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Infection, genetics and evolution : journal of mol... 26건

  1. [해외논문]   Genomic characterization and evolution of Tacaiuma orthobunyavirus (Peribunyaviridae family) isolated in Brazil   SCIE

    de Melo Junior, Aristides Bezerra (Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Pará, Brazil ) , de Souza Junior, William Marciel (Virology Research Center, School of Medicine of Ribeirão Preto of University of São Paulo, Ribeirão Preto, SP, Brazil ) , Acrani Junior, Gustavo Olszanski (Universidade Federal da Fronteira Sul, Passo Fundo, Rio Grande do Sul, Brazil ) , Carvalho Junior, Valé (Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Pará, Brazil ) , ria Lima (Virology Research Center, School of Medicine of Ribeirão Preto of University of São Paulo, Ribeirão Preto, SP, Brazil ) , Romeiro Junior, Marilia Farignoli (Virology Research Center, School of Medicine of Ribeirão Preto of University of São Paulo, Ribeirão Preto, SP, Brazil ) , Tolardo Junior, Aline Lavado (Center for Technological Innovations, Evandro Chagas Institute, Ministry of Health, Ananindeua, Pará, Brazil ) , da Silva Junior, Sandro Patroca (Center for Technological Innovations, Evandro Chagas Institute, Ministry of Health, Ananindeua, Pará, Brazil ;) , Cardoso Junior, Jedson Ferreira , de Oliveira Chiang Junior, Jannifer , da Silva Gonç , alves Vianez Jú , nior, Joã , o Lí , dio , do Socorro da Silva Azevedo Jú , nior, Raimunda , Figueiredo Jú , nior, Luiz Tadeu Moraes , da Costa Vasconcelos Jú , nior, Pedro Fernando , Nunes Jú , nior, Má , rcio Roberto Teixeira , de Almeida Medeiros Jú , nior, Daniele Barbosa
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases v.60 ,pp. 71 - 76 , 2018 , 1567-1348 ,

    초록

    Abstract Tacaiuma virus (TCMV) is antigenically characterized as a member of the Anopheles A complex in the Orthobunyavirus genus, Peribunyaviridae family ( Bunyavirales order). Clinically, the TCMV infection is characterized by acute febrile illness with myalgia and arthralgia lasting three to five days. However, the genomic and evolutionary aspect of this virus has not been elucidated. In this study, we described the complete coding sequences of three segments of two TCMV strains isolated in Brazil and three complete coding sequences of the small segment of three TCMV strains. All the strains sequenced in this study showed the typical genomic organization of orthobunyaviruses that infect vertebrates, except for the absence of the open reading frame that encodes the well-described non-structural small protein. This study presents the genomic and evolutionary characterization of TCMV strains and would be helpful for diagnostic purposes and epidemiology. Highlights First report of complete coding sequence of Tacaiuma orthobunyavirus Expansion of the orthobunyaviruses diversity Genomic and phylogenetic characterization of five strains of Tacaiuma orthobunyavirus

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  2. [해외논문]   Coexistence of mcr-1, bla KPC-2 and two copies of fosA3 in a clinical Escherichia coli strain isolated from urine   SCIE

    Zhao, Dongdong (Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, China ) , Zhou, Zhihui (Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, China ) , Hua, Xiaoting (Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, China ) , Zhang, Huichuan (Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, China ) , Quan, Jingjing (Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, China ) , Li, Xi (Centre of Laboratory Medicine, Zhejiang Provincial People's Hospital, Hangzhou 310014, China ) , Yu, Yunsong (Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, China)
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases v.60 ,pp. 77 - 79 , 2018 , 1567-1348 ,

    초록

    Abstract Here we report the first clinical Escherichia coli isolate co-harboring mcr-1 , bla KPC-2 and two copies of fosA3 from China. The five plasmids of the isolate were completely sequenced and analyzed. Gene mcr-1 and bla KPC-2 were located on IncI2 and IncR plasmid, respectively. A variety of other resistance determinants such as fosA3 (two copies), bla CTX-M-123 , bla OXA-1 and bla CTX-M-65 were also identified from the rest plasmids. Highlights First clinical Escherichia coli isolate co-harbored mcr-1 , bla KPC-2 and two copies of fosA3 from China. The isolate was sensitive only to amikacin and tetracyclines, including tigecycline and minocycline. Resistance to polymyxin and cabarpenems leaves very few therapeutic options and surveillance is in urgent need.

