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Epilepsy & behavior : E&B 20건

  1. [해외논문]   Are the clinical classifications for psychogenic nonepileptic seizures reliable?   SCIE

    Duwicquet, Coline (Department of Neurology, University Hospital of Tours, France ) , de Toffol, Bertrand (Department of Neurology, University Hospital of Tours, France ) , Corcia, Philippe (Department of Neurology, University Hospital of Tours, France ) , Bonnin, Maxime (Clinique Psychiatrique Universitaire, CHRU de Tours, Tours, France ) , El-Hage, Wissam (Clinique Psychiatrique Universitaire, CHRU de Tours, Tours, France ) , Biberon, Julien (Department of Neurology, University Hospital of Tours, France)
    Epilepsy & behavior : E&B v.77 ,pp. 53 - 57 , 2017 , 1525-5050 ,

    초록

    Abstract Background Psychogenic nonepileptic seizures (PNESs) are episodes that resemble epileptic seizures but are of psychological origin. A few studies have attempted to describe different types of PNES as a combination of clinical signs but their validation and robustness have not yet been reached. The aim of this study was to assess the inter-rater reliability (IRR) of five existing clinical PNES classifications. Methods A total of 107 PNESs from 54 patients were retrospectively analyzed independently by two trained epileptologists, who were blinded to each other's findings. The recorded events were grouped according to the five chosen classifications systems. The IRR was measured using a kappa ( κ ) coefficient for each PNES classification. We also report category-specific κ values. Results Our study demonstrated a mild to moderate IRR ( κ from 0.44–0.68) for classifying PNES using the 5 proposed classification schemes. Within these classifications, the most reproducible classes are the subjective ones followed by the dialeptic group. Classes based on motor signs are the least reproducible. Conclusion The IRR for current clinical classifications of PNES was only moderate. The difficulty to analyze motor signs could explain this poor reliability. It is necessary to ensure the reliability of clinical classifications of PNES in order for them to be a relevant tool in clinical practice or to explore correlations in clinical research. Future research would benefit from increased precision of diagnostic criteria specific to each class. Highlights Reliability for classification of psychogenic nonepileptic seizures is only moderate. Subjective and atonic classes are reliable, motor classes are not. Conscious state and subjective signs could be discriminant in PNES classification. More reliable classifications are needed to be used as a relevant tool.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  2. [해외논문]   Validation of the Polish version of the Beck Depression Inventory in patients with epilepsy   SCIE

    Wiglusz, Mariusz S. (Department of Psychiatry, Medical University of Gdańsk, Poland ) , Landowski, Jerzy (Department of Psychiatry, Medical University of Gdańsk, Poland ) , Michalak, Lidia (Regional Epilepsy Outpatient Unit, Copernicus Hospital, Gdańsk, Poland ) , Cubała, Wiesław J. (Department of Psychiatry, Medical University of Gdańsk, Poland)
    Epilepsy & behavior : E&B v.77 ,pp. 58 - 61 , 2017 , 1525-5050 ,

    초록

    Abstract Background Despite the fact that depressive disorders are the most common comorbidities among patients with epilepsy (PWE), such disorders often go unrecognized and untreated. In addition, the availability of validated screening instruments to detect depression in PWE is limited. The aim of the present study was thus to validate the Polish version of the Beck Depression Inventory (BDI) in adult PWE. Methods A group of 118 outpatient PWE were invited to participate in the study. Ninety-six patients meeting the inclusion criteria completed the Polish Version of Beck Depression Inventory-I (BDI-I) and were examined by a trained psychiatrist using the Structured Clinical Interview (SICD-I) for Diagnostic and statistical manual of mental disorders - fourth edition (Text revision) (DSM-IV-TR). Receiver operating characteristic (ROC) curves were used to determine the optimal threshold scores for BDI. Results Receiver operating characteristic analysis showed the area under the curve to be approximately 84%. For major depressive disorder (MDD) diagnosis, the BDI demonstrated the best psychometric properties for a cut-off score to be 18, with a sensitivity of 90.5%, specificity of 70.7%, positive predictive value (PPV) of 46.3%, and negative predictive value (NPV) of 96.4%. For the ‘any depressive disorder’ group, the BDI optimum cut-off score was 11, with a sensitivity of 82.5%, specificity of 73.2%, PPV of 68.8%, and NPV of 85.4%. Conclusions The BDI score is a valid psychometric indicator for depressive disorders in PWE maintaining adequate sensitivity and specificity, high NPV, and acceptable PPV with an optimum cut-off score of 18 for MDD diagnosis. Highlights Depressive disorders are the most common comorbidities among patients with epilepsy The availability of standardized clinical instruments in epilepsy is limited with few validation studies available so far The BDI-I optimal cut-off score in the epilepsy setting for indicating major depression was=18 points The BDI-I maintains proper sensitivity and specificity in screening for depressive disorders in epilepsy population In epilepsy the specific cut-off points should be adopted

