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Archives of pharmacal research : a publication of ... 19건

  1. [국내논문]   Synthesis and Antitumor Activity of Cannabigerol  

    Baek, Seung-Hwa (Department of Chemistry and Department of Oral Anatomy, Wonkwang University ) , Han, Du-Seok (Department of Chemistry and Department of Oral Anatomy, Wonkwang University ) , Yook, Chan-Nam (Department of Health Hygienic, Wonkwang Public Health Junior College ) , Kim, Young-Chae (Department of Chemistry and Department of Oral Anatomy, Wonkwang University ) , Kwak, Jung-Suk (Department of Chemistry and Department of Oral Anatomy, Wonkwang University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 228 - 230 , 1996 , 0253-6269 ,

    초록

    Cannabigerol(3) was synthesized and evaluated for its inhibitory activity against mouse skin melanoma cells. Cannabigerol displayed significant antitumor activity [inhibitory concentration $(IC_{50})=31.31\mug/mL]$ in vitro assay.

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  2. [국내논문]   Phenolic Constituents from the Aerial Parts of Artemisia stolonifera  

    Lee, Kang-Ro (College of Pharmacy, Sung Kyun Kwan University ) , Hong, Seung-Woo (College of Pharmacy, Sung Kyun Kwan University ) , Kwak, Jong-Hwan (College of Pharmacy, Sung Kyun Kwan University ) , Pyo, Suhkneung (College of Pharmacy, Sung Kyun Kwan University ) , Jee, Ok-Pyo (College of Pharmacy, Sung Kyun Kwan University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 231 - 234 , 1996 , 0253-6269 ,

    초록

    Two acetophenone glycosides, 2, 4-dihydroxy-6-methoxy acetophenone $4-O-\beta-D-glucopyranoside(I)$ , 2, 4, 6-trihydroxy acetophenone $2-O-\beta-D-glucopyranoside(II)$ , together with coniferin(III) were isolated from the aerial parts of Artemisia stolonifera (Max.) Kom. The structures of the compounds were elucidated on the basis of spectroscopic evidence. Compound IIwas also confirmed as a new phenolic glycoside from natural sources. In addition, compound I induced cytostatic activity of macrophasges, while compounds II and III did not.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [국내논문]   Synthesis and antitumor evaluation of α-methylene-γ-butyrolactone-linked to 5-Substituted uracil nucleic acid bases  

    Kim, Jack C. , Kim, Ji-A , Kim, Si-Hwan , Park, Jin Il , Kim, Seon-Hee , Choi, Soon-Kyu , Park, Won-Woo
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 235 - 239 , 1996 , 0253-6269 ,

    초록

    Two acetophenone glycosides, 2, 4-dihydroxy-6-methoxy acetophenone $4-O-\beta-D-glucopyranoside(I)$ , 2, 4, 6-trihydroxy acetophenone $2-O-\beta-D-glucopyranoside(II)$ , together with coniferin(III) were isolated from the aerial parts of Artemisia stolonifera (Max.) Kom. The structures of the compounds were elucidated on the basis of spectroscopic evidence. Compound IIwas also confirmed as a new phenolic glycoside from natural sources. In addition, compound I induced cytostatic activity of macrophasges, while compounds II and III did not.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [국내논문]   Synthesis and antitumor evaluation of $\alphamethylene-\gamma-butyrolactone-linked$ to 5-substituted uracil nucleic acid bases  

    Kim, Jack-C. (Department of Chemistry, College of Natural Science, Pusan National University ) , Kim, Ji-A (Department of Chemistry, College of Natural Science, Pusan National University ) , Kim, Si-Hwan (Department of Chemistry, College of Natural Science, Pusan National University ) , Park, Jin-Il (Department of Chemistry, College of Natural Science, Pusan National University ) , Kim, Seon-Hee (Department of Biochemisty, Collegef of Medicine, Pusan National University ) , Park, Soon-Kyu (Department of Chemistry, Dong-A University ) , Park, Won-Woo (Pusan Junior College Pusan)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 235 - 239 , 1996 , 0253-6269 ,

    초록

    Six, heretofore undescribed, $5^I-Methyl-5^I-(5-Substituted uracil-1-ylmethyl)-2^I-oxo-3^I-methylenetetrahydrofurans(F, Cl, Br, l, CH_3, H)(6a-f)$ were synthesized and evaluated against three cell lines (FM-3A, P-388 and U-937). For the preparation of .alpha.-methylene-.gamma.-butyrolactone bearing 5-substituted uracils (6a-f), the effcient Reformatsky type reaction was employed which involves the treatment of ethyl .alpha.(bromomethyl) acrylate and zinc with the respective 5-substituted uracil-1-ylacetones (5a-f). The acetone derivatives (5a-f) were directly obtained by the respective alkylation reaction of 5-substituted uracils with chloroacetone in the presence of $K_{2}$ $CO_{3}$ (or NaH). These lactone compounds 6a-f exhibited moderate to significant activity in all of the three cell lines, and 6b, 6c and 6e showed significant antitumor activities (inhibitory concentrations ( $IC_{50}$ ) ranged from 1.3-3.8 .mu.g/ml.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [국내논문]   A First Synthesis of Isofagar-idine:Topoisomerase I Inhibitor   피인용횟수: 1

    Cho, Won-Jea (Collegef of Pharmacy, Chonnam National University ) , Miyoji Hanaoka (Faculty of Pharmaceutical Sciences, Kanazawa University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 240 - 242 , 1996 , 0253-6269 ,