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  3. [해외논문]   Comparative genomics of Vibrio cholerae El Tor strains isolated at epidemic complications in Siberia and at the Far East   SCIE

    Mironova, Liliya V. (Irkutsk Antiplague Research Institute of Rospotrebnadzor, 78, Trillisser str., Irkutsk 664047, Russia ) , Gladkikh, Anna S. (Irkutsk Antiplague Research Institute of Rospotrebnadzor, 78, Trillisser str., Irkutsk 664047, Russia ) , Ponomareva, Anna S. (Irkutsk Antiplague Research Institute of Rospotrebnadzor, 78, Trillisser str., Irkutsk 664047, Russia ) , Feranchuk, Sergey I. (Irkutsk Antiplague Research Institute of Rospotrebnadzor, 78, Trillisser str., Irkutsk 664047, Russia ) , Bochalgin, Nikita О. (Irkutsk Antiplague Research Institute of Rospotrebnadzor, 78, Trillisser str., Irkutsk 664047, Russia ) , Basov, Evgenii A. (Irkutsk Antiplague Research Institute of Rospotrebnadzor, 78, Trillisser str., Irkutsk 664047, Russia ) , Yu. Khunkheeva, Zhanna (Irkutsk Antiplague Research Institute of Rospotrebnadzor, 78, Trillisser str., Irkutsk 664047, Russia ) , Balakhonov, Sergey V. (Irkutsk Antiplague Research Institute of Rospotrebnadzor, 78, Trillisser str., Irkutsk 664047, Russia)
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases v.60 ,pp. 80 - 88 , 2018 , 1567-1348 ,

    초록

    Abstract The territory of Siberia and the Far East of Russia is classified as epidemically safe for cholera; however, in the 1970s and 1990s a number of infection importation cases and acute outbreaks associated with the cholera importation were reported. Here, we analyze genomes of four Vibrio cholerae El Tor strains isolated from humans during epidemic complications (imported cases, an outbreak) in the 1990s. The analyzed strains harbor the classical allele of the cholera toxin subunit B gene ( ctx B1); thus, belong to genetically altered variants of the El Tor biotype. Analysis of the genomes revealed their high homology with the V. cholerae N16961 reference strain: 85–93 SNPs were identified in the core genome as compared to the reference. The determined features of SNPs in the CTX prophage made it possible to propose the presence of a new subtype – CTX-2a in two strains; the other two strains carried the prophage of CTX-3 type. Results of phylogenetic analysis based on SNP-typing demonstrated that two strains belonged to the second wave, and two – to the early third wave of cholera dissemination in the world. Phylogenetic reconstruction in combination with epidemiological data permitted to trace the origin of the strains and the way of their importation to the Russian Federation directly or through temporary cholera foci. Highlights V. cholerae isolated in the region in 1990s are altered variants of El Tor biovar. A new subtype of the CTX prophage – CTX-2a – was specified. Strains of the 2nd and the 3rd waves provided complications of cholera in the region. Origin of strains and ways of importation to the territory were traced.

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  4. [해외논문]   Identification of two novel CRESS DNA viruses associated with an Avipoxvirus lesion of a blue-and-gray Tanager (Thraupis episcopus)   SCIE

    Moens, Michaë (Department of Biodiversity, Ecology and Evolution, Faculty of Biology, Complutense University of Madrid. Calle José) , l A.J. (Antonio Nováis 12, 28040 Madrid, Spain ) , Pé (Department of Biodiversity, Ecology and Evolution, Faculty of Biology, Complutense University of Madrid. Calle José) , rez-Tris, Javier (Antonio Nováis 12, 28040 Madrid, Spain ) , Cortey, Martí (Departament de Sanitat i d'Anatomia Animals, Universitat Autònoma de Barcelona. 08193 Cerdanyola del Vallès, Spain ) , (Department of Physiology, Genetics and Microbiology, Faculty of Biology, Complutense University of Madrid. Calle José) , Bení (Antonio Nováis 12, 28040,Madrid, Spain) , tez, Laura
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases v.60 ,pp. 89 - 96 , 2018 , 1567-1348 ,