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   When adverse effects are seen as desirable: Abuse potential of the newer generation antiepileptic drugs   SCIE

    Hawkins, Kelsey L. (Kaiser Permanente Northwest, Department of Neurology, 10180 SE Sunnyside Rd, Clackamas, OR, United States ) , Gidal, Barry E. (University of Wisconsin, Department of Neurology, 777 Highland Ave, Madison, WI 53705, United States)
    Epilepsy & behavior : E&B v.77 ,pp. 62 - 72 , 2017 , 1525-5050 ,

    초록

    Abstract There has been growing recognition of the possible abuse potential of newer generation antiepileptic drugs, and several of these agents have been categorized as controlled substances in the United States. To properly schedule a new medication, the abuse potential, or the potential for a drug to be used for its nonmedical positive subjective effects, must be determined. Performing a human abuse potential study is one step in the overall abuse potential assessment. These studies analyze the abuse potential of a new drug in a very specific population of known recreational drug users. Studying the test drug in this population enables a more meaningful assessment of abuse, and likely represents the population most probable to abuse. In these double-blind, single-dose, active and placebo controlled studies subjects may report their subjective liking, estimated street value, and rate euphoric or depressive sensations of the test drug compared with placebo and scheduled active comparators with a known abuse potential. In order to provide an enhanced understanding of the abuse potential assessment and how it relates to controlled substance scheduling, this review will examine the human abuse potential studies of perampanel, eslicarbazepine, lacosamide, and brivaracetam. Highlights Growing evidence indicates that antiepileptic drugs have the potential to be abused. Human abuse potential studies are conducted to assess abuse liability of a medication. These studies enroll recreational drug users and assess subjective measures. Human abuse studies of antiepileptic drugs provide insight into drug scheduling.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Lennox–Gastaut syndrome in adulthood: Long-term clinical follow-up of 38 patients and analysis of their recorded seizures   SCIE

    Vignoli, Aglaia (Epilepsy Center, San Paolo Hospital, Milan, Italy ) , Oggioni, Gaia (Epilepsy Center, San Paolo Hospital, Milan, Italy ) , De Maria, Giovanni (Epilepsy Center, Spedali Civili, Brescia, Italy ) , Peron, Angela (Epilepsy Center, San Paolo Hospital, Milan, Italy ) , Savini, Miriam Nella (Epilepsy Center, San Paolo Hospital, Milan, Italy ) , Zambrelli, Elena (Epilepsy Center, San Paolo Hospital, Milan, Italy ) , Chiesa, Valentina (Epilepsy Center, San Paolo Hospital, Milan, Italy ) , La Briola, Francesca (Epilepsy Center, San Paolo Hospital, Milan, Italy ) , Turner, Katherine (Epilepsy Center, San Paolo Hospital, Milan, Italy ) , Canevini, Maria Paola (Epilepsy Center, San Paolo Hospital, Milan, Italy)
    Epilepsy & behavior : E&B v.77 ,pp. 73 - 78 , 2017 , 1525-5050 ,