    초록

    We have reported the convenient biomimetic methodology for the synthesis of all kinds of substituent pattern benzo[c]phenanthridine alkaloids (Hanaoka et al., 1990; Hanaoka et al., 1991). Regioselective demethylation of C-8 position on oxyfagaridine (5), an intermediate for the synthesis of Fagaridine (4), would afford the precursor for the synthesis of Isofagaridine because the strong hydrogen bonding between amide and hydroxyl group of C-7 position probably resists to be reacted with week base and electrophiles. Thus, a selective alkylation of dihydroxy compound supposed to be possible and be lead to the target compound, Isofagaridine.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [국내논문]   Synthesis and antiviral activity of fluoro sugar nucleosides 2: Synthesis and biological evaluations of 2′, 3′-dideoxy-2′-fluoro-3′-C-hydroxymethyl-β-D-arabinofuranosyl nucleosides  

    Chun, Moon Woo , Lee, Kyung , Choi, Yong Suk , Lee, Jeewoo , Kim, Joong Hyup , Lee, Chong Kyo , Choi, Bo Gil , Xu, Yong Can
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 243 - 245 , 1996 , 0253-6269 ,

    초록

    We have reported the convenient biomimetic methodology for the synthesis of all kinds of substituent pattern benzo[c]phenanthridine alkaloids (Hanaoka et al., 1990; Hanaoka et al., 1991). Regioselective demethylation of C-8 position on oxyfagaridine (5), an intermediate for the synthesis of Fagaridine (4), would afford the precursor for the synthesis of Isofagaridine because the strong hydrogen bonding between amide and hydroxyl group of C-7 position probably resists to be reacted with week base and electrophiles. Thus, a selective alkylation of dihydroxy compound supposed to be possible and be lead to the target compound, Isofagaridine.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [국내논문]   Synthesis of homovanillic amide derivatives and their analgesic activity  

    Lim, Hee-Jong (Korea Research Institute of Chemical Technology ) , Jung, Young-Sik (Korea Research Institute of Chemical Technology ) , Ha, Deok-Chan (Korea Research Institute of Chemical Technology ) , Seong, Churl-Min (Korea Research Institute of Chemical Technology ) , Lee, Jong-Cheol (Korea Research Institute of Chemical Technology ) , Choi, Jin-Il (Korea Research Institute of Chemical Technology ) , Choi, Seung-Won (Korea Research Institute of Chemical Technology ) , Han, Man-So (Korea Research Institute of Chemical Technology ) , Lee, Kwang-Sook (Korea Research Institute of Chemical Technology ) , Park, No-Sang (Korea Research Institute of Chemical Technology)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 246 - 247 , 1996 , 0253-6269 ,

    초록

    In the previous reports (Park et al., 1991, and 1993), we described the synthesis and analgesic effects of various homovanillic amides as analogs of capsaicin. In the study, we tried to enhance the analgesic actvity of capsaicin by structural modification. Our study has been performed in three directions. First, the amide bond of capsaicin was transposed. Second, a phenyl ring was introduced to replace a double bond of capsaicin. Finally, aminoethylation was performed on 4-hydroxy group of capsaicin to improve oral bioavailability. These studies have led to N-(3-phenylpropyl)homovanillic amide 2 which has high analgesic activity. Our continuing efforts in this area have focused on the introduction of various substituents on the phenyl ring of 2 as well as their pharmacological studies. We report herein the synthesis of homovanillic amide derivatives and their analgesic activity.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [국내논문]   Synthesis and anticonvulsant evaluation of A series ofN-Cbz-α-aminoglutarimides  

    Lee, Jaewon , Choi, Jongwon , Park, Minsoo
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 248 - 250 , 1996 , 0253-6269 ,

    초록

    In the previous reports (Park et al., 1991, and 1993), we described the synthesis and analgesic effects of various homovanillic amides as analogs of capsaicin. In the study, we tried to enhance the analgesic actvity of capsaicin by structural modification. Our study has been performed in three directions. First, the amide bond of capsaicin was transposed. Second, a phenyl ring was introduced to replace a double bond of capsaicin. Finally, aminoethylation was performed on 4-hydroxy group of capsaicin to improve oral bioavailability. These studies have led to N-(3-phenylpropyl)homovanillic amide 2 which has high analgesic activity. Our continuing efforts in this area have focused on the introduction of various substituents on the phenyl ring of 2 as well as their pharmacological studies. We report herein the synthesis of homovanillic amide derivatives and their analgesic activity.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [국내논문]   Synthesis and Anticonvulsant Evaluation of a Series of $N-Cbz-\alpha-aminoglutarimides$   피인용횟수: 1

    Lee, Jaewon (Koshin Medical Center ) , Choi, Jongwon (College of Pharmacy, Kyung-Sung University ) , Park, Minsoo (College of Pharmacy, Kyung-Sung University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.19 no.3 ,pp. 248 - 250 , 1996 , 0253-6269 ,

    초록

    In conclusion, a series of N-Cbz-.alpha.-amono-glutarimides (1a-f), combining common structures such as N-CO-C-N and cyclic imide in a single molecule, were prepared from the (R)- or (S)-N-Cbz-glutamic acid and evaluated for their anticonvulsant activities in MES and PTZ tests in order to develope new and broad spectrum anticonvulsant. In this study, N-Cbz-.alpha.-aminoglutarimides (1) except ac and af, showed significant anticonvulsant activity in both MES and PTZ tests enough to be recommended as promising new anticonvulsant drug candidates. Now we are continuing to investigate further anticonvulsant test (quantification)for these compounds and synthesize their analogues in order to develop more active anticonvulsant and define the structure activity relationship more precisely.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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