    초록

    Abstract The discovery of circular rep-encoding single stranded (CRESS) DNA viruses has increased spectacularly over the past decade. They represent the smallest animal viruses known worldwide infecting a wide variety of invertebrates and vertebrates in different natural and human-made environments. The extremely low similarity of nucleotide and protein sequences among different CRESS DNA genomes has challenged their classification. Moreover, the existence of capsid proteins (Cp) remains difficult to demonstrate which is crucial to understand the structural properties of these viruses. Here we describe two unclassified CRESS DNA viruses isolated from a cutaneous lesion, caused by a strain of Avipoxvirus , from a blue-and-gray tanager ( Thraupis episcopus ) in Southern Ecuador. Both viruses present replication-associated proteins (Rep) and one to two open reading frames (ORF), one of which represents a putative Cp. The two new Rep are long proteins characterized by the existence of the several highly conserved amino acid residues characteristic of rolling circle replication. Within the putative Cp we detected intrinsically disordered regions (IDR), potential protein and DNA binding regions, and nuclear localization signals (NLS), providing further evidence of presumed Cp. Despite being found on the same host lesion, both viruses show low similarity between each other ( Highlights Two new CRESSDNA viruses are described. They were found on an Avipoxvirus lesion from a tanager species in Ecuador. They present a replication-associated protein and several open reading frames. Characterized intrinsically disordered regions and nuclear localization signals indicate putative capsid proteins. Both genomes share features with Circoviridae although the similarity with the members of the family is below 65%.

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  5. [해외논문]   Recombination in the rabies virus and other lyssaviruses   SCIE

    Deviatkin, Andrei A. (Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia ) , Lukashev, Alexander N. (Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia)
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases v.60 ,pp. 97 - 102 , 2018 , 1567-1348 ,

    초록

    Abstract Recombination is a common event in RNA viruses; however, in the rabies virus there have been only a few reports of isolated recombination events. Comprehensive analysis found traces of recent recombination events within Arctic, Arctic-like and Africa 1b rabies virus groups, as well as recombination between distinct lyssaviruses. Recombination breakpoints were not linked to gene boundaries and could be detected all over the genome. However, there was no evidence that recombination is an important factor in the genetic variability of the rabies virus. It is therefore likely that recombination in the rabies virus is limited by ecological factors (e.g., rare co-circulation of distinguishable lineages and a narrow window for productive coinfection in most carnivore hosts), rather than molecular barriers (e.g., incompatibility of genome fragments). Highlights A comprehensive computational analysis of recombination in rabies viruses and other lyssaviruses was conducted. According to the results of the analysis natural recombination is quite possible (albeit rare) in lyssaviruses. Low recombination frequency is likely due to rare co-circulation of viruses and a narrow window for productive coinfection.

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  6. [해외논문]   Molecular evolution of H1N1 swine influenza in Guangdong, China, 2016–2017   SCIE

    Cai, Mengkai (College of Veterinary Medicine, South China Agricultural University, Guangzhou, China ) , Huang, Junming (College of Veterinary Medicine, South China Agricultural University, Guangzhou, China ) , Bu, Dexin (College of Veterinary Medicine, South China Agricultural University, Guangzhou, China ) , Yu, Zhiqing (College of Veterinary Medicine, South China Agricultural University, Guangzhou, China ) , Fu, Xinliang (College of Veterinary Medicine, South China Agricultural University, Guangzhou, China ) , Ji, Chihai (College of Veterinary Medicine, South China Agricultural University, Guangzhou, China ) , Zhou, Pei (College of Veterinary Medicine, South China Agricultural University, Guangzhou, China ) , Zhang, Guihong (College of Veterinary Medicine, South China Agricultural University, Guangzhou, China)
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases v.60 ,pp. 103 - 108 , 2018 , 1567-1348 ,

    초록

    Abstract Swine are the main host of the H1N1 swine influenza virus (SIV), however, H1N1 can also infect humans and occasionally cause serious respiratory disease. To trace the evolution of the SIV in Guangdong, China, we performed an epidemic investigation during the period of 2016–2017. Nine H1N1 influenza viruses were isolated from swine nasal swabs. Antigenic analysis revealed that these viruses belonged to two distinct antigenic groups, represented by A/Swine/Guangdong/101/2016 and A/Swine/Guangdong/52/2017. Additionally, three genotypes, known as GD52/17-like, GD493/17-like and GD101/16-like, were identified by phylogenetic analysis. Importantly, the genotypes including a minimum of 4 pdm/09-origin internal genes have become prevalent in China in recent years. A total of 2966 swine serum samples were used to perform hemagglutination inhibition (HI) tests, and the results showed that the seroprevalence values of SW/GD/101/16 (32.2% in 2016, 32.1% in 2017) were significantly higher than the seroprevalence values of SW/GD/52/17 (18.0% in 2016, 16.7% in 2017). Our study showed that the three reassortant genotypes of H1N1 SIV currently circulating in China are stable, but H1N1pdm09 poses challenges to human health by the introduction of internal genes into these reassortant genotypes. Strengthening SIV surveillance is therefore critical for SIV control and minimizing its potential threat to public health. Highlights Three genotypes of H1N1 SIVs, including two distinct antigenic groups, have recently become predominant. Pdm/09-origin internal genes continue to exist in current SIVs. TRIG origin NS segment has replaced other origin segment as a dominant H1N1 SIVs subtype. First report that documented the seroprevalence of two groups of EA H1N1 lineage in the Chinese swine population.