    초록

    Abstract Lennox–Gastaut syndrome (LGS) is a severe epileptic encephalopathy with childhood onset that usually continues through adolescence and into adulthood. In the long term, patients with this condition still have intractable seizures, intellectual disability, behavioral problems, and physical comorbidities. The aim of this study was to describe the clinical and EEG characteristics of a group of adults with Lennox–Gastaut syndrome. We identified 38 (22 females, 16 males) patients with LGS older than age 18years at their last evaluation, with mean age of 43.3±10.6years. Median follow-up was 14.4years (range: 2–40). All of our patients had 3 or more seizure types during their clinical history. The most prevalent seizure types at follow-up were atypical absences (28/38), tonic (28/38), generalized tonic–clonic (17/38), focal (11/38), and myoclonic seizures (9/38). All patients had drug-resistant seizures. Besides epilepsy, intellectual disability and behavioral problems were prominent features. Surprisingly, paroxysmal nonepileptic seizures were reported in 3 patients. Our observations confirm the poor outcome of Lennox–Gastaut syndrome through adulthood, regardless of age at seizure onset, etiology, and history of previous West syndrome. Highlights Lennox–Gastaut syndrome maintains its electroclinical characteristics throughout life. The main seizure type is represented by tonic seizures, but other types are reported. Behavioral and physical comorbidities may worsen the quality of life in these patients. The outcome is invariably poor regardless of age at epilepsy onset, etiology, and previous West syndrome.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Which information on women's issues in epilepsy does a community pharmacist need to know? A Delphi consensus study   SCIE

    Shawahna, Ramzi (Department of Physiology, Pharmacology and Toxicology, Faculty of Medicine & Health Sciences, New Campus, Building: 19, Office: 1340, An-Najah National University, P.O. Box 7, Nablus, Palestine.)
    Epilepsy & behavior : E&B v.77 ,pp. 79 - 89 , 2017 , 1525-5050 ,

    초록

    Abstract Objective The aim of this study was to develop and achieve consensus on a core list of important knowledge items that community pharmacists should know on women's issues in epilepsy. Methods This was a consensual study using a modified Delphi technique. Knowledge items were collected from the literature and from nine key contacts who were interviewed on their views on what information community pharmacists should have on women's issues in epilepsy. More knowledge items were suggested by five researchers with interest in women's issues who were contacted to rate and comment on the knowledge items collected. Two iterative Delphi rounds were conducted among a panel of pharmacists ( n = 30) to achieve consensus on the knowledge items to be included in the core list. Ten panelists ranked the knowledge items by their importance using the Analytical Hierarchy Process (AHP). Results Consensus was achieved to include 68 knowledge under 13 categories in the final core list. Items ranked by their importance were related to the following: teratogenicity (10.3%), effect of pregnancy on epilepsy (7.4%), preconception counseling (10.3%), bone health (5.9%), catamenial epilepsy (7.4%), menopause and hormonal replacement therapy (2.9%), contraception (14.7%), menstrual disorders and infertility (8.8%), eclampsia (2.9%), breastfeeding (4.4%), folic acid and vitamin K (5.9%), counseling on general issues (14.7%), and sexuality (4.4%). Conclusion Using consensual knowledge lists might promote congruence in educating and/or training community pharmacists on women's issues in epilepsy. Future studies are needed to investigate if such lists can improve health services provided to women with epilepsy (WWE). Highlights Community pharmacists can play a key role in caring for women with epilepsy. There are no gold standards in designing courses to educate/train pharmacists on women’s issues in epilepsy. A core list of 68 important knowledge items on women’s health issues in epilepsy was developed using a consensus technique. Using such consensual core list might promote congruence in educating pharmacists on women’s health issues in epilepsy. Graphical abstract [DISPLAY OMISSION]

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Seizure semiology in leucine-rich glioma-inactivated protein 1 antibody-associated limbic encephalitis   SCIE

    Chen, Chao (Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ) , Wang, Xiu (China National Clinical Research Center for Neurological Diseases, Beijing, China ) , Zhang, Chao (China National Clinical Research Center for Neurological Diseases, Beijing, China ) , Cui, Tao (Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ) , Shi, Wei-Xiong (Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ) , Guan, Hong-Zhi (Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China ) , Ren, Hai-Tao (Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China ) , Shao, Xiao-Qiu (Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China)
    Epilepsy & behavior : E&B v.77 ,pp. 90 - 95 , 2017 , 1525-5050 ,

