods We designed and built five identical chambers specifically for plant growth under stable subambient p CO 2 ( ca 100 to 400 ppm) and δ 13 C CO2 conditions. We tested the p CO 2 and δ 13 C CO2 stability of the chambers both with and without plants, across two 12‐hour daytime experiments and two extended 9‐day experiments. We also compared the temperature and relative humidity conditions among the chambers. Results The average δ 13 C CO2 value within the five chambers ranged from −18.76 to −19.10‰; the standard deviation never exceeded 0.14‰ across any experiment. This represents better δ 13 C CO2 stability than that achieved by all previous chamber designs, including superambient p CO 2 chambers. Every p CO 2 measurement ( n = 1225) was within 5% of mean chamber values. The temperature and relative humidity conditions differed by no more than 0.4°C and 1.6%, respectively, across all chambers within each growth experiment. Conclusions This growth chamber design extends the range of p CO 2 conditions for which plants can be grown for δ 13 C analysis of their tissues at subambient levels. This new capability allows for careful isolation of environmental effects on plant 13 C discrimination across the entire range of p CO 2 experienced by terrestrial land plants.

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    Fig. 1 이미지
  9. [해외논문]   Mass spectrometry for characterization of homologous piperidine alkaloids and their activity as acetylcholinesterase inhibitors  

    Freitas, Thamires R. (Instituto de Química, Universidade Federal de Uberlândia, Núcleo de Pesquisa em Produtos Naturais (NuPPeN), 38400‐902, Uberlândia‐MG, Brazil) , Danuello, Amanda (Instituto de Ciências Exatas, Naturais e Educação, Universidade Federal do Triângulo Mineiro, Núcleo de Desenvolvimento de Compostos Bioativos (NDCBio), Departamento de Química, 38064‐200, Uberaba‐MG, Brazil) , Viegas Jú (Instituto de Química, Universidade Federal de Alfenas, Laboratório de Pesquisa em Química Medicinal (PeQuiM), 37133‐840, Alfenas‐MG, Brazil) , nior, Claudio (Instituto de Química, Universidade Estadual Paulista, Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE), Departamento de Química Orgânica, PO Box 355, 14801‐970, Araraquara‐SP, Brazil<c) , Bolzani, Vanderlan S. , Pivatto, Marcos
    Rapid communications in mass spectrometry : RCM v.32 no.15 ,pp. 1303 - 1310 , 2018 , 0951-4198 ,

    초록

    Rationale Piperidine alkaloids from Senna spectabilis constitute a rare class of natural products with several biological activities. However, the absence of chromophores makes their structural elucidation by conventional methods a great challenge. In this context, mass spectrometry emerges as a powerful tool for metabolomics studies. Methods The piperidine alkaloids (−)‐cassine and (−)‐spectaline and the semisynthetic derivatives (−)‐3‐ O ‐acetylcassine and (−)‐3‐ O ‐acetylspectaline were investigated by electrospray ionization tandem mass spectrometry (ESI‐MS/MS) in the positive mode and electron ionization mass spectrometry (EI‐MS). ESI fragmentation studies were performed with a quadrupole time‐of‐flight instrument; N 2 was used as collision gas. The acetylcholinesterase inhibitory activity of the investigated compounds was evaluated by bioautography and microplate screening assays. Results ESI‐MS/MS and EI‐MS provided valuable and complementary information about the structure of the piperidine compounds. Collision‐induced dissociation experiments (MS/MS) revealed that neutral elimination of water or acetic acid is the major fragmentation pathway, which agrees with the stereochemistry proposed for (−)‐cassine and (−)‐spectaline and the semisynthetic derivatives (−)‐3‐ O ‐acetylcassine and (−)‐3‐ O ‐acetylspectaline. Conclusions The ESI‐MS/MS and EI‐MS studies allowed us to propose fragmentation mechanisms for piperidine alkaloids and derivatives. Therefore, mass spectrometry is an important tool for characterizing the structure of these compounds and for supporting further metabolomics studies.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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    Fig. 1 이미지
  10. [해외논문]   Isotopically labelled paroxetine standard allows for definite structure elucidation of the paroxetine tandem mass spectrum  

    Vay, Manuela (University Hospital Heidelberg, Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, Heidelberg, Germany) , Majewsky, Marius (University Hospital Heidelberg, Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, Heidelberg, Germany) , Mikus, Gerd (University Hospital Heidelberg, Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, Heidelberg, Germany)
    Rapid communications in mass spectrometry : RCM v.32 no.15 ,pp. 1311 - 1312 , 2018 , 0951-4198 ,

    초록

    Rationale Piperidine alkaloids from Senna spectabilis constitute a rare class of natural products with several biological activities. However, the absence of chromophores makes their structural elucidation by conventional methods a great challenge. In this context, mass spectrometry emerges as a powerful tool for metabolomics studies. Methods The piperidine alkaloids (−)‐cassine and (−)‐spectaline and the semisynthetic derivatives (−)‐3‐ O ‐acetylcassine and (−)‐3‐ O ‐acetylspectaline were investigated by electrospray ionization tandem mass spectrometry (ESI‐MS/MS) in the positive mode and electron ionization mass spectrometry (EI‐MS). ESI fragmentation studies were performed with a quadrupole time‐of‐flight instrument; N 2 was used as collision gas. The acetylcholinesterase inhibitory activity of the investigated compounds was evaluated by bioautography and microplate screening assays. Results ESI‐MS/MS and EI‐MS provided valuable and complementary information about the structure of the piperidine compounds. Collision‐induced dissociation experiments (MS/MS) revealed that neutral elimination of water or acetic acid is the major fragmentation pathway, which agrees with the stereochemistry proposed for (−)‐cassine and (−)‐spectaline and the semisynthetic derivatives (−)‐3‐ O ‐acetylcassine and (−)‐3‐ O ‐acetylspectaline. Conclusions The ESI‐MS/MS and EI‐MS studies allowed us to propose fragmentation mechanisms for piperidine alkaloids and derivatives. Therefore, mass spectrometry is an important tool for characterizing the structure of these compounds and for supporting further metabolomics studies.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지

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