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  7. [해외논문]   Genetic populations and virulence factors of Helicobacter pylori   SCIE

    Kabamba, Evariste Tshibangu (Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-City, Oita 879-5593, Japan ) , Tuan, Vo Phuoc (Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-City, Oita 879-5593, Japan ) , Yamaoka, Yoshio (Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-City, Oita 879-5593, Japan)
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases v.60 ,pp. 109 - 116 , 2018 , 1567-1348 ,

    초록

    Abstract Helicobacter pylori is a bacterium that has infected more than half of the human population worldwide. This bacterium is closely associated with serious human diseases, such as gastric cancer, and identifying and understanding factors that predict bacterial virulence is a priority. In addition, this pathogen shows high genetic diversity and co-evolution with human hosts. H . pylori population genetics, therefore, has emerged as a tool to track human demographic history. As the number of genome sequences available is increasing, studies on the evolution and virulence of H . pylori are gaining momentum. This review article summarizes the most recent findings on H . pylori virulence factors and population genetics. Highlights Virulence factors are ever key points for H . pylori related pathogenesis. The genetics of H . pylori prophage sequences bring interesting features. New H . pylori populations will enounce the usefulness for tracing human migrations.

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  8. [해외논문]   Up-regulated Th17 cell function is associated with increased peptic ulcer disease in Helicobacter pylori-infection   SCIE

    Bagheri, Nader (Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran ) , Razavi, Alireza (Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran ) , Pourgheysari, Batoul (Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran ) , Azadegan-Dehkordi, Fatemeh (Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran ) , Rahimian, Ghorbanali (Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran ) , Pirayesh, Ashkan (Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran ) , Shafigh, Mohammedhadi (Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran ) , Rafieian-Kopaei, Mahmoud (Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran ) , Fereidani, Rana (Department of Pathology, Shahrekord Un) , Tahmasbi, Kamran , Shirzad, Hedayatollah
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases v.60 ,pp. 117 - 125 , 2018 , 1567-1348 ,

    초록

    Abstract Background During Helicobacter pylori ( H. pylori ) infection CD4 + T cells in the gastric lamina propria are hyporesponsive and polarized by Th1/Th17 cell responses controlled by Treg cells. The objective of this study was to determine the number of Th17 cells in gastric mucosa of patients with gastritis and peptic ulcer and determined the relationship between main virulence factor of H. pylori and Th17 cells. Methods and materials A total of 89 H. pylori -infected gastritis patients, 63 H. pylori -infected peptic ulcer patients and 48 H. pylori -negative non-ulcer dysplasia patients were enrolled in this study. The number of Th17 was determined by immunohistochemistry. IL-8 and IL-17A expressions were determined by real-time polymerase chain reaction (qPCR). Also, the grade of chronic and active inflammation was investigated for involvement according to the density of neutrophils and mononuclear in gastric mucosal crypts, from one to all crypts. Results The number of Th17 cells and the expression of IL-8 and IL-17A in infected patients were significantly higher than uninfected subjects. The number of Th17 cells and the expression of IL-8 and IL-17A in infected patients with peptic ulcer were significantly higher than patients with gastritis. Additionally, the numbers of Th17 cells as well as the expression of IL-8 and IL-17A were positively correlated with the degree of H. pylori density in infected patients with peptic ulcer, while this correlation was negative in infected patients with gastritis. The numbers of Th17 cells as well as the expression of IL-8 and IL-17A were positively correlated with the degree of chronic inflammation. Conclusion The predominant Th17 cell responses may play a role in the pathogenesis of peptic ulcers disease in infected patients. Highlights The number of Th17 cells in infected patients had a significantly higher than uninfected. The number of Th17 cells was dependent on the oipA, but it was independent on cagA. The number of Th17 cells in infected patients with peptic ulcer was significantly higher. The numbers of Th17 cells was positively correlated with the degree of chronic inflammation. The numbers of Th17 cells was positively correlated with H. pylori density in patients with PUD.