    초록

    Abstract Objective The objective of this study was to advance the characterization of seizure semiology in leucine-rich glioma-inactivated protein 1 (LGI1) antibody-associated limbic encephalitis (LE). Methods Eighteen patients diagnosed with LGI1 LE were identified. Seizure semiology, demographic features, MRI and fluorodeoxyglucose positron emission tomography (FDG-PET), electroencephalograms, and outcomes following immunotherapy were evaluated. Results Patients were divided into the following groups based on seizure semiology: faciobrachial dystonic seizure only (FBDS-only, n=4), epileptic seizure without FBDS (Non-FBDS, n=6), and FBDS plus epileptic seizure (FBDS+, n=8). In the group with Non-FBDS, the majority of patients (5/6) manifested mesial temporal lobe epilepsy (MTLE) like semiology (i.e., fear, epigastric rising, staring, and automatisms) with a frequency of 7±5 times per day and a duration of 15.3±14.3s. In the group with FBDS+, the distinctive symptom was FBDS followed by epileptic events, especially automatisms (7/8), with a frequency of 16±12 times per day and a duration of 13.0±8.0s. In these cases, 67% and 50% of the patients showed abnormalities on MRI and FDG-PET, respectively, and the mesial temporal lobe structures were most often involved. Ictal discharges were observed in 0/4, 6/6, and 8/8 of the patients in the groups with FBDS only, Non-FBDS, and FBDS+, respectively. The temporal lobe was mainly affected. Immunotherapy had favorable therapeutic effects. Significance The LGI1 LE should be considered as one disease syndrome with a series of clinical manifestation. Identifying types of unique semiology features will facilitate the early diagnosis and the timely initiation of immunotherapy. Highlights Based on semiology, LGI1 LE patient can be divided into three groups. Non-FBDS group manifested MTLE-like semiology with frequent and short duration attacks. In the FBDS+ group, the most common phenotype was FBDS followed by automatisms. Immunotherapy had favorable therapeutic effects on LGI1 LE.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Physical activity, stigma, and quality of life in patients with epilepsy   SCIE

    Tedrus, Gloria Maria Almeida Souza (Corresponding author.) , Sterca, Guilherme Sabbag , Pereira, Renato Buarque
    Epilepsy & behavior : E&B v.77 ,pp. 96 - 98 , 2017 , 1525-5050 ,

    초록

    Abstract Indication of physical activity (PA) for people with epilepsy (PWE) is debatable. This study investigated whether the International Physical Activity Questionnaire (IPAQ) score is related to the clinical aspects of epilepsy, QOLIE-31, and the Stigma Scale of Epilepsy (SSE) score of 67 PWE at a significance level of 5% ( p About one-third (32.8%) of the PWE were sedentary/irregularly active. Lower QOLIE-31 scores and higher SSE scores were found in PWE who did not practice PA for fear of seizures and in sedentary/irregularly active PWE. Twenty-three percent of the PWE stopped practicing PA for fear of seizures. The predictive factors in the logistic regression equation for not practicing physical activity for fear of seizures were the presence of depressive disorder ( p = 0.049) and temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) ( p = 0.024). Most PWE are sedentary and do not practice PA for fear of seizures. Physical activity is negatively influenced by clinical aspects of epilepsy. Less PA is associated with depressive disorder, worse quality of life, and higher perception of stigma. Highlights The relationship between physical activity, stigma, and quality of life was investigated in 67 people with epilepsy (PWE). Most PWE are sedentary and do not practice physical activity (PA) for fear of seizures. Physical activity is negatively influenced by the clinical aspects of epilepsy. Less physical activity is associated with worse QoL and higher perception of stigma.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   White matter integrity correlates with depressive symptomatology in temporal lobe epilepsy   SCIE

    Kavanaugh, Brian (Department of Psychiatry & Human Behavior, Alpert Medical School of Brown University, USA ) , Correia, Stephen (Department of Psychiatry & Human Behavior, Alpert Medical School of Brown University, USA ) , Jones, Jacob (Department of Psychiatry & Human Behavior, Alpert Medical School of Brown University, USA ) , Blum, Andrew (Rhode Island Hospital, USA ) , LaFrance Jr, W.C. (Department of Psychiatry & Human Behavior, Alpert Medical School of Brown University, USA ) , Davis Jr, Jennifer Duncan (Department of Psychiatry & Human Behavior, Alpert Medical School of Brown University, USA)
    Epilepsy & behavior : E&B v.77 ,pp. 99 - 105 , 2017 , 1525-5050 ,

    초록

    Abstract Rationale White matter abnormalities occur in both temporal lobe epilepsy (TLE) and depression, but there is limited research examining the depression–white matter association in depressed individuals with TLE. This study examined the relationship between white matter integrity (WMI) and depression including the influence of age at seizure onset, in adults with TLE, TLE and depression, and depression only. Methods Thirty-one adults were in one of three groups: TLE without depression (TLE; n=11), TLE with depression (TLE+DEP; n=9), and depression without TLE (DEP; n=11). Participants completed structured interviews for depression diagnosis and severity. White matter integrity was estimated based on fractional anisotropy (FA) calculated in frontotemporolimbic (FTL) and non-FTL regions in the JHU DTI atlas. Results In adults with TLE (n=20), depressive symptomology was significantly correlated with FA in non-FTL regions and trended toward significance in FTL regions. These associations were found in FTL (statistically significant) and non-FTL (trended toward significance) regions in participants with childhood seizure onset but not in those with adolescent/adult seizure onset. Conclusions Current results suggest that WMI, within FTL and non-FTL regions, are associated with depressive symptomology in adults with TLE. This association may be most notable in those with childhood-onset epilepsy. These findings could have important implications for the conceptualization and clinical care of neuropsychiatric comorbidities in TLE. Highlights This study examined white matter integrity (WMI) in depression and temporal lobe epilepsy. Depression severity was associated with WMI in FTL and non-FTL regions. This association was found in childhood, but not in adolescent/adult, onset epilepsy. WMI may reflect one neurobiologic, pathogenic mechanism underlying TLE–depression.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Epilepsy as a Network Disorder (1): What can we learn from other network disorders such as autistic spectrum disorder and mood disorders?   SCIE

    Kanner, Andres M. (Department of Neurology, University of Miami, Miller School of Medicine, 1120 NW 14th Street, Room #1324, Miami, FL 33136, USA ) , Scharfman, Helen (New York University Langone Medical Center, New York, NY 10016, USA ) , Jette, Nathalie (Icahn School of Medicine at Mount Sinai, Department of Neurology, New York, NY, USA ) , Anagnostou, Evdokia (Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Road, Toronto, ON M4G 1R8, Canada ) , Bernard, Christophe (NS —) , Camfield, Carol (Institute de Neurosciences des Systemes, UMR INSERM 1106, Aix-Marseille Université, Equipe Physionet, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France ) , Camfield, Peter (Department of Pediatrics, Dalhousie University Halifax, Nova Scotia, Canada ) , Legg, Karen (Department of Pediatrics, Dalhousie University Halifax, Nova Scotia, Canada ) , Dinstein, Ilan (Division of Neurology, Department of Medicine, Halifax Infirmary, Halifax B3H4R2, Nova Scotia, Canada ) , Giacobbe, Peter (Departments of Psychology and Brain & Cognitive Sciences, Zlotowski Centre for Neuroscience, Ben-Gurion University of the Negev, Be'er Sheva, Israel ) , Friedman, Alon (Cen) , Pohlmann-Eden, Bernd
    Epilepsy & behavior : E&B v.77 ,pp. 106 - 113 , 2017 , 1525-5050 ,