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  9. [해외논문]   ArgO145, a Stx2a prophage of a bovine O145:H- STEC strain, is closely related to phages of virulent human strains   SCIE

    Krü (Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CONICET-CIC, Laboratorio de Inmunoquímica y Biotecnología, Argentina ) , ger, A. (Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CONICET-CIC, Laboratorio de Inmunoquímica y Biotecnología, Argentina ) , Burgá (University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, The Netherlands. ) , n, J. (University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, The Netherlands. ) , Friedrich, A.W. (Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CONICET-CIC, Laboratorio de Inmunoquímica y Biotecnología, Argentina) , Rossen, J.W.A. , Lucchesi, P.M.A.
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases v.60 ,pp. 126 - 132 , 2018 , 1567-1348 ,

    초록

    Abstract Shiga toxins (Stx) are the main virulence factor of a pathogroup of Escherichia coli strains that cause severe human diseases. These toxins are encoded in prophages (Stx prophages), and generally their expression depends on prophage induction. Several studies have reported high diversity among both Stx prophages and Stx. In particular, the toxin subtype Stx2a is associated with high virulence and HUS. Here, we report the genome of ArgO145, an inducible Stx2a prophage identified in a bovine O145:H‐ strain which produced high levels of Shiga toxin and Stx phage particles. The ArgO145 genome shared lambda phage organization, with recombination, regulation, replication, lysis, and head and tail structural gene regions, although some lambda genes encoding regulatory proteins could not be identified. Remarkably, some Stx2a phages of strains isolated from patients in other countries showed high similarity to ArgO145. Highlights The genome of ArgO145, an inducible Stx2a prophage of a bovine STEC, was analyzed. ArgO145 shared high identity with some phages detected in clinical O157:H7 strains It shows similar organization to other stx phages with differences in early genes. ArgO145 carried several genes probably associated with persistence in the host.

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  10. [해외논문]   The dynamics of norovirus genotypes and genetic analysis of a novel recombinant GII.P12-GII.3 among infants and children in Bangkok, Thailand between 2014 and 2016   SCIE

    Boonchan, Michittra (Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI), Nonthaburi 11000, Thailand ) , Guntapong, Ratigorn (National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand ) , Sripirom, Napas (Bhumibol Adulyadej Hospital, Bangkok 10220, Thailand ) , Ruchusatsawat, Kriangsak (National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand ) , Singchai, Phakapun (National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand ) , Rungnobhakhun, Pimpha (Bhumibol Adulyadej Hospital, Bangkok 10220, Thailand ) , Tacharoenmuang, Ratana (National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand ) , Mizushima, Hiroto (Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI), Nonthaburi 11000, Thailand ) , Tatsumi, Masashi (Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI), Nonthaburi 11000, Thailand ) , Takeda, Naokazu (Thailand-Japan Research Collaboration Center o) , Sangkitporn, Somchai , Mekmullica, Jutarat , Motomura, Kazushi
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases v.60 ,pp. 133 - 139 , 2018 , 1567-1348 ,

    초록

    Abstract Norovirus (NoV) is the leading cause of viral acute gastroenteritis among all age groups in the world. We performed a molecular epidemiological study of the NoVs prevalent in Bangkok between November 2014 and July 2016 to investigate the emergence of new NoV variants in Thailand. A total of 332 stool specimens were collected from hospitalized pediatric patients with acute gastroenteritis in Bangkok, Thailand. NoVs were detected by real-time PCR. The genome of the N-terminal/shell domain was amplified, the nucleotide sequence was determined, and phylogenetic analyses were performed. GII NoV was detected in 58 (17.5%) of the 332 specimens. GII.17, a genotype strain prevalent from 2014 to mid-2015, was hardly detected and replaced by the GII.3 genotype strain. Entire genome sequencing followed by phylogenetic analysis of the GII.3 genotype strains indicated that they are new recombinant viruses, because the genome encoding ORF1 is derived from a GII.12 genotype strain, whereas that encoding ORF2-3 is from a GII.3 genotype strain. The putative recombination breakpoints with the highest statistical significance were located around the border of 3D pol and ORF2. The change in the prevalent strain of NoV seems to be linked to the emergence of new forms of recombinant viruses. These findings suggested that the swapping of the structural and non-structural proteins of NoV is a common mechanism by which new epidemic variants are generated in nature. Highlights Detection of norovirus GII.3 cases in 2014–2016 in Thailand Phylogenetic tree with the nearly full genome sequence, ORF1, ORF2, and ORF3 of NoV GII.3 Recombination strain between GII.P12 and GII.3 from Recombination Detection Program

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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