    초록

    Abstract Epilepsy is a neurologic condition which often occurs with other neurologic and psychiatric disorders. The relation between epilepsy and these conditions is complex. Some population-based studies have identified a bidirectional relation, whereby not only patients with epilepsy are at increased risk of suffering from some of these neurologic and psychiatric disorders (migraine, stroke, dementia, autism, depression, anxiety disorders, Attention deficit hyperactivity disorder (ADHD), and psychosis), but also patients with these conditions are at increased risk of suffering from epilepsy. The existence of common pathogenic mechanisms has been postulated as a potential explanation of this phenomenon. To reassess the relationships between neurological and psychiatric conditions in general, and specifically autism, depression, Alzheimer's disease, schizophrenia, and epilepsy, a recent meeting brought together basic researchers and clinician scientists entitled “Epilepsy as a Network Disorder.” This was the fourth in a series of conferences, the “Fourth International Halifax Conference and Retreat”. This manuscript summarizes the proceedings on potential relations between Epilepsy on the one hand and autism and depression on the other. A companion manuscript provides a summary of the proceedings about the relation between epilepsy and Alzheimer's disease and schizophrenia, closed by the role of translational research in clarifying these relationships. The review of the topics in these two manuscripts will provide a better understanding of the mechanisms operant in some of the common neurologic and psychiatric comorbidities of epilepsy. Highlights Depression and ASD are common comorbidities in patients with epilepsy. The high comorbidity results from common pathogenic mechanisms. Disruptions of common neurocircuits in the brain can also explain the high comorbidity. Potential pathogenic mechanisms include genetic, neuroendocrine, inflammatory, and neurotransmitter disturbances.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  10. [해외논문]   Corrigendum to “Advanced morphological neuroimaging study in lateral temporal lobe epilepsy: A multicentric study” [Epilepsy Behav 74 (2017) Pages 69–72]   SCIE

    Vasta, Roberta (Institute of Molecular Bioimaging and Physiology of the National Research Council (IBFM-CNR), Catanzaro, Italy ) , Sarica, Alessia (Institute of Molecular Bioimaging and Physiology of the National Research Council (IBFM-CNR), Catanzaro, Italy ) , Bisulli, Francesca (IRCCS Institute of Neurological Science of Bologna and Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy ) , Di Gennaro, Giancarlo (IRCSS Neuromed, Pozzilli, Italy ) , D'Aniello, Alfredo (IRCSS Neuromed, Pozzilli, Italy ) , Difrancesco, Jacopo C. (Neurology Unit, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy ) , Canafoglia, Laura (Neurophysiology and Diagnostic Epilepsy, Besta's Institute, Milano, Italy ) , Casazza, Marina (Neurophysiology and Diagnostic Epilepsy, Besta's Institute, Milano, Italy ) , Franceschetti, Silvana (Neurophysiology and Diagnostic Epilepsy, Besta's Institute, Milano, Italy ) , Stipa, Carlotta (IRCCS Institute of Neurological Science of Bologna and Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy ) , Tinuper, Paolo (IRCCS Institute of Neurological Science of Bologna and Department of Biomedical and Neuromotor Sciences, University of Bolo) , Mumoli, Laura , Gambardella, Antonio , Labate, Angelo
    Epilepsy & behavior : E&B v.77 ,pp. 114 - 114 , 2017 , 1525-5050 ,

    초록

    Abstract Epilepsy is a neurologic condition which often occurs with other neurologic and psychiatric disorders. The relation between epilepsy and these conditions is complex. Some population-based studies have identified a bidirectional relation, whereby not only patients with epilepsy are at increased risk of suffering from some of these neurologic and psychiatric disorders (migraine, stroke, dementia, autism, depression, anxiety disorders, Attention deficit hyperactivity disorder (ADHD), and psychosis), but also patients with these conditions are at increased risk of suffering from epilepsy. The existence of common pathogenic mechanisms has been postulated as a potential explanation of this phenomenon. To reassess the relationships between neurological and psychiatric conditions in general, and specifically autism, depression, Alzheimer's disease, schizophrenia, and epilepsy, a recent meeting brought together basic researchers and clinician scientists entitled “Epilepsy as a Network Disorder.” This was the fourth in a series of conferences, the “Fourth International Halifax Conference and Retreat”. This manuscript summarizes the proceedings on potential relations between Epilepsy on the one hand and autism and depression on the other. A companion manuscript provides a summary of the proceedings about the relation between epilepsy and Alzheimer's disease and schizophrenia, closed by the role of translational research in clarifying these relationships. The review of the topics in these two manuscripts will provide a better understanding of the mechanisms operant in some of the common neurologic and psychiatric comorbidities of epilepsy. Highlights Depression and ASD are common comorbidities in patients with epilepsy. The high comorbidity results from common pathogenic mechanisms. Disruptions of common neurocircuits in the brain can also explain the high comorbidity. Potential pathogenic mechanisms include genetic, neuroendocrine, inflammatory, and neurotransmitter disturbances.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지

논문관련 이미지